Anxiolytic effect of saponins from Panax quinquefolium in mice

Journal of Ethnopharmacology

Volumn 111, Issue 3, 2007, Pages 613-618

  Wei, Xiu Yan ^a   Yang, Jing Yu ^a   Wang, Jin Hui ^a   Wu, Chun Fu ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Anxiolytic; Elevated plus maze test; Hole board test; Isolation induced aggressive test; Light dark test; PQS

Indexed keywords

BENZODIAZEPINE; DIAZEPAM; GINSENG EXTRACT;

AGGRESSION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; DRUG MECHANISM; GINSENG; LOCOMOTION; MALE; MAZE TEST; MOUSE; NONHUMAN; TRANQUILIZING ACTIVITY;

AGGRESSION; ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY; BEHAVIOR, ANIMAL; DARKNESS; DIAZEPAM; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; LIGHT; LOCOMOTION; MALE; MAZE LEARNING; MEDICINE, TRADITIONAL; MICE; PANAX; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; PLANTS, MEDICINAL; SAPONINS; SOCIAL ISOLATION; STRESS, PSYCHOLOGICAL;

MUS; PANAX QUINQUEFOLIUS;

EID: 34247266788     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2007.01.009     Document Type: Article

References (35)

1. Abramov U., Raud S., Koks S., Innos J., Kurrikoff K., Matsui T., and Vasar E. Targeted mutation of CCK(2) receptor gene antagonises behavioural changes induced by social isolation in female, but not in male mice. Behavioural Brain Research 155 (2004) 1-11
2. Benishin C.G. Actions of ginsenoside Rb1 on choline uptake in central cholinergic nerve endings. Neurochemistry International 21 (1992) 1-5
3. Benishin C.G., Lee R., Wang L.C.H., and Liu H.J. Effects of ginsenoside Rb1 on central cholinergic metabolism. Pharmacology 42 (1991) 223-229
4. Bensky D., and Gamble A. Chinese Herbal Medicine: Materia Medica (1993), Eastland Press, Seattle
5. Carr M.N., Bekku N., and Yoshimura H. Identification of anxiolytic ingredients in ginseng root using the elevated plus-maze test in mice. European Journal of Pharmacology 531 (2006) 160-165
6. Cha H.Y., Park J.H., Hong J.T., Yoo H.S., Song S., Hwang B.Y., Eun J.S., and Oh K.W. Anxiolytic-like effects of ginsenosides on the elevated plus-maze model in mice. Biological and Pharmaceutical Bulletin 28 (2005) 1621-1625
7. Chen S.W., Xin Q., Kong W.X., Min L., and Li J.F. Anxiolytic-like effect of succinic acid in mice. Life Sciences 73 (2003) 3257-3264
8. Court W.A., Hendel J.G., and Elmi J. Reversed-phase high-performance liquid chromatographic determination of ginsenosides of Panax quinquefolium. Journal of Chromatography A 755 (1996) 11-17
9. Dawson G.R., and Tricklebank M.D. Use of the elevated plus-maze in the search for novel anxiolytic agents. Trends in Pharmacological Sciences 16 (1995) 33-36
10. Fu Y., and Ji L.L. Chronic ginseng consumption attenuates age-associated oxidative stress in rats. Journal of Nutrition 133 (2003) 3603-3609
11. Gao N.N., Yu S.R., and Lu R.M. The facilitative effect of Panax quinquefolium saponin on learning and memory in mice. Pharmacology and Clinics of Chinese Materia Medica 5 (1995) 12-14
12. Guo M., Wu C.F., Liu W., Yang J.Y., and Chen D. Sex difference in psychological behavior changes induced by long-term social isolation in mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry 28 (2004) 115-121
13. Kimura T., Saunders P.A., Kim H.S., Rheu H.M., Oh K.W., and Ho I.K. Interactions of ginsenosides with ligand-bindings of GABAA and GABAB receptors. General Pharmacology 25 (1994) 193-199
14. Kulkarni S.K., and Reddy D.S. Animal behavioral models for testing antianxiety agents. Methods and Findings in Experimental and Clinical Pharmacology 18 (1996) 219-230
15. Lee S.P., Honda K., Rhee Y.H., and Inoue S. Chronic intake of Panax ginseng extract stabilizes sleep and wakefulness in food-deprived rats. Neuroscience Letters 111 (1990) 217-221
16. Lepicard E.M., Joubert C., Hagneau I., Perez-Diaz F., and Chapouthier G. Differences in anxiety-related behavior and response to diazepam in BALB/cByJ and C57BL/6J strains of mice. Pharmacology, Biochemistry and Behavior 67 (2000) 739-748
17. Li J., Lu Z.Z., and Lu Y.F. Lipoprotein-cholesterol metabolism and antioxidative effects of Panax quinquefolium saponins on experimental hyperlipidemic rat. Chung Kuo Yao Hsueh Tsa Chih 28 (1993) 355-357
18. Li Z., Guo Y.Y., Wu C.F., Li X., and Wang J.H. Protective effects of pseudoginsenoside-F11 on scopolamine-induced memory impairment in mice and rats. Journal of Pharmacy and Pharmacology 51 (1999) 435-440
19. Li Z., Wu C.F., Pei G., Guo Y.Y., and Li X. Antagonistic effect of pseudoginsenoside-F11 on the behavioral actions of morphine in mice. Pharmacology, Biochemistry and Behavior 66 (2000) 595-601
20. Lian X.Y., Zhang Z., and Stringer J.L. Anticonvulsant activity of ginseng on seizures induced by chemical convulsants. Epilepsia 46 (2005) 15-22
21. Lu Z.Z., and Sui D.Y. Recent progress on the effect of Panax quinquefolium saponins on the pharmacology of cardiovascular disease. Chinese Pharmacological Bulletin 12 (1996) 395-396
22. Moraira E.G., Nascimento N., and Rogero J.R. Gabaergic-benzodiazepine system is involved in the crotoxin-induced anxiogenic effect. Pharmacology, Biochemistry and Behavior 65 (2000) 7-13
23. Nagai M., Ando S., Tanaka N., Tanaka O., and Shibata S. Chemical studies on the oriental plant drugs. XXVIII. Saponins and sapogenins of ginseng: stereochemistry of the sapogenin of ginsenosides-Rb1, -Rb2 and -Rc. Chemical and Pharmaceutical Bulletin 20 (1972) 1212-1216
24. Persons W.S. American Ginseng: Green Gold (1986), Bright Mountain Books, Asheville
25. Petkov V.D., and Mosharov A.H. Effects of standardized ginseng extract on learning, memory and physical capabilities. American Journal of Chinese Medicine 15 (1987) 19-29
26. Silvestre J.S., Fernandez A.G., and Palacios J.M. Effects of 5-HT4 receptor antagonists on rat behavior in the elevated plus-maze test. European Journal of Pharmacology 309 (1996) 219-222
27. Takeda H., Tsuji M., and Matsumiya T. Changes in head-dipping behavior in the hole-board test reflect the anxiogenic and/or anxiolytic state in mice. European Journal of Pharmacology 350 (1998) 21-29
28. Vasar E., Peuranen E., Oopik T., Harro J., and Mannisto P.T. Ondansetron, an antagonist of 5-HT3 receptor, antagonizes the antiexploratory effect of caerulein, an agonist of CCK receptors, in the elevated plus-maze. Psychopharmacology 110 (1993) 213-218
29. White S.M., Kucharik R.F., and Moyer J.A. Effects of serotonergic agents on isolation-induced aggression. Pharmacology, Biochemistry and Behavior 39 (1991) 729-736
30. Wu C.F., Liu Y.L., Song M., Liu W., Wang J.H., Li X., and Yang J.Y. Protective effects of pseudoginsenoside-F11 on methamphetamine-induced neurotoxicity in mice. Pharmacology, Biochemistry and Behavior 76 (2003) 103-109
31. Yang S., Qu J., Zhong G., and Zhang W. Protective effects of Panax quinquefolium saponin on oxidative damage of cultured rat cardiac cells. Chung Kuo Chung Yao Tsa Chih 17 (1992) 555-557
32. Yoshimura H., Watanabe K., and Ogawa N. Psychotropic effects of ginseng saponins on agonistic behavior between resident and intruder mice. European Journal of Pharmacology 146 (1988) 291-297
33. Yoshimura H., Watanabe K., and Ogawa N. Acute and chronic effects of ginseng saponins on maternal aggression in mice. European Journal of Pharmacology 150 (1988) 319-324
34. Young R., and Johnson D.N. A fully automated light/dark apparatus useful for comparing anxiolytic agents. Pharmacology, Biochemistry and Behavior 40 (1991) 739-743
35. Yuan C.S., Attele A.S., Wu J.A., and Liu D. Modulation of American ginseng on brainstem GABAergic effects in rats. Journal of Ethnopharmacology 62 (1998) 215-222