Romidepsin inhibits Ras-dependent growth transformation of NIH 3T3 fibroblasts and RIE-1 epithelial cells independently of Ras signaling inhibition

Journal of Molecular Signaling

Volumn 4, Issue , 2009, Pages

  Hanker, Ariella B ^a   Healy, Kevin D ^b   Nichols, Jean ^c   Der, Channing J ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c Gloucester Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 69849099872     PISSN: None     EISSN: 17502187     Source Type: Journal    
DOI: 10.1186/1750-2187-4-5     Document Type: Article

References (45)

1. Ueda H Nakajima H Hori Y Fujita T Nishimura M Goto T Okuhara M FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity J Antibiot (Tokyo) 1994, 47:301-310. 7513682
2. Konstantinopoulos PA Vandoros GP Papavassiliou AG FK228 (depsipeptide): a HDAC inhibitor with pleiotropic antitumor activities Cancer Chemother Pharmacol 2006, 58:711-715. 10.1007/s00280-005-0182-5 16435156
3. Nakajima H Kim YB Terano H Yoshida M Horinouchi S FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor Exp Cell Res 1998, 241:126-133. 10.1006/excr.1998.4027 9633520
4. Glaser KB HDAC inhibitors: Clinical update and mechanism-based potential Biochem Pharmacol 2007, 74:659-671. 10.1016/j.bcp.2007.04.007 17498667
5. Yoo CB Jones PA Epigenetic therapy of cancer: Past, present and future Nat Rev Drug Discov 2006, 5:37-50. 10.1038/nrd1930 16485345
6. Marks P Rifkind RA Richon VM Breslow R Miller T Kelly WK Histone deacetylases and cancer: Causes and therapies Nat Rev Cancer 2001, 1:194-202. 10.1038/35106079 11902574
7. Pan LN Lu J Huang B HDAC inhibitors: A potential new category of anti-tumor agents Cell Mol Immunol 2007, 4:337-343. 17976313
8. Mottet D Castronovo V Histone deacetylases: Target enzymes for cancer therapy Clin Exp Metastasis 2008, 25:183-189. 10.1007/s10585-007-9131-5 18058245
9. ClinicalTrials.gov http://clinicaltrials.gov
10. Choudhary S Wang HC Proapoptotic ability of oncogenic H-Ras to facilitate apoptosis induced by histone deacetylase inhibitors in human cancer cells Mol Cancer Ther 2007, 6:1099-1111. 10.1158/ 1535-7163.MCT-06-0586 17363503
11. Choudhary S Wang HC Pro-apoptotic activity of oncogenic H-Ras for histone deacetylase inhibitor to induce apoptosis of human cancer HT29 cells J Cancer Res Clin Oncol 2007, 133:725-739. 10.1007/ s00432-007-0213-1 17487507
12. Downward J Targeting RAS signalling pathways in cancer therapy Nat Rev Cancer 2003, 3:11-22. 10.1038/nrc969 12509763
13. Cox AD Der CJ Ras family signaling: Therapeutic targeting Cancer Biol Ther 2002, 1:599-606. 12642680
14. Campbell PM Der CJ Oncogenic Ras and its role in tumor cell invasion and metastasis Semin Cancer Biol 2004, 14:105-114. 10.1016/ j.semcancer.2003.09.015 15018894
15. Malumbres M Barbacid M RAS oncogenes: The first 30 years Nat Rev Cancer 2003, 3:459-465. 10.1038/nrc1097 12778136
16. Ueda H Nakajima H Hori Y Goto T Okuhara M Action of FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum no. 968, on Ha-ras transformed NIH3T3 cells Biosci Biotechnol Biochem 1994, 58:1579-1583. 7765477
17. Fecteau KA Mei J Wang HC Differential modulation of signaling pathways and apoptosis of ras-transformed 10T1/2 cells by the depsipeptide FR901228 J Pharmacol Exp Ther 2002, 300:890-899. 10.1124/jpet.300.3.890 11861795
18. Catalogue of Somatic Mutations in Cancer http://www.sanger.ac.uk/ genetics/CGP/cosmic/
19. Haigis KM Kendall KR Wang Y Cheung A Haigis MC Glickman JN Niwa-Kawakita M Sweet-Cordero A Sebolt-Leopold J Shannon KM Settleman J Giovannini M Jacks T Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon Nat Genet 2008, 40:600-608. 10.1038/ng.115 2410301 18372904
20. Repasky GA Chenette EJ Der CJ Renewing the conspiracy theory debate: does Raf function alone to mediate Ras oncogenesis? Trends Cell Biol 2004, 14:639-647. 10.1016/j.tcb.2004.09.014 15519853
21. Yu X Guo ZS Marcu MG Neckers L Nguyen DM Chen GA Schrump DS Modulation of p53, ErbB1, ErbB2, and Raf-1 expression in lung cancer cells by depsipeptide FR901228 J Natl Cancer Inst 2002, 94:504-513. 11929951
22. Yu XD Wang SY Chen GA Hou CM Zhao M Hong JA Nguyen DM Schrump DS Apoptosis induced by depsipeptide FK228 coincides with inhibition of survival signaling in lung cancer cells Cancer J 2007, 13:105-113. 10.1097/PPO.0b013e318046eedc 17476138
23. Kobayashi Y Ohtsuki M Murakami T Kobayashi T Sutheesophon K Kitayama H Kano Y Kusano E Nakagawa H Furukawa Y Histone deacetylase inhibitor FK228 suppresses the Ras-MAP kinase signaling pathway by upregulating Rap1 and induces apoptosis in malignant melanoma Oncogene 2006, 25:512-524. 16186804
24. Song P Wei J Wang HC Distinct roles of the ERK pathway in modulating apoptosis of Ras-transformed and non-transformed cells induced by anticancer agent FR901228 FEBS Lett 2005, 579:90-94. 10.1016/ j.febslet.2004.11.050 15620695
25. Oldham SM Clark GJ Gangarosa LM Coffey RJ Jr Der CJ Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells Proc Natl Acad Sci USA 1996, 93:6924-6928. 10.1073/pnas.93.14.6924 38910 8692920
26. Shields JM Mehta H Pruitt K Der CJ Opposing roles of the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades in Ras-mediated downregulation of tropomyosin Mol Cell Biol 2002, 22:2304-2317. 10.1128/MCB.22.7.2304-2317.2002 133695 11884615
27. Buchanan FG McReynolds M Couvillon A Kam Y Holla VR Dubois RN Exton JH Requirement of phospholipase D1 activity in H-RasV12-induced transformation Proc Natl Acad Sci USA 2005, 102:1638-1642. 10.1073/ pnas.0406698102 547811 15668389
28. Song P Wei J Plummer H 3rd Wang HC Potentiated caspase-3 in Ras-transformed 10T1/2 cells Biochem Biophys Res Commun 2004, 322:557-564. 10.1016/j.bbrc.2004.07.152 15325266
29. Hanker AB Morita S Repasky GA Ross DT Seitz RS Der CJ Tools to study the function of the ras-related, estrogen-regulated growth inhibitor in breast cancer Methods Enzymol 2008, 439:53-72. full_text 18374156
30. Cox AD Der CJ Biological assays for cellular transformation Methods Enzymol 1994, 238:277-294. full_text 7799794
31. Solski PA Abe K Der CJ Analyses of transforming activity of Rho family activators Methods Enzymol 2000, 325:425-441. full_text 11036624
32. Galang CK Garcia-Ramirez J Solski PA Westwick JK Der CJ Neznanov NN Oshima RG Hauser CA Oncogenic Neu/ErbB-2 increases ets, AP-1, and NF-kappaB-dependent gene expression, and inhibiting ets activation blocks Neu-mediated cellular transformation J Biol Chem 1996, 271:7992-7998. 10.1074/jbc.271.14.7992 8626480
33. Pruitt K Pestell RG Der CJ Ras inactivation of the retinoblastoma pathway by distinct mechanisms in NIH 3T3 fibroblast and RIE-1 epithelial cells J Biol Chem 2000, 275:40916-40924. 10.1074/ jbc.M006682200 11007784
34. Ulku AS Schafer R Der CJ Essential role of Raf in Ras transformation and deregulation of matrix metalloproteinase expression in ovarian epithelial cells Mol Cancer Res 2003, 1:1077-1088. 14707291
35. McFall A Ulku A Lambert QT Kusa A Rogers-Graham K Der CJ Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase Mol Cell Biol 2001, 21:5488-5499. 10.1128/ MCB.21.16.5488-5499.2001 87271 11463831
36. Clark GJ Cox AD Graham SM Der CJ Biological assays for Ras transformation Methods Enzymol 1995, 255:395-412. full_text 8524126
37. Shields JM Pruitt K McFall A Shaub A Der CJ Understanding Ras: 'it ain't over 'til it's over' Trends Cell Biol 2000, 10:147-154. 10.1016/ S0962-8924(00)01740-2 10740269
38. Grana TM Sartor CI Cox AD Epidermal growth factor receptor autocrine signaling in RIE-1 cells transformed by the Ras oncogene enhances radiation resistance Cancer Res 2003, 63:7807-7814. 14633707
39. Origanti S Shantz LM Ras transformation of RIE-1 cells activates cap-independent translation of ornithine decarboxylase: Regulation by the Raf/MEK/ERK and phosphatidylinositol 3-kinase pathways Cancer Res 2007, 67:4834-4842. 10.1158/0008-5472.CAN-06-4627 17510413
40. Klampfer L Huang J Shirasawa S Sasazuki T Augenlicht L Histone deacetylase inhibitors induce cell death selectively in cells that harbor activated Krasv12: The role of signal transducers and activators of transcription 1 and p21 Cancer Res 2007, 67:8477-8485. 10.1158/ 0008-5472.CAN-07-0210 17875686
41. Rangarajan A Hong SJ Gifford A Weinberg RA Species- and cell type-specific requirements for cellular transformation Cancer Cell 2004, 6:171-183. 10.1016/j.ccr.2004.07.009 15324700
42. Khosravi-Far R White MA Westwick JK Solski PA Chrzanowska-Wodnicka M Van Aelst L Wigler MH Der CJ Oncogenic Ras activation of Raf/ mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation Mol Cell Biol 1996, 16:3923-3933. 231389 8668210
43. Hanahan D Weinberg RA The hallmarks of cancer Cell 2000, 100:57-70. 10.1016/S0092-8674(00)81683-9 10647931
44. Gazin C Wajapeyee N Gobeil S Virbasius CM Green MR An elaborate pathway required for Ras-mediated epigenetic silencing Nature 2007, 449:1073-1077. 10.1038/nature06251 2147719 17960246
45. Lee YS Lim KH Guo X Kawaguchi Y Gao Y Barrientos T Ordentlich P Wang XF Counter CM Yao TP The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis Cancer Res 2008, 68:7561-7569. 10.1158/ 0008-5472.CAN-08-0188 18794144