Impact of rhBMP-2 on regeneration of buccal alveolar defects during the osseointegration of transgingival inserted implants

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology

Volumn 108, Issue 4, 2009, Pages

  Smeets, Ralf ^a   Maciejewski, Oliver ^a   Gerressen, Markus ^a   Spiekermann, Hubertus ^a   Hanisch, Oliver ^a   Riediger, Dieter ^a   Blake, Felix ^b   Stein, Jamal ^a   Hölzle, Frank ^c   Kolk, Andreas ^c  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMEDICAL AND DENTAL MATERIALS; BONE MORPHOGENETIC PROTEIN; CALCIUM PHOSPHATE; DRUG CARRIER; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2; RECOMBINANT PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ALVEOLAR BONE LOSS; ANIMAL; ARTICLE; BONE DEVELOPMENT; BONE MATRIX; BONE REGENERATION; CERAMICS; CHEMISTRY; COMPARATIVE STUDY; DENTURE; DOG; DRUG EFFECT; HUMAN; JAW DISEASE; MALE; MANDIBLE; OSTEOBLAST; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SURFACE PROPERTY; TIME; TOOTH IMPLANTATION; TOOTH PROSTHESIS;

ALVEOLAR BONE LOSS; ANIMALS; BONE MATRIX; BONE MORPHOGENETIC PROTEINS; BONE REGENERATION; CALCIUM PHOSPHATES; CERAMICS; DENTAL ABUTMENTS; DENTAL IMPLANTS; DENTAL MATERIALS; DENTAL PROSTHESIS DESIGN; DOGS; DRUG CARRIERS; HUMANS; MALE; MANDIBLE; MANDIBULAR DISEASES; OSSEOINTEGRATION; OSTEOBLASTS; OSTEOGENESIS; RECOMBINANT PROTEINS; SURFACE PROPERTIES; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 70349178425     PISSN: 10792104     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tripleo.2009.05.025     Document Type: Article

References (72)

1. Urist M.R. Bone: formation by autoinduction. Science 150 (1965) 893-899
2. Butler W.T., Mikulski A., and Urist M.R. Noncollagenous protein of a rat dentin matrix prossesing bone morphogenic activity. J Dent Res 56 (1977) 228-232
3. Conover M.A., and Urist M.R. Transmembrane bone morphogenesis by implants of dentin matrix. J Den Res 58 (1979) 1911
4. Kawai T., and Urist M.R. Bovine tooth-derived bone morphogenic protein. J Dent Res 68 (1989) 1069-1074
5. Sampath T.K., and Reddi A.H. Homology of bone-inductive proteins from human, monkey, bovine, and rat extracellular matrix. Proc Natl Acad Sci U S A 80 (1983) 6591-6595
6. Muthukumaran N., and Reddi A.H. Bone matrix-induced local bone induction. Clin Orthop Relat Res 200 (1985) 159-164
7. Bessho K., Tagawa T., and Murata M. Purification of rabbit bone morphogenetic protein derived from bone, dentin, and wound tissue after tooth extraction. J Oral Maxillofac Surg 48 (1990) 162-169
8. Toom A., Arend A., Gunnarsson D., Ulfsparre R., Suutre S., Haviko T., and Selstam G. Bone formation zones in heterotopic ossifications: histologic findings and increased expression of bone morphogenetic protein 2 and transforming growth factors beta2 and beta3. Calcif Tissue Int 80 (2007) 259-267
9. Reddi A.H. Bone and cartilage differentiation. Curr Opin Genet Dev 4 (1994) 737-744
10. Reddi A.H. Role of morphogenetic proteins in skeletal tissue engineering and regeneration. Nat Biotechnol 16 (1998) 247-252
11. Bostrom M.P., and Asnis P. Transforming growth factor beta in fracture repair. Clin Orthop 355 Suppl (1998) S124-S131
12. Barnes G.L., Kostenuik P.J., Gerstenfeld L.C., and Einhorn T.A. Growth factor regulation of fracture repair. Bone Miner Res 14 (1999) 1805-1815
13. Bessa P.C., Casal M., and Reis R.L. Bone morphogenetic proteins in tissue engineering: the road from the laboratory to the clinic, part I (basic concepts). J Tissue Eng Regen Med 2 (2008) 1-13
14. Bessa P.C., Casal M., and Reis R.L. Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery). J Tissue Eng Regen Med 2 (2008) 81-96
15. Smith D.M., Cooper G.M., Mooney M.P., Marra K.G., and Losee J.E. Bone morphogenetic protein 2 therapy for craniofacial surgery. J Craniofac Surg 19 (2008) 1244-1259
16. Hanisch O., Tatakis D.N., Boskovic M.M., Rohrer M.D., and Wikesjö U.M. Bone formation and reosseointegration in peri-implantitis defects following surgical implantation of rhBMP-2. Int J Oral Maxillofac Implants 12 (1997) 604-610
17. Sigurdsson T.J., Fu E., Tatakis D.N., Rohrer M.D., and Wikesjö U.M. Bone morphogenetic protein-2 for peri-implant bone regeneration and osseointegration. Clin Oral Implants Res 8 (1997) 367-374
18. Cochran D.L., Schenk R., Buser D., Wozney J.M., and Jones A.A. Recombinant human bone morphogenetic protein-2 stimulation of bone formation around endosseous dental implants. J Periodontol 70 (1999) 139-150
19. Choi S.H., Kim C.K., Cho K.S., Huh J.S., Sorensen R.G., Wozney J.M., and Wikesjö U.M. Effect of recombinant human bone morphogenetic protein-2/absorbable collagen sponge (rhBMP-2/ACS) on healing in 3-wall intrabony defects in dogs. J Periodontol 73 (2002) 63-72
20. Jovanovic S.A., Hunt D.R., Bernard G.W., Spiekermann H., Nishimura R., Wozney J.M., and Wikesjö U.M. Long-term functional loading of dental implants in rhBMP-2 induced bone. A histologic study in the canine ridge augmentation model. Clin Oral Implants Res 14 (2003) 793-803
21. Selvig K.A., Sorensen R.G., Wozney J.M., and Wikesjö U.M. Bone repair following recombinant human bone morphogenetic protein-2 stimulated periodontal regeneration. J Periodontol 73 (2002) 1020-1029
22. Tatakis D.N., Koh A., Jin L., Wozney J.M., Rohrer M.D., and Wikesjö U.M. Periimplant bone regeneration using rhBMP-2/ACS in a canine model: a dose-response study. J Periodontal Res 37 (2002) 93-100
23. Bax B.E., Wozney J.M., and Ashhurst D.E. Bone morphogenetic protein-2 increases the rate of callus formation after fracture of the rabbit tibia. Calcif Tissue Int 65 (1999) 83-89
24. Schmidmaier G., Wildemann B., Cromme F., Kandziora F., Haas N.P., and Raschke M. Bone morphogenetic protein-2 coating of titanium implants increases biomechanical strength and accelerates bone remodeling in fracture treatment: a biomechanical and histological study in rats. Bone 30 (2002) 816-822
25. Lindholm T.S., and Gao T.J. Functional carriers for bone morphogenetic proteins. Ann Chir Gynaecol Suppl 207 (1993) 3-12
26. Boden S.D. Bioactive factors for bone tissue engineering. Clin Orthop Relat Res 367 Suppl (1999) S84-S94
27. Wozney J.M., and Rosen V. Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair. Clin Orthop Relat Res 346 (1998) 26-37
28. Li R.H., and Wozney J.M. Delivering on the promise of bone morphogenetic proteins. Trends Biotechnol 19 (2001) 255-265
29. Sakou T. Bone morphogenetic proteins: from basic studies to clinical approaches. Bone 22 (1998) 591-603
30. Kawamura M., and Urist M.R. Induction of callus formation by implants of bone morphogenetic protein and associated bone matrix noncollagenous proteins. Clin Orthop 236 (1988) 240-248
31. Gao T.J., Lindholm T.S., Marttinen A., and Puolakka T. Bone inductive potential and dose-dependent response of bovine bone morphogenetic protein combined with type IV collagen carrier. Ann Chir Gynaecol Suppl 207 (1993) 77-84
32. Winn S.R., Uludag H., and Hollinger J.O. Carrier systems for bone morphogenetic proteins. Clin Orthop 367 Suppl (1999) 95-106
33. Bouxsein M.L., Turek T.J., Blake C.A., D'Augusta D., Li X., Stevens M., et al. Recombinant human bone morphogenetic protein-2 accelerates healing in a rabbit ulnar osteotomy model. J Bone Joint Surg Am 83 A (2001) 1219-1230
34. Horisaka Y., Okamoto Y., Matsumoto N., Yoshimura Y., Kawada J., Yamashita K., and Takagi T. Subperiosteal implantation of bone morphogenetic protein absorbed to hydroxyapatite. Clin Orthop Relat Res 268 (1991) 303-312
35. Bolander M.E., and Balian G. The use of demineralized bone matrix in the repair of segmental defects. Augmentation with extracted matrix proteins and a comparison with autologous grafts. J Bone Joint Surg Am 68 (1986) 1264-1274
36. Hollinger J.O., Schmitt J.M., Buck D.C., Shannon R., Joh S.P., Zegzula H.D., and Wozney J. Recombinant human bone morphogenetic protein-2 and collagen for bone regeneration. J Biomed Mater Res 43 (1998) 356-364
37. Bessho K., Tanaka N., Matsumoto J., Tagawa T., and Murata M. Human dentin-matrix-derived bone morphogenetic protein. J Dent Res 70 (1991) 171-175
38. Boyne P.J., Marx R.E., Nevins M., Triplett G., Lazaro E., Lilly L.C., et al. A feasibility study evaluating rhBMP-2/absorbable collagen sponge for maxillary sinus floor augmentation. Int J Periodontics Restorative Dent 17 (1997) 11-25
39. Cochran D.L., Jones A.A., Lilly L.C., Fiorellini J.P., and Howell H. Evaluation of recombinant human bone morphogenetic protein-2 in oral applications including the use of endosseous implants: 3-year results of a pilot study in humans. J Periodontol 71 (2000) 1241-1257
40. Howell T.H., Fiorellini J., Jones A., Alder M., Nummikoski P., Lazaro M., et al. A feasibility study evaluating rhBMP-2/absorbable collagen sponge device for local alveolar ridge preservation or augmentation. Int J Periodontics Restorative Dent 17 (1997) 124-139
41. Meredith N., Book K., Friberg B., Jemt T., and Sennerby L. Resonance frequency measurements of implant stability in vivo. A cross-sectional and longitudinal study of resonance frequency measurements on implants in the edentulous and partially dentate maxilla. Clin Oral Implants Res 8 (1997) 226-233
42. Donath K. Die trenn-dünnschliff-technik zur herstellung histologischer präparate von nicht schneidbaren geweben und materialien. Präparator 34 (1988) 197-206
43. Esposito M., Grusovin M.G., Willings M., Coulthard P., and Worthington H.V. The effectiveness of immediate, early, and conventional loading of dental implants: a Cochrane systematic review of randomized controlled clinical trials. Int J Oral Maxillofac Implants 22 (2007) 893-904
44. Ono I., Gunji H., Kaneko F., Saito T., and Kuboki Y. Efficacy of hydroxyapatite ceramic as a carrier for recombinant human bone morphogenetic protein. J Craniofac Surg 6 (1995) 238-244
45. Hollinger J.O., and Leong K. Poly(alpha-hydroxy acids): carriers for bone morphogenetic proteins. Biomaterials 17 (1996) 187-194
46. Reddi A.H. Morphogenesis and tissue engineering of bone and cartilage: inductive signals, stem cells, and biomimetic biomaterials. Tissue Eng 6 (2000) 351-359
47. Liu Y., Huse R.O., de Groot K., Buser D., and Hunziker E.B. Delivery mode and efficacy of BMP-2 in association with implants. J Dent Res 86 (2007) 84-89
48. Li R.H., Bouxsein M.L., Blake C.A., D'Augusta D., Kim H., Li X.J., et al. rhBMP-2 injected in a calcium phosphate paste (alpha-BSM) accelerates healing in the rabbit ulnar osteotomy model. J Orthop Res 21 (2003) 997-1004
49. Liu Y., Layrolle P., de Bruijn J., van Blitterswijk C., and de Groot K. Biomimetic coprecipitation of calcium phosphate and bovine serum albumin on titanium alloy. J Biomed Mater Res 57 (2001) 327-335
50. Kokubo T., Kushitani H., Sakka S., Kitsugi T., and Yamamuro T. Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W. J Biomed Mater Res 24 (1990) 721-734
51. Liu Y., Hunziker E.B., de Groot K., and Lyrolle P. Introduction of ectopic bone formation by BMP-2 incorporated biomimetically into calcium phosphate coatings of titanium-alloy implants. In: Ben-Nissan B., Sher D., and Walsh W. (Eds). Bioceramics 15 (2003), Trans Tech Publications, Sydney 667-670
52. Liu Y., Hunziker E.B., Van de Vaal C., and de Groot K. Biomimetic coatings vs. collagen sponges as a carrier for BMP-2: a comparison of the osteogenic responses triggered in vivo using an ectopic rat model. Bioceramics 16 (2003), Trans Tech Publications, Sydney
53. Liu Y., Hunziker E.B., Layrolle P., De Bruijn J.D., and De Groot K. Bone morphogenetic protein-2 incorporated into biomimetic coatings retains its biological activity. Tissue Eng 10 (2004) 101-108
54. Liu Y., de Groot K., and Hunziker E.B. BMP-2 liberated from biomimetic implant coatings induces and sustains direct ossification in an ectopic rat model. Bone 36 (2005) 745-757
55. Tyllianakis M., Giannikas D., Panagopoulos A., Panagiotopoulos E., and Lambiris E. Use of injectable calcium phosphate in the treatment of intra-articular distal radius fractures. Orthopedics 25 (2002) 311-315
56. Issa J.P., Bentley M.V., Iyomasa M.M., Sebald W., and De Albuquerque R.F. Sustained release carriers used to delivery bone morphogenetic proteins in the bone healing process. Anat Histol Embryol 37 (2008) 181-187
57. Knaack D., Goad E., Aiolova M., Rey C., Tofighi A., Chakravarthy P., and Lee D.D. Novel filly resorbable calcium phosphate bone substitute. J Bone Miner Res 12 (1997) s202
58. Govender S., Csimma C., et al. BMP-2 Evaluation in Surgery for Tibia1 Trauma Study Group. Recombinant human bone morphogenetic protein-2 for open tibia1 fractures: a prospective, controlled, randomized study in 450 patients. J Bone Joint Surg 84 (2002) 2123-2134
59. Rutherford R.B., Sampath T.K., Rueger D.C., and Taylor T.D. Use of bovine osteogenic protein to promote rapid osseointegration of endosseous dental implants. Int J Oral Maxillofac Implants 7 (1992) 297-301
60. Wang X., Liu B., Jin Y., and Yang X. The effect of bone morphogenetic protein on osseointegration of titanium implants. J Oral Maxillofac Surg 51 (1993) 647-651
61. Wang X., Jin Y., Liu B., Zhou S., Yang L., Yang X., and White F.H. Tissue reactions to titanium implants containing bovine bone morphogenetic protein: a scanning electron microscopic investigation. Int J Oral Maxillofac Surg 23 (1994) 115-119
62. Yan J., Xiang W., Baolin L., and White F.H. Early histologic response to titanium implants complexed with bovine bone morphogenetic protein. J Prosthet Dent 71 (1994) 289-294
63. Cook S.D., Salkeld S.L., and Rueger D.C. Evaluation of recombinant human osteogenic protein-1 (rhOP-1) placed with dental implants in fresh extraction sites. J Oral Implantol 21 (1995) 281-289
64. Terheyden H., Jepsen S., Möller B., Tucker M.M., and Rueger D.C. Sinus floor augmentation with simultaneous placement of dental implants using a combination of deproteinized bone xenografts and recombinant human osteogenic protein-1. A histometric study in miniature pigs. Clin Oral Implants Res 10 (1999) 510-521
65. Arosarena O., and Collins W. Comparison of BMP-2 and -4 for rat mandibular bone regeneration at various doses. Orthod Craniofac Res 8 (2005) 267-276
66. Jones A.A., Buser D., Schenk R., Wozney J., and Cochran D.L. The effect of rhBMP-2 around endosseous implants with and without membranes in the canine model. J Periodontol 77 (2006) 1184-1193
67. Stadlinger B., Pilling E., Huhle M., Mai R., Bierbaum S., Scharnweber D., et al. Evaluation of osseointegration of dental implants coated with collagen, chondroitin sulphate and BMP-4: an animal study. Int J Oral Maxillofac Surg 37 (2008) 54-59
68. Ishikawa I., Kinoshsita A., Oda S., and Roongruanphol T. Regenerative therapy in periodontal diseases-histological observations after implantation of rhBMP-2 in the surgically created periodontal defects in adult dogs. Dent Jpn 31 (1994) 141-146
69. Sciadini M.F., Dawson J.M., Berman L.M., and Johnson K.D. Dose-response characteristics of recombinant human bone morphogenetic protein (rhBMP-2) in a canine segmental defect model. Trans Orthop Res Soc 20 (1995) 594
70. Trombelli L., Scabbia A., Tatakis D.N., Checchi L., and Calura G. Resorbable barrier and envelope flap surgery in the treatment of human gingival recession defects. Case reports. J Clin Periodontol 25 (1998) 24-29
71. Agata H., Asahina I., Yamazaki Y., Uchida M., Shinohara Y., Honda M.J., et al. Effective bone engineering with periosteum-derived cells. J Dent Res 86 (2007) 79-83
72. Kim S.H., Choi B.H., Li J., Kim H.S., Ko C.Y., Jeong S.M., et al. Peri-implant bone reactions at delayed and immediately loaded implants: an experimental study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105 (2008) 144-148