Multiple regions within the promoter of the murine Ifnar-2 gene confer basal and inducible expression

Biochemical Journal

Volumn 365, Issue 2, 2002, Pages 355-367

  Hardy, Matthew P ^a   Hertzog, Paul J ^a   Owczarek, Catherine M ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Gene structure; Interferon; Promoter

Indexed keywords

GENES; MEMBRANES; RNA;

GENE ENCODING;

BIOCHEMISTRY;

GAMMA INTERFERON; INTERFERON; INTERFERON RECEPTOR; LUCIFERASE; MESSENGER RNA; MULFNAR 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LINE; CHROMOSOME 16; DNA FLANKING REGION; EXON; FIBROBLAST; GENE; GENE EXPRESSION; GENE FUNCTION; GENE STRUCTURE; GENETIC CODE; GENETIC VARIABILITY; HEPATOMA CELL; IFNAR 2 GENE; INTRON; LEUKEMIA CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; RNA PROCESSING; UPREGULATION;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BLOTTING, NORTHERN; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 16; CLONING, MOLECULAR; DNA, COMPLEMENTARY; EXONS; GENE EXPRESSION REGULATION; HUMANS; INTRONS; MEMBRANE PROTEINS; MICE; PROMOTER REGIONS (GENETICS); RECEPTOR, INTERFERON ALPHA-BETA; RECEPTORS, INTERFERON; REGULATORY SEQUENCES, NUCLEIC ACID; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID;

ANIMALIA; MURINAE;

EID: 0037101766     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020105     Document Type: Article

References (56)

1. Isaacs, A. and Lindemann, J. (1957) Virus interference: the interferon. Proc. R. Soc. London Ser. B 147, 258-267
2. Pestka, S., Langer, J. A., Zoon, K. C. and Samuel, C. E. (1987) Interferons and their actions. Annu. Rev. Biochem 56, 727-777
3. LaFleur, D. W., Nardelli, B., Tsareva, T., Mather, D., Feng, P., Semenuk, M., Taylor, K., Buergin, M., Chinchilla, D., Roshke, V. et al. (2001) Interferon-κ, a novel type I interferon expressed in human keratinocytes. J. Biol. Chem. 276, 39765-39771
4. Kenji, O., Kincade, P. W., Zhang, C., Tomiyama, Y. and Matsuzawa, Y. (2001) Type I interferons and limitin: a comparison of structures, receptors, and functions. Cytokine Growth Fact. Rev. 12, 337-348
5. Mogensen, K. E., Lewerenz, M., Reboul, J., Lutfalla, G. and Uzé, G. (1999) The type I interferon receptor: structure, function, and evolution of a family business. J. Interferon Cytokine Res. 19, 1069-1098
6. Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H. and Schreiber, R. D. (1998) How cells respond to interferons. Annu. Rev. Biochem 67, 227-284
7. Bazan, J. F. (1990) Structural design and molecular evolution of a cytokine receptor superfamily. Proc. Natl. Acad. Sci. U.S.A. 87, 6934-6938
8. Kotenko, S. V. and Pestka, S. (2000) Jak-Stat signal transduction pathway through the eyes of cytokine class II receptor complexes. Oncogene 19, 2557-2265
9. Bazan, J. F. (1990) Haemopoietic receptors and helical cytokines. Immunol. Today 11, 350-354
10. Owczarek, C. M., Hwang, S. Y., Holland, K. A., Gulluyan, L. M., Tavaria, M., Weaver, B., Reich, N. C., Kola, I. and Hertzog, P. J. (1997) Cloning and characterization of soluble and transmembrane isoforms of a novel component of the murine type I interferon receptor, Ifnar-2. J. Biol. Chem. 272, 23865-23870
11. Kim, S. H., Cohen, B., Novick, D. and Rubinstein, M. (1997) Mammalian type I interferon receptors consists of two subunits: IFNαR1 and IFNαR2. Gene 196, 279-286
12. Hardy, M. P., Owczarek, C. M., Trajanovska, S., Liu, X., Kola, I. and Hertzog, P. J. (2001) The soluble murine type I interferon receptor Ifnar-2 is present in serum, is independently regulated, and has both agonistic and antagonistic properties. Blood 97, 473-482
13. Prestridge, D. S. (1991) SIGNAL SCAN: a computer program that scans DNA sequences for eukaryotic transcriptional elements. Comput. Appl. Biosci. 7, 203-206
14. Smith, R. F., Wiese, B. A., Wojzynski, M. K., Davison, D. B. and Worley, K. C. (1996) BCM search launcher - an integrated interface to molecular biology data base search and analysis services available on the World Wide Web. Genome Res. 6, 454-462
15. Heinemeyer, T., Wingender, E., Reuter, I., Hermjakob, H., Kel, A. E., Kel, O. V., Ignatieva, E. V., Ananko, E. A., Podkolodnaya, O. A., Kolpakov, F. A., Podkolodny, N. L. and Kolchanov, N. A. (1998) Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL. Nucleic Acids Res. 26, 362-367
16. Quandt, K., Frech, K., Karas, H., Wingender, E. and Werner, T. (1995) MatInd and MatInspector - new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res. 23, 4878-4884
17. Dubchak, I., Brudno, M., Loots, G. G., Mayor, C., Pachter, L., Rubin, E. M. and Frazer, K. A. (2000) Active conservation of noncoding sequences revealed by 3-way species comparisons. Genome Res. 10, 1304-1306
18. Mayor, C., Brudno, M., Schwartz, J. R., Poliakov, A., Rubin, E. M., Frazer, K. A., Pachter, L. S. and Dubchak, I. (2000) VISTA: visualizing global DNA sequence alignments of arbitrary length. Bioinformatics 16, 1046-1047
19. Morgenstern, B. (1999) DIALIGN 2: improvement of the segment-to-segment approach to multiple sequence alignment. Bioinformatics 15, 211-218
20. Gonda, T. J., Sheiness, D. K. and Bishop, J. M. (1982) Transcripts from the cellular homologues of retroviral oncogenes: distribution among chicken tissues. Mol. Cell. Biol. 2, 617-624
21. Loveland, B. E., Johns, T. G., Mackay, I. R., Vaillant, F., Wang, Z. X. and Hertzog, P. J. (1992) Validation of the MTT dye assay for enumeration of cells in proliferative and antiproriferative assays. Biochem. Int. 27, 501-510
22. Lutfalla, G., Holland, S. J., Cinato, E., Monneron, D., Reboul, J., Rogers, N. C., Smith, J. M., Stark, G. R., Gardiner, K. and Mogensen, K. E. (1995) Mutant U5A cells are complemented by an interferon-αβ receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster. EMBO J. 14, 5100-5108
23. Lutfalla, G., Gardiner, K., Proudhon, D., Vielh, E. and Uzé, G. (1992) The structure of the human interferon α/β receptor gene. J. Biol. Chem. 267, 2802-2809
24. Ferrigno, O., Virolle, T., Djabari, Z., Ortonne, J. P., White, R. J. and Aberdam, D. (2001) Transposable B2 SINE elements can provide mobile RNA polymerase II promoters. Nat. Genet. 28, 77-81
25. Bladon, T. S. and McBurney, M. W. (1991) The rodent B2 sequence can affect expression when present in the transcribed region of a reporter gene. Gene 98, 259-263
26. Saksela, K. and Baltimore, D. (1993) Negative regulation of immunoglobulin κ light-chain gene transcription by a short sequence homologous to the murine B1 repetitive element. Mol. Cell. Biol. 13, 3698-3705
27. Mallon, A. M., Platzer, M., Bate, R., Gloeckner, G., Botcherby, M. R., Nordsiek, G., Strivens, M. A., Kioschis, P., Dangel, A., Cunningham, D. et al. (2000) Comparative genome sequence analysis of the Bpa/Str region in mouse and Man. Genome Res. 10, 758-775
28. Shapiro, M. B. and Senepathy, P. (1987) RNA splice junctions of different classes: sequence statistics and functional implications in gene expression. Nucleic Acids Res. 15, 7155-7174
29. Breathnach, R. and Chambon, P. (1981) Organization and expression of eukaryotic split genes coding for proteins. Annu. Rev. Biochem. 50, 349-383
30. Kosugi, H., Nakgawa, Y., Arai, K. and Yokota, T. (1995) Gene structures of the α subunits of human IL-3 and granulocyte-macrophage colony stimulating factor receptor: comparison with the cytokine receptor superfamily. Allerg. Clin. Immunol. 96, 1115-1125
31. Prejean, C. and Colamonici, O. R. (2000) Role of the cytoplasmic domains of the type I interferon receptor subunits in signaling. Semin. Cancer Biol. 10, 83-92
32. Lutfalla, G., McInnis, M. G., Antonarakis, S. E. and Uzé, G. (1995) Structure of the human CRFB4 gene: comparison with its IFNAR neighbor J. Mol. Evol. 41, 338-344
33. Cheng, S., Lutfalla, G., Uzé, G., Chumakov, I. M. and Gardiner, K. (1993) GART, SON, IFNAR, and CRF2-4 genes cluster on human chromosome 21 and mouse chromosome 16. Mamm. Genome 4, 338-342
34. Levy, D. E., Lew, D. J., Decker, T., Kessler, D. S. and Darnell, J. E. J. (1990) Synergistic interaction between interferon-α and interferon-γ through induced synthesis of one subunit of the transcription factor ISGF3. EMBO J. 9, 1105-1111
35. Song, B. L., Qi, W., Yang, X. Y., Chang, C. C., Zhu, J. Q., Chan, T. Y. and Li, B. L. (2001) Organization of human ACAT-2 gene and its cell-type-specific promoter activity. Biochem. Biophys. Res. Commun. 282, 580-588
36. Neuschafer-Rube, F., Moller, U. and Puschel, G. P. (2000) Structure of the 5′-flanking region of the rat prostaglandin F2α receptor gene and its transcriptional control functions in hepatocytes. Biochem. Biophys. Res. Commun. 278, 278-285
37. Harada, H., Fujita, T., Miyamoto, M., Kimura, Y., Maruyama, M., Furia, A., Miyata, T. and Taniguchi, T. (1989) Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell (Cambridge, Mass.) 58, 729-739
38. Loots, G. G., Locksley, R. M., Blankespoor, C. M., Wang, Z. E., Miller, W., Rubin, E. M. and Frazer, K. A. (2000) Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons. Science (Washington, D.C.) 288, 136-140
39. Novick, D., Cohen, B. and Rubinstein, M. (1994) The human interferon α/β receptor: characterization and molecular cloning. Cell (Cambridge, Mass.) 77, 391-400
40. Pfeffer, L. M., Basu, L., Pfeffer, S. R., Yang, C. H., Murti, A., Russell-Harde, D. and Croze, E. (1997) The short form of the interferon α/β receptor chain 2 acts as a dominant negative for type I interferon action. J. Biol. Chem. 272, 11002-11005
41. Mullersman, J. E. and Pfeffer, L. M. (1995) An Alu cassette in the cytoplasmic domain of an interferon receptor subunit. J. Interferon Cytokine Res. 15, 815-817
42. Tavernier, J., Tuypens, T., Plaetinck, G., Verhee, A., Fiers, W. and Devos, R. (1992) Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor α subunit. Proc. Natl. Acad. Sci. U.S.A. 89, 7041-7045
43. Owczarek, C. M., Layton, M. J., Robb, L. G., Nicola, N. A. and Begley, C. G. (1996) Molecular basis of the soluble and membrane-bound forms of the murine leukemia inhibitory factor receptor α-chain - expression in normal, gestating, and leukemia inhibitory factor nullizygous mice. J. Biol. Chem. 271, 5495-5504
44. Bergers, G., Reikerstorfer, A., Braselmann, S., Graninger, P. and Busslinger, M. (1994) Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor. EMBO J. 13, 1176-1188
45. Chua, S. C. J., Koutras, I. K., Han, L., Liu, S. M., Kay, J., Young, S. J., Chung, W. K. and Leibel, R. L. (1997) Fine structure of the murine leptin receptor gene: splice site suppression is required to form two alternatively spliced transcripts. Genomics 45, 264-270
46. Mummidi, S., Ahuja, S. S., McDaniel, B. L. and Ahuja, S. K. (1997) The human CC chemokine receptor 5 (CCR5) gene. Multiple transcripts with 5′-end heterogeneity, dual promoter usage, and evidence for polymorphisms within the regulatory regions and noncoding exons. J. Biol. Chem. 272, 30662-30671
47. Matsumoto, M., Tanaka, N., Harada, H., Kimura, T., Yokochi, T., Kitagawa, M., Schindler, C. and Taniguchi, T. (1999) Activation of the transcription factor ISGF3 by interferon-γ. Biol. Chem. 380, 699-703
48. Lewis, J. A., Huq, A. and Shan, B. (1989) β and γ interferons act synergistically to produce an antiviral state in cells resistant to both interferons individually. J. Virol. 63, 4569-4578
49. Levy, D. E., Kessler, D. S., Pine, R. and Darnell, Jr, J. E. (1989) Cytoplasmic activation of ISGF3, the positive regulator of interferon-α-stimulated transcription, reconstituted in vitro. Genes Dev. 3, 1362-1371
50. Wong, L. H., Hatzinisiriou, I., Devenish, R. J. and Ralph, S. J. (1998) IFN-γ priming up-regulates IFN-stimulated gene factor 3 (ISGF3) components, augmenting responsiveness of IFN-resistant melanoma cells to type I IFNs. J. Immunol. 160, 5475-5484
51. Jiang, H., Okamura, C. S. and Lucy, M. C. (1999) Isolation and characterization of a novel promoter for the bovine growth hormone receptor gene. J. Biol. Chem. 274, 7893-7900
52. Jones, S. A., Horiuchi, S., Topley, N., Yamamoto, N. and Fuller, G. M. (2001) The soluble interleukin 6 receptor: mechanisms of production and implications in disease. FASEB J. 15, 43-58
53. Huang, L., Wang, Z. and Li, C. (2001) Modulation of circulating leptin levels by its soluble receptor. J. Biol. Chem. 276, 6343-6349
54. Tavernier, J., Van der Heyden, J., Verhee, A., Brusselle, G., Van Ostade, X., Vandekerckhove, J., North, J., Rankin, S. M., Kay, A. B. and Robinson, D. S. (2000) Interleukin 5 regulates the isoform expression of its own receptor α-subunit. Blood 95, 1600-1607
55. Mizukoshi, E., Kaneko, S., Yanagi, M., Ohno, H., Matsushita, E. and Kobayashi, K. (1999) Upregulation of type I interferon receptor by IFN-γ. J. Interferon Cytokine Res. 19, 1019-1023
56. Mizukoshi, E., Kaneko, S., Kaji, K., Terasaki, S., Matsushita, E., Muraguchi, M., Ohmoto, Y. and Kobayashi, K. (1999) Serum levels of soluble interferon α/β receptor as an inhibitor factor of interferon in the patients with chronic hepatitis C. Hepatology (Philadelphia) 30, 1325-1331