γ-aminobutyrate-A receptor modulation by 3-aryl-1-(arylsulfonyl)- 1,4,5,6-tetrahydropyridazines

Journal of Medicinal Chemistry

Volumn 42, Issue 13, 1999, Pages 2403-2408

  Rybczynski, Philip J ^a   Combs, Donald W ^a   Jacobs, Kimberly ^a   Shank, Richard P ^a   Dubinsky, Barry ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; PARTIAL AGONIST; PENTETRAZOLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG RECEPTOR BINDING; GABAERGIC SYSTEM; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOTOR ACTIVITY; NEUROMODULATION; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-ANXIETY AGENTS; BINDING, COMPETITIVE; BRAIN STEM; CEREBELLUM; CEREBRAL CORTEX; GABA AGONISTS; MALE; MICE; MOTOR ACTIVITY; PENTYLENETETRAZOLE; PYRIDAZINES; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, GABA-A; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033168908     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9805889     Document Type: Article

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33. 50 = 1.3 nM (manuscript in preparation). Formula presented