Synthesis of 1,6,7,8-tetrahydro-naphtho[2,3-d]-azepino[4,5-b]indole-9,14-diones and their inhibitory effects on pro-inflammatory cytokines

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 19, 2009, Pages 5753-5756

  Phutdhawong, Waya S ^a   Ruensamran, Wanwikar ^a   Phutdhawong, Weerachai ^b   Taechowisan, Thongchai ^a  

^a SILPAKORN UNIVERSITY   (Thailand)

^b KASETSART UNIVERSITY   (Thailand)

Author keywords

Aminonapthoquinones; Azepine; Indole derivatives; Naphthoquinone derivatives; Pro inflammatory cytokines

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 1,6,7,8 TETRAHYDRO NAPHTHO(2,3 D)AZEPINO(4,5 B)INDOLE 9,14 DIONE; ANTIINFLAMMATORY AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STIMULATION; CYTOKINE PRODUCTION; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; IMMUNOMODULATION; IRRADIATION; MACROPHAGE; MICROWAVE RADIATION; MOUSE; NONHUMAN; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN SYNTHESIS INHIBITION; REACTION TIME;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CYTOKINES; DINOPROSTONE; INDOLES; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICROWAVES; NAPHTHOQUINONES; NITRIC OXIDE; TUMOR NECROSIS FACTOR-ALPHA;

MURINAE;

EID: 69949109728     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.154     Document Type: Article

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