Intracellular delivery of bovine lactoferricin's antimicrobial core (RRWQWR) kills T-leukemia cells

Biochemical and Biophysical Research Communications

Volumn 388, Issue 4, 2009, Pages 736-741

  Richardson, Angela ^a   de Antueno, Roberto ^a   Duncan, Roy ^a   Hoskin, David W ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Antimicrobial peptide; Bovine lactoferricin; Cancer; Caspase; Cathepsin B; Fusogenic liposome

Indexed keywords

ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; ARGINYLARGINYLTRYPTOPHYLGLUTAMINYLTRYPTOPHYLARGININE; CASPASE; CASPASE INHIBITOR; CATHEPSIN B; CATHEPSIN B INHIBITOR; CYTOCHROME C; DNA; GLUTATHIONE; LACTOFERRICIN B; LIPOSOME; PEPTIDE DERIVATIVE; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG BINDING; DRUG CYTOTOXICITY; DRUG MECHANISM; FLOW CYTOMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LIPOSOMAL DELIVERY; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CATTLE; DRUG DELIVERY SYSTEMS; HUMANS; JURKAT CELLS; LACTOFERRIN; LEUKEMIA, T-CELL; LIPOSOMES;

BOVINAE;

EID: 69949150585     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.08.083     Document Type: Article

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