The low-frequency isoform of platelet glycoprotein VIb attenuates ligand-mediated signal transduction but not receptor expression or ligand binding

Blood

Volumn 114, Issue 9, 2009, Pages 1893-1899

  Trifiro, Elisabetta ^a,b   Williams, Shirley A ^c   Cheli, Yann ^a   Furihata, Kenichi ^a   Pulcinelli, Fabio M ^b   Nugent, Diane J ^c   Kunicki, Thomas J ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c CHILDREN S HOSPITAL OF ORANGE COUNTY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALMODULIN; COLLAGEN TYPE 1; CONVULXIN; GLYCOPROTEIN VI; ISOPROTEIN; PROTEIN KINASE FYN; PROTEIN KINASE LYN; PROTEIN KINASE SYK; COLLAGEN; FIBRINOGEN RECEPTOR; LECTIN; LIGAND; MESSENGER RNA; PLATELET MEMBRANE GLYCOPROTEIN VI; SNAKE VENOM;

ALLELE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYTOPLASM; GENETIC TRANSFECTION; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LIGAND BINDING; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; THROMBOCYTE; WESTERN BLOTTING; CELL LINE; CELL MEMBRANE; CHEMISTRY; METABOLISM; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE;

CELL LINE; CELL MEMBRANE; COLLAGEN; COLLAGEN TYPE I; CROTALID VENOMS; CYTOPLASM; HUMANS; LECTINS, C-TYPE; LIGANDS; PHOSPHORYLATION; PLATELET MEMBRANE GLYCOPROTEINS; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 70349249996     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-03-209510     Document Type: Article

References (33)

1. Clemetson JM, Polgar J, Magnenat E, Wells TNC, Clemetson KJ. The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcαR and the natural killer receptors. J Biol Chem. 1999;274:29019-29024. (Pubitemid 29477060)
2. Watson SP, Asazuma N, Atkinson B, et al. The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen. Thromb Haemostasis. 2001;86:276-288. (Pubitemid 32663958)
3. Furihata K, Kunicki TJ. Characterization of human glycoprotein VI gene 5 regulatory and promoter regions. Arterioscler Thromb Vasc Biol. 2002;22:1733-1739.
4. Ezumi Y, Uchiyama T, Takayama H. Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI. Biochem Biophys Res Commun. 2000;277:27-36. (Pubitemid 30796332)
5. Joutsi-Korhonen L, Smethurst PA, Rankin A, et al. The low-frequency allele of the platelet collagen signaling receptor glycoprotein VI is associated with reduced functional responses and expression. Blood. 2003;101:4372-4379. (Pubitemid 36857801)
6. 2β1 activity on human platelets. Blood. 1993;82:2693-2703.
7. Kato K, Furihata K, Cheli Y, Radis-Baptista G, Kunicki TJ. Effect of multimer size and a natural dimorphism on the binding of convulxin to platelet glycoprotein (GP)VI. J Thromb Haemost. 2006;4:1107-1113.
8. Suzuki-Inoue K, Tulasne D, Shen Y, et al. Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling. J Biol Chem. 2002;277:21561-21566. (Pubitemid 34952302)
9. Furihata K, Clemetson KJ, Deguchi H, Kunicki TJ. Variation in human platelet glycoprotein VI content modulates glycoprotein VI-specific prothrombinase activity. Arterioscler Thromb Vasc Biol. 2001;21:1857-1863. (Pubitemid 34219793)
10. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-δδCT) method. Methods. 2001;25:402-408. (Pubitemid 34164012)
11. Samaha FF, Hibbard C, Sacks J, et al. Measurement of platelet collagen receptor density in human subjects. Arterioscler Thromb Vasc Biol. 2004;24:e181-e182.
12. Samaha FF, Hibbard C, Sacks J, et al. Density of platelet collagen receptors glycoprotein VI and α2ss1 and prior myocardial infarction in human subjects, a pilot study. Med Sci Monit. 2005;11:CR224-CR229. (Pubitemid 40790935)
13. Gardiner EE, Karunakaran D, Shen Y, et al. Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases. J Thromb Haemost. 2007;5:1530-1537. (Pubitemid 46965384)
14. Mancini F, Rigacci S, Berti A, Balduini C, Torti M. The low-molecular-weight phosphotyrosine phosphatase is a negative regulator of FcγRIIA-mediated cell activation. Blood. 2007;110:1871-1878. (Pubitemid 47443899)
15. Andrews RK, Gardiner EE, Asazuma N, et al. A novel viper venom metalloproteinase, alborhagin, is an agonist at the platelet collagen receptor GPVI. J Biol Chem. 2001;276:28092-28097. (Pubitemid 37391509)
16. Newland SA, Macaulay IC, Floto AR, et al. The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro. Blood. 2007;109:4806-4809.
17. Best D, Senis YA, Jarvis GE, et al. GPVI levels in platelets: relationship to platelet function at high shear. Blood. 2003;102:2811-2818. (Pubitemid 37248851)
18. Bigalke B, Lindemann S, Ehlers R, et al. Expression of platelet collagen receptor glycoprotein VI is associated with acute coronary syndrome. Eur Heart J. 2006;27:2165-2169. (Pubitemid 44412829)
19. Bigalke B, Langer H, Geisler T, Lindemann S, Gawaz M. Platelet glycoprotein VI: a novel marker for acute coronary syndrome. Semin Thromb Hemost. 2007;33:179-184. (Pubitemid 46427761)
20. Jones CI, Garner SF, Angenent W, et al. Mapping the platelet profile for functional genomic studies and demonstration of the effect size of the GP6 locus. J Thromb Haemost. 2007;5:1756-1765. (Pubitemid 47091421)
21. Ollikainen E, Mikkelsson J, Perola M, Penttila A, Karhunen PJ. Platelet membrane collagen receptor glycoprotein VI polymorphism is associated with coronary thrombosis and fatal myocardial infarction in middle-aged men. Atherosclerosis. 2004;176:95-99. (Pubitemid 39078650)
22. Yu ZQ, Dong NZ, Gao WQ, Bai X, Ruan CG. [Study on T13254C polymorphism of the platelet membrane glycoprotein VI in Chinese Han population.] Zhonghua Xue Ye Xue Za Zhi. 2005;26:140-143.
23. Qin Q, Zhao BR, Mao YM, et al. [Association of matrix metalloproteinase-9 and platelet membrane glycoprotein VI polymorphisms with acute coronary syndrome.] Zhonghua Xin Xue Guan Bing Za Zhi. 2005;33:622-626.
24. Croft SA, Samani NJ, Teare MD, et al. Novel platelet membrane glycoprotein VI dimorphism is a risk factor for myocardial infarction. Circulation. 2001;104:1459-1463. (Pubitemid 32917335)
25. 1 C807T and GPVI Q317L and risk of ischemic stroke. J Thromb Haemost. 2003;1:963-970.
26. Lecut C, Arocas V, Ulrichts H, et al. Identification of residues within human GPVI involved in the binding to collagen: evidence for the existence of distinct binding sites. J Biol Chem. 2004;279:52293-52299. (Pubitemid 39656603)
27. Andrews RK, Suzuki-Inoue K, Shen Y, et al. Interaction of calmodulin with the cytoplasmic domain of platelet glycoprotein VI. Blood. 2002;99:4219-4221. (Pubitemid 35332069)
28. Locke D, Liu C, Peng X, Chen H, Kahn ML. FcRγ-independent signaling by the platelet collagen receptor glycoprotein VI. J Biol Chem. 2003;278:15441-15448. (Pubitemid 36799885)
29. Gardiner EE, Arthur JF, Berndt MC, Andrews RK. Role of calmodulin in platelet receptor function. Curr Med Chem Cardiovasc Hematol Agents. 2005;3:283-287.
30. Massberg S, Konrad I, Bultmann A, et al. Soluble glycoprotein VI dimer inhibits platelet adhesion and aggregation to the injured vessel wall in vivo. FASEB J. 2004;18:397-399.
31. Nieswandt B, Schulte V, Bergmeier W, et al. Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice. J Exp Med. 2001;193:459-470. (Pubitemid 32524477)
32. Hirao A, Huang XL, Suda T, Yamaguchi N. Overexpression of C-terminal Src kinase homologous kinase suppresses activation of Lyn tyrosine kinase required for VLA5-mediated Dami cell spreading. J Biol Chem. 1998;273:10004-10010. (Pubitemid 28183102)
33. Berlanga O, Tulasne D, Bori T, et al. The Fc receptor γ-chain is necessary and sufficient to initiate signalling through glycoprotein VI in transfected cells by the snake C-type lectin, convulxin. Eur J Biochem. 2002;269:2951-2960. (Pubitemid 34754024)