A new method for the determination of the relative affinity of a ligand against various DNA sequences by electrospray ionization mass spectrometry. Application to a polyamide minor groove binder

Journal of Mass Spectrometry

Volumn 44, Issue 8, 2009, Pages 1171-1181

  Buchmann, William ^a   Boutorine, Alexandre ^b,c,d   Halby, Ludovic ^b,c,d   Tortajadaa, Jeanine ^a   De Pauw, Edwin ^e  

^a UNIVERSITÉ D EVRY VAL D ESSONNE   (France)

^b MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

^c INSERM   (France)

^d CNRS   (France)

^e UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

DNA recognition; Electrospray ionization; Mass spectrometry; Minor groove binder; Noncovalent interactions; Polyamide

Indexed keywords

DISSOCIATION CONSTANT; DNA RECOGNITION; DOUBLE STRANDED DNA; ELECTROSPRAY IONIZATION MASS SPECTROMETRY; LIGAND CONCENTRATION; MINOR GROOVE BINDER; MINOR GROOVES; N-METHYLPYRROLE; NANOMOLAR RANGE; NONCOVALENT INTERACTIONS; TIME OF FLIGHT MASS SPECTROMETRY;

BINDERS; COMPLEXATION; DISSOCIATION; DNA; DNA SEQUENCES; GENES; IONIZATION; LIGANDS; MASS SPECTROMETERS; MASS SPECTROMETRY; NUCLEIC ACIDS; STOICHIOMETRY;

ELECTROSPRAY IONIZATION;

1 METHYLPYRROLE; DNA; DOUBLE STRANDED DNA; LIGAND; POLYAMIDE;

ACCURACY; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA BINDING; DNA SEQUENCE; ELECTROSPRAY IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; ELECTROSPRAY MASS SPECTROMETRY; LABELING INDEX; MOLECULAR INTERACTION; MOLECULAR STABILITY; PRIORITY JOURNAL; STOICHIOMETRY; TIME OF FLIGHT MASS SPECTROMETRY;

BINDING SITES; BINDING, COMPETITIVE; DNA; LIGANDS; MODELS, MOLECULAR; NYLONS; OLIGONUCLEOTIDES; PYRROLES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 70349102958     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.1592     Document Type: Article

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