Simultaneous determination of oxymatrine and its active metabolite matrine in dog plasma by liquid chromatography-mass spectrometry and its application to pharmacokinetic studies

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 817, Issue 2, 2005, Pages 319-325

  Wang, Sujun ^a   Wang, Guangji ^a   Li, Xiaotian ^a   Sun, Jianguo ^a   Ma, Renling ^a   Sheng, Longsheng ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Dog plasma; Liquid chromatography mass spectrometry; Matrine; Metabolite; Oxymatrine; Pharmacokinetics

Indexed keywords

DATA ACQUISITION; IONIZATION; LIQUID CHROMATOGRAPHY; METABOLITES; PHARMACOKINETICS;

DOG PLASMA; LIQUID-LIQUID EXTRACTION PROCEDURE; METABOLITE MATRINE (MT); OXYMATRINE (OMT);

BIOLOGICAL MEMBRANES;

MATRINE; OXYMATRINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; DOG; DRUG BLOOD LEVEL; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

ALKALOIDS; ANIMALS; ANTIVIRAL AGENTS; CALIBRATION; DOGS; FEMALE; MALE; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 15944391332     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2005.01.003     Document Type: Article

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