The hypolipidemic effect of an ethyl ester of algal-docosahexaenoic acid in rats fed a high-fructose diet

Lipids

Volumn 44, Issue 9, 2009, Pages 817-826

  Ryan, Alan S ^a   Bailey Hall, Eileen ^a   Nelson, Edward B ^a   Salem Jr , Norman ^a  

^a Martek Biosciences Corporation   (United States)

Author keywords

Cholesterol; Clinical chemistry; Docosahexaenoic acid; Omega 3 fatty acids; Triacylglycerol lowering

Indexed keywords

ANTILIPEMIC AGENT; CHOLESTEROL; CORN OIL; DOCOSAHEXAENOIC ACID; FATTY ACID; FISH OIL; FRUCTOSE; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MATK 90; OMEGA 3 FATTY ACID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIETARY INTAKE; DOSE RESPONSE; DRUG MEGADOSE; FATTY ACID ANALYSIS; FATTY ACID BLOOD LEVEL; FOOD INTAKE; HYPERTRIGLYCERIDEMIA; HYPOLIPEMIA; LIPID BLOOD LEVEL; LIPID COMPOSITION; MALE; NONHUMAN; RAT;

ALGAE; ANIMALS; ANTILIPEMIC AGENTS; BODY WEIGHT; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DIET; DOCOSAHEXAENOIC ACIDS; DRUG COMBINATIONS; EATING; EICOSAPENTAENOIC ACID; FATTY ACIDS; FRUCTOSE; HYPERTRIGLYCERIDEMIA; LIPID METABOLISM; MALE; RATS; RATS, WISTAR; TRIGLYCERIDES;

ALGAE; RATTUS; RATTUS NORVEGICUS; ZEA MAYS;

EID: 70349238603     PISSN: 00244201     EISSN: 15589307     Source Type: Journal    
DOI: 10.1007/s11745-009-3330-6     Document Type: Article

References (46)

1. CM Albert CH Hennekens CJ O'Donnell UA Ajani VJ Carey WC Willett JN Ruskin JE Manson 1998 Fish consumption and risk of sudden death JAMA 279 23 28 9424039 10.1001/jama.279.1.23 1:STN:280:DyaK1c%2FosVKmtw%3D%3D (Pubitemid 28070546)
2. GISSI-Prevenzione Investigators 1999 Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial Lancet 354 447 455 10.1016/S0140-6736(99)07072-5 (Pubitemid 29368922)
3. MK Chung 2008 Omega-3 fatty acid supplementation for the prevention of arrhythmias Curr Treat Options Cardiovasc Med 10 398 407 18814829 10.1007/s11936-008-0031-z
4. L Calo L Bianconi LF Colivicchi F Lamberti ML Loricchio E de Ruvo A Meo C Pandozi M Staibano M Santini 2005 N-3 fatty acids for the prevention of atrial fibrillation after coronary artery bypass surgery: a randomized controlled trial J Am Coll Cardiol 45 1723 1728 15893193 10.1016/j.jacc.2005.02.079 1:CAS:528:DC%2BD2MXktVOjt7w%3D (Pubitemid 40704512)
5. PM Kris-Etherton WS Harris LJ Appel for the Nutrition Committee 2002 Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease Circulation 106 2747 2757 12438303 10.1161/01.CIR.0000038493.65177.94 (Pubitemid 35364932)
6. F Thies J Garry P Yaqoob K Rerkasem J Williams CP Shearman PJ Gallagher PC Calder RF Grimble 2003 Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaque: a randomized controlled trial Lancet 361 477 485 12583947 10.1016/S0140-6736(03)12468-3 1:CAS:528:DC%2BD3sXhtVahurw%3D (Pubitemid 36173713)
7. KH Bonna DS Thelle 1991 Association between blood pressure and serum lipids in a population: the Tromso Study Circulation 83 1305 1314
8. TA Mori DQ Bao V Burke IB Puddey LJ Beilen 1999 Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans Hypertension 34 253 260 10454450 1:CAS:528:DyaK1MXlvFGmtbw%3D
9. D Mozaffarian A Geelen IA Brouwer JM Geleijnse PL Zock MB Katan 2005 Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials Circulation 112 1945 1952 16172267 10.1161/CIRCULATIONAHA.105. 556886 1:CAS:528:DC%2BD2MXhtVWmurzJ (Pubitemid 41377412)
10. WS Harris M Miller AP Tighe MH Davidson EJ Schaefer 2008 Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives Atherosclerosis 197 12 24 18160071 10.1016/j.atherosclerosis.2007.11.008 1:CAS:528:DC%2BD1cXisVSmurY%3D
11. JJ Agren O Hanninen A Julkunen L Fogelholm H Vidgren U Schwab O Pynnonen M Uustipa 1996 Fish diet, fish oil and docosahexaenoic acid rich oil lower fasting and postprandial plasma lipid levels Eur J Clin Nutr 50 765 771 8933125 1:STN:280:DyaK2s%2FoslSqtA%3D%3D
12. I Ikeda J Kumamaru N Nakatani M Sakono I Murota K Imaizumi 2001 Reduced hepatic triglyceride secretion in rats fed docosahexaenoic acid-rich fish oil suppresses postprandial hypertriglyceridemia J Nutr 131 1159 1164 11285319 1:CAS:528:DC%2BD3MXjsl2iurY%3D
13. N Willumsen S Hexeberg J Skorve M Lundquist RK Berge 1993 Docosahexaenoic acid shows no triglyceride-lowering effects but increases the peroxisomal fatty acid oxidation in liver of rats J Lipid Res 34 13 22 8445337 1:CAS:528:DyaK3sXnvF2ltw%3D%3D
14. N Willumsen J Skorve S Hexeberg AC Rustan RK Berge 1993 The hypotriglyceridemic effect of eicosapentaenoic acid in rats is reflected in increased mitochondrial fatty acid oxidation followed by diminished lipogenesis Lipids 28 683 690 8377581 10.1007/BF02535987 1:CAS:528:DyaK3sXmtVant70%3D
15. Y Kobatke K Kuroda H Jinnouchi E Nishide S Innami 1984 Differential effects of dietary eicosapentaenoic acid and docosahexaenoic fatty acids on lowering triglyceride and cholesterol levels in the serum of rats on hypercholesterolemic diet J Nutr Sci Vitaminol 30 357 372
16. Z Xu N Riediger S Innis MH Moghadasian 2007 Fish oil significantly alters fatty acid profiles in various lipid fractions but not atherogenesis in apo E-KO mice Eur J Nutr 46 103 110 17225919 10.1007/s00394-006-0638-3 1:CAS:528:DC%2BD2sXkt1Sqsro%3D (Pubitemid 46295315)
17. LH Storbien AB Jenkins DJ Chissholm WS Pascoe S Khouri EW Kraegen 1991 Influence of dietary fat composition on development of insulin resistance in rats: relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid Diabetes 40 280 289 10.2337/diabetes.40.2.280
18. M Behme 1996 Dietary fish oil enhances insulin sensitivity in miniature pigs J Nutr 126 1549 1553 8648427 1:CAS:528:DyaK28XjtlKksbk%3D
19. JA Nettleton R Katz 2005 N-3 long-chain polyunsaturated fatty acids in type 2 diabetes: a review J Am Diet Assoc 105 428 440 15746832 10.1016/j.jada.2004.11.029 1:CAS:528:DC%2BD2MXivVOnuro%3D (Pubitemid 40326734)
20. Farmer A, Montori V, Dinneen S, Clar C (2001) Fish oil in people with type 2 diabetes mellitus. Cochrane Database Syst Rev 3:CD003205
21. VA Mustad S DeMichele Y-S Huang A Mika N Lubbers N Berthiaume J Polakowski B Zinker 2006 Differential effects of n-3 polyunsaturated fatty acids on metabolic control and vascular reactivity in the type 2 diabetic ob/ob mouse Metab Clin Exp 55 1365 1374 16979408 1:CAS:528:DC%2BD28Xps1ajur4%3D
22. A Minami N Ishimura S Sakamoto E Takishita K Mawatari K Okada Y Nakaya 2002 Effect of eicosapentaenoic acid ethyl ester v. oleic acid-rich safflower oil on insulin resistance in type 2 diabetic model rats with hypertriacylglycerolaemia Br J Nutr 87 157 162 11895168 10.1079/BJN2001496 1:CAS:528:DC%2BD38Xht1Whtrk%3D (Pubitemid 34575539)
23. M Oarada T Tsuzuki T Gonoi M Igarashi K Kamei T Nikawa K Hirasaka T Ogawa T Miyazawa K Nakagawa N Kurita 2008 Effects of dietary fish oil on lipid peroxidation and serum triacylglycerol levels in psychologically stressed mice Nutrition 24 67 75 18070659 10.1016/j.nut.2007.10.006 1:CAS:528: DC%2BD2sXhsVWjsrrE (Pubitemid 350216376)
24. CL O'Connor LM Lawrence SH Hayes 2007 Dietary fish oil supplementation affects serum fatty acid concentrations in horses J Animal Sci 85 2183 2189 10.2527/jas.2006-528 (Pubitemid 47340383)
25. AS Ryan MA Keske JP Hoffman EB Nelson 2009 Clinical overview of algal-docosahexaenoic acid: effects on triglyceride levels and other cardiovascular risk factors Am J Ther 16 183 192 19145206 10.1097/MJT. 0b013e31817fe2be
26. S Grimsgaard KH Bonaa J-B Hansen A Nordoy 1997 Highly purified eicosapentaenoic acid and docosahexaenoic acid in humans have similar triacylglycerol-lowering effects but divergent effects on serum fatty acids Am J Clin Nutr 66 649 659 9280188 1:CAS:528:DyaK2sXlslKhs7s%3D
27. National Research Council (1996) Guide for the care and use of laboratory animals. National Academy Press, Washington DC
28. LM Arterburn HA Oken JP Hoffman E Bailey-Hall G Chung D Rom J Hamersley D McCarthy 2007 Bioequivalence of docosahexaenoic acid from different algal oils in capsules and in a DHA-fortified food Lipids 42 1011 1024 17713804 10.1007/s11745-007-3098-5 1:CAS:528:DC%2BD2sXhtlKqtLfN (Pubitemid 350127315)
29. JW Tukey JL Ciminera JF Heyse 1985 Testing the statistical certainty of a response to increasing doses of a drug Biometrics 41 295 301 4005384 10.2307/2530666 1:STN:280:DyaL2M3is1OgsQ%3D%3D
30. K Qi C Fan J Jiang H Zhu Z Haiyan H Jiao Q Meng RJ Deckelbaum 2008 Omega-3 fatty acid containing diets decrease plasma triglyceride concentrations in mice by reducing endogenous triglyceride synthesis and enhancing the blood clearance of triglyceride-rich particles Clin Nutr 27 424 430 18362042 10.1016/j.clnu.2008.02.001 1:CAS:528:DC%2BD1cXnt1Oqsb8%3D
31. DD Keller S Jurgilas B Perry J Blum B Farino J Reynolds L Keilson 2007 Docosahexaenoic acid (DHA) lowers triglyceride levels and improves low density lipoprotein particle size in a statin-treated cardiac risk population J Clin Lipidol 1 151(A)
32. M Davidson E Stein H Bays K Maki R Doyle R Shalwitz C Ballantyne H Ginsberg on behalf of the COMBination of prescription Omega-3 with Simvastatin (COMBOS) investigators 2007 Efficacy and tolerability of adding prescription omega-3 fatty acids 4 g/d to simvastatin 40 mg/d in hypertriglyceridemic patients: an 8-week, randomized, double-blind, placebo-controlled study Clin Ther 29 1354 1367 17825687 10.1016/j.clinthera.2007.07.018 1:CAS:528: DC%2BD2sXhtVemurjN (Pubitemid 47348116)
33. TA Mori R Woodman 2006 The independent effects of eicosapentanoic acid and docosahexaenoic acid on cardiovascular risk factors in humans Curr Opin Nutr Metab Care 9 95 104 1:CAS:528:DC%2BD28XjtlGntbc%3D
34. Brossard N, Croset M, Pachiaudi C, Riou JP, Tayot JL, Lagarde M (1996) Retroconversion and metabolism of [13C]22:6n-3-triaclygycerols. Am J Clin Nutr 64:577-586
35. K Boswell E-K Koskelo L Carl S Glaza DJ Hensen KD Williams DJ Kyle 1996 Preclinical evaluation of single-cell oils that are highly enriched with arachidonic acid and docosahexaenoic acid Food Chem Toxicol 34 585 593 8761351 10.1016/0278-6915(96)00019-1 1:CAS:528:DyaK28XlsVChtLo%3D (Pubitemid 26266033)
36. ® oil) Food Chem Toxicol 38 35 39 10685012 10.1016/S0278-6915(99)00119-2 1:CAS:528:DC%2BD3cXht1KktLg%3D (Pubitemid 30102212)
37. JA Conquer BJ Holub 1996 Supplementation with an algae source of docosahexaenoic acid increases (n-3) fatty acid status and alters selected risk factors for heart disease in vegetarian subjects J Nutr 126 3032 3039 9001371 1:CAS:528:DyaK2sXjsFKgtQ%3D%3D
38. JA Conquer BJ Holub 1997 Dietary docosahexaenoic acid as a source of eicosapentaenoic acid in vegetarians and omnivores Lipids 32 341 345 9076673 10.1007/s11745-997-0043-y 1:CAS:528:DyaK2sXhvF2jtrg%3D (Pubitemid 27131769)
39. GJ Wilbert RA Burns DA Diersen-Schade CM Kelley 1997 Evaluation of single cell sources of docosahexaenoic acid and arachidonic acid: a 4-week oral safety study Food Chem Toxicol 35 967 974 10.1016/S0278-6915(97)00067-7 (Pubitemid 28046621)
40. ® oil Food Chem Toxicol 38 971 976 11038233 10.1016/S0278-6915(00)00085-5 1:CAS:528: DC%2BD3cXntFyqurk%3D
41. LM Arterburn KD Boswell SM Henwood DJ Kyle 2000 A developmental safety study in rats using DHA- and ARA-rich single-cell oils Food Chem Toxicol 38 3761 3771
42. HA Weiler 2000 Dietary supplementation of arachidonic acid is associated with higher whole body weight and bone mineral density in growing pigs Pediatr Res 47 692 697 10813598 10.1203/00006450-200005000-00022 1:CAS:528: DC%2BD3cXjsFCgtL8%3D
43. SA Mathews WT Oliver OT Phillips J Odle DA Diersen-Schade RJ Harrell 2002 Comparison of triglycerides and phospholipids as supplemental sources of dietary long-chain polyunsaturated fatty acids in piglets J Nutr 132 3081 3089 12368399 1:CAS:528:DC%2BD38Xnsl2ktr4%3D
44. M-C Huang A Chao R Kirwan C Tschanz JM Peralta DA Diersen-Schade S Cha JT Brenna 2002 Negligible changes in piglet serum clinical indicators or organ weights due to dietary single-cell long-chain polyunsaturated oils Food Chem Toxicol 40 453 460 11893404 10.1016/S0278-6915(01)00105-3 1:CAS:528: DC%2BD38XhvVequ70%3D (Pubitemid 34219272)
45. GJ Nelson PS Schmidt GL Bartolini DS Kelley DJ Kyle 1997 The effect of dietary docosahexaenoic acid on platelet function, platelet fatty acid composition, and blood coagulation Lipids 32 1129 1136 9397397 10.1007/s11745-997-0145-6 1:CAS:528:DyaK2sXnsFaisLg%3D
46. C Von Schacky 2006 A review of omega-3 ethyl esters for cardiovascular prevention and treatment of increased blood triglyceride levels Vasc Health Risk Manag 2 251 262 10.2147/vhrm.2006.2.3.251 (Pubitemid 44275461)