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Volumn 37, Issue 18, 2009, Pages 6028-6041

Ionizing radiation-dependent and independent phosphorylation of the 32-kDa subunit of replication protein A during mitosis

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; CELL PROTEIN; CYCLIN B KINASE; CYCLIN DEPENDENT KINASE 1; DNA PROTEIN KINASE; MONOCLONAL ANTIBODY; REPLICATION FACTOR A; REPLICATION FACTOR A2; UNCLASSIFIED DRUG;

EID: 70349301958     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkp605     Document Type: Article
Times cited : (31)

References (74)
  • 1
    • 3943107573 scopus 로고    scopus 로고
    • Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
    • Sancar,A., Lindsey-Boltz,L.A., Unsal-Kacmaz,K. and Linn,S. (2004) Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu. Rev. Biochem., 73, 39-85.
    • (2004) Annu. Rev. Biochem , vol.73 , pp. 39-85
    • Sancar, A.1    Lindsey-Boltz, L.A.2    Unsal-Kacmaz, K.3    Linn, S.4
  • 2
    • 0032192140 scopus 로고    scopus 로고
    • The complexity of p53 modulation: Emerging patterns from divergent signals
    • Giaccia,A.J. and Kastan,M.B. (1998) The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev., 12, 2973-2983.
    • (1998) Genes Dev , vol.12 , pp. 2973-2983
    • Giaccia, A.J.1    Kastan, M.B.2
  • 4
    • 33645789832 scopus 로고    scopus 로고
    • Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks
    • Sakasai,R., Shinohe,K., Ichijima,Y., Okita,N., Shibata,A., Asahina,K. and Teraoka,H. (2006) Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks. Genes Cells, 11, 237-246.
    • (2006) Genes Cells , vol.11 , pp. 237-246
    • Sakasai, R.1    Shinohe, K.2    Ichijima, Y.3    Okita, N.4    Shibata, A.5    Asahina, K.6    Teraoka, H.7
  • 5
    • 0030908093 scopus 로고    scopus 로고
    • Replication protein A: A heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism
    • Wold,M.S. (1997) Replication protein A: A heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. Annu. Rev. Biochem., 66, 61-92.
    • (1997) Annu. Rev. Biochem , vol.66 , pp. 61-92
    • Wold, M.S.1
  • 6
    • 0032538561 scopus 로고    scopus 로고
    • Replication protein A stimulates long patch DNA base excision repair
    • DeMott,M.S., Zigman,S. and Bambara,R.A. (1998) Replication protein A stimulates long patch DNA base excision repair. J. Biol. Chem., 273, 27492.
    • (1998) J. Biol. Chem , vol.273 , pp. 27492
    • DeMott, M.S.1    Zigman, S.2    Bambara, R.A.3
  • 7
    • 0028929611 scopus 로고
    • RPA involvement in the damage-recognition and incision steps of nucleotide excision repair
    • He,Z., Henricksen,L.A., Wold,M.S. and Ingles,C.J. (1995) RPA involvement in the damage-recognition and incision steps of nucleotide excision repair. Nature, 374, 566-569.
    • (1995) Nature , vol.374 , pp. 566-569
    • He, Z.1    Henricksen, L.A.2    Wold, M.S.3    Ingles, C.J.4
  • 8
    • 0035937811 scopus 로고    scopus 로고
    • Basis for avid homologous DNA strand exchange by human Rad51 and RPA
    • Sigurdsson,S., Trujillo,K., Song,B., Stratton,S. and Sung,P. (2001) Basis for avid homologous DNA strand exchange by human Rad51 and RPA. J. Biol. Chem., 276, 8798-8806.
    • (2001) J. Biol. Chem , vol.276 , pp. 8798-8806
    • Sigurdsson, S.1    Trujillo, K.2    Song, B.3    Stratton, S.4    Sung, P.5
  • 9
    • 3442896884 scopus 로고    scopus 로고
    • Replication protein A phosphorylation and the cellular response to DNA damage
    • Binz,S.K., Sheehan,A.M. and Wold,M.S. (2004) Replication protein A phosphorylation and the cellular response to DNA damage. DNA Repair 3, 1015-1024.
    • (2004) DNA Repair , vol.3 , pp. 1015-1024
    • Binz, S.K.1    Sheehan, A.M.2    Wold, M.S.3
  • 10
    • 70350657685 scopus 로고    scopus 로고
    • Eukaryotic single-stranded DNA binding proteins: Central factors in genome stability
    • Nasheuer,H.P, ed, Springer, Berlin, Germany, in press
    • Broderick,S., Rehmet,K., Concannon,C. and Nasheuer,H.P. (2009) Eukaryotic single-stranded DNA binding proteins: Central factors in genome stability. In Nasheuer,H.P. (ed.), Genome Stability and Human Diseases Vol. 50. Springer, Berlin, Germany, in press.
    • (2009) Genome Stability and Human Diseases , vol.50
    • Broderick, S.1    Rehmet, K.2    Concannon, C.3    Nasheuer, H.P.4
  • 11
    • 33749134033 scopus 로고    scopus 로고
    • A dynamic model for replication protein A (RPA) function in DNA processing pathways
    • Fanning,E., Klimovich,V. and Nager,A.R. (2006) A dynamic model for replication protein A (RPA) function in DNA processing pathways. Nucleic Acids Res., 34, 4126-4137.
    • (2006) Nucleic Acids Res , vol.34 , pp. 4126-4137
    • Fanning, E.1    Klimovich, V.2    Nager, A.R.3
  • 12
    • 18244385718 scopus 로고    scopus 로고
    • ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation
    • Ball,H.L., Myers,J.S. and Cortez,D. (2005) ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation. Mol. Biol. Cell, 16, 2372-2381.
    • (2005) Mol. Biol. Cell , vol.16 , pp. 2372-2381
    • Ball, H.L.1    Myers, J.S.2    Cortez, D.3
  • 13
    • 44849093460 scopus 로고    scopus 로고
    • TopBP1 activates ATR through ATRIP and a PIKK regulatory domain
    • Mordes,D.A., Glick,G.G., Zhao,R. and Cortez,D. (2008) TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev., 22 1478-1489.
    • (2008) Genes Dev , vol.22 , pp. 1478-1489
    • Mordes, D.A.1    Glick, G.G.2    Zhao, R.3    Cortez, D.4
  • 14
    • 57349143725 scopus 로고    scopus 로고
    • The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling
    • Xu,X., Vaithiyalingam,S., Glick,G.G., Mordes,D.A., Chazin,W.J. and Cortez,D. (2008) The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling. Mol. Cell Biol. 28, 7345-7353.
    • (2008) Mol. Cell Biol , vol.28 , pp. 7345-7353
    • Xu, X.1    Vaithiyalingam, S.2    Glick, G.G.3    Mordes, D.A.4    Chazin, W.J.5    Cortez, D.6
  • 15
    • 0037567268 scopus 로고    scopus 로고
    • Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    • Zou,L. and Elledge,S.J. (2003) Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science, 300, 1542-1548.
    • (2003) Science , vol.300 , pp. 1542-1548
    • Zou, L.1    Elledge, S.J.2
  • 16
    • 0028355488 scopus 로고
    • UV light-induced DNA synthesis arrest in HeLa cells is associated with changes in phosphorylation of human single-stranded DNA-binding protein
    • Carty,M.P., Zernik-Kobak,M., McGrath,S. and Dixon,K. (1994) UV light-induced DNA synthesis arrest in HeLa cells is associated with changes in phosphorylation of human single-stranded DNA-binding protein. EMBO J., 13, 2114-2123.
    • (1994) EMBO J , vol.13 , pp. 2114-2123
    • Carty, M.P.1    Zernik-Kobak, M.2    McGrath, S.3    Dixon, K.4
  • 17
    • 0027428513 scopus 로고
    • The ionizing radiation-induced replication protein A phosphorylation response differs between ataxia telangiectasia and normal human cells
    • Liu,V.F. and Weaver,D.T. (1993) The ionizing radiation-induced replication protein A phosphorylation response differs between ataxia telangiectasia and normal human cells. Mol. Cell Biol., 13, 7222-7231.
    • (1993) Mol. Cell Biol , vol.13 , pp. 7222-7231
    • Liu, V.F.1    Weaver, D.T.2
  • 18
    • 0030810633 scopus 로고    scopus 로고
    • Sites of UV-induced phosphorylation of the p34 subunit of replication protein A from HeLa cells
    • Zernik-Kobak,M., Vasunia,K., Connelly,M., Anderson,C.W. and Dixon,K. (1997) Sites of UV-induced phosphorylation of the p34 subunit of replication protein A from HeLa cells. J. Biol. Chem., 272, 23896-23904.
    • (1997) J. Biol. Chem , vol.272 , pp. 23896-23904
    • Zernik-Kobak, M.1    Vasunia, K.2    Connelly, M.3    Anderson, C.W.4    Dixon, K.5
  • 19
    • 0030924695 scopus 로고    scopus 로고
    • Mapping of amino acid residues in the p34 subunit of human single-stranded DNA-binding protein phosphorylated by DNA-dependent protein kinase and Cdc2 kinase in vitro
    • Niu,H., Erdjument-Bromage,H., Pan,Z.Q., Lee,S.H., Tempst,P. and Hurwitz,J. (1997) Mapping of amino acid residues in the p34 subunit of human single-stranded DNA-binding protein phosphorylated by DNA-dependent protein kinase and Cdc2 kinase in vitro. J. Biol. Chem. 272, 12634-12641.
    • (1997) J. Biol. Chem , vol.272 , pp. 12634-12641
    • Niu, H.1    Erdjument-Bromage, H.2    Pan, Z.Q.3    Lee, S.H.4    Tempst, P.5    Hurwitz, J.6
  • 20
    • 2342618116 scopus 로고    scopus 로고
    • Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21
    • Block,W.D., Yu,Y. and Lees-Miller,S.P. (2004) Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21. Nucleic Acids Res., 32, 997-1005.
    • (2004) Nucleic Acids Res , vol.32 , pp. 997-1005
    • Block, W.D.1    Yu, Y.2    Lees-Miller, S.P.3
  • 21
    • 1642499359 scopus 로고    scopus 로고
    • Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities
    • Unsal-Kacmaz,K. and Sancar,A. (2004) Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities. Mol. Cell Biol., 24, 1292-1300.
    • (2004) Mol. Cell Biol , vol.24 , pp. 1292-1300
    • Unsal-Kacmaz, K.1    Sancar, A.2
  • 22
    • 20444375871 scopus 로고    scopus 로고
    • DNA damage induced hyperphosphorylation of replication protein A. 1. Identification of novel sites of phosphorylation in response to DNA damage
    • Nuss,J.E., Patrick,S.M., Oakley,G.G., Alter,G.M., Robison,J.G., Dixon,K. and Turchi,J.J. (2005) DNA damage induced hyperphosphorylation of replication protein A. 1. Identification of novel sites of phosphorylation in response to DNA damage. Biochemistry, 44, 8428-8437.
    • (2005) Biochemistry , vol.44 , pp. 8428-8437
    • Nuss, J.E.1    Patrick, S.M.2    Oakley, G.G.3    Alter, G.M.4    Robison, J.G.5    Dixon, K.6    Turchi, J.J.7
  • 23
    • 1342325347 scopus 로고    scopus 로고
    • Replication protein A (RPA) phosphorylation prevents RPA association with replication centers
    • Vassin,V.M., Wold,M.S. and Borowiec,J.A. (2004) Replication protein A (RPA) phosphorylation prevents RPA association with replication centers. Mol. Cell Biol., 24, 1930-1943.
    • (2004) Mol. Cell Biol , vol.24 , pp. 1930-1943
    • Vassin, V.M.1    Wold, M.S.2    Borowiec, J.A.3
  • 24
    • 33845991538 scopus 로고    scopus 로고
    • RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint
    • Olson,E., Nievera,C.J., Klimovich,V., Fanning,E. and Wu,X. (2006) RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint. J. Biol. Chem., 281, 39517-39533.
    • (2006) J. Biol. Chem , vol.281 , pp. 39517-39533
    • Olson, E.1    Nievera, C.J.2    Klimovich, V.3    Fanning, E.4    Wu, X.5
  • 25
    • 20444392406 scopus 로고    scopus 로고
    • DNA damage induced hyperphosphorylation of replication protein A. 2. Characterization of DNA binding activity, protein interactions, and activity in DNA replication and repair
    • Patrick,S.M., Oakley,G.G., Dixon,K. and Turchi,J.J. (2005) DNA damage induced hyperphosphorylation of replication protein A. 2. Characterization of DNA binding activity, protein interactions, and activity in DNA replication and repair. Biochemistry, 44, 8438-8448.
    • (2005) Biochemistry , vol.44 , pp. 8438-8448
    • Patrick, S.M.1    Oakley, G.G.2    Dixon, K.3    Turchi, J.J.4
  • 26
    • 37249080597 scopus 로고    scopus 로고
    • Sequential and synergistic modification of human RPA stimulates chromosomal DNA repair
    • Anantha,R.W., Vassin,V.M. and Borowiec,J.A. (2007) Sequential and synergistic modification of human RPA stimulates chromosomal DNA repair. J. Biol. Chem., 282, 35910-35923.
    • (2007) J. Biol. Chem , vol.282 , pp. 35910-35923
    • Anantha, R.W.1    Vassin, V.M.2    Borowiec, J.A.3
  • 27
    • 0025365192 scopus 로고
    • Cell-cycle-regulated phosphorylation of DNA replication factor A from human and yeast cells
    • Din,S., Brill,S.J., Fairman,M.P. and Stillman,B. (1990) Cell-cycle-regulated phosphorylation of DNA replication factor A from human and yeast cells. Genes Dev., 4, 968-977.
    • (1990) Genes Dev , vol.4 , pp. 968-977
    • Din, S.1    Brill, S.J.2    Fairman, M.P.3    Stillman, B.4
  • 28
    • 0026539144 scopus 로고
    • cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication
    • Dutta,A. and Stillman,B. (1992) cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication. EMBO J., 11, 2189-2199.
    • (1992) EMBO J , vol.11 , pp. 2189-2199
    • Dutta, A.1    Stillman, B.2
  • 29
    • 0242417571 scopus 로고    scopus 로고
    • RPA phosphorylation in mitosis alters DNA binding and protein-protein interactions
    • Oakley,G.G., Patrick,S.M., Yao,J., Carty,M.P., Turchi,J.J. and Dixon,K. (2003) RPA phosphorylation in mitosis alters DNA binding and protein-protein interactions. Biochemistry, 42, 3255-3264.
    • (2003) Biochemistry , vol.42 , pp. 3255-3264
    • Oakley, G.G.1    Patrick, S.M.2    Yao, J.3    Carty, M.P.4    Turchi, J.J.5    Dixon, K.6
  • 30
    • 0027517871 scopus 로고
    • Distinct roles of cdk2 and cdc2 in RP-A phosphorylation during the cell cycle
    • Fang,F. and Newport,J.W. (1993) Distinct roles of cdk2 and cdc2 in RP-A phosphorylation during the cell cycle. J. Cell Sci., 106 (Pt 3), 983-994.
    • (1993) J. Cell Sci , vol.106 , Issue.PART 3 , pp. 983-994
    • Fang, F.1    Newport, J.W.2
  • 31
    • 0029076734 scopus 로고
    • The role of the 34-kDa subunit of human replication protein A in simian virus 40 DNA replication in vitro
    • Lee,S.H. and Kim,D.K. (1995) The role of the 34-kDa subunit of human replication protein A in simian virus 40 DNA replication in vitro. J. Biol. Chem., 270, 12801-12807.
    • (1995) J. Biol. Chem , vol.270 , pp. 12801-12807
    • Lee, S.H.1    Kim, D.K.2
  • 32
    • 0027941616 scopus 로고
    • Replication protein A mutants lacking phosphorylation sites for p34cdc2 kinase support DNA replication
    • Henricksen,L.A. and Wold,M.S. (1994) Replication protein A mutants lacking phosphorylation sites for p34cdc2 kinase support DNA replication. J. Biol. Chem., 269, 24203-24208.
    • (1994) J. Biol. Chem , vol.269 , pp. 24203-24208
    • Henricksen, L.A.1    Wold, M.S.2
  • 33
    • 52049091055 scopus 로고    scopus 로고
    • Regulatory functions of the N-terminal domain of the 70-kDa subunit of replication protein A (RPA)
    • Binz,S.K. and Wold,M.S. (2008) Regulatory functions of the N-terminal domain of the 70-kDa subunit of replication protein A (RPA). J. Biol. Chem., 283, 21559-21570.
    • (2008) J. Biol. Chem , vol.283 , pp. 21559-21570
    • Binz, S.K.1    Wold, M.S.2
  • 34
    • 11044234004 scopus 로고    scopus 로고
    • Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway
    • Alderton,G.K., Joenje,H., Varon,R., Borglum,A.D., Jeggo,P.A. and O'Driscoll,M. (2004) Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway. Hum. Mol. Genet. 13, 3127-3138.
    • (2004) Hum. Mol. Genet , vol.13 , pp. 3127-3138
    • Alderton, G.K.1    Joenje, H.2    Varon, R.3    Borglum, A.D.4    Jeggo, P.A.5    O'Driscoll, M.6
  • 35
    • 33747614605 scopus 로고    scopus 로고
    • Involvement of novel autophosphorylation sites in ATM activation
    • Kozlov,S.V., Graham,M.E., Peng,C., Chen,P., Robinson,P.J. and Lavin,M.F. (2006) Involvement of novel autophosphorylation sites in ATM activation. EMBO J., 25, 3504-3514.
    • (2006) EMBO J , vol.25 , pp. 3504-3514
    • Kozlov, S.V.1    Graham, M.E.2    Peng, C.3    Chen, P.4    Robinson, P.J.5    Lavin, M.F.6
  • 38
    • 0025743047 scopus 로고
    • Cell cycle-dependent phosphorylation of human DNA polymerase alpha
    • Nasheuer,H.P., Moore,A., Wahl,A.F. and Wang,T.S. (1991) Cell cycle-dependent phosphorylation of human DNA polymerase alpha. J. Biol. Chem., 266, 7893-7903.
    • (1991) J. Biol. Chem , vol.266 , pp. 7893-7903
    • Nasheuer, H.P.1    Moore, A.2    Wahl, A.F.3    Wang, T.S.4
  • 39
    • 34250707267 scopus 로고    scopus 로고
    • Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases delta and epsilon during S phase
    • Bauerschmidt,C., Pollok,S., Kremmer,E., Nasheuer,H.P. and Grosse,F. (2007) Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases delta and epsilon during S phase. Genes Cells, 12, 745-758.
    • (2007) Genes Cells , vol.12 , pp. 745-758
    • Bauerschmidt, C.1    Pollok, S.2    Kremmer, E.3    Nasheuer, H.P.4    Grosse, F.5
  • 40
    • 33645366437 scopus 로고    scopus 로고
    • UV-induced RPA phosphorylation is increased in the absence of DNA polymerase eta and requires DNA-PK
    • Cruet-Hennequart,S., Coyne,S., Glynn,M.T., Oakley,G.G. and Carty,M.P. (2006) UV-induced RPA phosphorylation is increased in the absence of DNA polymerase eta and requires DNA-PK. DNA Repair (Amst), 5, 491-504.
    • (2006) DNA Repair (Amst) , vol.5 , pp. 491-504
    • Cruet-Hennequart, S.1    Coyne, S.2    Glynn, M.T.3    Oakley, G.G.4    Carty, M.P.5
  • 41
    • 8844254050 scopus 로고    scopus 로고
    • Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries
    • Leahy,J.J., Golding,B.T., Griffin,R.J., Hardcastle,I.R., Richardson,C., Rigoreau,L. and Smith,G.C. (2004) Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries. Bioorg. Med. Chem. Lett., 14 6083-6087.
    • (2004) Bioorg. Med. Chem. Lett , vol.14 , pp. 6083-6087
    • Leahy, J.J.1    Golding, B.T.2    Griffin, R.J.3    Hardcastle, I.R.4    Richardson, C.5    Rigoreau, L.6    Smith, G.C.7
  • 42
    • 0141619287 scopus 로고    scopus 로고
    • Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1
    • Veuger,S.J., Curtin,N.J., Richardson,C.J., Smith,G.C. and Durkacz,B.W. (2003) Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1. Cancer Res., 63, 6008-6015.
    • (2003) Cancer Res , vol.63 , pp. 6008-6015
    • Veuger, S.J.1    Curtin, N.J.2    Richardson, C.J.3    Smith, G.C.4    Durkacz, B.W.5
  • 44
    • 0037665145 scopus 로고    scopus 로고
    • Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials
    • Meijer,L. and Raymond,E. (2003) Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials. Acc. Chem. Res. 36, 417-425.
    • (2003) Acc. Chem. Res , vol.36 , pp. 417-425
    • Meijer, L.1    Raymond, E.2
  • 45
    • 0028245269 scopus 로고
    • Recombinant replication protein A: Expression, complex formation, and functional characterization
    • Henricksen,L.A., Umbricht,C.B. and Wold,M.S. (1994) Recombinant replication protein A: Expression, complex formation, and functional characterization. J. Biol. Chem., 269, 11121-11132.
    • (1994) J. Biol. Chem , vol.269 , pp. 11121-11132
    • Henricksen, L.A.1    Umbricht, C.B.2    Wold, M.S.3
  • 46
    • 0027080445 scopus 로고
    • Purification and functional characterization of bovine RP-A in an in vitro SV40 DNA replication system
    • Nasheuer,H.P., von Winkler,D., Schneider,C., Dornreiter,I., Gilbert,I. and Fanning,E. (1992) Purification and functional characterization of bovine RP-A in an in vitro SV40 DNA replication system. Chromosoma, 102, S52-S59.
    • (1992) Chromosoma , vol.102
    • Nasheuer, H.P.1    von Winkler, D.2    Schneider, C.3    Dornreiter, I.4    Gilbert, I.5    Fanning, E.6
  • 47
    • 0030945353 scopus 로고    scopus 로고
    • Phosphorylation of DNA polymerase alpha-primase by cyclin A-dependent kinases regulates initiation of DNA replication in vitro
    • Voitenleitner,C., Fanning,E. and Nasheuer,H.P. (1997) Phosphorylation of DNA polymerase alpha-primase by cyclin A-dependent kinases regulates initiation of DNA replication in vitro. Oncogene, 14, 1611-1615.
    • (1997) Oncogene , vol.14 , pp. 1611-1615
    • Voitenleitner, C.1    Fanning, E.2    Nasheuer, H.P.3
  • 48
    • 0035102810 scopus 로고    scopus 로고
    • Two immunologically distinct human DNA polymerase alpha-primase subpopulations are involved in cellular DNA replication
    • Dehde,S., Rohaly,G., Schub,O., Nasheuer,H.P., Bohn,W., Chemnitz,J., Deppert,W. and Dornreiter,I. (2001) Two immunologically distinct human DNA polymerase alpha-primase subpopulations are involved in cellular DNA replication. Mol. Cell Biol., 21, 2581-2593.
    • (2001) Mol. Cell Biol , vol.21 , pp. 2581-2593
    • Dehde, S.1    Rohaly, G.2    Schub, O.3    Nasheuer, H.P.4    Bohn, W.5    Chemnitz, J.6    Deppert, W.7    Dornreiter, I.8
  • 49
    • 0035851101 scopus 로고    scopus 로고
    • Multiple phosphorylation sites of DNA polymerase alpha-primase cooperate to regulate the initiation of DNA replication in vitro
    • Schub,O., Rohaly,G., Smith,R.W., Schneider,A., Dehde,S., Dornreiter,I. and Nasheuer,H.P. (2001) Multiple phosphorylation sites of DNA polymerase alpha-primase cooperate to regulate the initiation of DNA replication in vitro. J. Biol. Chem., 276, 38076-38083.
    • (2001) J. Biol. Chem , vol.276 , pp. 38076-38083
    • Schub, O.1    Rohaly, G.2    Smith, R.W.3    Schneider, A.4    Dehde, S.5    Dornreiter, I.6    Nasheuer, H.P.7
  • 50
    • 0037593945 scopus 로고    scopus 로고
    • Human replication protein A. The C-terminal RPA70 and the central RPA32 domains are involved in the interactions with the 3′-end of a primer-template DNA
    • Pestryakov,P.E., Weisshart,K., Schlott,B., Khodyreva,S.N., Kremmer,E., Grosse,F., Lavrik,O.I. and Nasheuer,H.P. (2003) Human replication protein A. The C-terminal RPA70 and the central RPA32 domains are involved in the interactions with the 3′-end of a primer-template DNA. J. Biol. Chem., 278, 17515-17524.
    • (2003) J. Biol. Chem , vol.278 , pp. 17515-17524
    • Pestryakov, P.E.1    Weisshart, K.2    Schlott, B.3    Khodyreva, S.N.4    Kremmer, E.5    Grosse, F.6    Lavrik, O.I.7    Nasheuer, H.P.8
  • 53
    • 0040952809 scopus 로고    scopus 로고
    • Protein-protein interactions of the primase subunits p58 and p48 with simian virus 40 T antigen are required for efficient primer synthesis in a cell-free system
    • Weisshart,K., Forster,H., Kremmer,E., Schlott,B., Grosse,F. and Nasheuer,H.P. (2000) Protein-protein interactions of the primase subunits p58 and p48 with simian virus 40 T antigen are required for efficient primer synthesis in a cell-free system. J. Biol. Chem., 275, 17328-17337.
    • (2000) J. Biol. Chem , vol.275 , pp. 17328-17337
    • Weisshart, K.1    Forster, H.2    Kremmer, E.3    Schlott, B.4    Grosse, F.5    Nasheuer, H.P.6
  • 54
    • 34548436939 scopus 로고    scopus 로고
    • Tension-sensitive Plk1 phosphorylation on BubR1 regulates the stability of kinetochore microtubule interactions
    • Elowe,S., Hummer,S., Uldschmid,A., Li,X. and Nigg,E.A. (2007) Tension-sensitive Plk1 phosphorylation on BubR1 regulates the stability of kinetochore microtubule interactions. Genes Dev., 21, 2205-2219.
    • (2007) Genes Dev , vol.21 , pp. 2205-2219
    • Elowe, S.1    Hummer, S.2    Uldschmid, A.3    Li, X.4    Nigg, E.A.5
  • 55
    • 12644291188 scopus 로고    scopus 로고
    • Cell cycle-dependent phosphorylation of mammalian protein phosphatase 1 by cdc2 kinase
    • Kwon,Y.G., Lee,S.Y., Choi,Y., Greengard,P. and Nairn,A.C. (1997) Cell cycle-dependent phosphorylation of mammalian protein phosphatase 1 by cdc2 kinase. Proc. Natl Acad. Sci. USA, 94, 2168-2173.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 2168-2173
    • Kwon, Y.G.1    Lee, S.Y.2    Choi, Y.3    Greengard, P.4    Nairn, A.C.5
  • 56
    • 0035584046 scopus 로고    scopus 로고
    • Replication protein A is sequentially phosphorylated during meiosis
    • Brush,G.S., Clifford,D.M., Marinco,S.M. and Bartrand,A.J. (2001) Replication protein A is sequentially phosphorylated during meiosis. Nucleic Acids Res., 29, 4808-4817.
    • (2001) Nucleic Acids Res , vol.29 , pp. 4808-4817
    • Brush, G.S.1    Clifford, D.M.2    Marinco, S.M.3    Bartrand, A.J.4
  • 57
    • 0343831400 scopus 로고    scopus 로고
    • Dynamics of human replication protein A subunit distribution and partitioning in the cell cycle
    • Murti,K.G., He,D.C., Brinkley,B.R., Scott,R. and Lee,S.H. (1996) Dynamics of human replication protein A subunit distribution and partitioning in the cell cycle. Exp. Cell Res., 223, 279-289.
    • (1996) Exp. Cell Res , vol.223 , pp. 279-289
    • Murti, K.G.1    He, D.C.2    Brinkley, B.R.3    Scott, R.4    Lee, S.H.5
  • 58
    • 0034284104 scopus 로고    scopus 로고
    • The majority of human replication protein A remains complexed throughout the cell cycle
    • Loo,Y.M. and Melendy,T. (2000) The majority of human replication protein A remains complexed throughout the cell cycle. Nucleic Acids Res., 28, 3354-3360.
    • (2000) Nucleic Acids Res , vol.28 , pp. 3354-3360
    • Loo, Y.M.1    Melendy, T.2
  • 60
    • 0842329845 scopus 로고    scopus 로고
    • Roscovitine sensitizes glioma cells to TRAIL-mediated apoptosis by downregulation of survivin and XIAP
    • Kim,E.H., Kim,S.U., Shin,D.Y. and Choi,K.S. (2004) Roscovitine sensitizes glioma cells to TRAIL-mediated apoptosis by downregulation of survivin and XIAP. Oncogene, 23, 446-456.
    • (2004) Oncogene , vol.23 , pp. 446-456
    • Kim, E.H.1    Kim, S.U.2    Shin, D.Y.3    Choi, K.S.4
  • 61
    • 0033561531 scopus 로고    scopus 로고
    • Roscovitine induces cell death and morphological changes indicative of apoptosis in MDA-MB-231 breast cancer cells
    • Mgbonyebi,O.P., Russo,J. and Russo,I.H. (1999) Roscovitine induces cell death and morphological changes indicative of apoptosis in MDA-MB-231 breast cancer cells. Cancer Res., 59, 1903-1910.
    • (1999) Cancer Res , vol.59 , pp. 1903-1910
    • Mgbonyebi, O.P.1    Russo, J.2    Russo, I.H.3
  • 62
    • 38349099227 scopus 로고    scopus 로고
    • Initiating the uninitiated: Replication of damaged DNA and carcinogenesis
    • Kaufmann,W.K. (2007) Initiating the uninitiated: Replication of damaged DNA and carcinogenesis. Cell Cycle, 6, 1460-1467.
    • (2007) Cell Cycle , vol.6 , pp. 1460-1467
    • Kaufmann, W.K.1
  • 63
    • 0029970505 scopus 로고    scopus 로고
    • Ionizing radiation-induced phosphorylation of RPA p34 is deficient in ataxia telangiectasia and reduced in aged normal fibroblasts
    • Cheng,X., Cheong,N., Wang,Y. and Iliakis,G. (1996) Ionizing radiation-induced phosphorylation of RPA p34 is deficient in ataxia telangiectasia and reduced in aged normal fibroblasts. Radiother. Oncol., 39, 43-52.
    • (1996) Radiother. Oncol , vol.39 , pp. 43-52
    • Cheng, X.1    Cheong, N.2    Wang, Y.3    Iliakis, G.4
  • 65
    • 0032189483 scopus 로고    scopus 로고
    • Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin
    • Sarkaria,J.N., Tibbetts,R.S., Busby,E.C., Kennedy,A.P., Hill,D.E. and Abraham,R.T. (1998) Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res., 58, 4375-4382.
    • (1998) Cancer Res , vol.58 , pp. 4375-4382
    • Sarkaria, J.N.1    Tibbetts, R.S.2    Busby, E.C.3    Kennedy, A.P.4    Hill, D.E.5    Abraham, R.T.6
  • 66
    • 0035577796 scopus 로고    scopus 로고
    • Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase
    • Wang,H., Guan,J., Wang,H., Perrault,A.R., Wang,Y. and Iliakis,G. (2001) Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase. Cancer Res., 61, 8554-8563.
    • (2001) Cancer Res , vol.61 , pp. 8554-8563
    • Wang, H.1    Guan, J.2    Wang, H.3    Perrault, A.R.4    Wang, Y.5    Iliakis, G.6
  • 67
    • 51349140504 scopus 로고    scopus 로고
    • RPA phosphorylation facilitates mitotic exit in response to mitotic DNA damage
    • Anantha,R.W., Sokolova,E. and Borowiec,J.A. (2008) RPA phosphorylation facilitates mitotic exit in response to mitotic DNA damage. Proc. Natl Acad. Sci. USA, 105, 12903-12908.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 12903-12908
    • Anantha, R.W.1    Sokolova, E.2    Borowiec, J.A.3
  • 68
    • 12844274301 scopus 로고    scopus 로고
    • DNA damage-induced mitotic catastrophe is mediated by the Chk1-dependent mitotic exit DNA damage checkpoint
    • Huang,X., Tran,T., Zhang,L., Hatcher,R. and Zhang,P. (2005) DNA damage-induced mitotic catastrophe is mediated by the Chk1-dependent mitotic exit DNA damage checkpoint. Proc. Natl Acad. Sci. USA, 102, 1065-1070.
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 1065-1070
    • Huang, X.1    Tran, T.2    Zhang, L.3    Hatcher, R.4    Zhang, P.5
  • 69
    • 0037195281 scopus 로고    scopus 로고
    • DNA damage during mitosis in human cells delays the metaphase/anaphase transition via the spindle-assembly checkpoint
    • Mikhailov,A., Cole,R.W. and Rieder,C.L. (2002) DNA damage during mitosis in human cells delays the metaphase/anaphase transition via the spindle-assembly checkpoint. Curr. Biol., 12, 1797-1806.
    • (2002) Curr. Biol , vol.12 , pp. 1797-1806
    • Mikhailov, A.1    Cole, R.W.2    Rieder, C.L.3
  • 72
    • 38949133032 scopus 로고    scopus 로고
    • Chk2 is required for optimal mitotic delay in response to irradiation-induced DNA damage incurred in G(2) phase
    • Rainey,M.D., Black,E.J., Zachos,G. and Gillespie,D.A. (2008) Chk2 is required for optimal mitotic delay in response to irradiation-induced DNA damage incurred in G(2) phase. Oncogene, 27, 896-906.
    • (2008) Oncogene , vol.27 , pp. 896-906
    • Rainey, M.D.1    Black, E.J.2    Zachos, G.3    Gillespie, D.A.4
  • 73
    • 33751301357 scopus 로고    scopus 로고
    • Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases
    • Syljuasen,R.G., Jensen,S., Bartek,J. and Lukas,J. (2006) Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases. Cancer Res., 66, 10253-10257.
    • (2006) Cancer Res , vol.66 , pp. 10253-10257
    • Syljuasen, R.G.1    Jensen, S.2    Bartek, J.3    Lukas, J.4


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