Reverse genetic characterization of the natural genomic deletion in SARS-Coronavirus strain Frankfurt-1 open reading frame 7b reveals an attenuating function of the 7b protein in-vitro and in-vivo

Virology Journal

Volumn 6, Issue , 2009, Pages

  Pfefferle, Susanne ^a   Krähling, Verena ^b   Ditt, Vanessa ^c   Grywna, Klaus ^a   Mühlberger, Elke ^b,d,e   Drosten, Christian ^a,c  

^a BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c UNIVERSITY OF BONN   (Germany)

^d National Emerging Infectious Diseases Laboratories Institute   (United States)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7B PROTEIN; BETA INTERFERON; COMPLEMENTARY DNA; INTERFERON; RNA POLYMERASE; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS RNA; ORF7B PROTEIN, SARS CORONAVIRUS; VIRULENCE FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BACTERIAL CHROMOSOME; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA FLANKING REGION; GENE DELETION; GENETIC TRANSFECTION; GENOME ANALYSIS; HAMSTER; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PROMOTER REGION; PROTEIN DETERMINATION; PROTEIN FUNCTION; SARS CORONAVIRUS; VERO CELL; VIRUS ISOLATION; VIRUS REPLICATION; VIRUS STRAIN; VIRUS TITRATION; VIRUS TRANSMISSION; VIRUS VIRULENCE; ANIMAL; BACTERIAL ARTIFICIAL CHROMOSOME; CELL LINE; CERCOPITHECUS; DNA SEQUENCE; GENE VECTOR; GENETICS; LUNG; MOLECULAR GENETICS; PATHOGENICITY; PATHOLOGY; PHYSIOLOGY; SEVERE ACUTE RESPIRATORY SYNDROME; SYRIAN HAMSTER; VIROLOGY; VIRULENCE;

BACTERIA (MICROORGANISMS); CRICETINAE; MESOCRICETUS AURATUS; SARS CORONAVIRUS;

ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; CHROMOSOMES, ARTIFICIAL, BACTERIAL; CRICETINAE; GENETIC VECTORS; HUMANS; LUNG; MESOCRICETUS; MOLECULAR SEQUENCE DATA; SARS VIRUS; SEQUENCE ANALYSIS, DNA; SEQUENCE DELETION; SEVERE ACUTE RESPIRATORY SYNDROME; VIRAL PROTEINS; VIRULENCE; VIRULENCE FACTORS; VIRUS REPLICATION;

EID: 70349121706     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/1743-422X-6-131     Document Type: Article

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