FK228 (depsipeptide): A HDAC inhibitor with pleiotropic antitumor activities

Cancer Chemotherapy and Pharmacology

Volumn 58, Issue 5, 2006, Pages 711-715

  Konstantinopoulos, Panagiotis A ^a,b   Vandoros, Gerasimos P ^c   Papavassiliou, Athanasios G ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Aeghion General Hospital   (Greece)

Author keywords

Antitumor activity; Epigenetics; FK228 (depsipeptide); Histone deacetylase inhibitors; Multitargeting

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOTOXIC AGENT; DEPSIPEPTIDE; FR 901228; HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 8; HISTONE DEACETYLASE INHIBITOR; IMMUNOMODULATING AGENT; TETRAPEPTIDE; TRICHOSTATIN A; UNCLASSIFIED DRUG; VORINOSTAT;

ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CANCER INHIBITION; CARCINOGENESIS; CARDIOTOXICITY; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CHEMOTHERAPY INDUCED EMESIS; CLINICAL TRIAL; COLORECTAL CARCINOMA; CUTANEOUS T CELL LYMPHOMA; CYTOTOXICITY; DRUG DOSE REGIMEN; DRUG INDUCED DISEASE; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; EPIGENETICS; FATIGUE; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; IMMUNOMODULATION; LUNG NON SMALL CELL CANCER; NAUSEA; NEUTROPENIA; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; SOLID TUMOR; STATISTICAL SIGNIFICANCE; THROMBOCYTOPENIA; THYROID CARCINOMA; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CELL LINE, TUMOR; DEPSIPEPTIDES; ENZYME INHIBITORS; HISTONE DEACETYLASES; HUMANS; MOLECULAR STRUCTURE; NEOPLASMS;

EID: 33746683091     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-005-0182-5     Document Type: Article

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