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Volumn 16, Issue 5, 2009, Pages 342-346

Animal models of thrombosis

Author keywords

Cerebral ischemia; Coagulation; Fibrinolysis; Myocardial infarction; Platelet

Indexed keywords

CLOPIDOGREL; ENDOTHELIN A RECEPTOR ANTAGONIST; LOW MOLECULAR WEIGHT HEPARIN; MATRIX METALLOPROTEINASE INHIBITOR; MONOCYCLINE; PADGEM PROTEIN; PADGEM PROTEIN INHIBITOR; PROTEIN INHIBITOR; S O138; TISSUE PLASMINOGEN ACTIVATOR; UNCLASSIFIED DRUG;

EID: 69549086459     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0b013e32832e9ddd     Document Type: Review
Times cited : (24)

References (28)
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    • This study demonstrated an important role of PDI in thrombus formation following vascular injury and demonstrated an important role for PDI in activation of TF via disulfide bond formation. The authors suggest that PDI inhibition will benefit several prothrombotic conditions but that additional studies are needed to further characterize the thrombotic and hemostatic effects of PDI inhibition
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    • The study provides evidence that an orally available p-selectin inhibitor, PSI-421, attenuates venous thrombosis and microparticle tissue factor activity in a nonhuman primate. The study demonstrates similar to better efficacy of PSI-421 compared with low-molecular-weight heparin
    • Meier TR, Myers DD Jr, Wrobleski SK, et al. Prophylactic P-selectin inhibition with PSI-421 promotes resolution of venous thrombosis without anticoagulation. Thromb Haemost 2008; 99:343-351. The study provides evidence that an orally available p-selectin inhibitor, PSI-421, attenuates venous thrombosis and microparticle tissue factor activity in a nonhuman primate. The study demonstrates similar to better efficacy of PSI-421 compared with low-molecular-weight heparin.
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    • This study demonstrated that an antibody to GP-1b-alpha which blocks binding to von Willebrand factor provides a significant reduction in cyclic flow reductions using a baboon model of injury and stenosis. The authors provide evidence that antithrombotic levels can be achieved without a significant induction of bleeding risk
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.