Synthesis and SAR of 1,4,5,6-tetrahydropyridazines as potent cannabinoid CB1 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 19, 2009, Pages 5675-5678

  Lange, Jos H M ^a   den Hartog, Arnold P ^a   van der Neut, Martina A W ^a   van Vliet, Bernard J ^a   Kruse, Chris G ^a  

^a Solvay Pharmaceuticals Inc   (Netherlands)

Author keywords

Antagonist; Cannabinoid CB1; Inverse agonist; Scaffold hopping; Tetrahydropyridazine

Indexed keywords

1,4,5,6 TETRAHYDROPYRIDAZINE; CANNABINOID 1 RECEPTOR; CANNABINOID 1 RECEPTOR ANTAGONIST; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL CULTURE; ARTICLE; CHIRALITY; CHO CELL; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; FEMALE; HYDROLYSIS; NONHUMAN; REDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; PYRIDAZINES; RECEPTOR, CANNABINOID, CB1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 69949123030     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.08.007     Document Type: Article

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