The synthesis of novel matrix metalloproteinase inhibitors employing the Ireland-Claisen rearrangement

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 11, 1998, Pages 1359-1364

  Pratt, Lisa M ^a   Beckett, R Paul ^a   Bellamy, Claire L ^a   Corkill, Dominic J ^a   Cossins, Judy ^a   Courtney, Paul F ^a   Davies, Stephen J ^a   Davidson, Alan H ^a   Drummond, Alan H ^a   Helfrich, Karen ^a   Lewis, Christopher N ^a   Mangan, Matthew ^a   Martin, Fionna M ^a   Miller, Karen ^a   Nayee, Prakash ^a   Rickerts, Michelle L ^a   Thomas, Wayne ^a   Todd, Richard S ^a   Whittaker, Mark ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

MARIMASTAT; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL MODIFICATION; CYTOKINE RELEASE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; NONHUMAN; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CALLITHRIX; DEPRESSION, CHEMICAL; HYDROXAMIC ACIDS; LIPOPOLYSACCHARIDES; METALLOENDOPEPTIDASES; PROTEASE INHIBITORS; RATS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 18344415400     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00218-2     Document Type: Article

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