Pyrimethamine induces apoptosis of melanoma cells via a caspase and cathepsin double-edged mechanism

Cancer Research

Volumn 68, Issue 13, 2008, Pages 5291-5300

  Giammarioli, Anna Maria ^a   Maselli, Angela ^a   Casagrande, Andrea ^a   Gambardella, Lucrezia ^a   Gallina, Angelo ^a   Spada, Massimo ^a   Giovannetti, Antonello ^a   Proietti, Enrico ^a   Malorni, Walter ^a,b   Pierdominici, Marina ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CASPASE 8; CASPASE 9; CATHEPSIN; CATHEPSIN B; PYRIMETHAMINE; TEMOZOLOMIDE; ANTINEOPLASTIC AGENT; FOLIC ACID ANTAGONIST;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE S PHASE; CELL GROWTH; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; MELANOMA; MELANOMA CELL; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE; TUMOR GROWTH; XENOTRANSPLANTATION; ANIMAL; CELL CULTURE; DRUG EFFECT; DRUG SCREENING; ENZYMOLOGY; METABOLISM; MITOCHONDRION; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; TUMOR VOLUME;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CATHEPSINS; CELL PROLIFERATION; FEMALE; FOLIC ACID ANTAGONISTS; HUMANS; MELANOMA; MICE; MICE, SCID; MITOCHONDRIA; NEOPLASM METASTASIS; PYRIMETHAMINE; S PHASE; TUMOR BURDEN; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 48549090651     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-0222     Document Type: Article

References (41)

1. Miller AJ, Mihm MC, Jr. Melanoma. N Engl J Med 2006;355:51-65.
2. Garbe C, Eigentler TK. Diagnosis and treatment of cutaneous melanoma: state of the art 2006. Melanoma Res 2007;17:117-27.
3. Tarhini AA, Agarwala SS. Cutaneous melanoma: available therapy for metastatic disease. Dermatol Ther 2006;19:19-25.
4. Kirkwood JM, Moschos S, Wang W. Strategies for the development of more effective adjuvant therapy of melanoma: current and future explorations of antibodies, cytokines, vaccines, and combinations. Clin Cancer Res 2006;12:2331-6s.
5. Soengas MS, Lowe SW. Apoptosis and melanoma chemoresistance. Oncogene 2003;22:3138-51.
6. Hersey P. Apoptosis and melanoma: how new insights are effecting the development of new therapies for melanoma. Curr Opin Oncol 2006;18:189-96.
7. Fulda S, Debatin KM. Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 2006;25:4798-811.
8. Chwieralski CE, Welte T, Buhling F. Cathepsin-regulated apoptosis. Apoptosis 2006;11:143-9.
9. Sloane BF, Rozhin J, Johnson K, Taylor H, Crissman JD, Honn KV. Cathepsin B: association with plasma membrane in metastatic tumors. Proc Natl Acad Sci U S A 1986;83:2483-7.
10. Matarrese P, Di Biase L, Santodonato L, et al. Type I interferon gene transfer sensitizes melanoma cells to apoptosis via a target activity on mitochondrial function. Am J Pathol 2002;160:1507-20.
11. 1999 USPHS/IDSA guidelines for the prevention of opportunistic infections in persons infected with human immunodeficiency virus. Clin Infect Dis 2000;30:S29-65.
12. Bygbjerg IC. Pyrimethamine-induced alterations in human lymphocytes in vitro. Mechanisms and reversal of the effect. Acta Pathol Microbiol Immunol Scand 1985;93:183-8.
13. Bygbjerg IC, Odum N, Theander TG. Effect of pyrimethamine and sulphadoxine on human lymphocyte proliferation. Trans R Soc Trop Med Hyg 1986;80:295-300.
14. Viora M, De Luca A, D'Ambrosio A, Antinori A, Ortona E. In vitro and in vivo immunomodulatory effects of anti-Pneumocystis carinii drugs. Antimicrob Agents Chemother 1996;40:1294-7.
15. van der Werff Ten Bosch J, Schotte P, Ferster A, et al. Reversion of autoimmune lymphoproliferative syndrome with an antimalarial drug: preliminary results of a clinical cohort study and molecular observations. Br J Haematol 2002;117:176-88.
16. Pierdominici M, Giammarioli AM, Gambardella L, et al. Pyrimethamine (2,4-diamino-5-p-chlorophenyl-6-ethylpyrimidine) induces apoptosis of freshly isolated human T lymphocytes, bypassing CD95/Fas molecule but involving its intrinsic pathway. J Pharmacol Exp Ther 2005;315:1046-57.
17. Kroemer G, Zamzami N, Susin SA. Mitochondrial control of apoptosis. Immunol Today 1997;18:44-51.
18. Lozupone F, Rivoltini L, Luciani F, et al. Adoptive transfer of an anti-MART-1(27-35)-specific CD8+ T cell clone leads to immunoselection of human melanoma antigen-loss variants in SCID mice. Eur J Immunol 2003;33:556-66.
19. Cossarizza A, Franceschi C, Monti D, et al. Protective effect of N-acetylcysteine in tumor necrosis factor-α-induced apoptosis in U937 cells: the role of mitochondria. Exp Cell Res 1995;220:232-40.
20. Ceruti S, Beltrami E, Matarrese P, et al. A key role for caspase-2 and caspase-3 in the apoptosis induced by 2-chloro-2′-deoxy-adenosine (cladribine) and 2-chloroadenosine in human astrocytoma cells. Mol Pharmacol 2003;63:1437-47.
21. Geran RI, Greenberg NH, Macdonald MM, Shumacher AM, Abbot BJ. Protocols for screening chemical agents and natural products against animal tumors and other biological systems. Cancer Chemother Rep 1972;3:1-88.
22. Klinker H, Langmann P, Richter E. Plasma pyrimethamine concentrations during long-term treatment for cerebral toxoplasmosis in patients with AIDS. Antimicrob Agents Chemother 1996;40:1623-7.
23. Quirt I, Verma S, Petrella T, Bak K, Charette M. Temozolomide for the treatment of metastatic melanoma: a systematic review. Oncologist 2007;12:1114-23.
24. Brada M, Judson I, Beale P, et al. Phase I dose-escalation and pharmacokinetic study of temozolomide (SCH 52365) for refractory or relapsing malignancies. Br J Cancer 1999;81:1022-30.
25. Strauss G, Osen W, Debatin KM. Induction of apoptosis and modulation of activation and effector function in T cells by immunosuppressive drugs. Clin Exp Immunol 2002;128:255-66.
26. Lugini L, Lozupone F, Matarrese P, et al. Potent phagocytic activity discriminates metastatic and primary human malignant melanomas: a key role of ezrin. Lab Invest 2003;83:1555-67.
27. Werneburg NW, Guicciardi ME, Bronk SF, Gores GJ. Tumor necrosis factor-a-associated lysosomal permeabilization is cathepsin B dependent. Am J Physiol Gastrointest Liver Physiol 2002;283:947-56.
28. Perl A, Gergely P, Jr., Nagy G, Koncz A, Banki K. Mitochondrial hyperpolarization: a checkpoint of T-cell life, death and autoimmunity. Trends Immunol 2004;25:360-7.
29. Matarrese P, Gambardella L, Cassone A, Vella S, Cauda R, Malorni W. Mitochondrial membrane hyperpolarization hijacks activated T lymphocytes toward the apoptotic-prone phenotype: homeostatic mechanisms of HIV protease inhibitors. J Immunol 2003;170:6006-15.
30. Ferri KF, Kroemer G. Organelle-specific initiation of cell death pathways. Nat Cell Biol 2001;3:E255-63.
31. Freund YR, Riccio ES, Phillips SJ, Dousman L, MacGregor JT. Pyrimethamine impairs host resistance to infection with Listeria monocytogenes in BALB/c mice. Toxicol Sci 1998;42:91-8.
32. Hersey P, Zhuang L, Zhang XD. Current strategies in overcoming resistance of cancer cells to apoptosis melanoma as a model. Int Rev Cytol 2006;251:131-58.
33. Graf D, Kurz AK, Fischer R, Reinehr R, Haussinger D. Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase-dependent manner. Gastroenterology 2002;122:1411-27.
34. Scheel-Toellner D, Wang K, Craddock R, et al. Reactive oxygen species limit neutrophil life span by activating death receptor signaling. Blood 2004;104:2557-64.
35. Brunk UT, Neuzil J, Eaton JW. Lysosomal involvement in apoptosis. Redox Rep 2001;6:91-7.
36. Jin S, White E. Role of autophagy in cancer: management of metabolic stress. Autophagy 2007;3:28-31.
37. Guicciardi ME, Leist M, Gores GJ. Lysosomes in cell death. Oncogene 2004;23:2881-90.
38. Hippert MM, O'Toole PS, Thorburn A. Autophagy in cancer: good, bad, or both? Cancer Res 2006;66:9349-51.
39. Lugini L, Matarrese P, Tinari A, et al. Cannibalism of live lymphocytes by human metastatic but not primary melanoma cells. Cancer Res 2006;66:3629-38.
40. Matarrese P, Ciarlo L, Tinari A, Piacentini M, Malorni W. Xeno-cannibalism as an exacerbation of self-cannibalism: a possible fruitful survival strategy for cancer cells. Curr Pharm Des 2008;14:245-52.
41. Salvador N, Aguado C, Horst M, Knecht E. Import of a cytosolic protein into lysosomes by chaperone-mediated autophagy depends on its folding state. J Biol Chem 2000;275:27447-56.