Phytochemical licochalcone A enhances antimalarial activity of artemisinin in vitro

Acta Tropica

Volumn 109, Issue 3, 2009, Pages 194-198

  Mishra, Lokesh C ^a   Bhattacharya, Amit ^a   Bhasin, Virendra K ^a  

^a UNIVERSITY OF DELHI   (India)

Author keywords

Antimalarial; Artemisinin; In vitro; Licochalcone A; Plasmodium falciparum; Synergy

Indexed keywords

ARTEMISININ; CHLOROQUINE; LICOCHALCONE A;

DISEASE CONTROL; DRUG RESISTANCE; MALARIA; MORTALITY; PHYTOCHEMISTRY; PLANT EXTRACT; PROTOZOAN;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; IN VITRO STUDY; MALARIA; MORTALITY; NONHUMAN; PHYTOCHEMISTRY; PLASMODIUM FALCIPARUM; SCREENING;

ANIMALS; ANTIMALARIALS; ARTEMISININS; CHALCONES; DRUG SYNERGISM; HEMEPROTEINS; HUMANS; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM;

PLASMODIUM FALCIPARUM;

EID: 59049101538     PISSN: 0001706X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actatropica.2008.11.006     Document Type: Article

References (39)

1. Agrawal L., Xihua L., Qingwen J., and Ghalib A. Anti-HIV therapy: current and future directions. Curr. Pharm. Des. 12 (2006) 2031-2055
2. Akompong T., Ghori N., and Haldar K. In vitro activity of riboflavin against the human malaria parasite Plasmodium falciparum. Antimicrob. Agents Chemother. 44 (2000) 88-96
3. Berenbaum M.C. A method for testing synergy with any number of agents. J. Infect. Dis. 137 (1978) 122-130
4. Bhasin V.K., and Nair L. ACT now - with caution - for malaria treatments. Lancet Infect. Dis. 3 (2003) 609
5. Bhattacharya A., Mishra L.C., and Bhasin V.K. In vitro activity of artemisinin in combination with clotrimazole or heat-treated amphotericin B against Plasmodium falciparum. Am. J. Trop. Med. Hyg. 78 (2008) 721-728
6. Blomberg B., and Fourie B. Fixed-dose combination drugs for tuberculosis: application in standardised treatment regimens. Drugs 63 (2003) 535-553
7. Canfield C.J., Pudney M., and Gutteridge W.E. Interaction of atovaquone with other antimalarial drugs against Plasmodium falciparum in vitro. Exp. Parasitol. 80 (1995) 373-381
8. Chen M., Christensen S.B., Blom J., Lemmich E., Nadelmann L., Fich K., Theander T.G., and Kharazmi A. Licochalcone A, a novel antiparasitic agent with potent activity against human pathogenic protozoan species of Leishmania. Antimicrob. Agents Chemother. 37 (1993) 2550-2556
9. Chen M., Theander T.G., Christensen S.B., Hviid L., Zhai L., and Kharazmi A. Licochalcone A, a new antimalarial agent, inhibits in vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. yoelii infection. Antimicrob. Agents Chemother. 38 (1994) 1470-1475
10. Colin O., Willingmyre G.D., Lee P., Knirsch C., and Milhous W. Assessment of azithromycin in combination with other antimalarial drugs against Plasmodium falciparum in vitro. Antimicrob. Agents Chemother. 46 (2002) 2518-2524
11. Egan T.J., Hempelmann E., and Mavuso W.W. Characterization of synthetic β-haematin and effects of the antimalarial drugs quinidine, halofantrine, desbutylhalofantrine and mefloquine on its formation. J. Inorg. Biochem. 73 (1999) 101-107
12. Ezzet F., van Vugt M., Nosten F., Looareesuwan S., and White N.J. Pharmacokinetics and pharmacodynamics of lumefantrine (benflumetol) in acute falciparum malaria. Antimicrob. Agents Chemother. 44 (2000) 697-704
13. Fivelman Q.L., Adagu I.S., and Warhurst D.C. Modified fixed ratio isobologram method for studying in vitro interactions between atovaquone and proguanil or dihydroartemisinin against drug resistant strains of Plasmodium falciparum. Antimicrob. Agents Chemother. 48 (2004) 4097-4102
14. Gafner S., Wolfender J.L., Mavi S., and Hostettmann K. Antifungal and antibacterial chalcones from Myrica serrata. Planta Med. 62 (1996) 67-69
15. Go M.L., Liu M., Wilairat P., Rosenthal P.J., Saliba K.J., and Kirk K. Antiplasmodial chalcones inhibit sorbitol-induced hemolysis of Plasmodium falciparum-infected erythrocytes. Antimicrob. Agents Chemother. 48 (2004) 3241-3245
16. Gupta S., Thapar M.M., Wernsdorfer W.H., and Bjorkman A. In vitro interactions of artemisinin with atovaquone, quinine, and mefloquine against Plasmodium falciparum. Antimicrob. Agents Chemother. 46 (2002) 1510-1515
17. Kindermans J.M., Vandenbergh D., Vreeke E., Olliaro P., and D'Altilia J.P. Estimating antimalarial drugs consumption in Africa before the switch to artemisinin-based combination therapies (ACTs). Malar. J. 6 (2007) 91 10.1186/1475-2875-6-91
18. Lambros C., and Vanderberg J.P. Synchronization of Plasmodium falciparum erythrocytic stages in culture. J. Parasitol. 65 (1979) 418-420
19. Liu M., Wilairat P., Croft S.L., Tan A.L., and Go M.L. Structure-activity relationships of antileishmanial and antimalarial chalcones. Bioorg. Med. Chem. 11 (2003) 2729-2738
20. Ludwig U.E., Webb R.J., van Goethem I.D.A., East J.M., Lee A.G., Kimura M., O'Neill P.M., Bray P.G., Ward S.A., and Krishna S. Artemisinins target the SERCA of Plasmodium falciparum. Nature 424 (2003) 957-961
21. McGready R., Stepniewska K., Lindegardh N., Ashley E.A., La Y., Singhasivanon P., White N.J., and Nosten F. The pharmacokinetics of artemether and lumefantrine in pregnant women with uncomplicated falciparum malaria. Eur. J. Clin. Pharmacol. 62 (2006) 1021-1031
22. Mi-Ichi F., Miyadera H., Kobayashi T., Takamiya S., Waki S., Iwata S., Shibata S., and Kita K. Parasite mitochondria as a target of chemotherapy: inhibitory effect of licochalcone A on the Plasmodium falciparum respiratory chain. Ann. N. Y. Acad. Sci. 1056 (2005) 46-54
23. Mishra L.C., Bhattacharya A., and Bhasin V.K. Antiplasmodial interaction between artemisinin and triclosan or ketoconazole combinations against blood stages of Plasmodium falciparum in vitro. Am. J. Trop. Med. Hyg. 76 (2007) 497-501
24. Mutabingwa T.K. Artemisinin-based combination therapies (ACTs): best hope for malaria treatment but inaccessible to the needy!. Acta Trop. 95 (2005) 305-315
25. Nandakumar D.N., Nagaraj V.A., Vathsala P.G., Rangarajan P., and Padmanaban G. Curcumin-artemisinin combination therapy for malaria. Antimicrob. Agents Chemother. 50 (2006) 1859-1860
26. Nduati E.W., and Kamau E.M. Multiple synergistic interactions between atovaquone and antifolates against Plasmodium falciparum in vitro: a rational basis for combination therapy. Acta Trop. 97 (2006) 357-363
27. Odds F.C. Synergy, antagonism, and what the chequerboard puts between them. J. Antimicrob. Chemother. 52 (2003) 1
28. Pandey A.V., Tekwani B.L., Singh R.L., and Chauhan V.S. Artemisinin, an endoperoxide antimalarial, disrupts the hemoglobin catabolism and heme detoxification systems in malarial parasite. J. Biol. Chem. 274 (1999) 19383-19388
29. Renan R. Identification of Traditional Chinese Material Medica (1986), Shanghai Scientific and Technical Publishing House, Shanghai, People's Republic of China pp. 109-113
30. Sannella A.R., Messori L., Casini A., Vincieri F.F., Bilia A.R., Majori G., and Severini C. Antimalarial properties of green tea. Biochem. Biophys. Res. Commun. 353 (2007) 177-181
31. Schmid G., and Hofheinz W. Total synthesis of Qinghaosu. J. Am. Chem. Soc. 105 (1983) 624-625
32. Trager W., and Jensen J.B. Human malaria parasites in continuous culture. Science 193 (1976) 673-675
33. Tsukiyama R.I., Katsura H., Tokuriki N., and Kobayashi M. Antibacterial activity of licochalcone A against spore-forming bacteria. Antimicrob. Agents Chemother. 46 (2002) 1226-1230
34. Vathsala P.G., Pramanik A., Dhanasekaran S., Devi U.C., Pillai C.R., Subbarao S.K., Ghosh S.K., Tiwari S.N., Sathyanarayan T.S., Deshpande P.R., Mishra G.C., Ranjit M.R., Dash A.P., Rangarajan P.N., and Padmanaban G. Widespread occurrence of the Plasmodium falciparum chloroquine resistance transporter (Pfcrt) gene haplotype SVMNT in P. falciparum malaria in India. Am. J. Trop. Med. Hyg. 70 (2004) 256-259
35. Vennerstrom J.L., Arbe-Barnes S., Brun R., Charman S.A., Chiu F.C.K., Chollet J., Dong Y., Dorn A., Hunziker D., Matile H., McIntosh K., Padmanilayam M., Tomas J.S., Scheurer C., Scorneaux B., Tang Y., Urwyler H., Wittlin S., and Charman W.N. Identification of an antimalarial synthetic trioxolane drug development candidate. Nature 430 (2004) 900-904
36. Waterhouse D.N., Gelmon K.A., Klasa R., Chi K., Huntsman D., Ramsay E., Wasan E., Edwards L., Tucker C., Zastre J., Wang Y.Z., Yapp D., Dragowska W., Dunn S., Dedhar S., and Bally M.B. Development and assessment of conventional and targeted drug combinations for use in the treatment of aggressive breast cancers. Curr. Cancer Drug Targets 6 (2006) 455-489
37. White N.J. Qinghaosu (artemisinin): the price of success. Science 320 (2008) 330-334
38. World Health Organisation, 2001. Antimalarial drug combination therapy. Report of WHO technical consultation (WHO/CDS/RBM/2001.35). WHO, Geneva.
39. Ziegler H.L., Hansen H.S., Staerk D., Christensen S.B., Hägerstrand H., and Jaroszewski J.W. The antiparasitic compound licochalcone A is a potent echinocytogenic agent that modifies the erythrocyte membrane in the concentration range where antiplasmodial activity is observed. Antimicrob. Agents Chemother. 48 (2004) 4067-4071