-
1
-
-
0031065219
-
Immunotherapy for cocaine addiction
-
Landry DW. Immunotherapy for cocaine addiction. Sci. Am. 276, 42-45 (1997).
-
(1997)
Sci. Am
, vol.276
, pp. 42-45
-
-
Landry, D.W.1
-
2
-
-
0030735986
-
Enhancing cocaine metabolism with butyrylcholinesterase as a treatment strategy
-
Gorelick DA. Enhancing cocaine metabolism with butyrylcholinesterase as a treatment strategy. Drug Alcohol. Depend. 48, 159-165 (1997).
-
(1997)
Drug Alcohol. Depend
, vol.48
, pp. 159-165
-
-
Gorelick, D.A.1
-
3
-
-
10344225664
-
Addiction as a computational process gone awry
-
Redish AD. Addiction as a computational process gone awry. Science 306, 1944-1947 (2004).
-
(2004)
Science
, vol.306
, pp. 1944-1947
-
-
Redish, A.D.1
-
4
-
-
3242755117
-
Agents in development for the management of cocaine abuse
-
Gorelick DA, Gardner EL, Xi ZX. Agents in development for the management of cocaine abuse. Drugs 64, 1547-1573 (2004).
-
(2004)
Drugs
, vol.64
, pp. 1547-1573
-
-
Gorelick, D.A.1
Gardner, E.L.2
Xi, Z.X.3
-
5
-
-
0033724861
-
Natural and artificial enzymes against cocaine. I. Monoclonal antibody 15A10 and the reinforcing effects of cocaine in rats
-
Baird TJ, Deng SX, Landry DW, Winger G, Woods JH. Natural and artificial enzymes against cocaine. I. Monoclonal antibody 15A10 and the reinforcing effects of cocaine in rats. J. Pharmacol. Exp. Ther. 295, 1127-1134 (2000).
-
(2000)
J. Pharmacol. Exp. Ther
, vol.295
, pp. 1127-1134
-
-
Baird, T.J.1
Deng, S.X.2
Landry, D.W.3
Winger, G.4
Woods, J.H.5
-
7
-
-
0029563411
-
Suppression of psychoactive effects of cocaine by active immunization
-
Carrera MRA, Ashley JA, Parsons LH, Wirsching P, Koob GF, Janda KD. Suppression of psychoactive effects of cocaine by active immunization. Nature 378, 727-730 (1995).
-
(1995)
Nature
, vol.378
, pp. 727-730
-
-
Carrera, M.R.A.1
Ashley, J.A.2
Parsons, L.H.3
Wirsching, P.4
Koob, G.F.5
Janda, K.D.6
-
8
-
-
0030746076
-
Anti-cocaine catalytic antibodies - a novel approach to the problem of addiction
-
Landry DW, Yang GX-Q. Anti-cocaine catalytic antibodies - a novel approach to the problem of addiction. J. Addict. Diseases 16, 1-17 (1997).
-
(1997)
J. Addict. Diseases
, vol.16
, pp. 1-17
-
-
Landry, D.W.1
Yang, G.X.-Q.2
-
9
-
-
0027193032
-
Antibody catalyzed degradation of cocaine
-
Landry DW, Zhao K, Yang GX-Q, Glickman M, Georgiadis TM. Antibody catalyzed degradation of cocaine. Science 259, 1899-1901 (1993).
-
(1993)
Science
, vol.259
, pp. 1899-1901
-
-
Landry, D.W.1
Zhao, K.2
Yang, G.X.-Q.3
Glickman, M.4
Georgiadis, T.M.5
-
10
-
-
0030043207
-
Participation of cytochromes P4502B and P4503A in cocaine toxicity in rat hepatocytes
-
Poet TS, McQueen CA, Halpert JR. Participation of cytochromes P4502B and P4503A in cocaine toxicity in rat hepatocytes. Drug Metab. Dispos. 24, 74-80 (1996).
-
(1996)
Drug Metab. Dispos
, vol.24
, pp. 74-80
-
-
Poet, T.S.1
McQueen, C.A.2
Halpert, J.R.3
-
11
-
-
0345148795
-
Cocaine and alcohol interactions in the rat: Contribution of cocaine metabolites to the pharmacological effects
-
Pan W-J, Hedaya MA. Cocaine and alcohol interactions in the rat: contribution of cocaine metabolites to the pharmacological effects. J. Pharm. Sci. 88, 468-476 (1999).
-
(1999)
J. Pharm. Sci
, vol.88
, pp. 468-476
-
-
Pan, W.-J.1
Hedaya, M.A.2
-
12
-
-
0029924913
-
Characterization of the properties of cocaine in blood: Blood clearance, blood to plasma ratio, and plasma protein binding
-
Sukbuntherng J, Martin DK, Pak Y, Mayersohn M. Characterization of the properties of cocaine in blood: blood clearance, blood to plasma ratio, and plasma protein binding. J. Pharm. Sci. 85, 567-571 (1996).
-
(1996)
J. Pharm. Sci
, vol.85
, pp. 567-571
-
-
Sukbuntherng, J.1
Martin, D.K.2
Pak, Y.3
Mayersohn, M.4
-
13
-
-
0031054145
-
A single amino acid substitution, Gly117His, confers phosphotriesterase (organophosphorus acid anhydride hydrolase) activity on human butyrylcholinesterase
-
Lockridge O, Blong RM, Masson P, Froment, M-T, Millard CB, Broomfield CA. A single amino acid substitution, Gly117His, confers phosphotriesterase (organophosphorus acid anhydride hydrolase) activity on human butyrylcholinesterase. Biochemistry 36, 786-795 (1997).
-
(1997)
Biochemistry
, vol.36
, pp. 786-795
-
-
Lockridge, O.1
Blong, R.M.2
Masson, P.3
Froment, M.-T.4
Millard, C.B.5
Broomfield, C.A.6
-
14
-
-
0034097143
-
Gene cloning and nucleotide sequencing and properties of a cocaine esterase from Rhodococcus sp. strain MB1
-
Bresler MM, Rosser SJ, Basran A, Bruce NC. Gene cloning and nucleotide sequencing and properties of a cocaine esterase from Rhodococcus sp. strain MB1. Appl. Environ. Microbiol. 66, 904-908 (2000).
-
(2000)
Appl. Environ. Microbiol
, vol.66
, pp. 904-908
-
-
Bresler, M.M.1
Rosser, S.J.2
Basran, A.3
Bruce, N.C.4
-
15
-
-
33751097261
-
Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase
-
Cooper ZD, Narasimhan D, Sunahara RK et al. Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase. Mol. Pharmacol. 70, 1885-1891 (2006).
-
(2006)
Mol. Pharmacol
, vol.70
, pp. 1885-1891
-
-
Cooper, Z.D.1
Narasimhan, D.2
Sunahara, R.K.3
-
16
-
-
33846439351
-
Cocaine esterase: Interactions with cocaine and immune responses in mice
-
Ko MC, Bowen LD, Narasimhan D et al. Cocaine esterase: interactions with cocaine and immune responses in mice. J. Pharmacol. Exp. Therap. 320, 926-933 (2007).
-
(2007)
J. Pharmacol. Exp. Therap
, vol.320
, pp. 926-933
-
-
Ko, M.C.1
Bowen, L.D.2
Narasimhan, D.3
-
17
-
-
70149113652
-
Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity
-
Gao D, Narasimhan DL, Macdonald J et al. Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity. Mol. Pharmacol. (2008)
-
(2008)
Mol. Pharmacol
-
-
Gao, D.1
Narasimhan, D.L.2
Macdonald, J.3
-
18
-
-
30344445104
-
Modeling evolution of hydrogen bonding and stabilization of transition states in the process of cocaine hydrolysis catalyzed by human butyrylcholinesterase
-
Gao D, Zhan C-G. Modeling evolution of hydrogen bonding and stabilization of transition states in the process of cocaine hydrolysis catalyzed by human butyrylcholinesterase. Proteins 62, 99-110 (2006).
-
(2006)
Proteins
, vol.62
, pp. 99-110
-
-
Gao, D.1
Zhan, C.-G.2
-
19
-
-
29444441881
-
Modeling effects of oxyanion hole on the ester hydrolyses catalyzed by human cholinesterases
-
Gao D, Zhan C-G. Modeling effects of oxyanion hole on the ester hydrolyses catalyzed by human cholinesterases. J. Phys. Chem. B 109, 23070-23076 (2005).
-
(2005)
J. Phys. Chem. B
, vol.109
, pp. 23070-23076
-
-
Gao, D.1
Zhan, C.-G.2
-
20
-
-
23044513572
-
First-principle studies of intermolecular and intramolecular catalysis of protonated cocaine
-
Zhan C-G, Deng S-X, Skiba JG et al. First-principle studies of intermolecular and intramolecular catalysis of protonated cocaine. J. Comput. Chem. 26, 980-986 (2005).
-
(2005)
J. Comput. Chem
, vol.26
, pp. 980-986
-
-
Zhan, C.-G.1
Deng, S.-X.2
Skiba, J.G.3
-
21
-
-
31044435861
-
Computational design of a human butyrylcholinesterase mutant for accelerating cocaine hydrolysis based on the transition-state simulation
-
Gao D, Cho H, Yang W et al. Computational design of a human butyrylcholinesterase mutant for accelerating cocaine hydrolysis based on the transition-state simulation. Angew. Chem. Int. Ed. 45, 653-657 (2006).
-
(2006)
Angew. Chem. Int. Ed
, vol.45
, pp. 653-657
-
-
Gao, D.1
Cho, H.2
Yang, W.3
-
22
-
-
0242669341
-
Fundamental reaction mechanism for cocaine metabolism in human butyrylcholinesterase
-
Zhan C-G, Zheng F, Landry DW. Fundamental reaction mechanism for cocaine metabolism in human butyrylcholinesterase. J. Am. Chem. Soc. 125, 2462-2474 (2003).
-
(2003)
J. Am. Chem. Soc
, vol.125
, pp. 2462-2474
-
-
Zhan, C.-G.1
Zheng, F.2
Landry, D.W.3
-
23
-
-
28444433108
-
Catalytic mechanism and energy barriers for butyrylcholinesterase-catalyzed hydrolysis of cocaine
-
Zhan C-G, Gao D. Catalytic mechanism and energy barriers for butyrylcholinesterase-catalyzed hydrolysis of cocaine. Biophys. J. 89, 3863-3872 (2005).
-
(2005)
Biophys. J
, vol.89
, pp. 3863-3872
-
-
Zhan, C.-G.1
Gao, D.2
-
24
-
-
15944420158
-
Molecular dynamics simulation of cocaine binding with human butyrylcholinesterase and its mutants
-
Hamza A, Cho H, Tai H-H, Zhan C-G. Molecular dynamics simulation of cocaine binding with human butyrylcholinesterase and its mutants. J. Phys. Chem. B 109, 4776-4782 (2005).
-
(2005)
J. Phys. Chem. B
, vol.109
, pp. 4776-4782
-
-
Hamza, A.1
Cho, H.2
Tai, H.-H.3
Zhan, C.-G.4
-
25
-
-
28044458963
-
Computational redesign of human butyrylcholinesterase for anti-cocaine medication
-
Pan Y, Gao D, Yang W et al. Computational redesign of human butyrylcholinesterase for anti-cocaine medication. Proc. Natl Acad. Sci. USA 102, 16656-16661 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 16656-16661
-
-
Pan, Y.1
Gao, D.2
Yang, W.3
-
26
-
-
35948998959
-
Free energy perturbation (FEP) simulation on the transition-states of cocaine hydrolysis catalyzed by human butyrylcholinesterase and its mutants
-
Pan Y, Gao D, Yang W, Cho H, Zhan C-G. Free energy perturbation (FEP) simulation on the transition-states of cocaine hydrolysis catalyzed by human butyrylcholinesterase and its mutants. J. Am. Chem. Soc. 129, 13537-13543 (2007).
-
(2007)
J. Am. Chem. Soc
, vol.129
, pp. 13537-13543
-
-
Pan, Y.1
Gao, D.2
Yang, W.3
Cho, H.4
Zhan, C.-G.5
-
27
-
-
51749096409
-
Most efficient cocaine hydrolase designed by virtual screening of transition States
-
Zheng F, Yang W, Ko M-C et al. Most efficient cocaine hydrolase designed by virtual screening of transition States. J. Am. Chem. Soc. 130, 12148-12155 (2008).
-
(2008)
J. Am. Chem. Soc
, vol.130
, pp. 12148-12155
-
-
Zheng, F.1
Yang, W.2
Ko, M.-C.3
-
28
-
-
48749118846
-
A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats
-
Brimijoin S, Gao Y, Anker JJ et al. A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats. Neuropsychopharmacology 33, 2715-2725 (2008).
-
(2008)
Neuropsychopharmacology
, vol.33
, pp. 2715-2725
-
-
Brimijoin, S.1
Gao, Y.2
Anker, J.J.3
|