Synthesis and biological evaluation of 5,6-dihydro-benzo[c] acridin-7-ol derivatives as anti-Alzheimer's disease drugs

Letters in Drug Design and Discovery

Volumn 6, Issue 8, 2009, Pages 623-628

  Zhou, Jinpei ^a   Hu, Xiaowen ^a,b   Zhang, Huibin ^a   Qian, Hai ^a,b   Huang, Wenlong ^a   Qi, Fan ^a   Zhang, Yanchun ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Cholinesterase inhibitors; Neuroprotection

Indexed keywords

1,2,3,4 TETRAHYDRO 6 METHOXYNAPHTHALENE; 3 [4 (5,6 DIHYDRO 3 METHOXYBENZO[C]ACRIDIN 7 YLOXYMETHYL)PHENYL]ACRYLIC ACID ETHYL ESTER; 3 METHOXY 7 (2 PHENOXY ETHOXY) 5,6 DIHYDROBENZO[C]ACRIDINE; 3 METHOXY 7 [2 (2 METHYLPHENOXY)ETHOXY] 5,6 DIHYDROBENZO[C]ACRIDINE; 3 METHOXY 7 [2 (4 METHYLPHENOXY)ETHOXY] 5,6 DIHYDROBENZO[C]ACRIDINE; 3,4 DIHYDRO 6 METHOXYNAPHTHALEN 1(2H) ONE; 4 [2 ((3 METHOXY 5,6 DIHYDROBENZO[C]ACRIDIN 7 YL)OXY)ETHOXY]BENZONITRILE; 4 [2 (3 METHOXY 5,6 DIHYDRO BENZO[C]ACRIDIN 7 YLOXY) ETHOXY] BENZOIC ACID ETHYL ESTER; 4-[((3 METHOXY 5,6 DIHYDROBENZO[C]ACRIDIN 7 YL)OXY)METHYL]BENZONITRILE; 5,6 DIHYDRO 3 METHOXYBENZO[C]ACRIDIN 7 OL; 5,6 DIHYDRO BENZO[C]ACRIDIN 7 OL DERIVATIVE; 7 (4 CHLOROBENZYLOXY) 5,6 DIHYDRO 3 METHOXYBENZO[C]ACRIDINE; 7 (4 CHLOROMETHYLBENZYLOXY) 5,6 DIHYDRO 3 METHOXYBENZO[C]ACRIDINE; 7 (4 NITROBENZYLOXY) 5,6 DIHYDRO 3 METHOXYBENZO[C]ACRIDINE; 7 [2 (2 METHOXY PHENOXY) ETHOXY] 3 METHOXY 5,6 DIHYDRO BENZO[C]ACRIDINE; 7 [2 (4 BROMO PHENOXY) ETHOXY] 3 METHOXY 5,6 DIHYDROBENZO[C]ACRIDINE; 7 [2 (4 CYANO PHENOXY) ETHOXY] 3 METHOXY 5,6 DIHYDROBENZO[C]ACRIDINE; 7 [2 (4 METHOXY PHENOXY) ETHOXY] 3 METHOXY 5,6 DIHYDROBENZO[C]ACRIDINE; 7 [2 (4 NITRO PHENOXY) ETHOXY] 3 METHOXY 5,6 DIHYDROBENZO[C]ACRIDINE; 7 ALKYLOXY 5,6 DIHYDRO 3 METHOXYBENZO[C]ACRIDINE; 7 BENZYLOXY 5,6 DIHYDRO 3 METHOXYBENZO[C]ACRIDINE; ACETYLCHOLINESTERASE; ETHYL 4 [((3 METHOXY 5,6 DIHYDROBENZO[C]ACRIDIN 7 YL)OXY)METHYL]BENZOATE; GLUTAMIC ACID; NEUROPROTECTIVE AGENT; NIMODIPINE; TACRINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; NEUROPROTECTION; NEUROTOXICITY; PRIORITY JOURNAL;

EID: 70349199206     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/157018009789353527     Document Type: Article

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