Linkage of a bipolar disorder susceptibility locus to human chromosome 13q32 in a new pedigree series

Molecular Psychiatry

Volumn 8, Issue 5, 2003, Pages 558-564

  Shaw, S H ^a,b,g   Mroczkowski Parker, Z ^a,c   Shekhtman, T ^a,c   Alexander, M ^a,c   Remick, R A ^d   Sadovnick, A D ^e   McElroy, S L ^f   Keck Jr , P E ^f   Kelsoe, J R ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^d ST PAUL S HOSPITAL   (Canada)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^f UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^g ILLUMINA INC   (United States)

Author keywords

Bipolar disorder; Genetic linkages; Human Chromosome 13; Manic depressive illness

Indexed keywords

ARTICLE; BIPOLAR DISORDER; CHROMOSOME 13; CHROMOSOME 13Q; CHROMOSOME MAP; GENE LOCUS; GENETIC DISORDER; GENETIC LINKAGE; GENETIC PREDISPOSITION; GENETIC SUSCEPTIBILITY; GENETICS; GENOME; HUMAN; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; MENTAL DISEASE; PEDIGREE; PRIORITY JOURNAL; SCHIZOPHRENIA;

BIPOLAR DISORDER; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 13; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LINKAGE (GENETICS); PEDIGREE;

EID: 0038235879     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4001267     Document Type: Article

References (34)

1. Goodwin FK, Jameson KR. Manic-Depressive Illness. Oxford University Press: New York, 1990.
2. Tsuang MT, Faraone SV. The Genetics of Mood Disorders. Johns Hopkins University Press: Baltimore, MD, 1990.
3. Kelsoe JR, Spence MA, Loetscher E, Foguet M, Sadovnick AD, Remick RA et al. A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome. Proc Natl Acad Sci USA 2001; 98: 585-590.
4. Detera-Wadleigh SD, Badner JA, Berrettini WH, Yoshikawa T, Goldin LR, Turner G et al. A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2. Proc Natl Acad Sci USA 1999; 96: 5604-5609.
5. Blouin JL, Dombroski BA, Nath SK, Lasseter VK, Wolyniec PS, Nestadt G et al. Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. Nat Genet 1998; 20: 70-73.
6. Brzustowicz LM, Honer WG, Chow EW, Little D, Hogan J, Hodgkinson K, et al. Linkage of familial schizophrenia to chromosome 13q32. Am J Hum Genet 1999; 65: 1096-1103.
7. Ott J. Computer-simulation methods in human linkage analysis. Proc Natl Acad Sci USA 1989; 86: 4175-4178.
8. Weeks DE, Ott J, Lathrop GM. SLINK: a general simulation program for linkage analysis. Am J Hum Genet 1990; 47: A204.
9. Lathrop GM, Lalouel JM. Easy calculations of lod scores and genetic risks on small computers. Am J Hum Genet 1984; 36: 460-465.
10. Cottingham Jr RW, Idury RM, Schaffer AA. Faster sequential genetic linkage computations. Am J Hum Genet 1993; 53: 252-263.
11. Abecasis GR, Cherny SS, Cookson WO, Cardon LR. MERLIN - rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 2002; 30: 97-101.
12. Ott J. Analysis of Human Genetic Linkage. 3rd edn. Johns Hopkins University Press: Baltimore, (1999).
13. Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 1995; 11: 241-247.
14. Stine OC, McMahon FJ, Chen L, Xu J, Meyers DA, MacKinnon DF, et al. Initial genome screen for bipolar disorder in the NIMH genetics initiative pedigrees: chromosomes 2, 11, 13, 14 and X. Am J Med Genet 1997; 74: 263-269.
15. Foroud T, Castelluccio PF, Koller DL, Edenberg HJ, Miller M, Bowman E et al. Suggestive evidence of a locus on chromosome 10p using the NIMH genetics initiative bipolar affective disorder pedigrees. Am J Med Genet 2000; 96: 18-23.
16. Cichon S, Schumacher J, Muller DJ, Hurter M, Windemuth C, Strauch K et al. A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q. Hum Mol Genet 2001; 10: 2933-2944.
17. Coon H, Jensen S, Hoff M, Holik J, Plaetke R, Reimherr F, et al. A genome-wide search for genes predisposing to manic-depression, assuming autosomal dominant inheritance. Am J Hum Genet 1993; 52: 1234-1249.
18. Friddle C, Koskela R, Ranade K, Hebert J, Cargill M, Clark CD et al. Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype. Am J Hum Genet 2000; 66: 205-215.
19. Bennett P, Segurado R, Jones I, Bort S, McCandless F, Lambert D et al. The Wellcome trust UK-Irish bipolar affective disorder sibling-pair genome screen: first stage report. Mol Psychiatry 2002; 7: 189-200.
20. Kelsoe JR. Recent progress in the search for genes for bipolar disorder. Curr Psychiatry Rep 1999; 1: 135-140.
21. Berrettini WH. Susceptibility loci for bipolar disorder: overlap with inherited vulnerability to schizophrenia. Biol Psychiatry 2000; 47: 245-251.
22. Wildenauer DB, Schwab SG, Maier W, Detera-Wadleigh SD. Do schizophrenia and affective disorder share susceptibility genes? Schizophr Res 1999; 39: 107-111.
23. Lin MW, Sham P, Hwu HG, Collier D, Murray R, Powell JF. Suggestive evidence for linkage of schizophrenia to markers on chromosome 13 in Caucasian but not Oriental populations. Hum Genet 1997; 99: 417-420.
24. Shaw SH, Kelly M, Smith AB, Shields G, Hopkins PJ, Loftus J et al. A genome-wide search for schizophrenia susceptibility genes. Am J Med Genet 1998; 81: 364-376.
25. Spitzer RL, Williams JBW, Gibbon M. Structured Clinical Interview for DSM-3-R (SCID). New York State Psychiatric Institute Biometrics Research: New York, 1987.
26. Don RH, Cox PT, Wainwright BJ, Baker K, Mattick JS. 'Touchdown' PCR to circumvent spurious priming during gene amplification. Nucleic Acids Res 1991; 19: 4008.
27. O'Connell JR, Weeks DE. PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 1998; 63: 259-266.
28. Matise TC, Perlin M, Chakravarti A. Automated construction of genetic linkage maps using an expert system (MultiMap): a human genome linkage map. Nat Genet 1994; 6: 384-390.
29. Lander ES, Green P. Construction of multilocus genetic linkage maps in humans. Proc Natl Acad Sci USA 1987; 84: 2363-2367.
30. Broman KW, Murray JC, Sheffield VC, White RL, Weber JL. Comprehensive human genetic maps: individual and sex-specific variation in recombination. Am J Hum Genet 1998; 63: 861-869.
31. Terwilliger JD, Spear M, Ott J. Chromosome-based method for rapid computer simulation in human genetic linkage analysis. Genet Epidemiol 1993; 10: 217-224.
32. Ott J. Linkage probability and its approximate confidence interval under possible heterogeneity. Genet Epidemiol Suppl 1986; 1: 251-257.
33. Kong A, Cox NJ. Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Genet 1997; 61: 1179-1188.
34. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES. Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 1996; 58: 1347-1363.