Targeting neural precursors in the adult brain rescues injured dopamine neurons

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 32, 2009, Pages 13570-13575

  Androutsellis Theotokis, Andreas ^a   Rueger, Maria A ^a   Park, Deric M ^a   Mkhikian, Haik ^a   Korb, Erica ^a   Poser, Steve W ^a   Walbridge, Stuart ^a   Munasinghe, Jeeva ^b   Koretsky, Alan P ^b   Lonser, Russel R ^a   McKay, Ronald D ^a,c  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c Porter Neuroscience Research Center   (United States)

Author keywords

Neural stem cell; Vascular system

Indexed keywords

ANGIOPOIETIN 2; ANGIOPOIETIN RECEPTOR; GROWTH FACTOR; INSULIN; JANUS KINASE INHIBITOR; NOTCH LIGAND DII4; NOTCH RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HES 3; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CELL PROTECTION; CONTROLLED STUDY; DENSITY; DOPAMINERGIC NERVE CELL; LOCOMOTION; MALE; NEURAL STEM CELL; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; VASCULARIZATION;

ANGIOGENESIS INDUCING AGENTS; ANGIOGENESIS INHIBITORS; ANIMALS; BLOOD VESSELS; BRAIN; CELL DEATH; CYTOPROTECTION; DOPAMINE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, TIE-2; STEM CELLS;

EID: 69449089987     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0905125106     Document Type: Article

References (40)

1. Kim JH, et al. (2002) Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease. Nature 418:50-56. (Pubitemid 34742566)
2. Perrier AL, et al. (2004) Derivation of midbrain dopamine neurons from human embryonic stem cells. Proc Natl Acad Sci USA 101:12543-12548. (Pubitemid 39122060)
3. Roy NS, et al. (2006) Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nat Med 12:1259-1268.
4. Freed CR, et al. (2001) Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N Engl J Med 344:710-719.
5. Hagell P, et al. (2002) Dyskinesias following neural transplantation in Parkinson's disease. Nat Neurosci 5:627-628. (Pubitemid 34742975)
6. Olanow CW, et al. (2003) A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Ann Neurol 54:403-414. (Pubitemid 37072046)
7. Kordower JH, et al. (2000) Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science 290:767-773.
8. Hatakeyama J, et al. (2004) Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation. Development 131:5539-5550. (Pubitemid 39625198)
9. Androutsellis-Theotokis A, et al. (2006) Notch signalling regulates stem cell numbers in vitro and in vivo. Nature 442:823-826. (Pubitemid 44258913)
10. Suri C, et al. (1996) Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 87:1171-1180. (Pubitemid 27010101)
11. Maisonpierre PC, et al. (1997) Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277:55-60.
12. Uemura A, et al. (2002) Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells. J Clin Invest 110:1619-1628. (Pubitemid 35424240)
13. Arai F, et al. (2004) Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 118:149-161. (Pubitemid 38962572)
14. Ferri AL, et al. (2004) Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain. Development 131:3805-3819.
15. Ravin R, et al. (2008) Potency and fate specification in CNS stem cell populations in vitro. Cell Stem Cell 3:670-680.
16. Androutsellis-Theotokis A, Rueger MA,Mkhikian H, Korb E, McKayRD(2008) Signaling pathways controlling neural stem cells slow progressive brain disease. Cold Spring Harb Symp Quant Biol 73:403-410.
17. Williams J, et al. (2007) Hypoinsulinemia regulates amphetamine-induced reverse transport of dopamine. PLoS Biol 5:e274.
18. Jagannathan J, Walbridge S, Butman JA, Oldfield EH, Lonser RR (2008) Effect of ependymal and pial surfaces on convection-enhanced delivery. J Neurosurg 109:547-552.
19. Craig CG, et al. (1996) In vivo growth factor expansion of endogenous subependymal neural precursor cell populations in the adult mouse brain. J Neurosci 16:2649-2658.
20. Paxinos G, Watson C (1998) The Rat Brain in Stereotaxic Coordinates. (Elsevier/ Academic Press, New York, NY).
21. Palmer TD, Willhoite AR, Gage FH (2000) Vascular niche for adult hippocampal neurogenesis. J Comp Neurol 425:479-494.
22. Yoshida S, Sukeno M, Nabeshima Y (2007) A vasculature-associated niche for undifferentiated spermatogonia in the mouse testis. Science 317:1722-1726. (Pubitemid 47461832)
23. Kiel MJ, Morrison SJ (2008) Uncertainty in the niches that maintain haematopoietic stem cells. Nat Rev Immunol 8:290-301.
24. Duarte A, et al. (2004) Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev 18:2474-2478. (Pubitemid 39362889)
25. Shen Q, et al. (2004) Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells. Science 304:1338-1340. (Pubitemid 38697433)
26. Przedborski S, et al. (1995) Dose-dependent lesions of the dopaminergic nigrostriatal pathway induced by intrastriatal injection of 6-hydroxydopamine. Neuroscience 67:631-647.
27. Silva AC, Lee JH, Aoki I, Koretsky AP (2004) Manganese-enhanced magnetic resonance imaging (MEMRI): Methodological and practical considerations. NMR Biomed 17:532-543. (Pubitemid 40124779)
28. Russo SJ, et al. (2007) IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates. Nat Neurosci 10:93-99.
29. Langston JW, Ballard P, Tetrud JW, Irwin I (1983) Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219:979-980. (Pubitemid 13189531)
30. Dauer W, Przedborski S (2003) Parkinson's disease: Mechanisms and models. Neuron 39:889-909.
31. Hoglinger GU, Rizk P, Muriel MP, Duyckaerts C, Oertel WH et al. (2004) Dopamine depletion impairs precursor cell proliferation in Parkinson disease. Nat Neurosci 7:726-735. (Pubitemid 38859057)
32. Brochard V, et al. (2009) Infiltration of CD4+lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J Clin Invest 119:182-192.
33. Evans JR, Barker RA (2008) Neurotrophic factors as a therapeutic target for Parkinson's disease. Expert Opin Ther Targets 12:437-447. (Pubitemid 351546370)
34. Marchetto MC, et al. (2008) Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell 3:649-657.
35. Zacchigna S, Lambrechts D, Carmeliet P (2008) Neurovascular signalling defects in neurodegeneration. Nat Rev Neurosci 9:169-181.
36. Armulik A, Abramsson A, Betsholtz C (2005) Endothelial/pericyte interactions. Circ Res 97:512-523.
37. Hellstrom M, et al. (2007) Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 445:776-780. (Pubitemid 46279716)
38. Langston JW, et al. (1999) Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine exposure. Ann Neurol 46:598-605.
39. Fiedler U, et al. (2006) Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Nat Med 12:235-239. (Pubitemid 43214752)
40. Amsen D, et al. (2004) Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell 117:515-526. (Pubitemid 38610236)