Structural origins for selectivity and specificity in an engineered bacterial repressor-inducer pair

FEBS Journal

Volumn 276, Issue 19, 2009, Pages 5610-5621

  Klieber, Michael A ^a   Scholz, Oliver ^a   Lochner, Susanne ^a   Gmeiner, Peter ^a   Hillen, Wolfgang ^a   Muller, Yves A ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Altered inducer selectivity; Altered inducer specificity; Bacterial transcription regulation; Crystal structures; Tetracycline repressor

Indexed keywords

4 DE DIMETHYLAMINO ANHYDROTETRACYCLINE; LEUCINE; TETRACYCLINE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; ELECTRICITY; GENE EXPRESSION; HYDROGEN BOND; PRIORITY JOURNAL; THERMODYNAMICS;

AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HYDROGEN BONDING; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; STATIC ELECTRICITY; TETRACYCLINE; TETRACYCLINE RESISTANCE;

BACTERIA (MICROORGANISMS); EUKARYOTA; PROKARYOTA;

EID: 70349249704     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2009.07254.x     Document Type: Article

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