Functional FEN1 polymorphisms are associated with DNA damage levels and lung cancer risk

Human Mutation

Volumn 30, Issue 9, 2009, Pages 1320-1328

  Yang, Ming ^a,b   Guo, Huan ^c   Wu, Chen ^a,b   He, Yuefeng ^c   Yu, Dianke ^a,b   Zhou, Li ^c   Wang, Fang ^c   Xu, Jian ^a   Tan, Wen ^a,b   Wang, Guanghai ^a,b   Shen, Binghui ^d   Yuan, Jing ^c   Wu, Tangchun ^c   Lin, Dongxin ^a,b  

^a CANCER HOSPITAL   (China)

^b Beijing Key Laboratory for Cancer Prevention   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^d CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

DNA damage; FEN1; Lung cancer

Indexed keywords

COKE; DNA; ENDONUCLEASE; FLAP ENDONUCLEASE 1; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ADULT; AGED; ARTICLE; CANCER RISK; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CASE CONTROL STUDY; COHORT ANALYSIS; COMET ASSAY; COMPARATIVE STUDY; CONTROLLED STUDY; DNA DAMAGE; DNA SEQUENCE; FEMALE; FEN1 GENE; GENE; GENE EXPRESSION; GENE FUNCTION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HETEROZYGOTE; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; SAMPLE; SINGLE NUCLEOTIDE POLYMORPHISM; WORKER;

CELL LINE, TUMOR; COHORT STUDIES; DNA DAMAGE; FLAP ENDONUCLEASES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HELA CELLS; HUMANS; LUNG NEOPLASMS; PHENOTYPE; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 69549123990     PISSN: 10597794     EISSN: None     Source Type: Journal    
DOI: 10.1002/humu.21060     Document Type: Article

References (42)

1. Bai Y, Xu L, Yang X, Hu Z, Yuan J, Wang F, Shao M, Yuan W, Qian J, Ma H, Wang Y, Liu H, Chen W, Yang L, Jing G, Huo X, Chen F, Liu Y, Jin L, Wei Q, Huang W, Shen H, Lu D, Wu T. 2007. Sequence variations in DNA repair gene XPC is associated with lung cancer risk in a Chinese population: a case-control study. BMC Cancer 7:81-89. (Pubitemid 46864915)
2. Brennan P. 2002. Gene-environment interaction and aetiology of cancer: what does it mean and how can we measure it? Carcinogenesis 23:381-387.
3. Chapados BR, Hosfield DJ, Han S, Qiu J, Yelent B, Shen B, Tainer JA. 2004. Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair. Cell 116:39-50. (Pubitemid 38156182)
4. Chen Y, Bai Y, Yuan J, Chen W, Sun J, Wang H, Liang H, Guo L, Yang X, Tan H, Su Y, Wei Q, Wu T. 2006. Association of polymorphisms in AhR, CYP1A1, GSTM1, and GSTT1 genes with levels of DNA damage in peripheral blood lymphocytes among coke-oven workers. Cancer Epidemiol Biomarkers Prev 15:1703-1707. (Pubitemid 44497107)
5. Conney AH. 1982. Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G.H.A. Clowes Memorial Lecture. Cancer Res 42:4875-4917.
6. Filipowicz W, Bhattacharyya SN, Sonenberg N. 2008. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 9:102-114.
7. Frenkel K. 1992. Carcinogen-mediated oxidant formation and oxidative DNA damage. Pharmacol Ther 53:127-166.
8. Guo Z, Chavez V, Singh P, Finger LD, Hang H, Hegde ML, Shen B. 2008. Comprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathways. J Mol Biol 377:679-690.
9. Hagan JP, Croce CM. 2007. MicroRNAs in carcinogenesis. Cytogenet Genome Res 118:252-259.
10. Hao B, Miao X, Li Y, Zhang X, Sun T, Liang G, Zhao Y, Zhou Y, Wang H, Chen X, Zhang L, Tan W, Wei Q, Lin D, He F. 2006. A novel T-77C polymorphism in DNA repair gene XRCC1 contributes to diminished promoter activity and increased risk of non-small cell lung cancer. Oncogene 25:3613-3620. (Pubitemid 43901683)
11. Harrington JJ, Lieber MR. 1994. The characterization of a mammalian DNA structure-specific endonuclease. EMBO J 13:1235-1246.
12. Hasan S, Stucki M, Hassa PO, Imhof R, Gehrig P, Hunziker P, Hübscher U, Hottiger MO. 2001. Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300. Mol Cell 7:1221-1231. (Pubitemid 32607356)
13. Hecht SS. 1999. Tobacco smoke carcinogens and lung cancer. J Natl Cancer Inst 91:1194-1210. (Pubitemid 29357186)
14. Henneke G, Friedrich-Heineken E, Hubscher U. 2003a. Flap endonuclease 1: a novel tumour suppresser protein. Trends Biochem Sci 28:384-390. (Pubitemid 36851620)
15. Henneke G, Koundrioukoff S, Hubscher U. 2003b. Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation. Oncogene 22:4301-4313. (Pubitemid 36897962)
16. Hoeijmakers JH. 2001. Genome maintenance mechanisms for preventing cancer. Nature 411:366-374.
17. IARC. 1983. Part 1. Chemical, environmental and experimental data. In: IARC Monographs on the evaluation of carcinogenic risks to humans. Polycyclic aromatic compounds. France: WHO Publications Centre. p 32.
18. Kucherlapati M, Yang K, Kuraguchi M, Zhao J, Lia M, Heyer J, Kane MF, Fan K, Russell R, Brown AM, Kneitz B, Edelmann W, Kolodner RD, Lipkin M, Kucherlapati R. 2002. Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression. Proc Natl Acad Sci USA 99:9924-9929. (Pubitemid 34831149)
19. Lehmann U, Kreipe H. 2001. Real-time PCR analysis of DNA and RNA extracted from formalin-fixed and paraffin-embedded biopsies. Methods 25:409-418. (Pubitemid 34164013)
20. Leng S, Dai Y, Niu Y, Pan Z, Li X, Cheng J, He F, Zheng Y. 2004. Effects of genetic polymorphisms of metabolic enzymes on cytokinesis-block micronucleus in peripheral blood lymphocyte among coke-oven workers. Cancer Epidemiol Biomarkers Prev 13:1631-1639. (Pubitemid 39331885)
21. Lieber MR. 1997. The FEN-1 family of structure-specific nucleases in eukaryotic DNA replication, recombination and repair. Bioessays 19:233-240.
22. Liu Y, Kao HI, Bambara RA. 2004. Flap endonuclease 1: a central component of DNA metabolism. Annu Rev Biochem 73:589-615. (Pubitemid 39050381)
23. Ma X, Jin Q, Forsti A, Hemminki K, Kumar R. 2000. Single nucleotide polymorphism analyses of the human proliferating cell nuclear antigen (pCNA) and flap endonuclease (FEN1) genes. Int J Cancer 88:938-942.
24. Mayr C, Hemann MT, Bartel DP. 2007. Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. Science 315:1576-1579. (Pubitemid 46449474)
25. Parkin DM, Bray F, Ferlay J, Pisani P. 2005. Global cancer statistics, 2002. CA Cancer J Clin 55:74-108.
26. Parrish JZ, Yang C, Shen B, Xue D. 2003. CRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation. EMBO J 22:3451-3460. (Pubitemid 36834875)
27. Paulovich AG, Armour CD, Hartwell LH. 1998. The Saccharomyces cerevisiae RAD9, RAD17, RAD24 and MEC3 genes are required for tolerating irreparable, ultraviolet-induced DNA damage. Genetics 150:75-93.
28. Popp W, Vahrenholz C, Schell C, Grimmer G, Dettbarn G, Kraus R, Brauksiepe A, Schmeling B, Gutzeit T, von Bülow J, Norpoth K. 1997. DNA single strand breakage, DNA adducts, and sister chromatid exchange in lymphocytes and phenanthrene and pyrene metabolites in urine of coke oven workers. Occup Environ Med 54:176-183. (Pubitemid 27092950)
29. Reagan MS, Pittenger C, Siede W, Friedberg EC. 1995. Characterization of a mutant strain of Saccharomyces cerevisiae with a deletion of the RAD27 gene, a structural homolog of the RAD2 nucleotide excision repair gene. J Bacteriol 177:364-371.
30. Schaid DJ, Rowland CM, Tines DE, Jacobson RM, Poland GA. 2002. Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet 70:425-434.
31. Shen B, Singh P, Liu R, Qiu J, Zheng L, Finger LD, Alas S. 2005. Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases. Bioessays 27:717-729. (Pubitemid 41153356)
32. Singh NP, McCoy MT, Tice RR, Schneider EL. 1988. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175:184-191.
33. Singh P, Yang M, Dai H, Yu D, Huang Q, Tan W, Kernstine KH, Lin D, Shen B. 2008. Overexpression and hypomethylation of flap endonuclease 1 gene in breast and other cancers. Mol Cancer Res 6:1710-1717.
34. Sun T, Gao Y, Tan W, Ma S, Shi Y, Yao J, Guo Y, Yang M, Zhang X, Zhang Q, Zeng C, Lin D. 2007. A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers. Nat Genet 39:605-613. (Pubitemid 46676113)
35. Tan H, Li J, Yang X, Bai Y, Long Z, Yang M, Yuan J, Wu T. 2006. Study on the correlation between metabolic syndrome and coke oven work. J Environ Med (in Chinese) 23:93-95.
36. Thun MJ, Lally CA, Flannery JT, Calle EE, Flanders WD, Heath Jr. CW 1997. Cigarette smoking and changes in the histopathology of lung cancer. J Natl Cancer Inst 89:1580-1586. (Pubitemid 27479717)
37. Tishkoff DX, Filosi N, Gaida GM, Kolodner RD. 1997. A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair. Cell 88:253-263. (Pubitemid 28015874)
38. Yang M, Guo Y, Zhang X, Miao X, Tan W, Sun T, Zhao D, Yu D, Liu J, Lin D. 2007. Interaction of P53 Arg72Pro and MDM2 T309G polymorphisms and their associations with risk of gastric cardia cancer. Carcinogenesis 28:1996-2001. (Pubitemid 47500614)
39. Yang X, Yuan J, Sun J, Wang H, Liang H, Bai Y, Guo L, Tan H, Yang M, Wang J, Su J, Chen Y, Tanguay RM, Wu T. 2008. Association between heat-shock protein 70 gene polymorphisms and DNA damage in peripheral blood lymphocytes among coke-oven workers. Mutat Res 649:221-229. (Pubitemid 350245471)
40. Zhang X, Miao X, Liang G, Hao B, Wang Y, Tan W, Li Y, Guo Y, He F, Wei Q, Lin D. 2005. Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer. Cancer Res 65:722-726. (Pubitemid 40216429)
41. Zheng L, Dai H, Zhou M, Li M, Singh P, Qiu J, Tsark W, Huang Q, Kernstine K, Zhang X, Lin D, Shen B. 2007. Fen1 mutations result in autoimmunity, chronic inflammation and cancers. Nat Med 13:812-819. (Pubitemid 47038189)
42. Zheng L, Zhou M, Chai Q, Parrish J, Xue D, Patrick SM, Turchi JJ, Yannone SM, Chen D, Shen B. 2005. Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks. EMBO Rep 6:83-89. (Pubitemid 41710079)