Antinociceptive and anti-inflammatory effects of the ethanolic extract of Alpinia conchigera griff. Leaves in various animal models

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 31, Issue 4, 2009, Pages 241-247

  Sulaiman, Mohd Roslan ^a   Zakaria, Z A ^b   Adilius, M ^a   Mohamad, A S ^a   Ismail, M ^a   Israf, D A ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b UNIVERSITI TEKNOLOGI MARA   (Malaysia)

Author keywords

Alpinia conchigera Griff.; Anti inflammatory activity; Antinociceptive activity; Opioid receptor

Indexed keywords

ACETIC ACID; ACETYLSALICYLIC ACID; ALCOHOL; ALPINIA CONCHIGERA EXTRACT; ANTIINFLAMMATORY AGENT; ANTINOCICEPTIVE AGENT; CARRAGEENAN; NALOXONE; PETHIDINE; PLACEBO; PLANT EXTRACT; UNCLASSIFIED DRUG; ANALGESIC AGENT; OPIATE RECEPTOR;

ALPINIA; ALPINIA CONCHIGERA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DERMIS; DOSE RESPONSE; DRUG MECHANISM; DRUG POTENCY; FEMALE; HOT PLATE TEST; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PAIN; PAW EDEMA; PLANT LEAF; RAT; WRITHING TEST; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; DISEASE MODEL; DRUG EFFECT; EDEMA; INFLAMMATION; ISOLATION AND PURIFICATION; METABOLISM; SPRAGUE DAWLEY RAT; TRADITIONAL MEDICINE;

ALPINIA; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; FEMALE; INFLAMMATION; MEDICINE, TRADITIONAL; MICE; MICE, INBRED BALB C; PAIN; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID;

EID: 69849096650     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2009.31.4.1371198     Document Type: Article

References (38)

1. Ibrahim, H., Ong, H.C., Rohani, H. Ethnobotanical survey of the ginger family in selected Malay villages in Peninsular Malaysia. Mal J Sci 2000, 19(1): 93-99
2. Hema, P.S., Nair, M.S. Isolation of anticancer and antioxidant compounds from Alpinia galanga. Med Chem Res 2006, 15(1-6): 150-151
3. Chen, I.N., Chang, C.C., Ng, C.C., Wang, C.Y., Shyu, Y.T., Chang, T.L. Antioxidant and antimicrobial activity of Zingiberaceae plants in Taiwan. Plant Food Hum Nutr 2008, 63(1): 15-20.
4. Thabrew, M.I., Dharmasiri, M.G., Senaratne, L. Anti-inflammatory and analgesic activity in the polyherbal formulation Maharasnadhi Quathar. J Ethnopharmacol 2003, 85(2-3): 261-267
5. Araújo Pinho, F.V.S, Coelho-de-Souza, A.N., Morais, S.M., Ferreira Santos, C., Leal-Cardoso, J.H. Antinociceptive effects of the essential oil of Alpinia zerumbet on mice. Phytomedicine 2005, 12(6-7): 482-486
6. Arambewela, L.S.R., Arawwawala, L.D.A.M., Ratnasooriya, W.D. Antinociceptive activities of aqueous and ethanolic extracts of Alpinia calcarata rhizomes in rats. J Ethnopharmacol 2004, 95(2-3): 311-316
7. Ikhiri, K., Boureima, D., Dan-Kouloudo, D. Chemical screening of medicinal plants used in the traditional pharmacopoeia of Niger. Int J Pharmacognosy 1992, 30(4): 251-262
8. Zimmermann, M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983, 16(2): 109-110
9. Collier, H.O.J., Dinneen, L.C., Johnson, C.A., Schneider, C. The abdominal constriction response and its suppression by analgesic drugs in the mouse. Br J Pharmacol Chemother 1968, 32(2): 295-310.
10. Eddy, N.B., Leimbach, D. Synthetic analgesics, II. Dithienylbutenyl- and dithienylbutenylamines. J Pharmacol Exp Ther 1953, 107(3): 385-393
11. Sulaiman, M.R., Somchit, M.N., Israf, D.A., Ahmad, Z., Moin, S. Antinociceptive effect of Melastoma malabathricum ethanolic extract in mice. Fitoterapia 2004, 75(7-8): 667-672
12. Hunskaar, S., Hole, K. The formalin test in mice: Dissociation between inflammatory and non-inflammatory pain. Pain 1987, 30(1): 103-104
13. Alexandre, M.S., Piuvezam, M.R., Araujo, C.C., Thomas, G. Studies on the anti-inflammatory and analgesic activity of Curatella americana L. J Ethnopharmacol 1999, 67(2): 171-177
14. Winter, C.A., Risley, E.A., Nuss, G.W. Carrageenin-induced edema in hind paw of the rats as an assay for antiinflammatory drugs. Proc Soc Exp Biol Med 1962, 111(3): 544-547
15. Speroni, E., Govoni, P., Guizzardi, S., Renzulli, C., Guerra, M.C. Antiinflammatory and cicatrizing activity of Echinacea pallida Nutt. root extract. J Ethnopharmacol 2002, 79(2): 265-272
16. Choi, J.-H., Jung, B.-H., Kang, O.-H. et al. The anti-inflammatory and antinociceptive effects of ethyl acetate fraction of Cynanchi Paniculati Radix. Biol Pharm Bull 2006, 29(5): 971-975
17. Amanlou, M., Dadkhah, F., Salehnia, A., Farsam, H., Dehpour, A.R. An antiinflammatory and anti-nociceptive effects of hydroalcoholic extract of Satureja khuzistanica Jamzad extract. J Pharm Pharm Sci 2005, 8(1): 102-106
18. Pini, L.A., Vitale, G., Ottani, A., Sandrini, M. Naloxone-reversible antinociception by paracetamol in the rat. J Pharmacol Exp Ther 1997, 280(2): 934-940
19. Hayashi, K., Nagamatsu, T., Ito, M., Hattori, T., Suzuki, Y. Acteoside, a component of Stachys sieboldii MIQ, may be a promising antinephritic agent. Effects of acteoside on crescentic-type anti-GBM nephritis in rats. Jpn J Pharmacol 1994, 65(2): 143-151
20. Deraedt, R., Jouquey, S., Delevallee, F., Flahaut, M. Release of prostaglandins E and F in an algogenic reaction and its inhibition. Eur J Pharmacol 1980, 61(1): 17-24.
21. Gamache, D.A., Povlishock, J.T., Ellis, E.F. Carrageenan-induced brain inflammation. Characterization of the model. J Neurosurg 1986, 65(5): 675-685
22. Berkenkopf, J.W., Weichman, B.M. Production of prostacyclin in mice following intraperitoneal injection of acetic acid, phenylbenzoquinone and zymosan: Its role in the writhing response. Prostaglandins 1988, 36(5): 693-709.
23. Shibata, M., Ohkubo, T., Takahashi, H., Inoki, R. Modified formalin test: Characteristic biphasic pain response. Pain 1989, 38(3): 347-352
24. Rosland, J.H., Tjolsen, A., Maehle, B., Hole, K. The formalin test in mice: Effect of formalin concentration. Pain 1990, 42(2): 235-242
25. Suh, H.W., Song, D.K., Son, K.H. et al. Antinociceptive mechanisms of Dipsacus saponin C administered intracerebroventricularly in the mouse. Gen Pharmacol 1996, 27(7): 1167-1172
26. Santos, A.R., Niero, R., Filho, V.C., Yunes, R.A., Pizzolatti, M.G., Delle Monache, F., Calixto, J.B. Antinociceptive properties of steroids isolated from Phyllanthus corcovadensis in mice. Planta Med 1995, 61(4): 329-332
27. Beirith, A., Santos, A.R.S., Calixto, J.B., Hess, S.C., Messana, I., Ferrari, F., Yunes, R.A. Study of the antinociceptive action of the ethanolic extract and the triterpene 24-hydroxytormentic acid isolated from the stem bark of Ocotea suaveolens. Planta Med 1999, 65(1): 50-55
28. Robak, J., Shridi, F., Wolbis, M., Krolikowska, M. Screening of the influence of flavonoids on lipoxygenase and cyclooxygenase activity, as well as on nonenzymic lipid oxidation. Pol J Pharmacol Pharm 1988, 40(5): 451-458
29. Oblak, M., Randic, M., Solmajer, T. Quantitative structure-activity relationship of flavonoid analogues. 3. Inhibition of p56lck protein tyrosine kinase. J Chem Inform Comput Sci 2000, 40(4): 994-1001.
30. Middleton, E. Jr., Kandaswami, C., Theoharides, T.C. The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer. Pharmacol Rev 2000, 52(4): 673-751.
31. Olszanecki, R., Gêbska, A., Kozlovski, V.I., Gryglewski, R.J. Flavonoids and nitric oxide synthase. J Physiol Pharmacol 2002, 53(4): 571-584
32. Otuki, M.F., Ferreira, J., Lima, F.V. et al. Antinociceptive properties of mixture of α-amyrin and β-amyrin triterpenes: Evidence for participation of protein kinase C and protein kinase A pathways. J Pharmacol Exp Ther 2005, 313(1): 310-318
33. Ferreira, S.H., Duarte, I.D., Lorenzetti, B.B. The molecular mechanism of action of peripheral morphine analgesia: Stimulation of the cGMP system via nitric oxide release. Eur J Pharmacol 1991, 201(1): 121-122
34. Machelska, H., Labuz, D., Przewlocki, R., Przewlocka, B. Inhibition of nitric oxide synthase enhances antinociception mediated by mu, delta and kappa opioid receptors in acute and prolonged pain in the rat spinal cord. J Pharmacol Exp Ther 1997, 282(2): 977-984
35. Kim, H.P., Son, K.H., Chang, H.W., Kang, S.S. Anti-inflammatory plant flavonoids and cellular action mechanisms. J Pharmacol Sci 2004, 96(3): 229-245
36. Meotti, F.C., Luiz, A.P., Pizzolatti, M.G., Kassuya, C.A.L., Calixto, J.B., Santos, A.R.S. Analysis of the antinociceptive effect of the flavonoid myricitrin: Evidence for a role of the L-arginine-nitric oxide and protein kinase C pathways. J Pharmacol Exp Ther 2006, 316(2): 789-796
37. Rajendran, N.N., Thirugnanasambandam, P., Viswanathan, S., Parvathavarthini, S., Ramaswamy, S. Antinociceptive pattern of flavone and its mechanism as tested by formalin assay. Ind J Exp Biol 2000, 38(2): 182-185
38. Nam, N.H. Naturally occurring NF-kappaB inhibitors. Mini Rev Med Chem 2006, 6(8): 945-951