Antimalarial activity of methanolic extracts from plants used in Kenyan ethnomedicine and their interactions with chloroquine (CQ) against a CQ-tolerant rodent parasite, in mice

Journal of Ethnopharmacology

Volumn 111, Issue 1, 2007, Pages 190-195

  Muregi, Francis W ^a,c   Ishih, Akira ^a   Miyase, Toshio ^b   Suzuki, Tohru ^a   Kino, Hideto ^a   Amano, Teruaki ^c   Mkoji, Gerald M ^c   Terada, Mamoru ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF SHIZUOKA   (Japan)

^c KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

Author keywords

Antimalarial activity; Drug resistance; Medicinal plants; Plasmodium berghei NK65; Synergistic effects; Traditional medicine

Indexed keywords

AJUGA REMOTA EXTRACT; ALBIZIA GUMMIFERA EXTRACT; AZADIRACHTA INDICA EXTRACT; CAESALPINIA VOLKENSII EXTRACT; CHLOROQUINE; CLERODENDRUM MYRICOIDES EXTRACT; EKEBERGIA CAPENSIS EXTRACT; FICUS SUR EXTRACT; MAYTENUS ACUMINATA EXTRACT; MAYTENUS HETEROPHYLLA EXTRACT; MAYTENUS SENEGALENSIS EXTRACT; METHANOL; PLANT EXTRACT; RHAMNUS PRINOIDES EXTRACT; RHAMNUS STADDO EXTRACT; TODDALIA ASIATICA EXTRACT; UNCLASSIFIED DRUG; VERNONIA LASIOPUS EXTRACT; WATER; WITHANIA SOMNIFERA EXTRACT;

AJUGA; AJUGA REMOTA; ALBIZIA GUMMIFERA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIMALARIAL ACTIVITY; ARTICLE; AZADIRACHTA INDICA; BARK; CAESALPINIA; CAESALPINIA VOLKENSII; CLERODENDRUM; CLERODENDRUM MYRICOIDES; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENTIATION; DRUG SCREENING; EKEBERGIA CAPENSIS; ETHNOPHARMACOLOGY; FICUS; FICUS SUR; IN VIVO STUDY; KENYA; MALARIA; MALE; MAYTENUS; MAYTENUS ACUMINATA; MAYTENUS HETEROPHYLLA; MAYTENUS SENEGALENSIS; MEDICINAL PLANT; MONOTHERAPY; MOUSE; NONHUMAN; PLANT LEAF; PLANT ROOT; PLANT SEED; PLANT STEM; PLASMODIUM BERGHEI; RHAMNUS; RHAMNUS PRINOIDES; RHAMNUS STADDO; TODDALIA ASIATICA; TRADITIONAL MEDICINE; TREATMENT DURATION; VERNONIA; VERNONIA LASIOPUS; WITHANIA SOMNIFERA;

ANIMALS; ANTIMALARIALS; CHLOROQUINE; DRUG RESISTANCE; DRUG SYNERGISM; KENYA; MALARIA; MEDICINE, TRADITIONAL; METHANOL; MICE; PARASITEMIA; PARASITIC SENSITIVITY TESTS; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; PLASMODIUM BERGHEI; SOLVENTS; TIME FACTORS;

ALBIZIA GUMMIFERA; CAESALPINIA; EKEBERGIA CAPENSIS; FICUS SUR; MAYTENUS; MAYTENUS SENEGALENSIS; MUS; PLASMODIUM BERGHEI; RHAMNUS PRINOIDES; RHAMNUS STADDO; RODENTIA; ROTHECA MYRICOIDES; TODDALIA ASIATICA; VERNONIA LASIOPUS; WITHANIA SOMNIFERA;

EID: 33947608177     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2006.11.009     Document Type: Article

References (28)

1. Abegaz B.M., Ngadjui B.T., Bezabih M., and Mdee L.K. Novel natural products from marketed plants of eastern and southern Africa. Pure and Applied Chemistry 71 (1999) 919-926
2. Ajaiyeoba E.O., Abiodun O.O., Falade M.O., Ogbole N.O., Ashidi J.S., Happi C.T., and Akinboye D.O. In vitro cytotoxicity studies of 20 plants used in Nigerian antimalarial ethnomedicine. Phytomedicine 13 (2006) 295-298
3. Basco L.K., Mitaku S., Skaltsounis A.L., Ravelomanaintsoa N., Tillequin F., Koch M., and Le Bras J. In vitro activities of acridone alkaloids against Plasmodium falciparum. Antimicrobial Agents and Chemotherapy 5 (1994) 1169-1171
4. Beentje H. Kenya Trees, Shrubs and Lianas (1994), National Museums of Kenya, Nairobi (Kenya) pp. 564-570
5. Dahanukar S.A., Kulkarni F.A., and Rege N.N. Pharmacology of medicinal plants and natural products. Indian Journal of Pharmacology 32 (2000) 81-118
6. Gakunju D.M.N., Mberu E.K., Dossaji S.F., Gray A.I., Waigh R.D., Waterman P.G., and Watkins W.M. Potent antimalarial activity from a Kenyan herbal remedy. Antimicrobial Agents and Chemotherapy 39 (1995) 2606-2609
7. Gessler M.C., Tanner M., Chollet J., Nkunya M.H.H., and Heinrick M. Tanzanian Medicinal plants used traditionally for the treatment of malaria: In vivo antimalarial and in vitro cytotoxic activities. Phytotherapy Research 9 (1995) 504-508
8. Ishih A., Miyase T., and Terada M. Comparison of antimalarial activity of the alkaloidal fraction of Hydrangea macrophylla var. Otaksa leaves with the hot-water extract in ICR mice infected with Plasmodium yoelii 17 XL. Phytotherapy Research 17 (2003) 633-639
9. ® or minocycline hydrochloride against blood-induced choloquine-resistant Plasmodium berghei NK65 infections. Tropical Medicine and Health 32 (2004) 15-19
10. Izhaki I. Emodin-a secondary metabolite with multiple ecological functions in higher plants. New Phytologist 155 (2002) 205-217
11. Kokwaro J.O. Medicinal Plants of East Africa (1976), East African Literature Bureau, Nairobi (Kenya) pp. 10-368
12. Muregi F.W., Chhabra S.C., Njagi E.N.M., Lang'at-Thoruwa C.C., Njue W.M., Orago A.S.S., Omar S.A., and Ndiege I.O. In vitro antiplasmodial activity of some plants used in Kisii, Kenya against malaria and their chloroquine potentiation effects. Journal of Ethnopharmacology 84 (2003) 235-239
13. Muregi F.W., Chhabra S.C., Njagi E.N.M., Lang'at-Thoruwa C.C., Njue W.M., Orago A.S.S., Omar S.A., and Ndiege I.O. Antiplasmodial activity of some Kenyan medicinal plants extracts singly and in combination with chloroquine. Phytotherapy Research 18 (2004) 379-384
14. Oduola A.M., Sowumi A., Milhow W.K., Brewer T.G., Kyle D.E., Gerena L., Salako L.K., and Schuster B.G. The effect of combining promathazine with chloroquine against Plasmodium falciparum in vitro. American Journal of Tropical Medicine and Hygiene 58 (1998) 625-629
15. Oketch-Rabah, H.A., 1996. Antimalarial and antileishmarial compounds from Kenyan medicinal plants. PhD thesis. Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Denmark, pp. 80-82.
16. Oketch-Rabah H.A., Lemmich E., Dossaji S.F., Theander T.G., Olsen C.E., Cornett C., Kharazmi A., and Christensen S.B. Two new antiprotozoal 5-methylcoumarins from Vernonia brachycalyx. Journal of Natural Products 60 (1997) 458-461
17. Oketch-Rabah H.A., Mwangi J.W., Lisgarten J., and Mberu E.K. A new antiplasmodial coumarin from Toddalia asiatica roots. Fitoterapia 71 (2000) 636-640
18. Peters W., Portus J.H., and Robinson B.L. The four-day suppressive in vivo antimalarial test. Annals of Tropical Medicine and Parasitology 69 (1975) 155-171
19. Phillipson J.D., and Wright C.W. Antiprotozoal agents from plant sources. Planta Medica 57 (1991) 53-59
20. Sosa S., Morelli C.F., Tubaro A., Cairoli P., Speranza G., and Manitto P. Anti-inflammatory activity of Maytenus senegalensis root extracts and of maytenoic acid. Phytomedicine 14 (2007) 109-114
21. Trigg P.I. In: Wagner H., Hikino H., and Farnsworth N.R. (Eds). Economic and Medicinal Plant Research vol. 3 (1989), Academic Press, London 19-55
22. Van Agtmael M.A., Eggelte T.A., and van Boxtel C.J. Artemisinin drugs in the treatment of malaria: from medicinal herb to registered medication. Trends in Pharmacological Sciences 20 (1999) 1-5
23. Waigh R. Medicinal chemistry at the University of Strathclyde. The Newsletter for the Society for Medicines Research (SMR) 8 (2002) 6-7
24. Weenen H., Nkunya M.H.H., Bray D.H., Mwasumbi L.B., Kinabo S., and Kilimani V.A. Antimalarial activity of Tanzanian medicinal plants. Planta Medica 56 (1990) 368-370
25. WHO (World Health Organization). Severe falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 94 (2000) 36-37
26. WHO (World Health Organization) Centre for Health Development, 2002. Traditional medicine: planning for cost-effective traditional health services in the new century-a discussion paper. Available at: http:/www.who.or.jp/tm/research/.
27. Winstanley P.A. Chemotherapy for falciparum malaria: the armoury, the problems and the prospects. Parasitology Today 16 (2000) 146-153
28. Zirihi G.N., Mambu L., Guede-Guina F., Bodo B., and Grellier P. In vitro antiplasmodial activity and cytotoxicity of 33 West African plants used for treatment of malaria. Journal of Ethnopharmacology 98 (2005) 281-285