Caspase-2: Killer, savior and safeguardemerging versatile roles for an ill-defined caspase

Oncogene

Volumn 28, Issue 35, 2009, Pages 3093-3096

  Krumschnabel, G ^a   Manzl, C ^a   Villunger, A ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Apoptosis; Caspase; DNA repair; Tumor suppression

Indexed keywords

CASPASE 2;

APOPTOSIS; CANCER INHIBITION; DNA REPAIR; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW;

ANIMALS; APOPTOSIS; CASPASE 2; CELL TRANSFORMATION, NEOPLASTIC; DNA REPAIR; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; MICE, NUDE; MICE, TRANSGENIC; MODELS, BIOLOGICAL;

EID: 69849101403     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.173     Document Type: Review

References (24)

1. Arama E, Agapite J, Steller H. (2003). Caspase activity and a specific cytochrome C are required for sperm differentiation in Drosophila. Dev Cell 4: 687-697.
2. Bergeron L, Perez GI, Macdonald G, Shi L, Sun Y, Jurisicova A et al (1998). Defects in regulation of apoptosis in caspase-2-deficient mice. Genes Dev 12: 1304-1314.
3. Braga M, Sinha Hikim AP, Datta S, Ferrini MG, Brown D, Kovacheva EL et al. (2008). Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice. Apoptosis 13: 822-832.
4. De Botton S, Sabri S, Daugas E, Zermati Y, Guidotti JE, Hermine O et al. (2002). Platelet formation is the consequence of caspase activation within megakaryocytes. Blood 100: 1310-1317.
5. Ditzel M, Broemer M, Tenev T, Bolduc C, Lee TV, Rigbolt KT et al. (2008). Inactivation of effector caspases through nondegradative polyubiquitylation. Mol Cell 32: 540-553.
6. Duan H, Dixit VM. (1997). RAIDD is a new 'death' adaptor molecule. Nature 385: 86-89.
7. Gonzalvez F, Schug ZT, Houtkooper RH, MacKenzie ED, Brooks DG, Wanders RJ et al. (2008). Cardiolipin provides an essential activating platform for caspase-8 on mitochondria. J Cell Biol 183: 681-696.
8. Ho LH, Taylor R, Dorstyn L, Cakouros D, Bouillet P, Kumar S. (2009). A tumor suppressor function for caspase-2. Proc Natl Acad Sci USA 106: 5336-5341.
9. Krumschnabel G, Sohm B, Bock F, Manzl C, Villunger A. (2009). The enigma of caspase-2: the laymen's view. Cell Death Differ 16: 195-207.
10. Kumar S, Tomooka Y, Noda M. (1992). Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun 185: 1155-1161.
11. Lamkanfi M, Festjens N, Declercq W, Vanden Berghe T, Vandena-beele P. (2007). Caspases in cell survival, proliferation and differentiation. Cell Death Differ 14: 44-55.
12. Lavrik IN, Golks A, Baumann S, Krammer PH. (2006). Caspase-2 is activated at the CD95 death-inducing signaling complex in the course of CD95-induced apoptosis. Blood 108: 559-565.
13. Li J, Yuan J. (2008). Caspases in apoptosis and beyond. Oncogene 27: 6194-6206.
14. Mancini M, Machamer CE, Roy S, Nicholson DW, Thornberry NA, Casciola-Rosen LA et al. (2000). Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis. J Cell Biol 149: 603-612.
15. Nutt LK, Margolis SS, Jensen M, Herman CE, Dunphy WG, Rathmell JC et al. (2005). Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. Cell 123: 89-103.
16. Olsson M, Vakifahmetoglu H, Abruzzo PM, Hogstrand K, Grandien A, Zhivotovsky B. (2009). DISC-mediated activation of caspase-2 in DNA damage-induced apoptosis. Oncogene 28: 1949-1959.
17. Samraj AK, Sohn D, Schulze-Osthoff K, Schmitz I. (2007). Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membrane depolarization. Mol Biol Cell 18: 84-93.
18. Scott CL, Schuler M, Marsden VS, Egle A, Pellegrini M, Nesic D et al. (2004). Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation. J Cell Biol 164: 89-96.
19. Shi M, Vivian CJ, Lee KJ, Ge C, Morotomi-Yano K, Manzl C et al. (2009). DNA-PKcs-PIDDosome: a nuclear caspase-2-activating complex with role in G2/M checkpoint maintenance. Cell 136: 508-520.
20. Sidi S, Sanda T, Kennedy RD, Hagen AT, Jette CA, Hoffmans R et al. (2008). Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell 133: 864-877.
21. Tinel A, Tschopp J. (2004). The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science 304: 843-846.
22. Yi CH, Yuan J. (2009). The Jekyll and Hyde functions of caspases. Dev Cell 16: 21-34.
23. Zhang Y, Padalecki SS, Chaudhuri AR, De Waal E, Goins BA, Grubbs B et al. (2007). Caspase-2 deficiency enhances aging-related traits in mice. Mech Ageing Dev 128: 213-221.
24. Zhivotovsky B, Orrenius S. (2006). Carcinogenesis and apoptosis: paradigms and paradoxes. Carcinogenesis 27: 939-1945.