Evaluation of the immobilized artificial membrane phosphatidylcholine: Drug discovery column for high-performance liquid chromatographic screening of drug-membrane interactions

Journal of Chromatography A

Volumn 800, Issue 2, 1998, Pages 161-169

  Caldwell, Gary W ^a   Masucci, John A ^a   Evangelisto, Mary ^a   White, Robert ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Blockers; Immobilized artificial membranes; LC; Mobile phase composition; Phospholipid stationary phase; Stationary phases

Indexed keywords

BIOLOGICAL MEMBRANES; DRUG INTERACTIONS; IONIC STRENGTH; LIPIDS; PHARMACOKINETICS; PHASE COMPOSITION; REGRESSION ANALYSIS;

BETA ADRENOLYTIC DRUGS; BETA BLOCKERS; DRUG DISCOVERY COLUMN; DRUG MEMBRANE INTERACTIONS; IMMOBILIZED ARTIFICIAL MEMBRANE; LINEAR REGRESSION ANALYSIS; MOBILE PHASE COMPOSITION; PHOSPHATIDYLCHOLINE;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ACEBUTOLOL; ALPRENOLOL; ANILINE DERIVATIVE; ATENOLOL; METOPROLOL; OXPRENOLOL; PINDOLOL; PROPRANOLOL; TIMOLOL;

ARTICLE; ARTIFICIAL MEMBRANE; DRUG DETERMINATION; DRUG SCREENING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MEMBRANE COMPONENT; MOLECULAR INTERACTION; PARTITION COEFFICIENT; PRIORITY JOURNAL; REGRESSION ANALYSIS;

ACEBUTOLOL; ACETONITRILES; ADRENERGIC BETA-ANTAGONISTS; ALPRENOLOL; ANILINE COMPOUNDS; ATENOLOL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROGEN-ION CONCENTRATION; MEMBRANES, ARTIFICIAL; METOPROLOL; MODELS, CHEMICAL; OSMOLAR CONCENTRATION; OXPRENOLOL; PHOSPHATIDYLCHOLINES; PINDOLOL; PROPRANOLOL; REPRODUCIBILITY OF RESULTS; TIMOLOL;

EID: 0032571576     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9673(97)01143-6     Document Type: Article

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