Antinociceptive mechanisms of Dipsacus saponin C administered intracerebroventricularly in the mouse

General Pharmacology

Volumn 27, Issue 7, 1996, Pages 1167-1172

  Shun, Hong Won ^a   Song, Dong Keun ^a   Son, Kun Ho ^b   Wei, Myung Bok ^c   Lee, Keun Ho ^c   Jung, Keun Young ^d   Do, Jae Chul ^d   Kim, Yung Hi ^a  

^a Hallym University   (South Korea)

^b Andong National University   (South Korea)

^c Samchundang Pharm Co Ltd   (South Korea)

^d Yeungnam University   (South Korea)

Author keywords

antinociception; Dipsacus saponin C; GABA; glutamate; opioid

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID B RECEPTOR BLOCKING AGENT; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; AMINO ACID RECEPTOR BLOCKING AGENT; BACLOFEN; CHOLECYSTOKININ OCTAPEPTIDE; DIPSACUS ASPER EXTRACT; DIZOCILPINE; EXCITATORY AMINO ACID RECEPTOR; METHYSERGIDE; MUSCIMOL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NALOXONE; OPIATE ANTAGONIST; OPIATE RECEPTOR; PLANT EXTRACT; SAPONIN C; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR; UNCLASSIFIED DRUG; YOHIMBINE;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CENTRAL NERVOUS SYSTEM; CHINESE HERB; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG MECHANISM; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRATHECAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TAIL FLICK TEST;

ADRENERGIC ALPHA-AGONISTS; ANALGESICS; ANIMALS; CARBOHYDRATE SEQUENCE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GABA AGONISTS; GABA ANTAGONISTS; INJECTIONS, INTRAVENTRICULAR; MALE; MICE; MICE, INBRED ICR; MOLECULAR SEQUENCE DATA; OLEANOLIC ACID; PAIN MEASUREMENT; REACTION TIME; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, CHOLECYSTOKININ; RECEPTORS, N-METHYL-D-ASPARTATE; SAPONINS; SEROTONIN AGONISTS;

EID: 0030272916     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(96)00052-3     Document Type: Article

References (33)

1. D'mour F. E. and Smith D. L. (1941) A method for determining loss of pain sensation. J. Pharmac. Exp. Ther. 72, 74-79.
2. Faris P. L., Komisaruk B. R., Watkins L. R. and Mayer D. J. (1983) Evidence for the neuropeptide cholecystokinin as an antagonist of opiate analgesia. Science 219, 310-312.
3. Haley T. J. and McCormick W. G. (1957) Pharmacological effects produced by intracerebral injections of drugs in the conscious mouse. Br. J. Pharmac. 12, 12-15.
4. Hylden J. L. K. and Wilcox G. L. (1980) Intrathecal morphine in mice: a new technique. Eur. J. Pharmac. 67, 313-316.
5. Itoh S., Katsura G. and Maeda Y. (1982) Caerulein and cholecystokinin suppress β-endorphin-induced analgesia in the rat. Eur. J. Pharmac. 80, 421-425.
6. Jacquet Y. F. (1988) The NMDA receptor: central role in pain inhibition in rat periaqueductal gray. Eur. J. Pharmac. 154, 271-276.
7. Jensen T. S. and Yaksh T. L. (1984) Spinal monoamine and opiate systems partly mediate the antinociceptive effects produced by glutamate at brainstem sites. Brain Res. 321, 287-297.
8. Jones S. L. and Gebhart G. F. (1988) Inhibition of spinal nociceptive transmission from the midbrain, pons and medulla in the rat: activation of descending inhibition by morphine, glutamate and electrical stimulation. Brain Res. 460, 281-296.
9. Jung K. Y., Son K. H. and Do J. C. (1993a) Triterpenoids from the root of Dipsacus asper. Arch. Pharm. Res. 16, 32-35.
10. Jung K. Y., Do J. C. and Son K. H. (1993b) Triterpene glycosides from the roots of Dipsacus asper. J. Nat. Prod. 56, 1912-1916.
11. Kouno I., Tsubol A., Naomi M. and Kawano N. (1990) Acylated triterpene glycoside from roots of Dipsacus asper. Phytochemistry 29, 338-339.
12. Li Y. and Han J. S. (1989) Cholecystokinin octapeptide antagonizes morphine analgesia in periaqueductal gray of the rat. Brain Res. 480, 105-110.
13. Mantegazza P., Tammiso R., Vicentini L., Zambotti F. and Zonta N. (1979) Muscimol antagonism of morphine analgesia in rats. Br. J. Pharmac. 67, 103-107.
14. Namba T. (1986) Coloured Illustrations of Wakan-Yaku (the crude drugs in Japan, China, and neighbouring countries), Vol. 1, pp. 187-188. Hoikusha Publishing, Osaka, Japan.
15. O'Neill M. F., Dourish C. T. and Iversen S. D. (1989) Morphine-induced analgesia in the rat paw pressure test is blocked by CCK and enhanced by the CCK antagonist MK-329. Neuropharmacology 28, 243-247.
16. 5]enkephalin in the mouse. J. Pharmac. Exp. Ther. 241, 393-400.
17. Suh H.H. and Tseng L. F. (1988) Intrathecal β-funaltrexamine antagonizes intracerebroventricular β-endorphin-but not morphine-induced analgesia in mice. J. Pharmac. Exp. Ther. 245, 587-593.
18. Suh H. H., Fujimoto J. M. and Tseng L. F. (1989) Differential mechanisms mediating β-endorphin- and morphine-induced analgesia in mice. Eur. J. Pharmac. 168, 61-70.
19. 5-enkephalin- and U50, 488H-induced analgesia in mice. Neuropharmacology 27, 957-963.
20. Suh H. H. and Tseng L. F. (1990a) Different types of opioid receptors mediating analgesia induced by morphine, DAMGO, DPDPE, DADLE and β-endorphin in mice. Naunyn-Schmiedeberg's Arch. Pharmac. 342, 67-71.
21. Suh H. H. and Tseng L. F. (1990b) Lack ot antinocicpetive cross-tolerance between intracerebroventricularly administered β-endorphin and morphine or DPDPE in mice. Life Sci. 46, 759-761.
22. Suh H. H., Collins K. A. and Tseng L. F. (1992) Intrathecal cholecystokinin octapeptide attenuates the antinociception and release of immunoreactive Met-enkephalin induced by intraventricular β-endorphin in the rat. Nueropeptides 21, 131-137.
23. Suh H. W., Song D. K., Kim Y. H., Yoo J. S. and Tseng L. F. (1994) Differential antagonism by MK-801 against antinociception induced by opioid receptor agonists administeredt supraspinally in mice. Eur. J. Pharmac. 263, 217-221.
24. 5-enkephalin, and U50, 488H administered intracerebroventricularly in mice. Neuropeptides 28, 125-129.
25. Watkins L. R., Kinscheck I. B. and Mayer D. J. (1984) Potentiation of opiate analgesia and apparent reversal of morphine tolerance by proglumide. Science 224, 395-296.
26. Watkins L. R., Kinscheck I. B., Kaufman E. F. S., Miller J., Frenk H. and Mayer D. J. (1985a) Cholecystokinin antagonists selectively potentiate analgesia induced by endogenous opiates. Brain Res. 327, 181-190.
27. Watkins L. R., Kinscheck I. B. and Mayer D. J. (1985b) Potentiation of morphine analgesia by the cholecystokinin antagonist proglumide. Brain Res. 327, 169-180.
28. Wigdor S. and Wilcox G. L. (1987) Central and systemic morphine-induced antinociception in mice: contribution of descending serotonergic and noradrenergic pathways. J. Pharmac. Exp. Ther. 242, 90-95.
29. Yaksh T. L. (1979) Direct evidence that spinal serotonin and noradrenaline terminals mediate the spinal antinociceptive effect of morphine in the periaqueductal gray. Brain Res. 160, 180-185.
30. Zambotti F., Zonta N., Parenti M., Tommasi R., Vincentini L., Conci F. and Mantegazza P. (1982) Periaqueductal gray matter involvment in the muscimol-induced decrease of morphine antinociception. Naunyn-Schmiedeberg's Arch. Pharmac. 316, 368-369.
31. Zhang, Y. W. and Xue Z. (1991a) Studies on the chemical constituents of Dipsacus asper Wall. Acta Pharmaceutica Sinica 26, 676-681.
32. Zhang Y. and Xue Z. (1991b) New triterpenoid glycosides from Dipsacus asper Wall. Acta Pharmaceutica Sinica 26, 911-917.
33. Zonta N., Zambotti F., Vicentini L., Tammiso R. and Mantegazza P. (1981) Effects of some GABA-mimetic drugs on the antinociceptive activity of morphine and β-endorphin in rats. Naunyn-Schmiedeberg's Arch. Pharmac. 316, 231-234.