Effect of furosemide and furosemide-carbazochrome combination on exercise-induced pulmonary hemorrhage in standardbred racehorses

Canadian Veterinary Journal

Volumn 50, Issue 8, 2009, Pages 821-827

  Perez Moreno, Cecilia I ^a   Couëtil, Laurent L ^a   Pratt, Suzanne M ^a   Ochoa Acuña, Hugo G ^a   Raskin, Rose E ^a   Russell, Mark A ^a  

^a Veterinary Clinical Sciences Couëtil   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENOCHROME; CARBAZOCHROME; DIURETIC AGENT; DRUG DERIVATIVE; FUROSEMIDE;

ANIMAL; ANIMAL DISEASE; ANIMAL EXPERIMENT; ARTICLE; BLEEDING; CROSSOVER PROCEDURE; CYTOLOGY; DRUG COMBINATION; EXERCISE TEST; FEMALE; HORSE; HORSE DISEASE; LUNG DISEASE; LUNG LAVAGE; MALE; RANDOMIZATION; TREATMENT OUTCOME;

ADRENOCHROME; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CROSS-OVER STUDIES; DIURETICS; DRUG THERAPY, COMBINATION; EXERCISE TEST; FEMALE; FUROSEMIDE; HEMORRHAGE; HORSE DISEASES; HORSES; LUNG DISEASES; MALE; PHYSICAL CONDITIONING, ANIMAL; RANDOM ALLOCATION; TREATMENT OUTCOME;

CONGIOPODIDAE; EQUIDAE;

EID: 70149109379     PISSN: 00085286     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Lapointe JM, Vrins A, McCarvill E. A survey of exercise-induced pulmonary haemorrhage in Quebec standardbred racehorses. Equine Vet J 1994;26:482-485.
2. Birks EK, Shuler KM, Soma LR, et al. EIPH: Postrace endoscopic evaluation of Standardbreds and Thoroughbreds. Equine Vet J Suppl 2002:375-378.
3. Kindig CA, McDonough P, Fenton G, Poole DC, Erickson HH. Efficacy of nasal strip and furosemide in mitigating EIPH in Thoroughbred horses. J Appl Physiol 2001;91:1396-1400.
4. Hinchcliff KW, Jackson MA, Morley PS, et al. Association between exercise-induced pulmonary hemorrhage and performance in Thoroughbred racehorses. J Am Vet Med Assoc 2005;227:768-774.
5. West JB, Mathieu-Costello O. Stress failure of pulmonary capillaries as a mechanism for exercise induced pulmonary haemorrhage in the horse. Equine Vet J 1994;26:441-447.
6. West JB, Mathieu-Costello O, Jones JH, et al. Stress failure of pulmonary capillaries in racehorses with exercise-induced pulmonary hemorrhage. J Appl Physiol 1993;75:1097-1109.
7. McKeever KH, Hinchcliff KW, Kociba GJ, Reed SM, Muir WW, 3rd. Changes in coagulation and fibrinolysis in horses during exercise. Am J Vet Res 1990;51:1335-1339.
8. Johnstone IB, Viel L, Crane S, Whiting T. Hemostatic studies in racing standardbred horses with exercise-induced pulmonary hemorrhage. Hemostatic parameters at rest and after moderate exercise. Can J Vet Res 1991;55:101-106.
9. Smith JM, Meyers KM, Barbee DD, Schott H, Bayly WM. Plasma von Willebrand factor in thoroughbreds in response to high-intensity treadmill exercise. Am J Vet Res 1997;58:71-76.
10. Weiss DJ, McClay CB, Smith CM, Rao GH, White JG. Platelet function in the racing thoroughbred: Implication for exercise-induced pulmonary hemorrhage. Vet Clin Pathol 1990;19:35-39.
11. Lester G, Clark C, Rice B, Steible-Hartless C, Vetro-Widenhouse T. Effect of timing and route of administration of furosemide on pulmonary hemorrhage and pulmonary arterial pressure in exercising thoroughbred racehorses. Am J Vet Res 1999;60:22-28.
12. Goetz TE, Manohar M, Magid JH. Repeated administration of frusemide does not offer an advantage over single dosing in attenuating exercise-induced pulmonary hypertension in thoroughbred horses. Equine Vet J Suppl 1999;30:539-545.
13. Pascoe JR, McCabe AE, Franti CE, Arthur RM. Efficacy of furosemide in the treatment of exercise-induced pulmonary hemorrhage in Thoroughbred racehorses. Am J Vet Res 1985;46:2000-2003.
14. Speirs VC, van Veenendaal JC, Harrison IW, et al. Pulmonary haemorrhage in standardbred horses after racing. Aust Vet J 1982;59:38-40.
15. Sendo T, Goromaru T, Aki K, Sakai N, Itoh Y, Oishi R. Carbazochrome attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats. Eur J Pharmacol 2002;450:203-208.
16. Sendo T, Itoh Y, Aki K, Oka M, Oishi R. Carbazochrome sodium sulfonate (AC-17) reverses endothelial barrier dysfunction through inhibition of phosphatidylinositol hydrolysis in cultured porcine endothelial cells. Naunyn Schmiedebergs Arch Pharmacol 2003;368:175-180.
17. Couetil LL, Denicola DB. Blood gas, plasma lactate and bronchoalveolar lavage cytology analyses in racehorses with respiratory disease. Equine Vet J Suppl 1999;30:77-82.
18. Sanchez A, Couetil LL, Ward MP, Clark SP. Effect of airway disease on blood gas exchange in racehorses. J Vet Intern Med 2005;19:87-92.
19. Courouce-Malblanc A, Pronost S, Fortier G, Corde R, Rossignol F. Physiological measurements and upper and lower respiratory tract evaluation in French Standardbred Trotters during a standardised exercise test on the treadmill. Equine Vet J Suppl 2002:402-407.
20. Hinchcliff KW, Jackson MA, Brown JA, et al. Tracheobronchoscopic assessment of exercise-induced pulmonary hemorrhage in horses. Am J Vet Res 2005;66:596-598.
21. Gerber V, Lindberg A, Berney C, Robinson NE. Airway mucus in recurrent airway obstruction - short-term response to environmental challenge. J Vet Intern Med 2004;18:92-97.
22. Courouce A. Field exercise testing for assessing fitness in French standardbred trotters. Vet J 1999;157:112-122.
23. Burrell MH. Endoscopic and virological observations on respiratory disease in a group of young Thoroughbred horses in training. Equine Vet J 1985;17:99-103.
24. Moore BR, Krakowka S, Robertson JT, Cummins JM. Cytologic evaluation of bronchoalveolar lavage fluid obtained from standardbred racehorses with inflammatory airway disease. Am J Vet Res 1995;56: 562-567.
25. Sweeney CR, Rossier Y, Ziemer EL, Lindborg SR. Effect of prior lavage on bronchoalveolar lavage fluid cell population of lavaged and unlavaged lung segments in horses. Am J Vet Res 1994;55:51501-1504.
26. Gerber V, Robinson NE, Luethi S, Marti E, Wampfler B, Straub R. Airway inflammation and mucus in two age groups of asymptomatic well-performing sport horses. Equine Vet J 2003;35:5491-495.
27. Newton JR, Wood JL. Evidence of an association between inflammatory airway disease and EIPH in young Thoroughbreds during training. Equine Vet J Suppl 2002:5417-424.
28. McKane SA, Slocombe RE Alveolar fibrosis and changes in equine lung morphometry in response to intrapulmonary blood. Equine Vet J Suppl 2002;34:451-458.
29. McKane SA, Canfield PJ, Rose RJ. Equine bronchoalveolar lavage cytology: Survey of thoroughbred racehorses in training. Aust Vet J 1993;70:401-404.
30. Meyer TS, Fedde MR, Gaughan EM, Langsetmo I, Erickson HH. Quantification of exercise-induced pulmonary haemorrhage with bronchoalveolar lavage. Equine Vet J 1998;30:284-288.
31. Geor RJ, Ommundson L, Fenton G, Pagan JD. Effects of an external nasal strip and frusemide on pulmonary haemorrhage in Thoroughbreds following high-intensity exercise. Equine Vet J 2001;33:577-584.
32. Weiss C, Seitel G, Bartsch P. Coagulation and fibrinolysis after moderate and very heavy exercise in healthy male subjects. Med Sci Sports Exerc 1998;30:246-251.
33. Weiss DJ, Smith CM, 2nd. Haemorrheological alterations associated with competitive racing activity in horses: Implications for exerciseinduced pulmonary haemorrhage (EIPH). Equine Vet J 1998;30: 7-12.
34. Rawlings CA, Byars TD, Van Noy MK, Bisgard GE. Activated coagulation test in normal and heparinized ponies and horses. Am J Vet Res 1975;36: 711-713.
35. Kociba GJ, Bayly WM, Milne DW, Wigton DH, Gabel AA, Muir WW. Furosemide: Effects on the hemostatic mechanism of resting and exercised standardbred horses. Am J Vet Res 1984;45:2603-2606.
36. Smith JE, Garbutt G, Lopes P, Pedoe DT. Effects of prolonged strenuous exercise (marathon running) on biochemical and haematological markers used in the investigation of patients in the emergency department. Br J Sports Med 2004;38:292-294.
37. Ferguson EW, Bernier LL, Banta GR, Yu-Yahiro J, Schoomaker EB. Effects of exercise and conditioning on clotting and fibrinolytic activity in men. J Appl Physiol 1987;62:1416-1421.
38. Matsumoto Y, Hayashi T, Hayakawa Y, Shinbo M, Niiya K, Sakuragawa N. Carbazochrome sodium sulphonate (AC-17) decreases the accumulation of tissue-type plasminogen activator in culture medium of human umbilical vein endothelial cells. Blood Coagul Fibrinolysis 1995;6:233-238.
39. Wagner PD, Gillespie JR, Landgren GL, et al. Mechanism of exerciseinduced hypoxemia in horses. J Appl Physiol 1989;66:1227-1233.
40. Vengust M, Staempfli H, Viel L, Heigenhauser G. Transvascular fluid flux from the pulmonary vasculature at rest and during exercise in horses. J Physiol 2006;570 (Pt 2) : 397-405.
41. Evans DL, Rose RJ. Cardiovascular and respiratory responses in Thoroughbred horses during treadmill exercise. J Exp Biol 1988; 134: 397-408.
42. Bayly WM, Hodgson DR, Schulz DA, Dempsey JA, Gollnick PD. Exercise-induced hypercapnia in the horse. J Appl Physiol 1989;67: 1958-1966.
43. Art T, Anderson L, Woakes AJ, et al. Mechanics of breathing during strenuous exercise in Thoroughbred horses. Respir Physiol 1990;82: 279-294.
44. Chrisdey RM, Hodgson DR, Evans DL, Rose RJ. Effects of training on the development of exercise-induced arterial hypoxemia in horses. Am J Vet Res 1997;58:653-657.
45. Harkins JD, Hackett RP, Ducharme NG. Effect of furosemide on physiologic variables in exercising horses. Am J Vet Res 1993;54: 2104-2109.