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Volumn 88, Issue 4, 1999, Pages 468-474

Cocaine and alcohol interactions in the rat: Contribution of cocaine metabolites to the pharmacological effects

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; BENZOYLECGONINE; COCAINE; DRUG METABOLITE; HOMOCOCAINE; NORCOCAINE;

EID: 0345148795     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js980283h     Document Type: Article
Times cited : (36)

References (28)
  • 1
    • 0018394181 scopus 로고
    • Cocaine metabolism: Cocaine and norcocaine hydrolysis by liver and serum esterases
    • Stewart, D. J.; Inaba, T.; Lucassen, M.; Kalow, W. Cocaine Metabolism: Cocaine and Norcocaine Hydrolysis by Liver and Serum Esterases. Clin. Pharmacol. Ther. 1979, 25, 464-468.
    • (1979) Clin. Pharmacol. Ther. , vol.25 , pp. 464-468
    • Stewart, D.J.1    Inaba, T.2    Lucassen, M.3    Kalow, W.4
  • 2
    • 0025955766 scopus 로고
    • Human liver cocaine esterases: Ethanol-mediated formation of ethylcocaine
    • Dean, R. A.; Christian, C. D.; Sample, R. H.; Bosron, W. F. Human Liver Cocaine Esterases: Ethanol-Mediated Formation of Ethylcocaine. FASEB J. 1991, 5, 2735-2739.
    • (1991) FASEB J. , vol.5 , pp. 2735-2739
    • Dean, R.A.1    Christian, C.D.2    Sample, R.H.3    Bosron, W.F.4
  • 3
    • 0020632379 scopus 로고
    • N-Demethylation of cocaine to norcocaine. Evidence for participation by cytochrome P-450 and FAD-containing monooxygenase
    • Kloss, M. W.; Rosen, G. M.; Rauckman, E. J. N-Demethylation of Cocaine to Norcocaine. Evidence for Participation by Cytochrome P-450 and FAD-Containing Monooxygenase. Mol. Pharmacol. 1983, 23, 482-485.
    • (1983) Mol. Pharmacol. , vol.23 , pp. 482-485
    • Kloss, M.W.1    Rosen, G.M.2    Rauckman, E.J.3
  • 4
    • 0025786037 scopus 로고
    • Human microsomal N-oxidative metabolism of cocaine
    • Roberts, S. M.; Harbison, R. D.; James, R. C. Human Microsomal N-oxidative Metabolism of Cocaine. Drug Metab. Dispos. 1991, 19, 1046-1051.
    • (1991) Drug Metab. Dispos. , vol.19 , pp. 1046-1051
    • Roberts, S.M.1    Harbison, R.D.2    James, R.C.3
  • 5
    • 0030043207 scopus 로고    scopus 로고
    • Participation of cytochromes P4502B and P4503A in cocaine toxicity in rat hepatocytes
    • Poet, T. S.; McQueen, C. A.; Halpert, J. R. Participation of Cytochromes P4502B and P4503A in Cocaine Toxicity in Rat Hepatocytes. Drug Metab. Dispos. 1996, 24, 74-80.
    • (1996) Drug Metab. Dispos. , vol.24 , pp. 74-80
    • Poet, T.S.1    McQueen, C.A.2    Halpert, J.R.3
  • 6
    • 0024439526 scopus 로고
    • The pharmacology of cocaine related to its abuse
    • Johanson, C. E.; Fischman, M. W. The Pharmacology of Cocaine Related to Its Abuse. Pharmacol. Rev. 1989, 41, 3-52
    • (1989) Pharmacol. Rev. , vol.41 , pp. 3-52
    • Johanson, C.E.1    Fischman, M.W.2
  • 7
    • 0023265754 scopus 로고
    • Cocaine receptors on dopamine transporters are related to self-administration of cocaine
    • Ritz, M. C.; Lamb, R. J.; Goldberg, S. R.; Kuhar, M. J. Cocaine Receptors on Dopamine Transporters Are Related to Self-administration of Cocaine. Science 1987, 237, 1219-1223.
    • (1987) Science , vol.237 , pp. 1219-1223
    • Ritz, M.C.1    Lamb, R.J.2    Goldberg, S.R.3    Kuhar, M.J.4
  • 8
    • 0019311630 scopus 로고
    • Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens
    • Roberts, D. C.; Koob, G. F.; Klonoff, P.; Fibiger, H. C. Extinction and Recovery of Cocaine Self-Administration Following 6-Hydroxydopamine Lesions of the Nucleus Accumbens. Pharmacol. Biochem. Behav. 1980, 12, 781-787.
    • (1980) Pharmacol. Biochem. Behav. , vol.12 , pp. 781-787
    • Roberts, D.C.1    Koob, G.F.2    Klonoff, P.3    Fibiger, H.C.4
  • 10
    • 0026724259 scopus 로고
    • Characterization of the sodium channel blocking properties of the major metabolites of cocaine in single cardiac myocytes
    • Crumb, W. J., Jr.; Clarkson, C. W. Characterization of the Sodium Channel Blocking Properties of the Major Metabolites of Cocaine in Single Cardiac Myocytes. J. Pharmacol. Exp. Ther. 1992, 261, 910-917.
    • (1992) J. Pharmacol. Exp. Ther. , vol.261 , pp. 910-917
    • Crumb W.J., Jr.1    Clarkson, C.W.2
  • 11
    • 0027374143 scopus 로고
    • Comparison of the effects of cocaine and its metabolites on cardiovascular function in anesthetized rats
    • Erzouki, H. K.; Baum, I.; Goldberg, S. R.; Schindler, C. W. Comparison of the Effects of Cocaine and Its Metabolites on Cardiovascular Function in Anesthetized Rats. J. Cardiovasc. Pharmacol. 1993, 22, 557-563.
    • (1993) J. Cardiovasc. Pharmacol. , vol.22 , pp. 557-563
    • Erzouki, H.K.1    Baum, I.2    Goldberg, S.R.3    Schindler, C.W.4
  • 12
    • 0030070328 scopus 로고    scopus 로고
    • Effect of cocaine metabolites on behavior: Possible neuroendocrine mechanisms
    • Schuelke, G. S.; Konkol, R. J.; Terry, L. C.; Madden, J. A. Effect of Cocaine Metabolites on Behavior: Possible Neuroendocrine Mechanisms. Brain Res. Bull. 1996, 39, 43-48.
    • (1996) Brain Res. Bull. , vol.39 , pp. 43-48
    • Schuelke, G.S.1    Konkol, R.J.2    Terry, L.C.3    Madden, J.A.4
  • 14
    • 0025763080 scopus 로고
    • Cocaethylene: A neuropharmacologically active metabolite associated with concurrent cocaine-ethanol ingestion
    • Jatlow, P.; Elsworth, J. D.; Bradberry, C. W.; Winger, G.; Taylor, J. R.; Russell, R.; Roth, R. H. Cocaethylene: A Neuropharmacologically Active Metabolite Associated with Concurrent Cocaine-Ethanol Ingestion. Life Sci. 1991, 48, 1787-1794.
    • (1991) Life Sci. , vol.48 , pp. 1787-1794
    • Jatlow, P.1    Elsworth, J.D.2    Bradberry, C.W.3    Winger, G.4    Taylor, J.R.5    Russell, R.6    Roth, R.H.7
  • 17
    • 0031954163 scopus 로고    scopus 로고
    • An animal model for simultaneous pharmacokinetic/pharmacodynamic investigations: Application to cocaine
    • Pan, W. J.; Hedaya, M. A. An Animal Model for Simultaneous Pharmacokinetic/Pharmacodynamic Investigations: Application to Cocaine. J. Pharmacol. Toxicol. Meth. 1998, 39, 1-8.
    • (1998) J. Pharmacol. Toxicol. Meth. , vol.39 , pp. 1-8
    • Pan, W.J.1    Hedaya, M.A.2
  • 18
    • 0032945477 scopus 로고    scopus 로고
    • Cocaine and alcohol interactions in the rat: Effect on cocaine pharmacokinetics and pharmacodynamics
    • Pan, W. J.; Hedaya, M. A. Cocaine and Alcohol Interactions in the Rat: Effect on Cocaine Pharmacokinetics and Pharmacodynamics. J. Pharm. Sci. 1999, 88, 459-467.
    • (1999) J. Pharm. Sci. , vol.88 , pp. 459-467
    • Pan, W.J.1    Hedaya, M.A.2
  • 19
    • 0031448883 scopus 로고    scopus 로고
    • Sensitive and specific high-performance liquid chromatographic assay with ultraviolet detection for the determination of cocaine and its metabolites in rat plasma
    • Pan, W. J.; Hedaya, M. A. Sensitive and Specific High-Performance Liquid Chromatographic Assay with Ultraviolet Detection for the Determination of Cocaine and Its Metabolites in Rat Plasma. J. Chromatogr. B Biomed. Sci. Appl. 1997, 703, 129-138.
    • (1997) J. Chromatogr. B Biomed. Sci. Appl. , vol.703 , pp. 129-138
    • Pan, W.J.1    Hedaya, M.A.2
  • 21
    • 0019723001 scopus 로고
    • Drug metabolite kinetics
    • Houston, J. B. Drug Metabolite Kinetics. Pharmacol. Ther. 1982, 15, 521-552.
    • (1982) Pharmacol. Ther. , vol.15 , pp. 521-552
    • Houston, J.B.1
  • 22
    • 0030429755 scopus 로고    scopus 로고
    • Characterization of four basic models of indirect pharmacodynamic responses
    • Sharma, A.; Jusko, W. J. Characterization of Four Basic Models of Indirect Pharmacodynamic Responses. J. Pharmacokinet. Biopharm. 1996, 24, 611-635.
    • (1996) J. Pharmacokinet. Biopharm. , vol.24 , pp. 611-635
    • Sharma, A.1    Jusko, W.J.2
  • 23
    • 0030662187 scopus 로고    scopus 로고
    • Mathematical formalism for the properties of four basic models of indirect pharmacodynamic responses
    • Krzyzanski, W.; Jusko, W. J. Mathematical Formalism for the Properties of Four Basic Models of Indirect Pharmacodynamic Responses. J. Pharmacokinet. Biopharm. 1997, 25, 107-123.
    • (1997) J. Pharmacokinet. Biopharm. , vol.25 , pp. 107-123
    • Krzyzanski, W.1    Jusko, W.J.2
  • 24
    • 0028051609 scopus 로고
    • Cocaethylene, a metabolite of cocaine and ethanol, is a potent blocker of cardiac sodium channels
    • Xu, Y. Q.; Crumb, W. J. Jr.; Clarkson, C. W. Cocaethylene, A Metabolite of Cocaine and Ethanol, Is a Potent Blocker of Cardiac Sodium Channels. J. Pharmacol. Exp. Ther. 1994, 277, 319-325.
    • (1994) J. Pharmacol. Exp. Ther. , vol.277 , pp. 319-325
    • Xu, Y.Q.1    Crumb W.J., Jr.2    Clarkson, C.W.3
  • 25
    • 0000106986 scopus 로고    scopus 로고
    • Biotransformation of xenobiotics
    • Klaassen, C. D., Ed.; McGraw-Hill: New York
    • th ed.; Klaassen, C. D., Ed.; McGraw-Hill: New York, 1996; pp 113-186.
    • (1996) th Ed. , pp. 113-186
    • Parkinson, A.1
  • 26
    • 0025915542 scopus 로고
    • Biomechanisms of cocaine-induced hepatocyte injury mediated by the formation of reactive metabolites
    • Boelsterli, U. A.; Göldlin, C. Biomechanisms of Cocaine-Induced Hepatocyte Injury Mediated by the Formation of Reactive Metabolites. Arch. Toxicol. 1991, 65, 351-360.
    • (1991) Arch. Toxicol. , vol.65 , pp. 351-360
    • Boelsterli, U.A.1    Göldlin, C.2
  • 27
    • 0019351131 scopus 로고
    • Ethanol enhancement of cocaine-induced hepatotoxicity
    • Smith, A. C.; Freeman, R. W.; Harbison, R. D. Ethanol Enhancement of Cocaine-Induced Hepatotoxicity. Biochem. Pharmacol. 1981, 30, 453-458.
    • (1981) Biochem. Pharmacol. , vol.30 , pp. 453-458
    • Smith, A.C.1    Freeman, R.W.2    Harbison, R.D.3
  • 28
    • 0026567872 scopus 로고
    • Identification of cytochrome P-450IIB1 as a cocaine-bioactivating isoform in rat hepatic microsomes and in cultured rat hepatocytes
    • Boelsterli, U. A.; Lanzotti, A.; Göldlin, C.; Oertle, M. Identification of Cytochrome P-450IIB1 as A Cocaine-Bioactivating Isoform in Rat Hepatic Microsomes and in Cultured Rat Hepatocytes. Drug Metab. Dispos. 1992, 20, 96-101.
    • (1992) Drug Metab. Dispos. , vol.20 , pp. 96-101
    • Boelsterli, U.A.1    Lanzotti, A.2    Göldlin, C.3    Oertle, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.