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Volumn 14, Issue 8, 2009, Pages 794-799

Trabectedin

Author keywords

DNA repair; Drug profile; Trabectedin

Indexed keywords

ANTHRACYCLINE DERIVATIVE; BRCA1 PROTEIN; CISPLATIN; DEXAMETHASONE; DOXORUBICIN; GEMCITABINE; IFOSFAMIDE; IRINOTECAN; KETOCONAZOLE; PACLITAXEL; TRABECTEDIN; TROLEANDOMYCIN;

EID: 70249135331     PISSN: 10837159     EISSN: 1549490X     Source Type: Journal    
DOI: 10.1634/theoncologist.2009-0104     Document Type: Review
Times cited : (13)

References (61)
  • 1
    • 0034611483 scopus 로고    scopus 로고
    • A new, more efficient, and effective process for the synthesis of a key pentacyclic intermediate for production of ecteinascidin and phthalascidin antitumor agents
    • Martinez EJ, Corey EJ. A new, more efficient, and effective process for the synthesis of a key pentacyclic intermediate for production of ecteinascidin and phthalascidin antitumor agents. Org Lett 2000;2:993-996.
    • (2000) Org Lett , vol.2 , pp. 993-996
    • Martinez, E.J.1    Corey, E.J.2
  • 7
    • 41549089846 scopus 로고    scopus 로고
    • Randomized phase II study of trabectedin in patients with liposarcoma and leiomyosarcoma (L-sarcomas) after failure of prior anthracyclines (A) and ifosfamide (I)
    • (part 1) (suppl)
    • Morgan JA, Le Cesne A, Chawla S et al. Randomized phase II study of trabectedin in patients with liposarcoma and leiomyosarcoma (L-sarcomas) after failure of prior anthracyclines (A) and ifosfamide (I). J Clin Oncol (ASCO Annual Meeting Proceedings) 2007;(part 1)25(18S)(suppl):10060.
    • (2007) J Clin Oncol (ASCO Annual Meeting Proceedings) , vol.25 , Issue.18 S , pp. 10060
    • Morgan, J.A.1    Le Cesne, A.2    Chawla, S.3
  • 12
    • 60849129809 scopus 로고    scopus 로고
    • Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors
    • Forni C, Minuzzo M, Virdis E et al. Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors. Mol Cancer Ther 2009;8:449-457.
    • (2009) Mol Cancer Ther , vol.8 , pp. 449-457
    • Forni, C.1    Minuzzo, M.2    Virdis, E.3
  • 13
    • 0034786774 scopus 로고    scopus 로고
    • Sequence-dependent enhancement of cytotoxicity produced by ecteinascidin 743 (ET-743) with doxorubicin or paclitaxel in soft tissue sarcoma cells
    • Takahashi N, Li WW, Banerjee D, et al. Sequence-dependent enhancement of cytotoxicity produced by ecteinascidin 743 (ET-743) with doxorubicin or paclitaxel in soft tissue sarcoma cells. Clin Cancer Res 2001;7:3251-3257. (Pubitemid 32963850)
    • (2001) Clinical Cancer Research , vol.7 , Issue.10 , pp. 3251-3257
    • Takahashi, N.1    Wei Wei, L.2    Banerjee, D.3    Scotto, K.W.4    Bertino, J.R.5
  • 15
    • 0242559104 scopus 로고    scopus 로고
    • Preclinical and clinical results with the natural marine product ET-743
    • DOI 10.1517/eoid.12.11.1843.21875
    • D'Incalci M, Jimeno J. Preclinical and clinical results with the natural marine product ET-743. Expert Opin Investig Drugs 2003;12:1843-1853. (Pubitemid 37408131)
    • (2003) Expert Opinion on Investigational Drugs , vol.12 , Issue.11 , pp. 1843-1853
    • D'Incalci, M.1    Jimeno, J.2
  • 18
    • 53149133906 scopus 로고    scopus 로고
    • Phase I trial of weekly trabectedin (ET-743) and gemcitabine in patients with advanced solid tumors
    • Messersmith WA, Jimeno A, Ettinger D et al. Phase I trial of weekly trabectedin (ET-743) and gemcitabine in patients with advanced solid tumors. Cancer Chemother Pharmacol 2008;63:181-188.
    • (2008) Cancer Chemother Pharmacol , vol.63 , pp. 181-188
    • Messersmith, W.A.1    Jimeno, A.2    Ettinger, D.3
  • 19
    • 67651089735 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of trabectedin and cisplatin in solid tumours
    • Epub ahead of print
    • Sessa C, Cresta S, Noberasco C et al. Phase I clinical and pharmacokinetic study of trabectedin and cisplatin in solid tumours. Eur J Cancer 2009 [Epub ahead of print[.
    • (2009) Eur J Cancer
    • Sessa, C.1    Cresta, S.2    Noberasco, C.3
  • 20
    • 64449085620 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of trabectedin and doxorubicin in advanced soft tissue sarcoma and breast cancer
    • Sessa C, Perotti A, Noberasco C et al. Phase I clinical and pharmacokinetic study of trabectedin and doxorubicin in advanced soft tissue sarcoma and breast cancer. Eur J Cancer 2009;45:1153-1161.
    • (2009) Eur J Cancer , vol.45 , pp. 1153-1161
    • Sessa, C.1    Perotti, A.2    Noberasco, C.3
  • 21
    • 58149186082 scopus 로고    scopus 로고
    • Phase I combination study of trabectedin and doxorubicin in patients with soft-tissue sarcoma
    • Blay JY, von Mehren M, Samuels BL et al. Phase I combination study of trabectedin and doxorubicin in patients with soft-tissue sarcoma. Clin Cancer Res 2008;14:6656-6662.
    • (2008) Clin Cancer Res , vol.14 , pp. 6656-6662
    • Blay, J.Y.1    Von Mehren, M.2    Samuels, B.L.3
  • 22
    • 53049092830 scopus 로고    scopus 로고
    • A phase I study of the safety and pharmacokinetics of trabectedin in combination with pegylated liposomal doxorubicin in patients with advanced malignancies
    • von Mehren M, Schilder RJ, Cheng JD et al. A phase I study of the safety and pharmacokinetics of trabectedin in combination with pegylated liposomal doxorubicin in patients with advanced malignancies. Ann Oncol 2008;19:1802-1809.
    • (2008) Ann Oncol , vol.19 , pp. 1802-1809
    • Von Mehren, M.1    Schilder, R.J.2    Cheng, J.D.3
  • 23
    • 60749085569 scopus 로고    scopus 로고
    • A randomized phase III study of trabectedin with pegylated liposomal doxorubicin (PLD) versus PLD in relapsed, recurrent ovarian cancer (OC)
    • Monk BJ, Herzog T, Kaye S, et al. A randomized phase III study of trabectedin with pegylated liposomal doxorubicin (PLD) versus PLD in relapsed, recurrent ovarian cancer (OC). Ann Oncol Presidential Symposium Abstract LBA4, 2008;19.
    • (2008) Ann Oncol Presidential Symposium Abstract LBA4 , vol.19
    • Monk, B.J.1    Herzog, T.2    Kaye, S.3
  • 24
    • 19944426087 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic study of ecteinascidin-743 (Yondelis) in children with refractory solid tumors. a Children's Oncology Group study
    • Lau L, Supko JG, Blaney S et al. A phase I and pharmacokinetic study of ecteinascidin-743 (Yondelis) in children with refractory solid tumors. A Children's Oncology Group study. Clin Cancer Res 2005;11:672-677.
    • (2005) Clin Cancer Res , vol.11 , pp. 672-677
    • Lau, L.1    Supko, J.G.2    Blaney, S.3
  • 25
    • 0026402109 scopus 로고
    • Human diseases associated with defective DNA excision repair
    • Wood RD. Human diseases associated with defective DNA excision repair. J R Coll Physicians Lond 1991;25:300-303.
    • (1991) J R Coll Physicians Lond , vol.25 , pp. 300-303
    • Wood, R.D.1
  • 26
    • 0028596398 scopus 로고
    • Transcription-coupled repair and human disease
    • Hanawalt PC. Transcription-coupled repair and human disease. Science 1994;266:1957-1958.
    • (1994) Science , vol.266 , pp. 1957-1958
    • Hanawalt, P.C.1
  • 27
    • 0036204121 scopus 로고    scopus 로고
    • Pathways defective in the human premature aging disease Werner syndrome
    • DOI 10.1023/A:1015223917491
    • Bohr VA, Brosh RM Jr, von Kobbe C, et al. Pathways defective in the human premature aging disease Werner syndrome. Biogerontology 2002;3:89-94. (Pubitemid 34284984)
    • (2002) Biogerontology , vol.3 , Issue.1-2 , pp. 89-94
    • Bohr, V.A.1    Brosh Jr., R.M.2    Von Kobbe, C.3    Opresko, P.4    Karmakar, P.5
  • 28
    • 32644450616 scopus 로고    scopus 로고
    • Molecular mechanisms of mammalian global genome nucleotide excision repair
    • DOI 10.1021/cr040483f
    • Gillet LC, Scharer OD. Molecular mechanisms of mammalian global genome nucleotide excision repair. Chem Rev 2006;106:253-276. (Pubitemid 43316557)
    • (2006) Chemical Reviews , vol.106 , Issue.2 , pp. 253-276
    • Gillet, L.C.J.1    Scharer, O.D.2
  • 29
    • 56749157389 scopus 로고    scopus 로고
    • Transcription-coupled DNA repair: Two decades of progress and surprises
    • Hanawalt PC, Spivak G. Transcription-coupled DNA repair: two decades of progress and surprises. Nat Rev Mol Cell Biol 2008;9:958-970.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 958-970
    • Hanawalt, P.C.1    Spivak, G.2
  • 30
    • 0029838307 scopus 로고    scopus 로고
    • DNA sequence- And structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the caribbean tunicate Ecteinascidia turbinata
    • DOI 10.1021/bi960306b
    • Pommier Y, Kohlhagen G, Bailly C et al. DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata. Biochemistry 1996;35:13303-13309. (Pubitemid 26349423)
    • (1996) Biochemistry , vol.35 , Issue.41 , pp. 13303-13309
    • Pommier, Y.1    Kohlhagen, G.2    Bailly, C.3    Waring, M.4    Mazumder, A.5    Kohn, K.W.6
  • 31
    • 0037096739 scopus 로고    scopus 로고
    • Ecteinascidin-743 inhibits activated but not constitutive transcription
    • Friedman D, Hu Z, Kolb EA, et al. Ecteinascidin-743 inhibits activated but not constitutive transcription. Cancer Res 2002;62:3377-3381. (Pubitemid 34651382)
    • (2002) Cancer Research , vol.62 , Issue.12 , pp. 3377-3381
    • Friedman, D.1    Hu, Z.2    Kolb, E.A.3    Gorfajn, B.4    Scotto, K.W.5
  • 37
    • 40249097419 scopus 로고    scopus 로고
    • Role of homologous recombination in trabectedin-induced DNA damage
    • Tavecchio M, Simone M, Erba E et al. Role of homologous recombination in trabectedin-induced DNA damage. Eur J Cancer 2008;44:609-618.
    • (2008) Eur J Cancer , vol.44 , pp. 609-618
    • Tavecchio, M.1    Simone, M.2    Erba, E.3
  • 39
    • 33748035692 scopus 로고    scopus 로고
    • Cross-talk between nucleotide excision and homologous recombination DNA repair pathways in the mechanism of action of antitumor trabectedin
    • DOI 10.1158/0008-5472.CAN-06-0179
    • Herrero AB, Martin-Castellanos C, Marco E et al. Cross-talk between nucleotide excision and homologous recombination DNA repair pathways in the mechanism of action of antitumor trabectedin. Cancer Res 2006;66:8155-8162. (Pubitemid 44299183)
    • (2006) Cancer Research , vol.66 , Issue.16 , pp. 8155-8162
    • Herrero, A.B.1    Martin-Castellanos, C.2    Marco, E.3    Gago, F.4    Moreno, S.5
  • 41
    • 14644423300 scopus 로고    scopus 로고
    • Hepatotoxicity and metabolism of trabectedin: A literature review
    • DOI 10.1016/j.phrs.2004.12.001
    • Beumer JH, Schellens JH, Beijnen JH. Hepatotoxicity and metabolism of trabectedin: a literature review. Pharmacol Res 2005;51:391-398. (Pubitemid 40321008)
    • (2005) Pharmacological Research , vol.51 , Issue.5 , pp. 391-398
    • Beumer, J.H.1    Schellens, J.H.M.2    Beijnen, J.H.3
  • 42
    • 42149182830 scopus 로고    scopus 로고
    • Assessment of trabectedin (T) induced liver toxicity with correlation to liver morphology in a phase I study of T + pegylated liposomal doxorubicin (PLD)
    • (part 1) (suppl)
    • Yver A, Cohen R, Williams D et al. Assessment of trabectedin (T) induced liver toxicity with correlation to liver morphology in a phase I study of T + pegylated liposomal doxorubicin (PLD). J Clin Oncol (ASCO Annual Meeting Proceedings) 2006;(part 1)24(18S)(suppl):9568.
    • (2006) J Clin Oncol (ASCO Annual Meeting Proceedings) , vol.24 , Issue.18 S , pp. 9568
    • Yver, A.1    Cohen, R.2    Williams, D.3
  • 43
    • 0036387382 scopus 로고    scopus 로고
    • Pharmacokinetics of ecteinascidin 743 administered as a 24-h continuous intravenous infusion to adult patients with soft tissue sarcomas: Associations with clinical characteristics, pathophysiological variables and toxicity
    • Puchalski TA, Ryan DP, Garcia-Carbonero R et al. Pharmacokinetics of ecteinascidin 743 administered as a 24-h continuous intravenous infusion to adult patients with soft tissue sarcomas: associations with clinical characteristics, pathophysiological variables and toxicity. Cancer Chemother Pharmacol 2002;50:309-319.
    • (2002) Cancer Chemother Pharmacol , vol.50 , pp. 309-319
    • Puchalski, T.A.1    Ryan, D.P.2    Garcia-Carbonero, R.3
  • 45
    • 1942516814 scopus 로고    scopus 로고
    • Simple and sensitive liquid chromatographic quantitative analysis of the novel marine anticancer drug Yondelis (ET-743, trabectedin) in human plasma using column switching and tandem mass spectrometric detection
    • DOI 10.1002/jms.608
    • Stokvis E, Rosing H, Lopez-Lazaro L et al. Simple and sensitive liquid chromatographic quantitative analysis of the novel marine anticancer drug Yondelis (ET-743, trabectedin) in human plasma using column switching and tandem mass spectrometric detection. J Mass Spectrom 2004;39:431-436. (Pubitemid 38515357)
    • (2004) Journal of Mass Spectrometry , vol.39 , Issue.4 , pp. 431-436
    • Stokvis, E.1    Rosing, H.2    Lopez-Lazaro, L.3    Beijnen, J.H.4
  • 46
    • 65549101664 scopus 로고    scopus 로고
    • Evaluation of human plasma protein binding of trabectedin (Yondelis, ET-743)
    • Beumer JH, Lopez-Lazaro L, Schellens JH et al. Evaluation of human plasma protein binding of trabectedin (Yondelis, ET-743). Curr Clin Pharmacol 2009;4:38-42.
    • (2009) Curr Clin Pharmacol , vol.4 , pp. 38-42
    • Beumer, J.H.1    Lopez-Lazaro, L.2    Schellens, J.H.3
  • 47
    • 31544458696 scopus 로고    scopus 로고
    • In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug
    • Brandon EF, Sparidans RW, Guijt KJ et al. In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug. Invest New Drugs 2006;24:3-14.
    • (2006) Invest New Drugs , vol.24 , pp. 3-14
    • Brandon, E.F.1    Sparidans, R.W.2    Guijt, K.J.3
  • 48
    • 64449087319 scopus 로고    scopus 로고
    • In vitro studies on the metabolism of trabectedin (YONDELIS) in monkey and man, including human CYP reaction phenotyping
    • Vermeir M, Hemeryck A, Cuyckens F et al. In vitro studies on the metabolism of trabectedin (YONDELIS) in monkey and man, including human CYP reaction phenotyping. Biochem Pharmacol 2009;77:1642-1654.
    • (2009) Biochem Pharmacol , vol.77 , pp. 1642-1654
    • Vermeir, M.1    Hemeryck, A.2    Cuyckens, F.3
  • 51
    • 70249112524 scopus 로고    scopus 로고
    • European Medicines Agency (EMEA) Available from: Available at: Accessed June 30, 2009
    • European Medicines Agency (EMEA). Trabectedin 2007. Available from: Available at: http://www.emea.europa.eu/humandocs/PDFs/EPAR/yondelis/H-773-en6. pdf. Accessed June 30, 2009.
    • Trabectedin 2007
  • 52
    • 69249095009 scopus 로고    scopus 로고
    • Phase I clinical and pharmacological trial of trabectedin (T) in 3 hour infusion every 3 weeks (3h/q3w) in patients with advanced cancer and hepatic function disorder
    • Salazar R, Pardo B, Majem M et al. Phase I clinical and pharmacological trial of trabectedin (T) in 3 hour infusion every 3 weeks (3h/q3w) in patients with advanced cancer and hepatic function disorder. American Society of Clinical Oncology (ASCO) Annual Meeting 2006;24:2080.
    • (2006) American Society of Clinical Oncology (ASCO) Annual Meeting , vol.24 , pp. 2080
    • Salazar, R.1    Pardo, B.2    Majem, M.3
  • 53
    • 47549083451 scopus 로고    scopus 로고
    • DNA repair functionality as a molecular signature for sensitivity (S)/resistance (R) in sarcoma patients (pts) treated with trabectedin (ET-743, Yondelis)
    • Abstract #144, Los Angeles April
    • Schoffski P, Grosso F, Taron M et al. DNA repair functionality as a molecular signature for sensitivity (S)/resistance (R) in sarcoma patients (pts) treated with trabectedin (ET-743, Yondelis). AACR Annual Meeting, Abstract #144, Los Angeles April 2007, 200.
    • (2007) AACR Annual Meeting , pp. 200
    • Schoffski, P.1    Grosso, F.2    Taron, M.3
  • 57
    • 33644816649 scopus 로고    scopus 로고
    • The molecular mechanisms responsible for resistance to ET-743 (Trabectidin; Yondelis) in the Ewing's sarcoma cell line, TC-71
    • Manara MC, Perdichizzi S, Serra M et al. The molecular mechanisms responsible for resistance to ET-743 (Trabectidin; Yondelis) in the Ewing's sarcoma cell line, TC-71. Int J Oncol 2005;27:1605-1616.
    • (2005) Int J Oncol , vol.27 , pp. 1605-1616
    • Manara, M.C.1    Perdichizzi, S.2    Serra, M.3
  • 59
    • 37549038238 scopus 로고    scopus 로고
    • Mechanism-based pharmacokinetic/pharmacodynamic meta-analysis of trabectedin (ET-743, Yondelis) induced neutropenia
    • Hing J, Perez-Ruixo JJ, Stuyckens K et al. Mechanism-based pharmacokinetic/pharmacodynamic meta-analysis of trabectedin (ET-743, Yondelis) induced neutropenia. Clin Pharmacol Ther 2008;83:130-143.
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 130-143
    • Hing, J.1    Perez-Ruixo, J.J.2    Stuyckens, K.3


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