CD4+ T cells which react to the Leishmania major LACK antigen rapidly secrete interleukin-4 and are detrimental to the host in resistant B10.D2 mice

Infection and Immunity

Volumn 67, Issue 7, 1999, Pages 3641-3644

  Julia, Valérie ^a   Glaichenhaus, Nicolas ^a,b  

^a INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; INTERLEUKIN 4; PROTEIN KINASE C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; HELPER CELL; HOST RESISTANCE; HOST SUSCEPTIBILITY; IMMUNE RESPONSE; IMMUNOREGULATION; INFECTION SENSITIVITY; LEISHMANIA MAJOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; TRANSGENIC MOUSE;

EID: 0033045577     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.7.3641-3644.1999     Document Type: Article

References (26)

1. Beebe, A. M., S. Mauze, N. J. Schork, and R. L. Coffman. 1997. Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice. Immunity 6:551-557.
2. + T cells. J. Exp. Med. 182:1591-1596.
3. Gabaglia, C. R., B. Pedersen, M. Hitt, N. Burdin, E. E. Sercarz, F. L. Graham, J. Gauldie, and T. A. Braciak. 1999. A single intramuscular injection with an adenovirus-expressing IL-12 protects BALB/c mice against Leishmania major infection, while treatment with an IL-4-expressing vector increases disease susceptibility in B10.D2 mice. J. Immunol. 162:753-760.
4. Gajewski, T. F., M. Pinnas, T. Wong, and F. W. Fitch. 1991. Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations. J. Immunol. 144:1750-1759.
5. Gorham, J. D., M. L. Güler, R. G. Steen, A. J. Mackey, M. J. Daly, K. Frederick, W. F. Dietrich, and K. M. Murphy. 1996. Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses. Proc. Natl. Acad. Sci. USA 93:12467-12472.
6. Güler, M. L., J. D. Gorham, C.-S. Hsieh, A. J. Mackey, R. G. Steen, W. F. Dietrich, and K. M. Murphy. 1996. Genetic susceptibility to Leishmania: IL-12 responsiveness in Th1 development. Science 271:984-987.
7. Güler, M. L., N. G. Jacobson, U. Gubler, and K. M. Murphy. 1997. T cell genetic background determines maintenance of IL-12 signaling - effects on BALB/c and B10.D2 T helper cell type 1 phenotype development. J. Immunol. 159:1767-1774.
8. Julia, V., M. Rassoulzadegan, and N. Glaichenhaus. 1996. Resistance to Leishmania major induced by tolerance to a single antigen. Science 274:421-423.
9. Kopf, M., F. Brombacher, G. Köhler, G. Krienzle, K.-H. Widmann, K. Lefrang, C. Humborg, B. Ledermann, and W. Solbach. 1996. IL-4-deficient BALB/c mice resist infection with Leishmania major. J. Exp. Med. 184:1127-1136.
10. Kumar, V., V. Bhardwaj, V. Soares, J. Alexander, A. Sette, and E. Sercarz. 1995. Major histocompatibility complex affinity of an antigenic determinant is crucial for the differential secretion of interleukin 4/5 or interferon-γ by T cells. Proc. Natl. Acad. Sci. USA 92:9510-9514.
11. + T cells instructs the development and susceptibility to Leishmania major in BALB/c mice. Immunity 6:541-549.
12. -. Eur. J. Immunol. 25:3298-3307.
13. Launois, P., K. G. Swihart, G. Milon, and J. A. Louis. 1997. Early production of IL-4 in susceptible mice infected with Leishmania major rapidly induces IL-12 unresponsiveness. J. Immunol. 158:3317-3324.
14. Leal, L. M. C. C., D. W. Moss, R. Kuhn, W. Muller, and F. Y. Liew. 1993. Interleukin-4 transgenic mice of resistant background are susceptible to Leishmania major infection. Eur. J. Immunol. 23:566-569.
15. Noben-Trauth, N., P. Kropf, and I. Müller. 1996. Susceptibility to Leishmania major infection in interleukin-4-deficient mice. Science 271:987-989.
16. + T cells. Immunity 1:553-562.
17. Reiner, S. L., and R. M. Locksley. 1995. The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13:151-177.
18. Reiner, S. L., S. Zheng, D. B. Corry, and R. M. Locksley. 1993. Constructing polycompetitor cDNAs for quantitative PCR. J. Immunol. Methods 165:37-46.
19. + T cells during initiation of infection. J. Exp. Med. 179:447-456.
20. Roberts, L. J., T. M. Baldwin, J. M. Curtis, E. Handman, and S. J. Foote. 1997. Resistance to Leishmania major is linked to the H2 region on chromosome 17 and to chromosome 9. J. Exp. Med. 185:1705-1710.
21. Sadick, M. D., F. P. Heinzel, B. J. Holoway, R. T. Pu, R. Dawkins, and R. M. Locksley. 1990. Cure of murine leishmaniasis with anti-interleukin-4 monoclonal antibody. J. Exp. Med. 171:115-127.
22. Scott, P., A. Eaton, W. C. Gause, X. Zhou, and B. Hondowicz. 1996. Early IL-4 production does not predict susceptibility to Leishmania major. Exp. Parasitol. 84:178-187.
23. + T cells from T cell receptor transgenic mice. J. Exp. Med. 176:1091-1098.
24. Shankar, A. H., and R. G. Titus. 1995. T cell and non-T cell compartments can independently determine resistance to Leishmania major. J. Exp. Med. 181:845-855.
25. + T cell subset expression. Int. Immunol. 6:785-794.
26. Stenger, S., N. Donhauser, H. Thüring, M. Röllinghoff, and C. Bogdan. 1996. Reactivation of latent leishmaniasis by inhibition of inducible nitric oxide synthase. J. Exp. Med. 183:1501-1514.