X11α haploinsufficiency enhances Aβ amyloid deposition in Alzheimer's disease transgenic mice

Neurobiology of Disease

Volumn 36, Issue 1, 2009, Pages 162-168

  Saluja, Inderjeet ^a   Paulson, Henry ^a   Gupta, Ashwin ^a   Turner, R Scott ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

A ; Alzheimer's disease; Amyloid; Amyloid precursor protein; APBA 1; Knockout mice; Mint 1; Transgenic mice; X11

Indexed keywords

ADAPTOR PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; MUNC18 INTERACTING PROTEIN 1; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); APBA1 PROTEIN, RAT; MEMBRANE PROTEIN; PEPTIDE FRAGMENT; PRESENILIN 1; PSEN1 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; HIPPOCAMPUS; KNOCKOUT MOUSE; MOUSE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SENILE PLAQUE; TRANSGENIC MOUSE; ANIMAL; BRAIN; C57BL MOUSE; CLASSIFICATION; DISEASE MODEL; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; METHODOLOGY; MUTATION; PATHOLOGY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; HUMANS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; PEPTIDE FRAGMENTS; PRESENILIN-1;

EID: 69749118887     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2009.07.006     Document Type: Article

References (33)

1. Araki Y., Tomita S., Yamaguchi H., Miyagi N., Sumioka A., Kirino Y., and Suzuki T. Novel cadherin-related membrane proteins, alcadeins, enhance the X11-like protein-mediated stabilization of amyloid β-protein precursor metabolism. J. Biol. Chem. 278 (2003) 49448-49458
2. Biederer T., Cao X., Südhof T.C., and Liu X. Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms. J. Neurosci. 22 (2002) 7340-7351
3. Borg J.P., Straight S.W., Kaech S.M., de Taddéo-Borg M., Kroon D.E., Karnak D., Turner R.S., Kim S.K., and Margolis B. Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting. J. Biol. Chem. 273 (1998) 31633-31636
4. Borg J.P., Yang Y., De Taddéo-Borg M., Margolis B., and Turner R.S. The X11α protein slows cellular amyloid precursor protein processing and reduces Aβ40 and Aβ42 secretion. J. Biol. Chem. 273 (1998) 14761-14766
5. Duyckaerts C., Potier M.-C., and Delatour B. Alzheimer disease models and human neuropathology: similarities and differences. Acta Neuropathol. 115 (2008) 5-38
6. Gross G.G., Feldman R.M.R., Ganguly A., Wang J., Yu H., and Guo M. Role of X11 and ubiquilin as in vivo regulators of the amyloid precursor protein in Drosophila. PLoS ONE 3 6 (2008) e2495 10.1371/journal.pone.0002495
7. Ho A., Morishita W., Atasoy D., Liu X., Tabuchi K., Hammer R.E., Malenka R.C., and Südhof T.C. Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family. J. Neurosci. 26 (2006) 13089-13101
8. Ho A., Liu X., and Südhof T.C. Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease. J. Neurosci. 28 (2008) 14392-14400
9. Hong C.J., and Hsueh Y.P. CASK associates with glutamate receptor interacting protein and signaling molecules. Biochem. Biophys. Res. Commun. 351 (2006) 771-776
10. King G.D., and Turner R.S. Adaptor protein interactions: modulators of amyloid precursor protein metabolism and Alzheimer's disease risk?. Exp. Neurol. 185 (2004) 208-219
11. King G.D., Perez R.G., Steinhilb M.L., Gaut J.R., and Turner R.S. X11α modulates secretory and endocytic trafficking and metabolism of amyloid precursor protein: mutational analysis of the YENPTY sequence. Neuroscience 120 (2003) 143-154
12. King G.D., Cherian K., and Turner R.S. X11α impairs γ- but not β-cleavage of amyloid precursor protein. J. Neurochem. 88 (2004) 971-982
13. Lee J.H., Lau K.F., Perkinton M.S., Standen C.L., Shemilt S.J., Mercken L., Cooper J.D., McLoughlin D.M., and Miller C.C. The neuronal adaptor protein X11α reduces Aβ levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice. J. Biol. Chem. 278 (2003) 47025-47029
14. Lee J.H., Lau K.F., Perkinton M.S., Standen C.L., Rogelj B., Falinska A., McLoughlin D.M., and Miller C.C. The neuronal adaptor protein X11β reduces amyloid β-protein levels and amyloid plaque formation in the brains of transgenic mice. J. Biol. Chem. 279 (2004) 49099-49104
15. Loewer A., Soba P., Beyreuther K., Paro R., and Merdes G. Cell-type-specific processing of the amyloid precursor protein by Presenilin during Drosophila development. EMBO Rep. 5 (2004) 405-411
16. McLoughlin D.M., Irving N.G., Brownlees J., Brion J.P., Leroy K., and Miller C.C. Mint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease. Eur. J. Neurosci. 11 (1999) 1988-1994
17. Miller C.C., McLoughlin D.M., Lau K.F., Tennant M.E., and Rogelj B. The X11 proteins, Aβ production and Alzheimer's disease. Trends Neurosci. 29 (2006) 280-285
18. Mori A., Okuyama K., Horie M., Taniguchi Y., Wadatsu T., Nishino N., Shimada Y., Miyazawa N., Takeda S., Niimi M., Kyushiki H., Kondo M., and Mitsumoto Y. Alteration of methamphetamine-induced striatal dopamine release in mint-1 knockout mice. Neurosci. Res. 43 (2002) 251-257
19. Mueller H.T., Borg J.P., Margolis B., and Turner R.S. Modulation of amyloid precursor protein metabolism by X11α/mint-1. A deletion analysis of protein-protein interaction domains. J. Biol. Chem. 275 50 (2000) 39302-39306
20. Nakajima Y., Okamoto M., Nishimura H., Obata K., Kitano H., Sugita M., and Matsuyama T. Neuronal expression of mint1 and mint2, novel multimodular proteins, in adult murine brain. Brain Res. Mol. Brain Res. 92 (2001) 27-42
21. Okamoto M., and Südhof T.C. Mints, Munc18-interacting proteins in synaptic vesicle exocytosis. J. Biol. Chem. 272 (1997) 31459-31464
22. Okamoto M., Matsuyama T., and Sugita M. Ultrastructural localization of mint1 at synapses in mouse hippocampus. Eur. J. Neurosci. 12 (2000) 3067-3072
23. Parisiadou L., and Efthimiopoulos S. Expression of mDab1 promotes the stability and processing of amyloid precursor protein and this effect is counteracted by X11. Neurobiology of Aging 28 (2007) 377-388
24. Paxinos G., and Franklin K.B.J. The Mouse Brain in Stereotaxic Coordinates (2001), Academic Press, San Diego
25. Rongo C., Whitfield C.W., Rodal A., Kim S.K., and Kaplan J.M. LIN-10 is a shared component of the polarized protein localization pathways in neurons and epithelia. Cell 94 (1998) 751-759
26. Saito Y., Sano Y., Vassar R., Gandy S., Nakaya T., Yamamoto T., and Suzuki T. X11 proteins regulate the translocation of APP into detergent resistant membrane and suppress the amyloidogenic cleavage of APP by BACE in brain. J. Biol. Chem. (2008) 2008 Oct 9. [Electronic publication ahead of print]
27. Sakurai T., Kaneko K., Okuno M., Wada K., Kashiyama T., Shimizu H., Akagi T., Hashikawa T., and Nukina N. Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing. J. Cell. Biol. 183 (2008) 339-352
28. Saluja I., Saunders T.L., and Turner R.S. Modulation of neuronal APP metabolism by X11α/mint-1/APBA1. In: Iqbal K., Winblad B., and Avila J. (Eds). Alzheimer's Disease: New Advances (2007), Medimond, Bologna, Italy 385-392
29. Sano Y., Syuzo-Takabatake A., Nakaya T., Saito Y., Tomita S., Itohara S., and Suzuki T. Enhanced amyloidogenic metabolism of the amyloid β-protein precursor in the X11L-+/- mouse brain. J. Biol. Chem. 281 (2006) 37853-37860
30. Sastre M., Turner R.S., and Levy E. X11 interaction with β-amyloid precursor protein modulates its cellular stabilization and reduces amyloid β-protein secretion. J. Biol. Chem. 273 (1998) 22351-22357
31. Selkoe D.J., and Schenk D. Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics. Annu. Rev. Pharmacol. Toxicol. 43 (2003) 545-584
32. Turner R.S. Alzheimer's disease. Semin. Neurol. 26 (2006) 499-506
33. Xie Z., Romano D.M. and Tanzi R.E. (2005) RNA interference-mediated silencing of X11α and X11β attenuates amyloid β protein levels via differential effects on β-amyloid precursor protein processing.