Statistical validation of endophenotypes using a surrogate endpoint analytic analogue

Genetic Epidemiology

Volumn 33, Issue 6, 2009, Pages 549-558

  Huang, Guan Hua ^a   Hsieh, Chin Chiang ^a   Chen, Chen Hsin ^b,c   Chen, Wei J ^c  

^a NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

^b INSTITUTE OF STATISTICAL SCIENCE   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Continuous Performance Test; Heritability; Liability threshold model; Schizophrenia related personalitydisorder; Variance component analysis

Indexed keywords

ARTICLE; COMPUTER SIMULATION; CRITERION RELATED VALIDITY; GENETIC SUSCEPTIBILITY; HERITABILITY; HUMAN; NULL HYPOTHESIS; PHENOTYPE; SCHIZOPHRENIA;

DISEASE SUSCEPTIBILITY; HUMANS; MODELS, STATISTICAL; PHENOTYPE; SCHIZOPHRENIA;

EID: 69949126470     PISSN: 07410395     EISSN: 10982272     Source Type: Journal    
DOI: 10.1002/gepi.20407     Document Type: Article

References (32)

1. Almasy L, Blangero J. 1998. Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198-1211.
2. Almasy L, Blangero J. 2001. Endophenotypes as quantitative risk factors for psychiatric disease: rationale and study design. Am J Med Genet B Neuropsychiatr Genet 105:42-44.
3. Amos CI. 1994. Robust variance-components approach for assessing genetic linkage in pedigrees. Am J Hum Genet 54:535-543.
4. Begg C, Leung DHY. 2000. On the use of surrogate end points in randomized trials (with comments). J R Stat Soc A 163:15-28.
5. Blangero J, Lange K, Dyer T, Almasy L, Goring H, Williams J, Peterson C. 2004. SOLAR v.2.1.4. http://www.sfbr.org/solar/index.html. San Antonio: Southwest Foundation for Biomedical Research.
6. Breslow NE, Clayton DG. 1993. Approximate inference in generalized linear mixed models. J Am Stat Assoc 88:9-25.
7. Burton PR, Tobin MD. 2003. Epidemiology and genetic epidemiology. In: Balding DJ, Bishop M, Cannings C, editors. Handbook of Statistical Genetics, 2nd edition. West Sussex: Wiley, p 855-879.
8. Burton PR, Tiller KJ, Gurrin LC, Cookson WOCM, Musk AW, Palmer LJ. 1999. Genetic variance components analysis for binary phenotypes using generalized linear mixed models GLMMs and Gibbs sampling. Genet Epidemiol 17:118-140.
9. Buyse M, Molenberghs G. 1998. Criteria for validation of surrogate endpoints in randomized experiments. Biometrics 54:1014-1029.
10. Casella G, Berger RL. 2001. Statistical Inference, 2nd edition. Belmont: Brooks/Cole, p 240-245.
11. Chang CJ, Chen WJ, Liu SK, Cheng JJ, Ou Yang WC, Chang HJ, Lane HY, Lin SK, Yang TW, Hwu HG. 2002. Morbidity risk of psychiatric disorders among the first degree relatives of schizophrenia patients in Taiwan. Schizophr Bull 28:379-392.
12. Chen WJ, Faraone SV. 2000. Sustained attention deficits as markers of genetic susceptibility to schizophrenia. Am J Med Genet 97:52-57.
13. Chen WJ, Hsiao CK, Hsiao LL, Hwu HG. 1998a. Performance of the continuous performance test among community samples. Schizophr Bull 24:163-174.
14. Chen WJ, Liu SK, Chang CJ, Lien YJ, Chang YH, Hwu HG. 1998b. Sustained attention deficit and schizotypal personality features in nonpsychotic relatives of schizophrenic patients. Am J Psychiatry 155:1214-1220.
15. Chen WJ, Chang CH, Liu SK, Hwang TJ, Hwu HG, collaborators from the Multidimensional Psychopathology Group Research Project. 2004. Sustained attention deficits in nonpsychotic relatives of schizophrenic patients: a recurrence risk ratio analysis. Biol Psychiatry 55:995-1000.
16. Cornblatt BA, Keilp JG. 1994. Impaired attention, genetics, and the pathophysiology of schizophrenia. Schizophr Bull 20:31-46.
17. De Gruttola VG, Clax P, DeMets DL, Downing GJ, Ellenberg SS, Friedman L, Gail MH, Prentice R, Wittes J, Zeger SL. 2001. Considerations in the evaluation of surrogate endpoints in clinical trials: summary of a National Institutes of Health Workshop. Control Clin Trials 22:485-502.
18. Duggirala R, Williams JT, Williams-Blangero S, Blangero J. 1997. A variance component approach to dichotomous trait linkage analysis using a threshold model. Genet Epidemiol 14:987-992.
19. Eaton WW, Dryman A, Sorenson A, McCutcheon A. 1989. DSM-III major depressive disorder in the community: a latent class analysis of data from the NIMH epidemiologic catchment-area program. Br J Psychiatry 155:48-54.
20. Falconer DS. 1989. Introduction to Quantitative Genetics, 3rd edition. New York: Wiley.
21. Freedman LS, Graubard BI, Schatzkin A. 1992. Statistical validation of intermediate endpoints for chronic diseases. Stat Med 11:167-178.
22. Gottesman II, Gould TD. 2003. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160:636-645.
23. Herson J. 1975. Fieller's theorem versus the delta method for significance intervals for ratios. J Stat Comput Sim 3:265-274.
24. Hopper JL. 2002. Heritability. In: Elston RC, Olson JM, Palmer L, editors. Biostatistical Genetics and Genetic Epidemiology. West Sussex: Wiley, p 371-372.
25. Hopper JL, Visscher PM. 2002. Variance component analysis. In: Elston RC, Olson JM, Palmer L, editors. Biostatistical Genetics and Genetic Epidemiology. West Sussex: Wiley, p 778-788.
26. Pan W-H, Lynn K-S, Chen C-H, Wu Y-L, Lin C-Y, Chang H-Y. 2006. Using endophenotypes for pathway clusters to map complex disease genes. Genet Epidemiol 30:143-154.
27. Piantadosi S. 1997. Clinical Trials: A Methodologic Perspective. New York: Wiley.
28. Prentice RL. 1989. Surrogate endpoints in clinical trials: Definitions and operational criteria. Stat Med 8:431-440.
29. Prentice RL, Zhao LP. 1991. Estimating equations for parameters in means and covariances of multivariate discrete and continuous responses. Biometrics 47:825-839.
30. Rosvold HE, Mirsky AF, Sarason I, Bransome ED, Beck LH. 1956. A continuous performance test of brain damage. J Consult Psychol 20:343-350.
31. Waldman ID. 2005. Statistical approaches to complex phenotypes: Evaluating neuropsychological endophenotypes for attention-deficit/ hyperactivity disorder. Biol Psychiatry 57:1347-1356.
32. Williams JT, Eerdewegh PV, Almasy L, Blangero J. 1999. Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. I. Likelihood formulation and simulation results. Am J Hum Genet 65:1134-1147.