Seroreactivity against raw insect-derived recombinant KMPII, TRYP, and LACK Leishmania infantum proteins in infected dogs

Veterinary Parasitology

Volumn 164, Issue 2-4, 2009, Pages 154-161

  Todolí, Felicitat ^a   Pérez Filgueira, Mariano ^b   Galindo, Inmaculada ^c   Gómez Sebastián, Silvia ^d   Escribano, José M ^c   Rodríguez Cortés, Alhelí ^a   Alberola, Jordi ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^c INIA   (Spain)

^d Centro Empresarial   (Spain)

Author keywords

Diagnosis; Dog; Insect larvae; Leishmaniasis; Recombinant protein

Indexed keywords

KINETOPLASTID MEMBRANE 11 PROTEIN; LEISHMANIA HOMOLOGUE OF RECEPTOR FOR ACTIVATED C KINASE; RECOMBINANT ANTIGEN; RECOMBINANT PROTEIN; TRYPAREDOXIN PEROXIDASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DIAGNOSTIC VALUE; DOG; ENDEMIC DISEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMORAL IMMUNITY; LEISHMANIA INFANTUM; LEISHMANIASIS; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; SENSITIVITY AND SPECIFICITY; SERODIAGNOSIS; WESTERN BLOTTING;

ANIMALS; CELL LINE; CLONING, MOLECULAR; DOG DISEASES; DOGS; LEISHMANIA INFANTUM; LEISHMANIASIS; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS; SENSITIVITY AND SPECIFICITY; SEROLOGIC TESTS;

CANIS FAMILIARIS; HEXAPODA; LEISHMANIA INFANTUM; PROKARYOTA; TRICHOPLUSIA NI;

EID: 70349173088     PISSN: 03044017     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetpar.2009.05.032     Document Type: Article

References (53)

1. Almeida M.A., Jesus E.E., Sousa-Atta M.L., Alves L.C., Berne M.E., and Atta A.M. Antileishmanial antibody profile in dogs naturally infected with Leishmania chagasi. Vet. Immunol. Immunopathol. 106 (2005) 151-158
2. Barbieri C.L. Immunology of canine leishmaniasis. Parasite Immunol. 28 (2006) 329-337
3. Barderas M.G., Rodriguez F., Gomez-Puertas P., Aviles M., Beitia F., Alonso C., and Escribano J.M. Antigenic and immunogenic properties of a chimera of two immunodominant African swine fever virus proteins. Arch. Virol. 146 (2001) 1681-1691
4. Berberich C., Requena J.M., and Alonso C. Cloning of genes and expression and antigenicity analysis of the Leishmania infantum KMP-11 protein. Exp. Parasitol. 85 (1997) 105-108
5. Berrahal F., Mary C., Roze M., Berenger A., Escoffier K., Lamouroux D., and Dunan S. Canine leishmaniasis: identification of asymptomatic carriers by polymerase chain reaction and immunoblotting. Am. J. Trop. Med. Hyg. 55 (1996) 273-277
6. Carrera L., Fermin M.L., Tesouro M., Garcia P., Rollan E., Gonzalez J.L., Mendez S., Cuquerella M., and Alunda J.M. Antibody response in dogs experimentally infected with Leishmania infantum: infection course antigen markers. Exp. Parasitol. 82 (1996) 139-146
7. Carrillo E., Crusat M., Nieto J., Chicharro C., Thomas Mdel C., Martinez E., Valladares B., Canavate C., Requena J.M., Lopez M.C., Alvar J., and Moreno J. Immunogenicity of HSP-70, KMP-11 and PFR-2 leishmanial antigens in the experimental model of canine visceral leishmaniasis. Vaccine 26 (2008) 1902-1911
8. Courtenay O., Quinnell R.J., Garcez L.M., Shaw J.J., and Dye C. Infectiousness in a cohort of Brazilian dogs: why culling fails to control visceral leishmaniasis in areas of high transmission. J. Infect. Dis. 186 (2002) 1314-1320
9. Chamizo C., Moreno J., and Alvar J. Semi-quantitative analysis of cytokine expression in asymptomatic canine leishmaniasis. Vet. Immunol. Immunopathol. 103 (2005) 67-75
10. Dantas-Torres F. The role of dogs as reservoirs of Leishmania parasites, with emphasis on Leishmania (Leishmania) infantum and Leishmania (Viannia) braziliensis. Vet. Parasitol. 149 (2007) 139-146
11. de Carvalho L.P., Soto M., Jeronimo S., Dondji B., Bacellar O., Luz V., Orge Orge G., Alonso C., Jesus A.R., and Carvalho E.M. Characterization of the immune response to Leishmania infantum recombinant antigens. Microbes Infect. 5 (2003) 7-12
12. Fujiwara R.T., Vale A.M., Franca da Silva J.C., da Costa R.T., Quetz Jda S., Martins Filho O.A., Reis A.B., Correa Oliveira R., Machado-Coelho G.L., Bueno L.L., Bethony J.M., Frank G., Nascimento E., Genaro O., Mayrink W., Reed S., and Campos-Neto A. Immunogenicity in dogs of three recombinant antigens (TSA, LeIF and LmSTI1) potential vaccine candidates for canine visceral leishmaniasis. Vet. Res. 36 (2005) 827-838
13. Gomez-Sebastian S., Perez-Filgueira D.M., Gomez-Casado E., Nunez M.C., Sanchez-Ramos I., Tabares E., and Escribano J.M. DIVA diagnostic of Aujeszkys disease using an insect-derived virus glycoprotein E. J. Virol. Methods (2008)
14. Gonzalez-Aseguinolaza G., Taladriz S., Marquet A., and Larraga V. Molecular cloning, cell localization and binding affinity to DNA replication proteins of the p36/LACK protective antigen from Leishmania infantum. Eur. J. Biochem. 259 (1999) 909-916
15. Iniesta L., Gallego M., and Portus M. Immunoglobulin G and E responses in various stages of canine leishmaniosis. Vet. Immunol. Immunopathol. 103 (2005) 77-81
16. Jardim A., Funk V., Caprioli R.M., and Olafson R.W. Isolation and structural characterization of the Leishmania donovani kinetoplastid membrane protein-11, a major immunoreactive membrane glycoprotein. Biochem. J. 305 Pt 1 (1995) 307-313
17. Julia V., and Glaichenhaus N. CD4(+) T cells which react to the Leishmania major LACK antigen rapidly secrete interleukin-4 and are detrimental to the host in resistant B10.D2 mice. Infect. Immun. 67 (1999) 3641-3644
18. Kelly B.L., Stetson D.B., and Locksley R.M. Leishmania major LACK antigen is required for efficient vertebrate parasitization. J. Exp. Med. 198 (2003) 1689-1698
19. Kost T.A., Condreay J.P., and Jarvis D.L. Baculovirus as versatile vectors for protein expression in insect and mammalian cells. Nat. Biotechnol. 23 (2005) 567-575
20. Kubar J., and Fragaki K. Recombinant DNA-derived leishmania proteins: from the laboratory to the field. Lancet Infect. Dis. 5 (2005) 107-114
21. Landis J.R., and Koch G.G. An application of hierarchical kappa-type statistics in the assessment of majority agreement among multiple observers. Biometrics 33 (1977) 363-374
22. Landis J.R., and Koch G.G. The measurement of observer agreement for categorical data. Biometrics 33 (1977) 159-174
23. Levick M.P., Tetaud E., Fairlamb A.H., and Blackwell J.M. Identification and characterisation of a functional peroxidoxin from Leishmania major. Mol. Biochem. Parasitol. 96 (1998) 125-137
24. Maalej I.A., Chenik M., Louzir H., Ben Salah A., Bahloul C., Amri F., and Dellagi K. Comparative evaluation of ELISAs based on ten recombinant or purified Leishmania antigens for the serodiagnosis of Mediterranean visceral leishmaniasis. Am. J. Trop. Med. Hyg. 68 (2003) 312-320
25. Maia C., and Campino L. Methods for diagnosis of canine leishmaniasis and immune response to infection. Vet. Parasitol. 158 (2008) 274-287
26. Mauricio I.L., Stothard J.R., and Miles M.A. The strange case of Leishmania chagasi. Parasitol. Today 16 (2000) 188-189
27. Medin J.A., Hunt L., Gathy K., Evans R.K., and Coleman M.S. Efficient, low-cost protein factories: expression of human adenosine deaminase in baculovirus-infected insect larvae. Proc. Natl. Acad. Sci. U.S.A. 87 (1990) 2760-2764
28. Moreno J., and Alvar J. Canine leishmaniasis: epidemiological risk and the experimental model. Trends Parasitol. 18 (2002) 399-405
29. Na Z., Huipeng Y., Lipan L., Cuiping C., Umashankar M.L., Xingmeng L., Xiaofeng W., Bing W., Weizheng C., and Cenis J.L. Efficient production of canine interferon-alpha in silkworm Bombyx mori by use of a BmNPV/Bac-to-Bac expression system. Appl. Microbiol. Biotechnol. 78 (2008) 221-226
30. Nieto C.G., Garcia-Alonso M., Requena J.M., Miron C., Soto M., Alonso C., and Navarrete I. Analysis of the humoral immune response against total and recombinant antigens of Leishmania infantum: correlation with disease progression in canine experimental leishmaniasis. Vet. Immunol. Immunopathol. 67 (1999) 117-130
31. O'Connell K.P., Kovaleva E., Campbell J.H., Anderson P.E., Brown S.G., Davis D.C., Valdes J.J., Welch R.W., Bentley W.E., and van Beek N.A. Production of a recombinant antibody fragment in whole insect larvae. Mol. Biotechnol. 36 (2007) 44-51
32. O'Reilly D.R. Use of baculovirus expression vectors. Methods Mol. Biol. 62 (1997) 235-246
33. Passos S., Carvalho L.P., Orge G., Jeronimo S.M., Bezerra G., Soto M., Alonso C., and Carvalho E.M. Recombinant leishmania antigens for serodiagnosis of visceral leishmaniasis. Clin. Diagn. Lab. Immunol. 12 (2005) 1164-1167
34. Peng Z.K., Simons F.E., and Becker A.B. Differential binding properties of protein A and protein G for dog immunoglobulins. J. Immunol. Methods 145 (1991) 255-258
35. Perez-Filgueira D.M., Gonzalez-Camacho F., Gallardo C., Resino-Talavan P., Blanco E., Gomez-Casado E., Alonso C., and Escribano J.M. Optimization and validation of recombinant serological tests for African Swine Fever diagnosis based on detection of the p30 protein produced in Trichoplusia ni larvae. J. Clin. Microbiol. 44 (2006) 3114-3121
36. Perez-Filgueira D.M., Resino-Talavan P., Cubillos C., Angulo I., Barderas M.G., Barcena J., and Escribano J.M. Development of a low-cost, insect larvae-derived recombinant subunit vaccine against RHDV. Virology 364 (2007) 422-430
37. Perez-Martin E., Grau-Roma L., Argilaguet J.M., Nofrarias M., Escribano J.M., Gomez-Sebastian S., Segales J., and Rodriguez F. Development of two Trichoplusia ni larvae-derived ELISAs for the detection of antibodies against replicase and capsid proteins of porcine circovirus type 2 in domestic pigs. J. Virol. Methods 154 (2008) 167-174
38. Quinnell R.J., Courtenay O., Davidson S., Garcez L., Lambson B., Ramos P., Shaw J.J., Shaw M.A., and Dye C. Detection of Leishmania infantum by PCR, serology and cellular immune response in a cohort study of Brazilian dogs. Parasitology 122 (2001) 253-261
39. Rabah N., Gauthier D.J., Gauthier D., and Lazure C. Improved PC1/3 production through recombinant expression in insect cells and larvae. Protein Expr. Purif. 37 (2004) 377-384
40. Ramirez J.R., Berberich C., Jaramillo A., Alonso C., and Velez I.V. Molecular and antigenic characterization of the Leishmania (Viannia) panamensis kinetoplastid membrane protein-11. Mem. Inst. Oswaldo Cruz 93 (1998) 247-254
41. Ramiro M.J., Zarate J.J., Hanke T., Rodriguez D., Rodriguez J.R., Esteban M., Lucientes J., Castillo J.A., and Larraga V. Protection in dogs against visceral leishmaniasis caused by Leishmania infantum is achieved by immunization with a heterologous prime-boost regime using DNA and vaccinia recombinant vectors expressing LACK. Vaccine 21 (2003) 2474-2484
42. Requena J.M., Soto M., Doria M.D., and Alonso C. Immune and clinical parameters associated with Leishmania infantum infection in the golden hamster model. Vet. Immunol. Immunopathol. 76 (2000) 269-281
43. Riera C., Valladares J.E., Gallego M., Aisa M.J., Castillejo S., Fisa R., Ribas N., Carrio J., Alberola J., and Arboix M. Serological and parasitological follow-up in dogs experimentally infected with Leishmania infantum and treated with meglumine antimoniate. Vet. Parasitol. 84 (1999) 33-47
44. Rodriguez-Cortes A., Ojeda A., Lopez-Fuertes L., Timon M., Altet L., Solano-Gallego L., Sanchez-Robert E., Francino O., and Alberola J. Vaccination with plasmid DNA encoding KMPII, TRYP, LACK and GP63 does not protect dogs against Leishmania infantum experimental challenge. Vaccine 25 (2007) 7962-7971
45. Rodriguez A., Solano-Gallego L., Ojeda A., Quintana J., Riera C., Gallego M., Portus M., and Alberola J. Dynamics of Leishmania-specific immunoglobulin isotypes in dogs with clinical leishmaniasis before and after treatment. J. Vet. Intern. Med. 20 (2006) 495-498
46. Russo D.M., Turco S.J., Burns Jr. J.M., and Reed S.G. Stimulation of human T lymphocytes by Leishmania lipophosphoglycan-associated proteins. J. Immunol. 148 (1992) 202-207
47. Solano-Gallego L., Morell P., Arboix M., Alberola J., and Ferrer L. Prevalence of Leishmania infantum infection in dogs living in an area of canine leishmaniasis endemicity using PCR on several tissues and serology. J. Clin. Microbiol. 39 (2001) 560-563
48. Stebeck C.E., Beecroft R.P., Singh B.N., Jardim A., Olafson R.W., Tuckey C., Prenevost K.D., and Pearson T.W. Kinetoplastid membrane protein-11 (KMP-11) is differentially expressed during the life cycle of African trypanosomes and is found in a wide variety of kinetoplastid parasites. Mol. Biochem. Parasitol. 71 (1995) 1-13
49. Tolson D.L., Jardim A., Schnur L.F., Stebeck C., Tuckey C., Beecroft R.P., Teh H.S., Olafson R.W., and Pearson T.W. The kinetoplastid membrane protein 11 of Leishmania donovani and African trypanosomes is a potent stimulator of T-lymphocyte proliferation. Infect. Immun. 62 (1994) 4893-4899
50. Trujillo C., Ramirez R., Velez I.D., and Berberich C. The humoral immune response to the kinetoplastid membrane protein-11 in patients with American leishmaniasis and Chagas disease: prevalence of IgG subclasses and mapping of epitopes. Immunol. Lett. 70 (1999) 203-209
51. Van Oers M. Vaccines for viral and parasitic diseases produced with baculovirus vectors. Adv. Virus Res. 68 (2006) 193-253
52. Webb J.R., Campos-Neto A., Ovendale P.J., Martin T.I., Stromberg E.J., Badaro R., and Reed S.G. Human and murine immune responses to a novel Leishmania major recombinant protein encoded by members of a multicopy gene family. Infect. Immun. 66 (1998) 3279-3289
53. Wyllie S., Vickers T.J., and Fairlamb A.H. Roles of trypanothione S-transferase and tryparedoxin peroxidase in resistance to antimonials. Antimicrob. Agents Chemother. 52 (2008) 1359-1365