CD-spectroscopy as a powerful tool for investigating the mode of action of unmodified drugs in live cells

Journal of the American Chemical Society

Volumn 131, Issue 36, 2009, Pages 13031-13036

  Tietze, Lutz F ^a   Krewer, Birgit ^a   Major, Felix ^a   Schuberth, Ingrid ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACHIRAL COMPOUND; ANTI-CANCER AGENTS; BIOACTIVE COMPOUNDS; CD SIGNALS; CD SPECTRA; CD SPECTROSCOPY; CELLULAR TARGETS; CELLULAR UPTAKE; CHIRAL CHEMICALS; CIRCULAR DICHROISM; COVALENT BINDING; CYTOTOXIC; GENERAL APPROACH; LIVE CELL; MODE OF ACTION; MOLECULAR LEVELS; NATURAL ANTIBIOTICS; NON-COVALENT COMPLEXES; TIME-DEPENDENT CHANGES; TOXIC COMPOUNDS;

CHEMICAL COMPOUNDS; CIRCULAR DICHROISM SPECTROSCOPY; CYTOLOGY; DATA STORAGE EQUIPMENT; DICHROISM; DNA; GENES; HYDROCARBONS; NUCLEIC ACIDS;

CELL MEMBRANES;

RACHELMYCIN;

ALKYLATION; ANIMAL CELL; ARTICLE; CELL ACTIVITY; CHIRALITY; CIRCULAR DICHROISM; COMPLEX FORMATION; CONTROLLED STUDY; COVALENT BOND; DRUG CYTOTOXICITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN PROTEIN INTERACTION; TARGET CELL;

ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE, TUMOR; CIRCULAR DICHROISM; DNA; HUMANS; INDOLES; MOLECULAR STRUCTURE;

EID: 70349095343     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja902767f     Document Type: Article

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