Antiprotozoal and cytotoxic screening of 45 plant extracts from Democratic Republic of Congo

Journal of Ethnopharmacology

Volumn 115, Issue 3, 2007, Pages 409-415

  Mesia, G K ^a,b   Tona, G L ^a   Nanga, T H ^a   Cimanga, R K ^a,b   Apers, S ^b   Cos, P ^b   Maes, L ^b   Pieters, L ^b   Vlietinck, A J ^b  

^a UNIVERSITY OF KINSHASA   (Congo)

^b UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Antiprotozoal activity; Cytotoxicity; DRCongo; Medicinal plants

Indexed keywords

ALCHORNEA CORDIFOLIA EXTRACT; ALCHORNEA FLORIBUNDA EXTRACT; ALSTONIA BOONEI EXTRACT; ALSTONIA CONGENSIS EXTRACT; ANTIPROTOZOAL AGENT; CANTHIUM ODDONII EXTRACT; CASSIA FLORIBUNDA EXTRACT; CASSIA HIRSUTA EXTRACT; CISSIUS AURANTHUS EXTRACT; CROSSOPTERYX FEBRIFUGUM EXTRACT; CYMBOPOGON CITRATUS EXTRACT; CYMBOPOGON DENSIFLORUS EXTRACT; DICHOSTEMMA GLAUCESCENS EXTRACT; DRYPETES GOSSWEILERI EXTRACT; ERAMOSPATHA HAULLEVILEANA EXTRACT; GARCINIA KOLA EXTRACT; GGUILBOURTIA DEMENSII EXTRACT; HYMENOCALLIS SENEGAMBICA EXTRACT; LAGERA ALATA EXTRACT; LANDOLPHIA OVARIENSIS EXTRACT; LANTANA CAMARA EXTRACT; LUFFA CYLINDRICA EXTRACT; MAMMEA AFRICANUM EXTRACT; MOMORDICA CHARANTIA EXTRACT; OMPHALOCARPUM GLOMERATA EXTRACT; PIPTADENIA AFRICANUM EXTRACT; POLYATHIA SWAVELEONS EXTRACT; SAPIUM CORNUTUM EXTRACT; TRICLISIA GILETTI EXTRACT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONGO; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG RESEARCH; DRUG SCREENING; FETAL CALF SERUM; FLUORESCENCE; HERBAL MEDICINE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; NONHUMAN; PLASMODIUM FALCIPARUM; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

ALCHORNEA CORDIFOLIA; MOMORDICA CHARANTIA; OMPHALOCARPUM; PIPTADENIA; PLASMODIUM FALCIPARUM; PROTOZOA; SAPIUM; TRICLISIA; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA CRUZI;

EID: 37449013363     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2007.10.028     Document Type: Article

References (40)

1. Amorin C.Z., marques A.D., and Cordeiro R.S. Screening of the antimalarial activity of plants of the Cucurbitaceae family. Memory of Institute Oswaldo Cruz 86 (1991) 177-180
2. Atindehou K.K., Koné M., Terreaux C., Traore D., Hostettmann K., and Dosso M. Evaluation of the antimicrobial potential of medicinal plants from the Ivory Coast. Phytotherapy Research 16 (2002) 497-502
3. Atindehou K.K., Schimid C., Brun R., Koné M.W., and Traoré D. Antitrypanosomal and antiplasmodial activity of medicinal plants from Côte d'Ivoire. Journal of Ethnopharmacology 93 (2004) 43-49
4. Banzouzi J.T., Prado R., Mena H., Valentin A., Roumestan C., Mallie M., Pelissier Y., and Blache Y. In vitro antiplasmodial activity of Alchornea cordifolia and identification of an active constituent: ellagic acid. Journal of Ethnopharmacology 81 (2002) 399-401
5. Barrett M.P., Burchmore R.J.S., Stich A., Lazzari J.O., Frasch A.C., Cazzulo J.J., and Krishna S. The trypanosomiases. The Lancet 362 (2003) 1469-1480
6. Begun S., Ahmed M., Siddiqui B.S., Khan A., Saipfy Z.S., and Arif M. Triterpenes, a sterol and a monocyclic alcohol from Momordica charantia. Phytochemistry 44 (1997) 1313-1320
7. Camacho M.d.R., Phillipson J.D., Simons L., Croft S.L., Rock P., Marshall S.J., and Schiff Jr. P.L. In vitro activity of Triclisia patens and some bisbenzylisoquinoline alkaloids against Leishmania donovani and Trypanosoma brucei brucei. Phytotherapy Research 16 (2002) 432-436
8. Camacho M.d.R., Phillipson J.D., Croft S.L., Solis P.N., Marshall S.J., and Ghazanfar S.A. Screening of plant extracts for antiprotozoal and cytotoxic activities. Journal of Ethnopharmacology 89 (2003) 185-195
9. Chang C.I., Chen C.R., Liao Y.W., Cheng H.L., Chen Y.C., and Chou C.H. Cucurbitane-type triterpenoids from Momordica charantia. Journal of Natural Products 69 (2006) 1167-1171
10. Fournet A., Barrios A.A., and Muňoz V. Leishmanicidal and trypanocidal activities of Bolivian medicinal plants. Journal of Ethnopharmacology 41 (1994) 19-47
11. Freiburghaus F., Kaminsky R., Nkunya M.H.H., and Brun R. Evaluation of African medicinal plants for their in vitro trypanocidal activity. Journal of Ethnopharmacology 55 (1996) 1-11
12. Gracia A., Courtin D., Solano P., Koffi M., and Jamonneau V. Human African trypanosomiasis: connecting parasite and host genetics. Trends in Parasitology 22 (2006) 405-409
13. Hoet S., Opperdoes F., Brun R., Adjakidjé V., and Quetin-Leclercq J. In vitro antitrypanosomal activity of ethnopharmacologically selected Beninese plants. Journal of Ethnopharmacology 91 (2004) 37-42
14. Kambu, K., 1990. Eléménts de Phytothérapie Comparés. Plantes Médicinales Africaines. CRP-Kinshasa.
15. Kimura Y., Akihisa T., Yuasa N., Ukiya M., Suzuki T., Toriyama M., Motohashi S., and Tokuda H. Cucurbitane-type triterpenoids from the fruit of Momordica charantia. Journal of Natural Products 68 (2005) 807-809
16. Kuypers K., Cos P., Ortega-Barria E., Vanden Berghe D., and Maes L. Bioassays for some parasitic protozoa: screening concepts and standard in vitro and in vivo laboratory model. In: Gupta M.P., Handa S.S., and Vanish K. (Eds). Biological Screening of Plant Constituents (2006), International Centre for Science and High Technology, Trieste 7-18
17. Mabika, K., 1983. Plantes Médicinales et médecine Traditionnelle du Kasaï-Occidental. Thèse de doctorat en Sciences. Univesité de Kisangani, Zaïre.
18. Makler M.T., Ries J.M., Williams J.A., Bancroft J.E., Piper R.C., Gibbins B.L., and Hinrichs D.J. Parasite lactate deshydrogenase as an assay for Plasmodium falciparum drug sensitivity. American Journal of Tropical Medicine and Hygiene 48 (1993) 739-741
19. Marshall S.J., Russell P.F., Wright C.V., Anderson M.M., Phillipson J.D., Kirby G.C., Warhurst D.C., and Schiff P.L. In vitro antiplasmodial, antiamoebic, and cytotoxic activities of a series of benzylisoquinoline alkaloids. Antimicrobial Agents and Chemotherapy 38 (1994) 96-103
20. Marshall S.J., Russell P.F., Phillipson J.D., Kirby G.C., Warhurst D.C., and Wright C.W. Antiplasmodial and antiamoebic activities of medicinal plants from Sierra Leone. Phytotherapy Research 14 (2000) 356-358
21. Muňoz V., Sauvain M., Bourdy G., Callapa J., Rojas I., Vargas L., Tae A., and Deharo E. The search for natural bioactive compounds trough a multidisciplinary approach in Bolivia. Part II. Antimalarial activity of some plants used by Mosetene indians. Journal of Ethnopharmacology 69 (2000) 139-155
22. Mustofa, Valentin A., Benoit-Vical F., Pélissier Y., Koné-Bamba D., and Mallié M. Antiplasmodial activity of extracts used in west African traditional medicine. Journal of Ethnopharmacology 73 (2000) 145-151
23. Neuwinger H.D. African Traditional Medicine. A Dictionary of Plant Use and Applications (2000), Medpharm Scientific Publishers, Stuttgart
24. Okorie D.A. Polyavolinamide, an indolosesquiterpene alkaloid from Polyathia suaveolens. Phytochemistry 20 (1981) 2575-2578
25. Okpekon T., Yolou S., Gleye C., Roblot F., Loiseau P., Borie C., Grellier P., Frappier F., Laurens A., and Hocquemiller R. Antiparasitic activities of medicinal plants used in Ivory Coast. Journal of Ethnopharmacology 90 (2004) 91-97
26. Owusu P.D., Slatktin D.J., Knap J.E., and Schiff Jr. P.L. Constituents of West African medicinal plants. XXVIII. Additional alkaloids of Triclisia gilletii. Journal of Natural Products 46 (1980) 123
27. Phillipson J.D., and Wright C.W. Antiprotozoal agents from plant sources. Planta Medica 57 (1991) S53-S59
28. Pieters L., and Vlietinck A.J. Bioguided isolation of pharmaceutically active plant components, still a valuable strategy for the finding of new lead compounds?. Journal of Ethnopharmacology 100 (2005) 57-60
29. Schwikkard S., and Heerden F.R. Antimalarial activity of plant metabolites. Natural Product Reports 19 (2002) 675-692
30. Simonsen H.T., Nordskjold J.B., Smitt U.W., Nyman U., Palpu P., Joshi P., and Varughese G. In vitro screening of Indian medicinal plants for antiplasmodial activity. Journal of Ethnopharmacology 74 (2001) 195-204
31. Tackie A.N., Dwuma D., Okarter T., Knapp J.E., Statkin D.J., and Schiff Jr. P.L. Trigilletine and tricordatine: two new bisbenzylisoquinoline alkaloids from Triclisia species. Phytochemistry 12 (1973) 2509-2511
32. Tangenyi Okito, H., 1996. Contribution à l'étude des plantes médicinales utilisées contre le paludisme au Sankuru. Dissertation en D.E.S. Université Patrice Emery Lumumba. Campus Méthodiste de Wembo-Nyama, Kasaï-Oriental, République Démocratique du Congo.
33. Tona L., Kambu K., Ngimbi N., Cimanga K., and Vlietinck A.J. Antiamoebic and phytochemical screening of some Congolese medicinal plants. Journal of Ethnopharmacology 61 (1998) 57-65
34. Trager W., and Jensen J. Human malaria parasites in continuous culture. Science 193 (1976) 673-675
35. Ueda-Nakamura T., MendonÇa-Filho R.R., Morgado-Diaz J.A., Maza P.K., Filho B.P.D., Cortez D.A.G., Alviano D.S., Rosa M.S.S., Lopes A.H.C.S., Alviano C.S., and Nakamura C.V. Antileishmanial activity of eugenol-rich oil from Ocimum gratissimum. Parasitology International 55 (2006) 99-105
36. Ueno H.M., Doyama J.T., Padovani C.R., and Salata E. Effect of Momordica charantia L. in mice infected with Plasmodium berghei. Review of Brasilian Medicine Tropical 29 (1996) 455-460
37. Van Miert S., Hostyn S., Maes B.U.W., Cimanga K., Brun R., Kaiser M., Mátyus P., Dommisse R., Lemière G., Vlietinck A., and Pieters L. Isoneocryptolepine, a synthetic indoloquinoline alkaloid, as an antiplasmodial lead compound. Journal of Natural Products 68 (2005) 674-677
38. Wellems T., and Plowe C. Chloroquine-resistant malaria. The Journal of Infectious Diseases 184 (2000) 770-776
39. Weniger B., Robledo S., Arango G.j., Deharo E., AragÓn R., Muňoz V., Callapa J., Lobestein A., and Anton R. Antiprotozoal activities of Colombian plants. Journal of Ethnopharmacology 78 (2001) 193-200
40. WHO, 1998. Control and surveillance of African trypanosomiasis. Report of WHO Expert Committee. World Health Organization Technical Report Series 881, I-VI, pp. 1-114.