Secretory phospholipase A2 plays an essential role in microglial inflammatory responses to Mycobacterium tuberculosis

GLIA

Volumn 57, Issue 10, 2009, Pages 1091-1103

  Yang, Chul Su ^a   Yuk, Jae Min ^a   Shin, Dong Min ^a   Kang, Junghee ^b   Lee, Sung Joong ^b   Jo, Eun Kyeong ^a  

^a Chungnam National University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Inflammation; Microglia; Mycobacteria; Secretory PLA2

Indexed keywords

CYCLOOXYGENASE 2; CYTOSOLIC PHOSPHOLIPASE A2; GELATINASE A; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE C; RAF PROTEIN; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; SECRETORY PHOSPHOLIPASE A2; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR; AUTACOID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; GLIA CELL; INFLAMMATION; MEDIATOR RELEASE; MICROGLIA; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NERVE CELL CULTURE; NERVE CELL STIMULATION; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CELL CULTURE; COCULTURE; DRUG EFFECT; ENCEPHALITIS; ENZYMOLOGY; GLIOSIS; IMMUNOLOGY; INTRACRANIAL TUBERCULOMA; METABOLISM; MICROBIOLOGY; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; SECRETION; TUBERCULOUS MENINGITIS;

ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; COCULTURE TECHNIQUES; ENCEPHALITIS; GLIOSIS; INFLAMMATION MEDIATORS; MAP KINASE KINASE 1; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASE 3; MYCOBACTERIUM TUBERCULOSIS; NF-KAPPA B; PHOSPHOLIPASES A2, SECRETORY; PHOSPHORYLATION; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-RAF; RAS PROTEINS; REACTIVE OXYGEN SPECIES; TUBERCULOMA, INTRACRANIAL; TUBERCULOSIS, MENINGEAL;

EID: 69449092758     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.20832     Document Type: Article

References (61)

1. Akiba S, Sato T. 2004. Cellular function of calcium-independent phospholipase A2. Biol Pharm Bull 27:1174-1178.
2. Akundi RS, Candelario-Jalil E, Hess S, Hull M, Lieb K, Gebicke-Haerter PJ, Fiebich BL. 2005. Signal transduction pathways regulating cyclooxygenase-2 in lipopolysaccharide-activated primary rat microglia. Glia 51:199-208.
3. Arai K, Ikegaya Y, Nakatani Y, Kudo I, Nishiyama N, Matsuki N. 2001. Phospholipase A2 mediates ischemic injury in the hippocampus: A regional difference of neuronal vulnerability. Eur J Neurosci 13:2319-2323.
4. Baek SH, Lim JH, Park DW, Kim SY, Lee YH, Kim JR, Kim JH. 2001. Group IIA secretory phospholipase A(2) stimulates inducible nitric oxide synthase expression via ERK and NF-kappaB in macrophages. Eur J Immunol 31:2709-2717.
5. Baek SH, Yun SS, Kwon TK, Kim JR, Chang HW, Kwak JY, Kim JH, Kwun KB. 1999. The effects of two new antagonists of secretory PLA2 on TNF, iNOS, and COX-2 expression in activated macrophages. Shock 12:473-478.
6. Balsinde J, Winstead MV, Dennis EA. 2002. Phospholipase A(2) regulation of arachidonic acid mobilization. FEBS Lett 531:2-6.
7. Beutler B, Cerami A. 1989. The biology of cachectin/TNF-a primary mediator of the host response. Annu Rev Immunol 7:625-655. Bhat NR, Zhang P, Bhat AN. 1999. Cytokine induction of inducible nitric oxide synthase in an oligodendrocyte cell line: Role of p38 mitogen-activated protein kinase activation. J Neurochem 72:472-478.
8. Bhat NR, Zhang P, Lee JC, Hogan EL. 1998. Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures. J Neurosci 18:1633-1641.
9. Chakraborti S, Chakraborti T. 1998. Oxidant-mediated activation of mitogen-activated protein kinases and nuclear transcription factors in the cardiovascular system: A brief overview. Cell Signal 10:675-683.
10. Contreras X, Bennasser Y, Bahraoui E. 2004. IL-10 production induced by HIV-1 Tat stimulation of human monocytes is dependent on the activation of PKC beta(II) and delta isozymes. Microbes Infect 6:1182-1190.
11. Corke C, Glenister K, Watson T. 2001. Circulating secretory phospholipase A2 in critical illness - The importance of the intestine. Crit Care Resusc 3:244-249.
12. Cummings BS. 2007. Phospholipase A2 as targets for anti-cancer drugs. Biochem Pharmacol 74:949-959.
13. Cummings BS, McHowat J, Schnellmann RG. 2000. Phospholipase A(2)s in cell injury and death. J Pharmacol Exp Ther 294:793-799.
14. D'Aversa TG, Eugenin EA, Berman JW. 2008. CD40-CD40 ligand interactions in human microglia induce CXCL8 (interleukin-8) secretion by a mechanism dependent on activation of ERK1/2 and nuclear translocation of nuclear factor-kappaB (NFkappaB) and activator protein-1 (AP-1). J Neurosci Res 86:630-639.
15. Dan P, Nitzan DW, Dagan A, Ginsburg I, Yedgar S. 1996. H2O2 renders cells accessible to lysis by exogenous phospholipase A2: A novel mechanism for cell damage in inflammatory processes. FEBS Lett 383:75-78.
16. Dastur DK, Manghani DK, Udani PM. 1995. Pathology and pathogenetic mechanisms in neurotuberculosis. Radiol Clin North Am 33:733-752.
17. Dimayuga FO, Wang C, Clark JM, Dimayuga ER, Dimayuga VM, Bruce-Keller AJ. 2007. SOD1 overexpression alters ROS production and reduces neurotoxic inflammatory signaling in microglial cells. J Neuroimmunol 182:89-99.
18. Farooqui AA, Yang HC, Rosenberger TA, Horrocks LA. 1997. Phospholipase A2 and its role in brain tissue. J Neurochem 69:889-901.
19. Foey AD, Brennan FM. 2004. Conventional protein kinase C and atypical protein kinase Czeta differentially regulate macrophage production of tumour necrosis factor-alpha and interleukin-10. Immunology 112:44-53.
20. Fonteh AN, Marion CR, Barham BJ, Edens MB, Atsumi G, Samet JM, High KP, Chilton FH. 2001. Enhancement of mast cell survival: A novel function of some secretory phospholipase A(2) isotypes. J Immunol 167:4161-4171.
21. Gao HM, Hong JS, Zhang W, Liu B. 2002. Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons. J Neurosci 22:782-790.
22. Gao HM, Hong JS, Zhang W, Liu B. 2003. Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: Relevance to the etiology of Parkinson's disease. J Neurosci 23:1228-1236.
23. Gilroy DW, Newson J, Sawmynaden P, Willoughby DA, Croxtall JD. 2004. A novel role for phospholipase A2 isoforms in the checkpoint control of acute inflammation. FASEB J 18:489-498.
24. Girgis NI, Sultan Y, Farid Z, Mansour MM, Erian MW, Hanna LS, Mateczun AJ. 1998. Tuberculosis meningitis, Abbassia fever hospital-naval medical research unit No 3-Cairo, Egypt, from 1976 to 1996. Am J Trop Med Hyg 58:28-34.
25. Giulian D, Baker TJ. 1986. Characterization of ameboid microglia isolated from developing mammalian brain. J Neurosci 6:2163-2178.
26. Granata F, Frattini A, Loffredo S, Del Prete A, Sozzani S, Marone G, Triggiani M. 2006. Signaling events involved in cytokine and chemokine production induced by secretory phospholipase A2 in human lung macrophages. Eur J Immunol 36:1938-1950.
27. Granata F, Petraroli A, Boilard E, Bezzine S, Bollinger J, Del Vecchio L, Gelb MH, Lambeau G, Marone G, Triggiani M. 2005. Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor. J Immunol 174:464-474.
28. Gronroos JO, Laine VJ, Janssen MJ, Egmond MR, Nevalainen TJ. 2001. Bactericidal properties of group IIA, group V phospholipases A2. J Immunol 166:4029-4034.
29. Häacker H, Karin M. 2006. Regulation and function of IKK and IKK-related kinases. Sci STKE 2006:re13.
30. Hanasaki K. 2004. Mammalian phospholipase A2: Phospholipase A2 receptor. Biol Pharm Bull 27:1165-1167.
31. Harris JE, Nuttall RK, Elkington PT, Green JA, Horncastle DE, Graeber MB, Edwards DR, Friedland JS. 2007. Monocyte-astrocyte networks regulate matrix metalloproteinase gene expression and secretion in central nervous system tuberculosis in vitro and in vivo. J Immunol 178:1199-1207.
32. Hosoglu S, Geyik MF, Balik I, Aygen B, Erol S, Aygencel TG, Mert A, Saltoglu N, Dokmetas I, Felek S, Sunbul M, Irmak H, Aydin K, Kokoglu OF, Ucmak H, Altindis M, Loeb M. 2002. Predictors of outcome in patients with tuberculous meningitis. Int J Tuberc Lung Dis 6:64-70.
33. Hurt-Camejo E, Camejo G, Peilot H, Oorni K, Kovanen P. 2001. Phospholipase A(2) in vascular disease. Circ Res 89:298-304.
34. Huwiler A, Staudt G, Kramer RM, Pfeilschifter J. 1997. Cross-talk between secretory phospholipase A2 and cytosolic phospholipase A2 in rat renal mesangial cells. Biochim Biophys Acta 1348:257-272.
35. Kreutzberg GW. 1996. Microglia: A sensor for pathological events in the CNS. Trends Neurosci 19:312-318.
36. Lambeau G, Gelb MH. 2008. Biochemistry and physiology of mammalian secreted phospholipases A(2). Annu Rev Biochem 77:495-520.
37. Leonard JM, Des Prez RM. 1990. Tuberculous meningitis. Infect Dis Clin North Am 4:769-787.
38. Mathisen GH, Thorkildsen IH, Paulsen RE. 2007. Secretory PLA2-IIA and ROS generation in peripheral mitochondria are critical for neuronal death. Brain Res 1153:43-51.
39. Matsuura E, Umehara F, Hashiguchi T, Fujimoto N, Okada Y, Osame M. 2000. Marked increase of matrix metalloproteinase 9 in cerebrospinal fluid of patients with fungal or tuberculous meningoencephalitis. J Neurol Sci 173:45-52.
40. Meyer MC, Rastogi P, Beckett CS, McHowat J. 2005. Phospholipase A2 inhibitors as potential anti-inflammatory agents. Curr Pharm Des 11:1301-1312.
41. Mucke L, Eddleston M. 1993. Astrocytes in infectious and immunemediated diseases of the central nervous system. FASEB J 7:1226-1232.
42. Murakami M, Shimbara S, Kambe T, Kuwata H, Winstead MV, Tischfield JA, Kudo I. 1998. The functions of five distinct mammalian phospholipase A2S in regulating arachidonic acid release. Type IIa and type V secretory phospholipase A2S are functionally redundant and act in concert with cytosolic phospholipase A2. J Biol Chem 273:14411-14423.
43. Muralikrishna Adibhatla R, Hatcher JF. 2006. Phospholipase A2, reactive oxygen species, and lipid peroxidation in cerebral ischemia. Free Radic Biol Med 40:376-387.
44. Nevalainen TJ, Graham GG, Scott KF. 2008. Antibacterial actions of secreted phospholipases A2. Review. Biochim Biophys Acta 1781: 1-9.
45. Perry VH, Andersson PB, Gordon S. 1993. Macrophages and inflammation in the central nervous system. Trends Neurosci 16:268-273.
46. Price NM, Farrar J, Tran TT, Nguyen TH, Tran TH, Friedland JS. 2001. Identification of a matrix-degrading phenotype in human tuberculosis in vitro and in vivo. J Immunol 166:4223-4230.
47. Pruzanski W, Vadas P, Browning J. 1993. Secretory non-pancreatic group II phospholipase A2: Role in physiologic and inflammatory processes. J Lipid Mediat 8:161-167.
48. Pyo H, Jou I, Jung S, Hong S, Joe EH. 1998. Mitogen-activated protein kinases activated by lipopolysaccharide and beta-amyloid in cultured rat microglia. Neuroreport 9:871-874.
49. Ramilo O, Saez-Llorens X, Mertsola J, Jafari H, Olsen KD, Hansen EJ, Yoshinaga M, Ohkawara S, Nariuchi H, McCracken GH Jr. 1990. Tumor necrosis factor alpha/cachectin and interleukin 1 beta initiate meningeal inflammation. J Exp Med 172:497-507.
50. Rock RB, Hu S, Gekker G, Sheng WS, May B, Kapur V, Peterson PK. 2005. Mycobacterium tuberculosis-induced cytokine and chemokine expression by human microglia and astrocytes: Effects of dexamethasone. J Infect Dis 192:2054-2058.
51. Sapirstein A, Spech RA, Witzgall R, Bonventre JV. 1996. Cytosolic phospholipase A2 (PLA2), but not secretory PLA2, potentiates hydrogen peroxide cytotoxicity in kidney epithelial cells. J Biol Chem 271:21505-21513.
52. Springer DM. 2001. An update on inhibitors of human 14 kDa Type II s-PLA2 in development. Curr Pharm Des 7:181-198.
53. Sun GY, Xu J, Jensen MD, Simonyi A. 2004. Phospholipase A2 in the central nervous system: Implications for neurodegenerative diseases. J Lipid Res 45:205-213.
54. Thwaites GE, Simmons CP, Than Ha Quyen N, Thi Hong Chau T, Phuong Mai P, Thi Dung N, Hoan Phu N, White NP, Tinh Hien T, Farrar JJ. 2003. Pathophysiology and prognosis in vietnamese adults with tuberculous meningitis. J Infect Dis 188:1105-1115.
55. Triggiani M, Granata F, Giannattasio G, Marone G. 2005. Secretory phospholipases A2 in inflammatory and allergic diseases: Not just enzymes. J Allergy Clin Immunol 116:1000-1006.
56. Xu J, Weng YI, Simonyi A, Krugh BW, Liao Z, Weisman GA, Sun GY. 2002. Role of PKC and MAPK in cytosolic PLA2 phosphorylation and arachadonic acid release in primary murine astrocytes. J Neurochem 83:259-270.
57. Yang CS, Ko SR, Cho BG, Shin DM, Yuk JM, Li S, Kim JM, Evans RM, Jung JS, Song DK, Jo EK. 2007a. The ginsenoside metabolite compound K, a novel agonist of glucocorticoid receptor, induces tolerance to endotoxin-induced lethal shock. J Cell Mol Med doi:10.1111/j. 1582-4934.2007.00181.x
58. Yang CS, Lee DS, Song CH, An SJ, Li S, Kim JM, Kim CS, Yoo DG, Jeon BH, Yang HY, Lee TH, Lee ZW, El-Benna J, Yu DY, Jo EK. 2007b. Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock. J Exp Med 204:583-594.
59. Yang CS, Lee HM, Lee JY, Kim JA, Lee SJ, Shin DM, Lee YH, Lee DS, El-Benna J, Jo EK. 2007c. Reactive oxygen species and p47phox activation are essential for the Mycobacterium tuberculosis-induced proinflammatory response in murine microglia. J Neuroinflammation 4:27.
60. Yang CS, Lee JS, Song CH, Hur GM, Lee SJ, Tanaka S, Akira S, Paik TH, Jo EK. 2007d. Protein kinase C zeta plays an essential role for Mycobacterium tuberculosis-induced extracellular signal-regulated kinase 1/2 activation in monocytes/macrophages via Toll-like receptor 2. Cell Microbiol 9:382-396.
61. Zhang XF, Settleman J, Kyriakis JM, Takeuchi-Suzuki E, Elledge SJ, Marshall MS, Bruder JT, Rapp UR, Avruch J. 1993. Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. Nature 364:308-313.