Cellular basis for complex T waves and arrhythmic activity following combined IKr and IKs block

Journal of Cardiovascular Electrophysiology

Volumn 12, Issue 12, 2001, Pages 1369-1378

  Emori, Tetsuro ^a   Antzelevitch, Charles ^a  

^a MASONIC MEDICAL RESEARCH LABORATORY   (United States)

Author keywords

Electrophysiology; Long QT syndrome; M cell; Pharmacology; Torsades de pointes; Ventricular wall

Indexed keywords

SOTALOL;

ACTION POTENTIAL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DOG; ELECTROCARDIOGRAPHY; ENDOCARDIUM; EPICARDIUM; EXTRASYSTOLE; HEART REPOLARIZATION; LONG QT SYNDROME; NONHUMAN; PRIORITY JOURNAL; QT INTERVAL; T WAVE;

EID: 0035690558     PISSN: 10453873     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1540-8167.2001.01369.x     Document Type: Article

References (40)

1. Cellular basis for the normal T wave and the electrocardiographic manifestations of the long QT syndrome
2. Cellular basis for the electrocardiographic features of the LQT1 form of the long QT syndrome: Effects of β-adrenergic agonists, antagonists and sodium channel blockers on transmural dispersion of repolarization and torsade de pointes
3. Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade de pointes in LQT2 and LQT3 models of the long-QT syndrome
4. KVLQT1 C-terminal missense mutation causes a forme fruste long-QT syndrome
5. Taking the "Idio" out of "Idiosyncratic": Predicting torsades de pointes
6. Molecular mechanisms of myocardial remodeling
7. Electrophysiological remodeling in hypertrophy and heart failure
8. Enhanced susceptibility for acquired torsade de pointes arrhythmias in the dog with chronic, complete AV block is related to cardiac hypertrophy and electrical remodeling
9. Ks are larger in right than left canine ventricular midmyocardium
10. Characteristics and distribution of M cells in arterially-perfused canine left ventricular wedge preparations
11. The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome: Tridimensional mapping of activation and recovery patterns
12. The M cell. Its contribution to the ECG and to normal and abnormal electrical function of the heart
13. Quinidine-induced long QTU interval and torsade de pointes: Role of bradycardia-dependent early afterdepolarizations
14. Electrocardiographic and electrophysiologic studies in patients with torsades de pointes: Role of monophasic action potentials
15. Early afterdepolarization in a patient with complete atrioventricular block and torsades de pointes
16. Polymorphic ventricular tachycardia induced by intracoronary injection of ioxaglate in a patient with borderline QT prolongation
17. Early afterdepolarization like activity in patients with class IA induced long QT syndrome and torsade de pointes
18. Ks contributes to the longer action potential of the M cell
19. Larger late sodium current contributes to the longer action potential of the M cell in canine ventricular myocardium
20. Na-Ca contributes to electrical heterogeneity within the canine ventricle
21. ECG T-wave patterns in genetically distinct forms of the hereditary long QT syndrome
22. A recessive variant of the Romano-Ward long-QT syndrome?
23. Low penetrance in the long-QT syndrome: Clinical impact
24. KvLQT1 mutation in drug induced torsade de pointes
25. QTU prolongation and polymorphic ventricular tachyarrhythmias due to bradycardia-dependent early-afterdepolarizations
26. Cesium chloride-induced long QT syndrome: Demonstration of afterdepolarizations and triggered activity in vivo
27. Canine left ventricular hypertrophy predisposes to ventricular tachycardia induction by phase 2 early afterdepolarizations after administration of BAY K 8644
28. Quinidine-induced action potential prolongation, early afterdepolarizations, and triggered activity in canine Purkinje fibers. Effects of stimulation rate, potassium, and magnesium
29. Effects of pacing on triggered activity induced by early afterdepolarizations
30. Clinical relevance of cardiac arrhythmias generated by afterdepolarizations: The role of M cells in the generation of U waves, triggered activity and torsade de pointes
31. Phase 2 early afterdepolarization as a trigger of polymorphic ventricular tachycardia in acquired long-QT syndrome: Direct evidence from intracellular recordings in the intact left ventricular wall
32. Early afterdepolarizations and triggered activity in clinical arrhythmias
33. Acceleration-induced action potential prolongation and early afterdepolarizations
34. Heterogeneity within the ventricular wall: Electrophysiology and pharmacology of epicardial, endocardial and M cells
35. Afterdepolarizations and triggered activity develop in a select population of cells (M cells) in canine ventricular myocardium: The effects of acetylstrophanthidin and Bay K 8644
36. Drug-induced afterdepolarizations and triggered activity occur in a discrete subpopulation of ventricular muscle cell (M cells) in the canine heart: Quinidine and digitalis
37. Ks heterogeneity on action potential duration and its rate-dependence: A simulation study
38. Pause induced early afterdepolarizations in the long QT syndrome: A simulation study
39. Long QT syndrome
40. Mechanism of arrhythmogenicity of the short-long cardiac sequence that precedes ventricular tachyarrhythmias in the long QT syndrome