Effect of timing and route of administration of furosemide on pulmonary hemorrhage and pulmonary arterial pressure in exercising thoroughbred racehorses

American Journal of Veterinary Research

Volumn 60, Issue 1, 1999, Pages 22-28

  Lester, Guy ^a   Clark, Carol ^a,c   Rice, Brett ^a   Steible Hartless, Christine ^b   Vetro Widenhouse, Tamara ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b University of Florida College of Veterinary Medicine   (United States)

^c Smith and Associates   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUMETANIDE; FUROSEMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHOSPASM; CONTROLLED STUDY; DRUG ABSORPTION; DRUG EFFECT; ERYTHROCYTE COUNT; EXERCISE; FEMALE; HORSE; INHALATIONAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LUNG ARTERY PRESSURE; LUNG HEMORRHAGE; LUNG LAVAGE; NEBULIZATION; NONHUMAN;

ANIMALS; BRONCHOALVEOLAR LAVAGE; CROSS-OVER STUDIES; DIURETICS; ERYTHROCYTE COUNT; FEMALE; FUROSEMIDE; HEMORRHAGE; HORSE DISEASES; HORSES; LUNG DISEASES; MALE; PHYSICAL CONDITIONING, ANIMAL; PULMONARY WEDGE PRESSURE; RANDOM ALLOCATION;

ANIMALIA; EQUIDAE; EQUUS CABALLUS;

EID: 0032943499     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Pascoe JR, Ferraro GL, Cannon JH, et al. Exercise-induced pulmonary hemorrhage in racing Thoroughbreds: a preliminary study. Am J Vet Res 1981;42:703-707.
2. Pascoe JR. Why does exercise induced pulmonary haemorrhage occur? Equine Vet J 1985;17:159-161.
3. Raphel CF, Soma LR. Exercise-induced pulmonary hemorrhage in Thoroughbreds after racing and breezing. Am J Vet Res 1982;43:1123-1127.
4. Sweeney CR, Soma LR, Bucan CA, et al. Exercise-induced pulmonary hemorrhage in exercising Thoroughbreds: preliminary results with pre-race medication. Cornell Vet 1984;74:263-268.
5. Sweeney CR, Soma LR. Exercise-induced pulmonary hemorrhage in Thoroughbred horses: response to furosemide or hesperidin-citrus bioflavinoids. J Am Vet Med Assoc 1984;185:195-197.
6. West JB, Mathieu-Costello O, Jones JH, et al. Stress failure of pulmonary capillaries in racehorses with exercise-induced pulmonary hemorrhage. J Appl Physiol 1993;75:1097-1109.
7. O'Callaghan MW, Pascoe JR, Tyler WS, et al. Exercise-induced pulmonary haemorrhage in the horse: results of a detailed clinical, post mortem and imaging study. II. Gross lung pathology. Equine Vet J 1987;19:389-393.
8. Goetz TE, Manohar M. Pressures in the right side of the heart and esophagus (pleura) in ponies during exercise before and after furosemide administration. Am J Vet Res 1986;47:270-276.
9. Erickson BK, Erickson HH, Coffman JR. Pulmonary artery, aortic, and esophageal pressure changes during high intensity exercise in the horse: a possible relation to exercise-induced pulmonary haemorrhage. Equine Vet J 1990;22 (Suppl):47-52.
10. Manohar M. Pulmonary artery wedge pressure increases with high-intensity exercise in horses. Am J Vet Res 1993;54:142-146.
11. Clarke AF. Review of exercise induced pulmonary haemorrhage and its possible relationship with mechanical stress. Equine Vet J 1985;17:166-172.
12. Robinson NE. Exercise induced pulmonary haemorrhage (EIPH): could Leonardo have got it right? Equine Vet J 1987;19: 370-371.
13. Pascoe JR, McCabe AE, Franti CE, et al. Efficacy of furosemide in the treatment of exercise-induced pulmonary hemorrhage in Thoroughbred racehorses. Am J Vet Res 1985;46:2000-2003.
14. Manohar M. Furosemide attenuates the exercise-induced increase in pulmonary artery wedge pressure in horses. Am J Vet Res 1993;54:952-958.
15. Broadstone RV, Robinson NE, Gray PE, et al. Effects of furosemide on ponies with precurrent airway obstruction. Pulmon Pharmacol 1991;4:203-208.
16. Hinchcliff KW, McKeever KH, Muir WW. Furosemide-induced changes in plasma and blood volume of horses. J Vet Pharmacol Ther 1991;14:411-417.
17. Muir WW, Milne DW, Skarda RT. Acute hemodynamic effects of furosemide administered intravenously in the horse. Am J Vet Res 1976;37:1177-1180.
18. Rubie S, Robinson NE, Stoll M, et al. Flunixin meglumine blocks frusemide-induced bronchodilatation in horses with chronic obstructive pulmonary disease. Equine Vet J 1993;25:138-142.
19. Bianco S, Pieroni MG, Refini RM, et al. Protective effect of inhaled furosemide on allergen-induced early and laic asthmatic reactions. N Engl J Med 1989;321:1069-1073.
20. Bianco S, Vaghi A, Robuschi M, et al. Prevention of exercise-induced bronchoconstriction by inhaled frusemide. Lancet 1988;2:252-255.
21. Shimizu T, Mochizuki H, Morikawa A, et al. Inhaled furosemide prevents ultrasonically nebulized water bronchoconstriction in children with both atopic and nonatopic asthma. Chest 1993;104:1723-1726.
22. Robuschi M, Pieroni M, Refini M, et al. Prevention of antigen-induced early obstructive reaction by inhaled furosemide in (atopic) subjects with asthma and (actively sensitized) guinea pigs. J Allergy Clin Immunol 1990;85:10-16.
23. Hopkins SR, Schoene RB, Henderson WR, et al. Intense exercise impairs the integrity of the pulmonary blood-gas barrier in elite athletes. Am J Respir Crit Care Med 1997;155:1090-1094.
24. Muir WW, Skarda RT, Milne DW. Estimation of cardiac output in the horse by thermodilution techniques. Am J Vet Res 1976;37:697-700.
25. Aguilera-Tejero E, Pascoe JR, Smith BL, et al. Evaluation of a technique for detection of pulmonary hemorrhage in horses, using carbon monoxide uptake. Am J Vet Res 1994;55:1032-1036.
26. Soma LR, Laster L, Oppenlander F, et al. Effects of furosemide on the racing times of horses with exercise-induced pulmonary hemorrhage. Am J Vet Res 1985;46:763-768.
27. Speirs VC, van Veenendaal JC, Harrison IW, et al. Pulmonary haemorrhage in standardbred horses after racing. Ausf Vet J 1982;59:38-40.
28. Sweeney CR, Soma LR, Maxson AD, et al. Effects of furosemide on the racing times of Thoroughbreds. Am J Vet Res 1990;51:772-778.
29. Voynick BT, Sweeney CR. Exercised-induced pulmonary hemorrhage in polo and racing horses. J Am Vet Med Assoc 1986;188:301-302.
30. Pascoe JR, Raphel CE Pulmonary hemorrhage in exercising horses. Compend Contin Educ Pract Vet 1982;4:S411-S416.
31. Sweeney CR, Rossier Y, Ziemer EL, et al. Effect of prior lavage on bronchoalveolar lavage fluid cell population of lavaged and unlavaged lung segments in horses. Am J Vet Res 1994;55:1501-1504.
32. Clark CK, Lester GD, Vetro T, et al. Bronchoalveolar lavage in horses: effect of exercise and repeated sampling on cytology. Aust Vet J 1995;72:249-252.
33. Fogarty U. Evaluation of a bronchoalveolar lavage technique. Equine Vet J 1990;22:174-176.
34. Aguilera Tejero E, Pascoe JR, Tyler WS, et al. Autologous blood instillation alters respiratory mechanics in horses Equine Vet J 1995;27:46-50.
35. Erickson BK, Erickson HH, Coffman JR. Pulmonary artery and aortic pressure changes during high intensity treadmill exercise in the horse: effect of frusemide and phentolamine. Equine Vet J 1992; 24:215-219.
36. Manohar M, Goetz TE. Pulmonary vascular pressures of exercising thoroughbred horses with and without endoscopie evidence of EIPH. J Appl Physiol 1996;81:1589-1593.
37. Milne DW, Gabel AA, Muir WW, et al. Effects of furosemide on cardiovascular function and performance when given prior to simulated races: a double-blind study. Am J Vet Res 1980;41: 1183-1189.
38. Gabel AA, Tobin T, Ray RS, et al. Furosemide in horses: a review. J Equine Med Surg 1977;1:215-218.
39. Birks EK, Mathieu Costello O, Fu Z, et al. Very high pressures are required to cause stress failure of pulmonary capillaries in thoroughbred racehorses. J Appl Physiol 1997;82:1584-1592.
40. Olsen SC, Coyne CP, Lowe BS. et al. Influence of furosemide on hemodynamic responses during exercise in horses. Am J Vet Res 1992;53:742-747.
41. Stevenson AJ, Weber MP, Todi F, et al. The influence of furosemide on plasma elimination and urinary excretion of drugs in standardbred horses. J Vet Pharmacol Ther 1990;13:93-104.
42. Ono Y, Kondo T, Tanigaki T, et al. Furosemide given by inhalation ameliorates acute exacerbation of asthma. J Asthma 1997;34:283-289.
43. Levasseur-Acker GM, Molimard M, Regnard J, et al. Effect of furosemide on prostaglandin synthesis by human nasal and bronchial epithelial cells in culture. Am J Respir Cell Mol Biol 1994;10:378-383.