Anxiolytic-like effects of cyclopeptide fraction alkaloids of Zizyphi Spinosi Semen: Possible involvement of GABAa receptors

Biomolecules and Therapeutics

Volumn 16, Issue 3, 2008, Pages 261-269

  Han, Huishan ^a   Ma, Yuan ^a   Eun, Jae Soon ^b   Hong, Jin Tae ^a   Oh, Ki Wan ^a  

^a Chungbuk National University   (South Korea)

^b Woosuk University   (South Korea)

Author keywords

Anxiolytic like effects; Chloride influx; Cyclopeptide fraction alkaloids; Elevated plus maze; GABAa subunit; Grip strength; Hole board; Locomotor; Open field; Zizyphi Spinosi Semen

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CYCLOPEPTIDE; DIAZEPAM; TRANQUILIZER; UNCLASSIFIED DRUG; ZIZYPHI SPINOSI SEMEN EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY DISORDER; ARTICLE; BRAIN CELL; CEREBELLUM; CHLORIDE TRANSPORT; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; GENE OVEREXPRESSION; GRANULE CELL; GRIP STRENGTH; LOCOMOTION; LOW DRUG DOSE; MALE; MAZE TEST; MEDICINAL PLANT; MOUSE; NONHUMAN; OPEN FIELD BEHAVIOR; PROTEIN EXPRESSION; TRANQUILIZING ACTIVITY; ZIZYPHI SPINOSI SEMEN;

EID: 69749127248     PISSN: 19769148     EISSN: None     Source Type: Journal    
DOI: 10.4062/biomolther.2008.16.3.261     Document Type: Article

References (39)

1. Ahn, N. Y., Jung, J. W., Oh, H. R., Shin, J. S. and Hyeon, S. Y. (2004). Anxiolytic-like effects of Sanjoin-Tang extracts and its ingredients in the elevated plus-maze in mice. J. Appl. Pharmacol. 12, 151-156.
2. Adzu, B., Amos, S., Dzarma, S., Wambebe, C. and Gamaniel, K. (2002). Effect of Zizyphus spina-christi wild aqueous extract on the central nervous system in mice. J. Ethnopharmacol. 79, 13-16 (Pubitemid 34017234)
3. A receptor: an old target with new potential? Sleep Med. 5, 9-15.
4. Brailowsky, S. and Garcia, O. (1999). Ethanol, GABA and epilepsy. Arch. Med. Res. 30, 3-9.
5. Bonnert, T. P., McKernan, R. M., Farrar, S., le Bourdellès, B., Heavens, R. P., Smith, D. W., Hewson, L., Rigby, M. R., Sirinathsinghji, D. J., Brown, N., Wafford, K. A. and Whiting, P. J. (1999). theta, a novel gamma-aminobutyric acid type A receptor subunit. Proc. Natl. Acad. Sci. U S A. 96, 9891-9896. (Pubitemid 29398828)
6. Barnard, E. A., Skolnick, P., Olsen, R.W., Mohler, H., Sieghart, W., Biggio, G., Braestrup, C., Bateson, A. N. and Langer, S. Z. (1998). International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function. Pharmacol. Rev. 50, 291-313. (Pubitemid 28304030)
7. Beck, A. T. (1988). Cognitive approaches to panic: theory and therapy. In Panic: Psychological Perspective (J. D. Mater and S. Rachman Ed.), pp. 91-109. Hillsdale: Lawrence Erlbaum Associates.
8. Chen, S. W., Xin, Q., Kong, W. X., Min, L. and Li, J. F. (2003). Anxiolytic-like effect of succinic acid in mice. Life Sci. 773, 3257-3264. (Pubitemid 37237578)
9. Chung, K. F. and Lee, C. K. (2002). Over-the-counter sleeping pills: a survey of use in Hong Kong and a review of their constituents. Gen. Hosp. Psychiatry. 24, 430-435.
10. Cheng, G., Bai, Y. J., Zhao, Y. Y., Yao, J., Liu, Y., Tu, G. Z., Ma, L. B., Liao, N. and Xu, X. Y. (2000). Flavonoids from Zizyphus jujube Mill var. Spinosa. Tetrahedron. 56, 8915-8920.
11. Duarte, F. S., Duzzioni, M., Mendes, B. G., Pizzolatti, M. G., De Lima, T. C. (2007). Participation of dihydrostyryl-2-pyrones and styryl-2-pyrones in the central effects of Polygala sabulosa (Polygalaceae), a folk medicine topical anesthetic. Pharmacol. Biochem. Behav. 86, 150-161. (Pubitemid 46274980)
12. de Melo, C. T., Monteiro, A. P., Leite, C. P., de Araújo, F. L., Lima, V. T., Barbosa-Filho, J. M., de França Fonteles, M. M., de Vasconcelos, S. M., de Barros Viana, G. S. and de Sousa, F. C. (2006). Anxiolytic-like effects of (O-methyl)-N-2,6-dihydroxybenzoyl-tyramine (riparin III) from Aniba riparia (Nees) Mez (Lauraceae) in mice. Biol. Pharm. Bull. 29, 451-454
13. Eisenberg, D. M., Davis, R. B., Ettner, S. L., Appel, S., Wilkey, S., Van Rompay, M. and Kessler, R. C. (1998). Trends in Alternative Medicine Use in the Unites States, 1990-1997: Results of A Follow-up National Survey. Complement Ther. Med. 7, 1569-1575. (Pubitemid 28520643)
14. Gardner, C. R., Tully, W. R. and Hedgecock, C. J. (1993). The rapidly expanding range of neuronal benzodiazepine receptor ligands. Prog. Neurobiol. 40, 1-61.
15. Han, H. S., Ma, Y., Eun, J. S., Hong, J. T. and Oh, K. W. (2007) Anxiolytic-like Effects of Methanol Extract of Zizyphi Spinosi Semen in Mice. J. Appl. Pharmacol. 15, 175-181.
16. Houston, C. M. and Smart, T. G. (2006). CaMK-II modulation of GABA(A) receptors expressed in HEK293, NG108-15 and rat cerebellar granule neurons. Eur. J. Neurosci. 24, 2504-2514.
17. Hui, K. M., Huen, M. S., Wang, H. Y., Zheng, H., Sigel, E., Baur, R., Ren, H., Li, Z. W., Wong, J. T. and Xue, H. (2002). Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi. Biochem. Pharmacol. 64, 1415-1424. (Pubitemid 35248258)
18. Klodzinska, A., Tatarczyñska, E., Chojnacka-Wójcik, E., Nowak, G., Cosford, N. D. and Pilc, A. (2004) Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling. Neuropharmacol. 47, 342-350. (Pubitemid 38953225)
19. Korpi, E. R., Mihalek, R. M., Sinkkonen, S. T., Hauer, B., Hevers, W., Homanics, G. E., Sieghart, W. and Lüddens, H. (2002). Altered receptor subtypes in the forebrain of GABA(A) receptor delta subunit-deficient mice: recruitment of gamma 2 subunits. Neurosci. 109, 733-743. (Pubitemid 34260857)
20. Kehl, L. J., Trempe, T. M. and Hargreaves, K. M. (2000). A new animal model for assessing mechanisms and management of muscle hyperalgesia. Pain 85, 333-343.
21. Kaupmann, K., Huggel, K., Heid, J., Flor, P. J., Bischoff, S., Mickel, S. J., McMaster, G., Angst, C., Bittiger, H., Froestl, W. and Bettler, B. (1997). Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature. 386, 239-246. (Pubitemid 27142503)
22. Lee, S. S., Lin, B. F. and Liu, K. C. (1996). Three triterpence esters from Zizyphus Jujuba. Phytochem. 43, 847-851.
23. Ma, Y., Han, H. S., Nam, S. Y., Kim, Y. B. Hong, J. T., Yun, Y. P., Oh, K. W. (2008). Cyclopeptide alkaloid fraction from Zizyphi Spinosi Semen enhances pentobarbital-induced sleeping behavoirs. J. Ethanopharmacol., 117, 318-324.
24. Nolan, N. A. and Parkes, M. W. (1973). The effects of benzodiazepines on the behavior of mice on a hole-board. Psychopharmacol. 29, 277-286.
25. Park, J. H., Cha, H. Y., Seo, J. J., Hong, J. T., Han, K. and Oh, K. W. (2005). Anxiolytic-like effects of ginseng in the elevated plus-maze model: comparison of red ginseng and sun ginseng. Prog. Neuropsychopharmacol. Biol. Psychiatry. 29, 895-900. (Pubitemid 41080109)
26. Park, J. H., Lee, H. J., Koh, S. B., Ban, J. Y., Seong, Y. H. (2004). Protection of NMDA-induced neuronal cell damage by methanol extract of Zizyphi Spinosi Semen in cultured rat cerebellar granule cells. J Ethnopharmacol. 95, 39-45. (Pubitemid 39221409)
27. Peng, Z. C. and Zhu, J. J. (2001). Research advances in chemical constituents and pharmacological effects of Semen Zizyphi Spinosae. Lishizhen Med. Medica Res. 12, 86-87.
28. Peng, W. H., Hsieh, M. T., Lee, Y. S., Lin, Y. C., Liao, J. (2000). Anxiolytic effect of seed of Ziziphus jujuba in mouse models of anxiety. J Ethnopharmacol. 72, 435-441.
29. Rex, A., Morgenstern, E. and Fink, H. (2002). Anxiolytic-like effects of kava-kava in the elevated plus maze test - a comparison with diazepam. Prog. Neuropsychopharmacol. Biol. Psychiatry. 26, 855-860. (Pubitemid 35245552)
30. Rouillon, F. (1999). Anxiety with depression: a treatment need. Eur. Neuropsychopharmacol. 3, 87-92.
31. Silva, M. I., de Aquino Neto, M. R., Teixeira Neto, P. F., Moura, B. A., do Amaral, J. F., de Sousa, D. P., Vasconcelos, S. M. and de Sousa, F. C. (2007). Central nervous system activity of acute administration of isopulegol in mice. Pharmacol. Biochem. Behav. 88, 141-147.
32. Takeda, H., Tsuji, M. and Matsumiya, T. (1998). Changes in head-dipping behavior in the hole-board test reflect the anxiogenic and/or anxiolytic state in mice. Eur. J. Pharmacol. 350, 21-29. (Pubitemid 28288304)
33. Une, H. D., Sarveiya, V. P., Pal, S. C., Kasture, V. S. and Kasture, S. B. (2001). Nootropic and anxiolytic activity of saponins of Albizzia lebbeck leaves. Pharmacol. Biochem. Behav. 69, 439-444.
34. Whiting, P. J. (1999). The GABA-A receptor gene family: new targets for therapeutic intervention. Neurochem. Int. 34, 387-390. (Pubitemid 29240635)
35. Weiss, S. M., Wadsworth, G., Fletcher, A. and Dourish, C. T. (1998). Utility of ethological analysis to overcome locomotor confounds in elevated maze models of anxiety. Neurosci. Biobehav. Rev. 23, 265-271. (Pubitemid 29011628)
36. West, M. R. and Molloy, C. R. (1996). A microplate assay measuring chloride ion channel activity. Anal. Biochem. 241, 51-58.
37. Wei, X. Y., Yang, J. Y., Wang, J. H. and Wu, C. F. (2007). Anxiolytic effect of saponins from Panax quinquefolium in mice. J Ethnopharmacol. 111, 613-618. (Pubitemid 46617105)
38. Yu, H. S., Lee, S. Y. and Jang, C. G. (2007). Involvement of 5-HT1A and GABAA receptors in the anxiolytic-like effects of Cinnamomum cassia in mice. Pharmacol. Biochem. Behav. 87, 164-170.
39. Yuzurihara, M., Ikarashi, Y., Ishihara, K., Kushida, H., Ishige, A., Sasaki, H. and Maruyama, Y. (2000). Effects of subacutely administered saiboku-to, an oriental herbal medicine, on pharmacodynamics and pharmacokinetics of diazepam in rodents. Eur J Drug Metab. Pharmacokinet. 25, 127-136. (Pubitemid 30943577)