Prediction of drug bioavailability in humans using immobilized artificial membrane phosphatidylcholine column chromatography and in vitro hepatic metabolic clearance

Biomedical Chromatography

Volumn 23, Issue 7, 2009, Pages 764-769

  Shin, Beom Soo ^a   Yoon, Chi Ho ^b   Balthasar, Joseph P ^c   Choi, Bu Young ^b   Hong, Seok Hyun ^d   Kim, Hyoung Jun ^d   Lee, Jong Bong ^d   Hwang, Sang Wook ^d   Yoo, Sun Doong ^d  

^a Catholic University of Daegu   (South Korea)

^b Choongwae Pharma Co   (South Korea)

^c UNIVERSITY AT BUFFALO   (United States)

^d Sungkyunkwan University   (South Korea)

Author keywords

Bioavailability; High throughput screening; Immobilized artificial membrane (IAM); Intrinsic clearance

Indexed keywords

BIOCHEMISTRY; DRUG PRODUCTS; METABOLISM;

BIOAVAILABILITY; CAPACITY FACTORS; HALF LIVES; HIGH THROUGHPUT SCREENING; IMMOBILIZED ARTIFICIAL MEMBRANE; IMMOBILIZED ARTIFICIAL MEMBRANES; IN-VITRO; INTRINSIC CLEARANCE; ORAL BIOAVAILABILITIES; PHOSPHATIDYL CHOLINE;

COLUMN CHROMATOGRAPHY;

ATENOLOL; CEFUROXIME; CHLORPROMAZINE; CLONIDINE; CROMOGLYCATE DISODIUM; DEXAMETHASONE; ENALAPRIL; ETOPOSIDE; IMIPRAMINE; NADOLOL; PARACETAMOL; PHOSPHATE BUFFERED SALINE; PHOSPHATIDYLCHOLINE; PRAZOSIN; PROGESTERONE; RANITIDINE; VERAPAMIL;

ARTICLE; CHROMATOGRAPHY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG HALF LIFE; HUMAN; HUMAN CELL; IMMOBILIZED CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CLEARANCE; LIVER MICROSOME; METABOLIC CAPACITY; PREDICTION; ARTIFICIAL MEMBRANE; BIOAVAILABILITY; BIOLOGICAL MODEL; CHEMISTRY; LIQUID CHROMATOGRAPHY; METABOLIC CLEARANCE RATE; METABOLISM; METHODOLOGY; ORAL DRUG ADMINISTRATION; PREDICTION AND FORECASTING; STATISTICAL ANALYSIS;

ADMINISTRATION, ORAL; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, LIQUID; DATA INTERPRETATION, STATISTICAL; HUMANS; MEMBRANES, ARTIFICIAL; METABOLIC CLEARANCE RATE; MICROSOMES, LIVER; MODELS, BIOLOGICAL; PHOSPHATIDYLCHOLINES; PREDICTIVE VALUE OF TESTS;

EID: 70149107501     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1182     Document Type: Article

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