Activated liver stellate cells in chronic viral C hepatitis: Histopathological and immunohistochemical study

Journal of Gastrointestinal and Liver Diseases

Volumn 18, Issue 2, 2009, Pages 163-167

  Tomanovic, Nada R ^a   Boricic, Ivan V ^a   Brasanac, Dimitrije C ^a   Stojsic, Zorica M ^a   Delic, Dragan S ^a   Brmbolic, Branko J ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

SMA immunoreactivity; Hepatic stellate cells; Hepatitis C; Liver fibrosis

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; EOSIN; FUCHSINE; HEMATOXYLIN; IRON; PERIODIC ACID; RETICULIN; SCHIFF BASE;

ACTIVATED LIVER STELLATE CELL; ADULT; ARTICLE; CELL COUNT; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE CLASSIFICATION; HEPATITIS C; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOREACTIVITY; LIVER; LIVER BIOPSY; LIVER FIBROSIS; PROGNOSIS; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; STELLATE CELL; BIOPSY; HOSPITALIZATION; IMMUNOHISTOCHEMISTRY; ITO CELL; LIVER CIRRHOSIS; NECROSIS; PATHOLOGY; VIROLOGY;

BIOPSY; HEPATIC STELLATE CELLS; HEPATITIS C, CHRONIC; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER CIRRHOSIS; NECROSIS; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX;

EID: 70149125058     PISSN: 18418724     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Mengshol JA, Golden-Mason L, Rosen HR. Mechanisms of disease: HCV-induced liver injury. Nat Clin Pract Gastroenterol Hepatol 2007; 4: 622-634. (Pubitemid 350055563)
2. Speengler U, Nattermann J. Immunopathogenesis in hepatitis C virus cirrhosis. Clin Sci (Lond) 2007; 112: 141-155.
3. Poynard T, Bedossa P, Opolon P. Natural history of liver fi brosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups. Lancet 1997; 349: 825-832. (Pubitemid 27129209)
4. Burt AD. Pathobiology of hepatic stellate cells. J Gastroenterol 1999; 34: 299-304.
5. Brenner DA, Waterboer T, Choi SK, et al. New aspects of hepatic fi brosis. J Hepatol 2000; 32 (1 Suppl): 32-38.
6. Cassiman D, Libbrecht L, Desmet V, Denef C, Roskams T. Hepatic stellate cell/myofi broblast subpopulations in fi brotic human and rat livers. J Hepatol 2002; 36: 200-209. (Pubitemid 34146426)
7. Tsukada S, Parsons CJ, Rippe RA. Mechanisms of liver fi brosis. Clin Chim Acta 2006; 364: 33-60.
8. Reimann T, Hempel U, Krautwald S, et al. Transforming growth factor-beta1 induces activation of Ras, Raf-1, MEK and MAPK in rat hepatic stellate cells. FEBS Lett 1997; 403: 57-60. (Pubitemid 27079809)
9. Poniachik J, Baraona E, Zhao J, Lieber CS. Dilinoleoylphosphatidylcholine decreases hepatic stellate cell activation. J Lab Clin Med 1999; 133: 342-348. (Pubitemid 29373031)
10. Lindert S, Wickert L, Sawitza J, et al. Transdifferentiationdependent expression of alpha-SMA in hepatic stellate cells does not involve TGF-beta pathways leading to coinduction of collagen type I and thrombospondin-2. Matrix Biol 2005; 24: 198-207. (Pubitemid 40732593)
11. Buniatian G, Hamprecht B, Gebhardt R. Glial fi brillary acidic protein as a marker of perisinusoidal stellate cells that can distinguish between the normal and myofi broblast-like phenotypes. Biol Cell 1996; 87: 65-73. (Pubitemid 27033699)
12. Kinnman N, Housset C. Peribiliary myofi broblasts in biliary type liver fi brosis. Front Biosci 2002; 7: d496-503.
13. Guyot C, Lepreux S, Combe C, et al. Hepatic fi brosis and cirrhosis: the (myo)fi broblastic cell subpopulations involved. Int J Biochem Cell Biol 2006; 38: 135-151. (Pubitemid 41619443)
14. Chu CM, Shyu WC, Liaw YF. Comparative studies on expression of alpha-smooth muscle actin in hepatic stellate cells in chronic hepatitis B and C. Dig Dis Sci 2008; 53: 1364-1369.
15. Martinelli AL, Ramalho LN, Zucoloto S. Hepatic stellate cells in hepatitis C patients: relationship with liver iron deposits and severity of liver disease. J Gastroenterol Hepatol 2004; 19: 91-98. (Pubitemid 38130613)
16. Ishak K, Baptista A, Bianchi L, et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995; 22: 696-699.
17. Falcon V, Acosta-Rivero N, Shibayama M, et al. HCV core protein localizes in the nuclei of nonparenchymal liver cells from chronically HCV-infected patients. Biochem Bioph Res Commun 2005; 329: 1320-1328.
18. Kanto T, Hayashi N. Immunopathogenesis of hepatitis C virus infection: multifaceted strategies subverting innate and adaptive immunity. Intern Med 2006; 4: 183-191.
19. Imbert-Bismut F, Ratziu V, et al; MULTIVIRC Group. Biochemical markers of liver fi brosis in patients with hepatitis C virus infection: a prospective study. Lancet 2001; 357: 1069-1075.
20. Carpino G, Morini S, Ginanni Corradini G, et al. Alpha-SMA expression in hepatic stellate cells and quantitative analysis of hepatic fi brosis in cirrhosis and in recurrent chronic hepatitis after liver transplantation. Dig Liver Dis 2005; 37: 349-356. (Pubitemid 44356038)
21. Knittel T, Kobold D, Saile B, et al. Rat liver myofi broblasts and hepatic stellate cells: different cell populations of the fi broblast lineage with fi brogenic potential. Gastroenterology 1999; 117: 1205-1221. (Pubitemid 29512681)
22. Jarmay K, Gallai M, Karacsony G, et al. Decorin and actin expression and distribution in patients with chronic hepatitis C following interferon-alpha-2b- treatment. J Hepatol 2000; 32: 993-1002.
23. Svegliati Baroni G, D'Ambrosio L, Ferretti G, et al. Fibrogenic effect of oxidative stress on rat hepatic stellate cells. J Hepatol 1999; 30: 868-875.
24. Hautekeete ML, Geerts A. The hepatic (Ito) cell: its role in human liver disease. Virchows Arch 1997; 430: 195-207.
25. Reeves HL, Burt AD, Wood S, Day CP. Hepatic stellate cell activation occurs in the absence of hepatitis in alcoholic liver disease and correlates with the severitiy of steatosis. J Hepatol 1996; 25: 677-683.
26. Tomanovic N, Boricic I, Brasanac D. Immunohistochemical analysis of alpha-SMA and GFAP expression in liver stellate cells. Vojnosanit Pregl 2006; 63: 553-557.
27. Khan MA, Poulos JE, Brunt EM, et al. Hepatic alpha-smooth muscle expression in hepatitis C patients before and after interferon therapy. Hepatogastroenterology 2001; 48: 212-215.
28. Chu CM, Shyu WC, Liaw YF. Comparative studies on expression of alpha-smooth muscle actin in hepatic stellate cells in chronic hepatitis B and C. Dig Dis Sci 2008; 53: 1364-1369.
29. Schultze-Krebs A, Preimel D, Popov Y, et al. Hepatitis C virusreplicating hepatocytes induce fi brogenic activation of hepatic stellate cells. Gastroenterology 2005; 129: 246-258.
30. Delic D, Nesic Z, Prostran M, et al. Histopathology of chronic hepatitis C in relation to virus genotype. Vojnosanit Pregl 2006; 63: 819-825.
31. Rosenberg WM. Success in treating mild chronic hepatitis C: different outcomes - new guidelines? Eur J Gastroenterol Hepatol 2002; 14: 595-597.
32. Iredale JP, Benyon RC, Pickering J, et al. Mechanisms of spontaneous resolution of rat liver fi brosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest 1998; 102: 538-549. (Pubitemid 28376157)
33. Issa R, Williams E, Trim N, et al. Apoptosis of hepatic stellate cells: involvement in resolution of biliary fi brosis and regulation by soluble growth factors. Gut 2001; 48: 548-557. (Pubitemid 32234801)
34. Zhang LJ, Zheng WD, Shi MN, Wang XZ. Effects of interleukin-10 activation and apoptosis of hepatic stellate cells in fi brotic rat live. World J Gastroenterol 2006; 12: 1918-1923.
35. Akpolat N, Yahsi S, Godekmerdan H, Yalniz M, Demirbag K. The value of alpha-SMA in the evaluation of hepatic fi brosis severity in hepatitis B infection and cirrhosis development: a histopathological and immunohistochemical study. Histopathology 2005; 47: 276-280. (Pubitemid 41243265)