Opposing effects of bepridil on ventricular repolarization in humans - Inhomogeneous prolongation of the action potential duration vs flattening of its restitution kinetics

Circulation Journal

Volumn 73, Issue 9, 2009, Pages 1612-1618

  Osaka, Toshiyuki ^a   Yokoyama, Eriko ^a   Kushiyama, Yasunori ^a   Hasebe, Hideyuki ^a   Kuroda, Yusuke ^a   Suzuki, Tomoyuki ^a   Kodama, Itsuo ^b  

^a SHIZUOKA SAISEIKAI GENERAL HOSPITAL   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

Author keywords

Bepridil; Monophasic action potential; QT prolongation; Repolarization; Torsades de pointes

Indexed keywords

BEPRIDIL;

ACTION POTENTIAL; ADULT; ARTICLE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; DRUG EFFECT; DRUG MECHANISM; ELECTROCARDIOGRAM; HEART CYCLE; HEART PACING; HEART REPOLARIZATION; HEART RIGHT VENTRICLE OUTFLOW TRACT; HUMAN; KINETICS; QT PROLONGATION; STEADY STATE; T WAVE;

ACTION POTENTIALS; AGED; ANTI-ARRHYTHMIA AGENTS; ATRIAL FIBRILLATION; BEPRIDIL; CASE-CONTROL STUDIES; ELECTROCARDIOGRAPHY; FEMALE; HEART CONDUCTION SYSTEM; HEART VENTRICLES; HUMANS; KINETICS; MALE; MIDDLE AGED; TORSADES DE POINTES; TREATMENT OUTCOME; VENTRICULAR FUNCTION, RIGHT;

EID: 69549109782     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.CJ-09-0139     Document Type: Article

References (46)

1. Yatani A, Brown AM, Schwartz A. Bepridil block of cardiac calcium and sodium channels. J Pharmacol Exp Ther 1986; 237: 9-17. (Pubitemid 16116336)
2. Berger F, Borchard U, Hafner D. Effects of the calcium entry blocker bepridil on repolarizing and pacemaker currents in sheep cardiac Purkinje fibres. Naunyn Schmiedebergs Arch Pharmacol 1989; 339: 638-646. (Pubitemid 19159821)
3. Ks, in guinea-pig ventricular myocytes. Br J Pharmacol 1999; 128: 1733-1738. (Pubitemid 30011887)
4. Yumoto Y, Horie M, Kubota T, Ninomiya T, Kobori A, Takenaka K, et al. Bepridil block of recombinant human cardiac IKs current shows a time-dependent unblock. J Cardiovasc Pharmacol 2004; 43: 178-182. (Pubitemid 38129674)
5. Kamiya K, Niwa R, Mitcheson JS, Sanguinetti MC. Molecular determinants of HERG channel block. Mol Pharmacol 2006; 69: 1709-1716.
6. Nakazato Y, Yasuda M, Sasaki A, Iida Y, Kawano Y, Nakazato K, et al. Conversion and maintenance of sinus rhythm by bepridil in patients with persistent atrial fibrillation. Circ J 2005; 69: 44-48. (Pubitemid 40139606)
7. Fujiki A, Tsuneda T, Sakabe M, Nakagawa K, Mizumaki K, Hirai T, et al. Maintenance of sinus rhythm and recovery of atrial mechanical function after cardioversion with bepridil or in combination with aprindine in long-lasting persistent atrial fibrillation. Circ J 2004; 68: 834-839. (Pubitemid 39243804)
8. Miyaji K, Tada H, Fukushima Kusano K, Hashimoto T, Kaseno K, Hiramatsu S, et al. Efficacy and safety of the additional bepridil treatment in patients with atrial fibrillation refractory to class I antiarrhythmic drugs. Circ J 2007; 71: 1250-1257. (Pubitemid 47195342)
9. Imai S, Saito F, Takase H, Enomoto M, Aoyama H, Yamaji S, et al. Use of bepridil in combination with Ic antiarrhythmic agent in converting persistent atrial fibrillation to sinus rhythm. Circ J 2008; 72: 709-715. (Pubitemid 351716674)
10. Singh BN. Safety profile of bepridil determined from clinical trials in chronic stable angina in the United States. Am J Cardiol 1992; 69: 68D-74D.
11. Coumel P. Safety of bepridil: From review of the European data. Am J Cardiol 1992; 69: 75D-78D.
12. Yasuda M, Nakazato Y, Sasaki A, Kawano Y, Nakazato K, Tokano T, et al. Clinical evaluation of adverse effects during bepridil administration for atrial fibrillation and flutter. Circ J 2006; 70: 662-666. (Pubitemid 43797774)
13. Yamashita T, Ogawa S, Sato T, Aizawa Y, Atarashi H, Fujiki A, et al; for the J-BAF Investigators. Dose-response effects of bepridil in patients with persistent atrial fibrillation monitored with transtelephonic electrocardiograms: A multicenter, randomized, placebo-controlled, double-blind study (J-BAF study). Circ J 2009; 73: 1020-1027.
14. Yan GX, Antzelevitch C. Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome. Circulation 1998; 98: 1928-1936. (Pubitemid 28509291)
15. Cheng J, Kamiya K, Liu W, Tsuji Y, Toyama J, Kodama I. Heterogeneous distribution of the two components of delayed rectifier K+ current: A potential mechanism of the proarrhythmic effects of methanesulfonanilideclass III agents. Cardiovasc Res 1999; 43: 135-147. (Pubitemid 29322873)
16. Ks block. J Cardiovasc Electrophysiol 2001; 12: 1369-1378. (Pubitemid 34073216)
17. Laurita KR, Girouard SD, Rosenbaum DS. Modulation of ventricular repolarization by a premature stimulus: Role of epicardial dispersion of repolarization kinetics demonstrated by optical mapping of the intact guinea pig heart. Circ Res 1996; 79: 493-503.
18. Laurita KR, Girouard SD, Akar FG, Rosenbaum DS. Modulated dispersion explains changes in arrhythmia vulnerability during premature stimulation of the heart. Circulation 1998; 98: 2774-2780.
19. Weiss JN, Garfinkel A, Karagueuzian HS, Qu Z, Chen PS. Chaos and the transition to ventricular fibrillation: A new approach to antiarrhythmic drug evaluation. Circulation 1999; 99: 2819-2826. (Pubitemid 29250030)
20. Cao JM, Qu Z, Kim YH, Wu TJ, Garfinkel A, Weiss JN, et al. Spatiotemporal heterogeneity in the induction of ventricular fibrillation by rapid pacing: Importance of cardiac restitution properties. Circ Res 1999; 84: 1318-1331. (Pubitemid 29270047)
21. Qu Z, Garfinkel A, Chen PS, Weiss JN. Mechanisms of discordant alternans and induction of reentry in simulated cardiac tissue. Circulation 2000; 102: 1664-1670. (Pubitemid 30736933)
22. Weiss JN, Qu Z, Chen PS, Lin SF, Karagueuzian HS, Hayashi H, et al. The dynamics of cardiac fibrillation. Circulation 2005; 112: 1232-1240.
23. Clayton RH, Taggart P. Regional differences in APD restitution can initiate wavebreak and re-entry in cardiac tissue: A computational study. Biomed Eng Online 2005; 4: 54. (Pubitemid 41461205)
24. Nash MP, Bradley CP, Sutton PM, Clayton RH, Kallis P, Hayward MP, et al. Whole heart action potential duration restitution properties in cardiac patients: A combined clinical and modeling study. Exp Physiol 2006; 91: 339-354. (Pubitemid 43356960)
25. Taggart P, Sutton P, Chalabi Z, Boyett MR, Simon R, Elliott D, et al. Effect of adrenergic stimulation on action potential duration restitu- tion in humans. Circulation 2003; 107: 285-289. (Pubitemid 36135225)
26. Koller ML, Maier SK, Gelzer AR, Bauer WR, Meesmann M, Gilmour RF Jr. Altered dynamics of action potential restitution and alternans in humans with structural heart disease. Circulation 2005; 112: 1542-1548. (Pubitemid 41324514)
27. Nawada T, Tanaka Y, Hisatome I, Sasaki N, Ohtahara A, Kotake H, et al. Mechanism of inhibition of the sodium current by bepridil in guinea-pig isolated ventricular cells. Br J Pharmacol 1995; 116: 1775-1780.
28. Nobe S, Aomine M, Arita M. Bepridil prolongs the action potential duration of guinea pig ventricular muscle only at rapid rates of stimulation. Gen Pharmacol 1993; 24: 1187-1196. (Pubitemid 23283088)
29. Kato R, Singh BN. Effects of bepridil on the electrophysiologic properties of isolated canine and rabbit myocardial fibers. Am Heart J 1986; 111: 271-279. (Pubitemid 16107264)
30. Winslow E, Campbell JK, Marshall RJ. Comparative electrophysiological effects of disopyramide and bepridil on rabbit atrial, papillary, and Purkinje tissue: Modification by reduced extracellular potassium. J Cardiovasc Pharmacol 1986; 8: 1208-1216. (Pubitemid 17211586)
31. Peralta AO, John RM, Gaasch WH, Taggart PI, Martin DT, Venditti FJ. The class III antiarrhythmic effect of Sotalol exerts a reverse use-dependent positive inotropic effect in the intact canine heart. J Am Coll Cardiol 2000; 36: 1404-1410.
32. Yamazaki M, Honjo H, Nakagawa H, Ishiguro YS, Okuno Y, Amino M, et al. Mechanisms of destabilization and early termination of spiral wave reentry in the ventricle by a class III antiarrhythmic agent, nifekalant. Am J Physiol Heart Circ Physiol 2007; 292: H539-H548. (Pubitemid 46105218)
33. Ks blockade at high heart rate in guinea pig and rabbit: Implications for arrhythmogenesis in humans. Circulation 2001; 104: 951-956. (Pubitemid 32778049)
34. Osaka T, Kodama I, Toyama J, Yamada K. Effects of bepridil on ventricular depolarization and repolarization of rabbit isolated hearts with particular reference to its possible proarrhythmic properties. Br J Pharmacol 1988; 93: 775-780. (Pubitemid 18093383)
35. di Bernardo D, Murray A. Explaining the T-wave shape in the ECG. Nature 2000; 403: 40.
36. Van Huysduynen BH, Swenne CA, Draisma HH, Antoni ML, Van De Vooren H, Van Der Wall EE, et al. Validation of ECG indices of ventricular repolarization heterogeneity: A computer simulation study. J Cardiovasc Electrophysiol 2005; 16: 1-7. (Pubitemid 43920032)
37. Xia Y, Liang Y, Kongstad O, Holm M, Olsson B, Yuan S. Tpeak-Tend interval as an index of global dispersion of ventricular repolarization: Evaluations using monophasic action potential mapping of the epi- and endocardium swine. J Interv Card Electrophysiol 2005; 14: 79-87. (Pubitemid 43004736)
38. Xia Y, Liang Y, Kongstad O, Liao Q, Holm M, Olsson B, et al. In vivo validation of the coincidence of the peak and end of the T wave with full repolarization of the epicardium and endocardium in swine. Heart Rhythm 2005; 2: 162-169.
39. Yoshiga Y, Shimizu A, Yamagata T, Hayano T, Ueyama T, Ohmura M, et al. Beta-blocker decreases the increase in QT dispersion and transmural dispersion of repolarization induced by bepridil. Circ J 2002; 66: 1024-1028. (Pubitemid 35416340)
40. Riccio ML, Koller ML, Gilmour RF Jr. Electrical restitution and spatiotemporal organization during ventricular fibrillation. Circ Res 1999; 84: 955-963. (Pubitemid 29196741)
41. Garfinkel A, Kim YH, Voroshilovsky O, Qu Z, Kil JR, Lee MH, et al. Preventing ventricular fibrillation by flattening cardiac restitution. Proc Natl Acad Sci USA 2000; 97: 6061-6066.
42. Wu TJ, Lin SF, Weiss JN, Ting CT, Chen PS. Two types of ventricular fibrillation in isolated rabbit hearts: Importance of excitability and action potential duration restitution. Circulation 2002; 106: 1859-1866.
43. + current kinetics and cardiac wave stability. Am J Physiol Heart Circ Physiol 2007; 293: H1805-H1815. (Pubitemid 47367231)
44. Koller ML, Riccio ML, Gilmour RF Jr. Dynamic restitution of action potential duration during electrical alternans and ventricular fibrillation. Am J Physiol 1998; 275: H1635-H1642. (Pubitemid 28543697)
45. + currents in pressure-overload heart failure. J Cardiovasc Electrophysiol 2007; 18: 869-875. (Pubitemid 47093072)
46. Poelzing S, Veeraraghavan R. Heterogeneous ventricular chamber response to hypokalemia and inward rectifier potassium channel blockade underlies bifurcated T wave in guinea pig. Am J Physiol Heart Circ Physiol 2007; 2926: H3043-H3051. (Pubitemid 47084558)