Targeted generation of DNA strand breaks using pyrene-conjugated triplex-forming oligonucleotides

Biochemistry

Volumn 47, Issue 23, 2008, Pages 6279-6288

  Benfield, Aaron P ^a   Macleod, Michael C ^a   Liu, Yaobin ^a   Wu, Qi ^a   Wensel, Theodore G ^b   Vasquez, Karen M ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; BIOSENSORS; CELLS; DNA; FREE RADICALS; GENES; GENETIC ENGINEERING; MAMMALS; MODULATION; NUCLEOTIDES; OLIGONUCLEOTIDES; OPTICAL PROPERTIES; ORGANIC ACIDS; OXYGEN; PHOTOREACTIVITY; PIGMENTS;

AMERICAN CHEMICAL SOCIETY (ACS); CHROMOSOMAL LOCATIONS; CLINICAL APPLICATIONS; DIRECT SEQUENCE (DS); DNA ADDUCTS; DNA DAMAGES; DNA STRANDS; DOUBLE-STRANDED DNA (DS-DNA); FREE RADICAL SCAVENGING; GENE TARGETING; HIGH EFFICIENCY; IN-VIVO; MAMMALIAN CELLS; PHOTOPRODUCTS; PHOTOREACTIVE REAGENTS; POTENTIALLY POWERFUL; SINGLET EXCITED STATES; SINGLET OXYGEN (1O2); TRIPLEX-FORMING OLIGONUCLEOTIDES (TFO);

NUCLEIC ACIDS;

PYRENE; SCAVENGER; SINGLET OXYGEN;

ARTICLE; DNA DAMAGE; DNA STRAND BREAKAGE; GENE DELETION; GENE FUNCTION; GENE MUTATION; GENE SEQUENCE; GENE STRUCTURE; GENE TARGETING; GENOTOXICITY; MAMMAL CELL; NONHUMAN; PHOTOACTIVATION; PHOTOREACTIVITY; PRIORITY JOURNAL; TRIPLEX FORMING OLIGONUCLEOTIDE;

DNA DAMAGE; FREE RADICAL SCAVENGERS; KINETICS; MUTAGENESIS; MUTATION; OLIGONUCLEOTIDES; PHOTOCHEMISTRY; PYRENES; SEQUENCE DELETION;

MAMMALIA;

EID: 44949095614     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi7024029     Document Type: Article

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