X-ray structure of cytotoxic trans-[PtCl2(dimethylamine) (isopropylamine)]: Interstrand cross-link efficiency, DNA sequence specificity, and inhibition of the B-Z transition

Journal of Medicinal Chemistry

Volumn 43, Issue 12, 2000, Pages 2411-2418

  Pérez, José M ^a   Montero, Eva I ^a   González, Ana M ^a   Solans, Xavier ^b   Font Bardia, Mercé ^b   Fuertes, Miguel A ^a   Alonso, Carlos ^a   Navarro Ranninger, Carmen ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; PLATINUM DERIVATIVE; PLATINUM DICHLORIDE(DIMETHYLAMINE)(ISOPROPYLAMINE); PURINE; PYRIMIDINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CIRCULAR DICHROISM; CROSS LINKING; CRYSTAL STRUCTURE; DNA BINDING; DNA SEQUENCE; DRUG STRUCTURE; POLYACRYLAMIDE GEL ELECTROPHORESIS; X RAY;

ANTINEOPLASTIC AGENTS; CIRCULAR DICHROISM; CROSS-LINKING REAGENTS; CRYSTALLOGRAPHY, X-RAY; DNA; DNA, SUPERHELICAL; KINETICS; ORGANOPLATINUM COMPOUNDS; POLYDEOXYRIBONUCLEOTIDES; SODIUM CHLORIDE;

EID: 0038039840     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000925p     Document Type: Article

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