Density of platelet collagen receptors glycoprotein VI and α2β1 and prior myocardial infarction in human subjects, a pilot study

Medical Science Monitor

Volumn 11, Issue 5, 2005, Pages

  Samaha, Frederick F ^a,b   Hibbard, Christopher ^a   Sacks, Jay ^a   Chen, Hong ^a   Varello, Michael A ^a   George, Thomas ^a   Kahn, Mark L ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Collagen; Myocardial infarction; Platelets; Thrombus

Indexed keywords

COLLAGEN RECEPTOR; FLUORESCEIN ISOTHIOCYANATE; GLYCOPROTEIN; GLYCOPROTEIN 6; MONOCLONAL ANTIBODY; THROMBOCYTE RECEPTOR; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 2;

ADULT; AGED; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA POLYMORPHISM; FEMALE; FLOW CYTOMETRY; HEART INFARCTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; PILOT STUDY; PREVALENCE; RECEPTOR DENSITY; RISK FACTOR;

AGED; BLOOD PLATELETS; CASE-CONTROL STUDIES; FLOW CYTOMETRY; GENOTYPE; HUMANS; INTEGRIN ALPHA2BETA1; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PILOT PROJECTS; PLATELET MEMBRANE GLYCOPROTEINS; POLYMORPHISM, GENETIC; RECEPTORS, COLLAGEN;

EID: 20344366552     PISSN: 12341010     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Lusis AJ: Atherosclerosis. Nature. 2000; 407: 233-41
2. Wilner GD, Nossel HL, LeRoy EC: Actuation of Hageman factor by collagen. J Clin Invest, 1968; 12: 2608-15
3. Clemetson JM, Polgar J, Magnenat E et al: The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors. J Biol Chem, 1999; 274: 29019-24
4. Santoro SA: Identification of a 160,000 dalton platelet membrane protein that mediates the initial divalent cation-dependent adhesion of platelets to collagen. Cell, 1986; 46: 913-20
5. Moroi M, Jung SM, Okuma M, Shinmyozu K: A patient with platelets deficient in glycoprotein VI that lack collagen-induced aggregation and adhesion. J Clin Invest, 1989; 84: 1440-45
6. Nieswandt B, Bergmeier W, Schulte V et al: Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain. J Biol Chem. 2000; 275: 23998-4002
7. Nieswandt B, Schulte Y, Bergmeier W et al: Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice. J Exp Med, 2001; 193: 459-69
8. Chen J, Diacovo TG, Grenache DG et al: The alpha(2) integrin subunit-deficient mouse: a mnltifaceted phenotype including defects of branching morphogenesis and hemostasis. Am J Pathol, 2002; 161: 337-44
9. Nieswandt B, Brakebusch C, Bergmeier W et al: Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen. EMBO, 2001; 20(9): 2120-30
10. Massberg S, Gawaz M, Gruner S et al: A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo. J Exp Med, 2003; 197: 41-49
11. Holtkotter O, Nieswandt B, Smyth N et al: Integrin alpha 2-deficient mice develop normally, are fertile, but display partially defective platelet interaction with collagen. J Biol Chem, 2002; 277: 10789-94
12. Chen H, Locke D, Lin Y et al: The Platelet Receptor GPVI Mediates Both Adhesion and Signaling Responses to Collagen in a Receptor Density-dependent Fashion. J Biol Chem. 2002; 277: 3011-19
13. Jontsi-Korhonen L, Smethurst PA, Rankin A et al: The low frequency allele of the platelet collagen signalling receptor glycoprotein VI is associated with reduced functional responses and expression. Blood, 2003; 101: 4372-79
14. Kunicki TJ, Orchekowski R, Annis D, Honda Y: Variability of integrin alpha 2 beta 1 activity on human platelets. Blood, 1993; 82: 2693-703
15. Kunicki TJ, Kritzik M, Annis DS, Nngent DJ: Hereditary variation in platelet integrin alpha 2 beta 1 density is associated with two silent polymorphisms in the alpha 2 gene coding sequence. Blood, 1997; 89: 1939-43
16. Moshfegh K, Wuillemin WA, Redondo M et al: Association of two silent polymorphisms of platelet glycoprotein Ia/IIa receptor with risk of myocardial infarction: a case-control study. Lancet, 1999; 353: 351-54
17. Carlsson LE, Santoso S, Spitzer C et al: The alpha2 gene coding sequence T807/A873 of the platelet collagen receptor integrin alpha2beta1 might be a genetic risk factor for the development of stroke in younger patients. Blood, 1999; 93: 3583-86
18. Santoso S, Kunicki TJ, Kroll H et al: Association of the Platelet Glycoprotein Ia C807T Gene Polymorphism With Nonfatal Myocardial Infarction in Younger Patients. Blood, 1999; 93(8): 2449-53
19. Furihata K, Nugent DJ, Kunicki TJ: Influence of platelet collagen receptor polymorphisms on risk for arterial thrombosis. Arch Pathol Lab Med. 2002; 126: 305-9
20. Croft SA, Samani NJ, Teare MD et al: Novel Platelet Membrane Glycoprotein VI Dimorphism Is a Risk Factor for Myocardial Infarction. Circulation, 2001; 104: 1459-63
21. Samaha FF, Hibbard C, Sacks J et al: Measurement of Platelet Collagen Receptor Density in Human Subjects. Arteriosder Thromb Vasc Biol, 2004; 24: e181-e182
22. Chen H, Kahn ML: Reciprocal signaling by integrin and nonintegrin receptors during collagen activation of platelets. Mol Cell Biol. 2003; 14:4764-77
23. Weiss EJ, Bray PF, Tayback M, et al: A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis. N Engl J Med, 1996; 334: 1090-94
24. Bray PF, Weiss EJ, Tayback M, Goldschmidt-Clermont PJ: PIA1/A2 polymorphism of platelet glycoprotein IIIa and risk of cardiovascular disease. Lancet, 1997; 349: 9058: 1100-101
25. Santoro SA: Platelet surface collagen receptor polymorphisms: variable receptor expression and thrombotic/hemorrhagic risk. Blood, 1999; 93: 3575-77
26. Bray PF: Platelet glycoprotein polymorphisms as risk factor for thrombosis. Curr Opin Hematol, 2000; 7: 284-89
27. Kunicki TJ: The role of platelet collagen receptor (glycoprotein Ia/IIa; integrin alpha2 beta1) polymorphisms in thrombotic disease. Curr Opin Hematol, 2001; 8: 277-85
28. Nurden AT: Polymorphisms of platelet receptors as risk factors in coronary thrombosis. Eur Heart J, 1996; 17: 1293-94
29. Kroll H, Gardemann A, Fechter A et al: The impact of the glycoprotein Ia collagen receptor subunit A1648G gene polymorphism on coronary artery disease and acute myocardial infarction. Thromb Haemost, 2000; 83: 392-96
30. Kato K, Kanaji T, Russell S et al: The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion. Blood, 2003; 102: 1701-7
31. Bautista LE, Ardila ME, Gainarra G et al: Angiotensin-converting enzyme gene polymorphism and risk of myocardial infarction in Colombia. Med Sci Monit. 2004; 10(8): CR473-CR479
32. Stephens G, Yan V, Jandrot-Perrus M et al: Platelet activation induces metalloproteinase-dependent GP VI cleavage to down-regulate platelet reactivity to collagen. Blood, 2005; 105: 186-91
33. Gardiner EE, Arthur JF, Kahn ML et al: Regulation of platelet membrane levels of glycoprotein VI by a platelet-derived metalloproteinase. Blood, 2004; 104: 3611-17
34. Boylan B, Chen H, Rathore V et al: Anti-GPVI-associated ITP: an acquired platelet disorder caused by autoantibody-mediated clearance of the GPVI/FcRγ-chain complex from the human platelet surface. Blood. 2004; 104: 1350-55