Manganese-enhanced magnetic resonance imaging (MEMRI): Methodological and practical considerations

NMR in Biomedicine

Volumn 17, Issue 8, 2004, Pages 532-543

  Silva, Afonso C ^a   Lee, Jung Hee ^a   Aoki, Ichio ^b   Koretsky, Alan P ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b MEIJI UNIVERSITY OF INTEGRATIVE MEDICINE   (Japan)

Author keywords

Animal models; Brain; Contrast agents; Heart; Imaging; Manganese; Mouse; Rat

Indexed keywords

BRAIN; DRUG DOSAGE; ECOLOGY; LIVING SYSTEMS STUDIES; MANGANESE; NEURAL NETWORKS; POSITIVE IONS;

ANATOMY; HEART; MANGANESE-ENHANCED MAGNETIC RESONANCE IMAGING (MEMRI); MOLECULAR IMAGING; NEURAL CIRCUITS;

MAGNETIC RESONANCE IMAGING;

BICINE; BUFFER; MANGANESE CHLORIDE; NUCLEAR MAGNETIC RESONANCE IMAGING AGENT; UNCLASSIFIED DRUG;

ATAXIA; BRAIN CELL; BRAIN FUNCTION; CENTRAL NERVOUS SYSTEM DISEASE; CONTRAST ENHANCEMENT; CONVULSION; CYTOARCHITECTURE; DIAGNOSTIC APPROACH ROUTE; DOSE TIME EFFECT RELATION; DRUG CYTOTOXICITY; DRUG FORMULATION; DRUG SYNTHESIS; EMOTIONAL DISORDER; EYE IRRITATION; FACIES; GAIT DISORDER; GELASTIC SEIZURE; HEART CONTRACTION; HUMAN; IN VIVO STUDY; LEG MUSCLE; LOW DRUG DOSE; LUNG TOXICITY; MALE INFERTILITY; MANGANESE ENHANCED MAGNETIC RESONANCE IMAGING; METABOLISM; METHODOLOGY; MOLECULAR IMAGING; MUSCLE WEAKNESS; NERVE CELL NETWORK; NEUROANATOMY; NEUROTOXICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PARKINSONISM; PNEUMONIA; PRIORITY JOURNAL; REVIEW; SAFETY; SKIN IRRITATION; SOMNOLENCE; TREMOR;

ANIMALS; BRAIN; CONTRAST MEDIA; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART; HUMANS; IMAGE ENHANCEMENT; MAGNETIC RESONANCE IMAGING; MANGANESE; MYOCARDIUM; NEURAL PATHWAYS;

ANIMALIA;

EID: 12344296675     PISSN: 09523480     EISSN: None     Source Type: Journal    
DOI: 10.1002/nbm.945     Document Type: Review

References (63)

1. Lin YJ, Koretsky AP. Manganese ion enhances T 1-weighted MRI during brain activation: an approach to direct imaging of brain function. Magn. Reson. Med. 1997; 38: 378-388.
2. 2. Ph.D. Dissertation, Carnegie Mellon University, Pittsburgh, PA, 1997; 1-149.
3. Duong TQ, Silva AC, Lee SP, Kim SG. Functional MRI of calcium-dependent synaptic activity: cross correlation with CBF and BOLD measurements. Magn. Reson. Med. 2000; 43: 383-392.
4. Aoki I, Tanaka C, Takegami T, Ebisu T, Umeda M, Fukunaga M, Fukuda K, Silva AC, Koretsky AP, Naruse S. Dynamic activity-induced manganese-dependent contrast magnetic resonance imaging (DAIM MRI). Magn. Reson. Med. 2002; 48: 927-933.
5. Hu TC, Pautler RG, MacGowan GA, Koretsky AP. Manganese-enhanced MRI of mouse heart during changes in inotropy. Magn. Reson. Med. 2001; 46: 884-890.
6. Krombach GA, Saeed M, Higgins CB, Novikov V, Wendland MF. Contrast-enhanced MR delineation of stunned myocardium with administration of MnCl(2) in rats. Radiology 2004; 230: 183-190.
7. Pautler RG, Silva AC, Koretsky AP. In vivo neuronal tract tracing using manganese-enhanced magnetic resonance imaging. Magn. Reson. Med. 1998; 40: 740-748.
8. Pautler RG, Koretsky AP. Tracing odor-induced activation in the olfactory bulbs of mice using manganese-enhanced magnetic resonance imaging. Neuroimage 2002; 16: 441-448.
9. 2+-induced contrast. Magn. Reson. Med. 2001; 46: 424-429.
10. Lin CP, Tseng WY, Cheng HC, Chen JH. Validation of diffusion tensor magnetic resonance axonal fiber imaging with registered manganese-enhanced optic tracts. Neuroimage 2001; 14: 1035-1047.
11. Ryu S, Brown SL, Kolozsvary A, Ewing JR, Kim JH. Noninvasive detection of radiation-induced optic neuropathy by manganese-enhanced MRI. Radiat. Res. 2002; 157: 500-505.
12. 2. NMR Biomed. 2003; 16: 252-256.
13. Van der LA, Verboye M, Van MV, Tindemans I, Eens M, Absil P, Balthazart J. In vivo manganese-enhanced magnetic resonance imaging reveals connections and functional properties of the songbird vocal control system. Neuroscience 2002; 112: 467-474.
14. Saleem KS, Pauls JM, Augath M, Trinath T, Prause BA, Hashikawa T, Logothetis NK. Magnetic resonance imaging of neuronal connections in the macaque monkey. Neuron 2002; 34: 685-700.
15. Aoki I, Wu YJ, Silva AC, Lynch RM, Koretsky AP. In vivo detection of neuroarchitecture in the rodent brain using manganese-enhanced MRI. Neuroimage 2004; 22: 1046-1059.
16. Natt O, Watanabe T, Boretius S, Radulovic J, Frahm J, Michaelis T. High-resolution 3D MRI of mouse brain reveals small cerebral structures in vivo. J. Neurosci. Meth. 2002; 120: 203-209.
17. 2. Magn. Reson. Med. 2002; 48: 852-859.
18. Olanow CW. Manganese-induced parkinsonism and Parkinson's disease. Ann. NY Acad. Sci. 2004; 1012: 209-223.
19. Chandra SV, Shukla GS. Role of iron deficiency in inducing susceptibility to manganese toxicity. Arch. Toxicol. 1976; 35 319-323.
20. 1 response to manganese injection in the dog and rabbit. AJR Am. J. Roentgenol. 1983; 141: 193-197.
21. Guyton AC. Textbook of Medical Physiology, Wonsiewicz MJ (ed.). WB Saunders: Philadelphia, PA, 1991; 1-1014.
22. 1-weighted MRI. Auton. Neurosci. 2004; 113: 43-54.
23. Desoize B. Metals and metal compounds in carcinogenesis. In Vivo 2003; 17: 529-539.
24. 1 contrast. Magn. Reson. Med. 2004 (in press).
25. Mendonca-Dias MH, Gaggelli E, Lauterbur PC. Paramagnetic contrast agents in nuclear magnetic resonance medical imaging. Semin. Nucl. Med. 1983; 13: 364-376.
26. Fornasiero D, Bellen JC, Baker RJ, Chatterton BE. Paramagnetic complexes of manganese(II), iron(III), and gadolinium(III) as contrast agents for magnetic resonance imaging. The influence of stability constants on the biodistribution of radioactive amino-polycarboxylate complexes. Invest. Radiol. 1987; 22: 322-327.
27. Kang YS, Gore JC. Studies of tissue NMR relaxation enhancement by manganese: dose and time dependences. Invest. Radiol. 1984; 19: 399-407.
28. Nordhoy W, Anthonsen HW, Bruvold M, Jynge P, Krane J, Brurok H. Manganese ions as intracellular contrast agents: proton relaxation and calcium interactions in rat myocardium. NMR Biomed. 2003; 16: 82-95.
29. 1 relaxation in rat myocardium. Magn. Reson. Med. 2004; 52: 506-514.
30. Unger E, Fritz T, Shen DK, Wu G. Manganese-based liposomes. Comparative approaches. Invest. Radiol. 1993; 28: 933-938.
31. Mauss Y, Grucker D, Fornasiero D, Chambron J. NMR compartmentalization of free water in the perfused rat heart. Magn. Reson. Med. 1985; 2: 187-194.
32. Lauterbur PC, Mendonca-Dias M, Rudin A. Augmentation of tissue water proton spin-lattice relaxation rates by in vivo addition of paramagnetic ions. In Frontiers of Biological Energetics Dutton P, Leigh JS, Scarpa A (eds). Academic Press: New York, 1978; 752-759.
33. Hollis DP, Bulkley BH, Nunnally RL, Jacobus WE, Weisfeldt ML. Effect of manganese ion on phosphorus nuclear magnetic-resonance spectra of perfused rabbit heart - possible new membrane probe. Clin. Res. 1978; 26: A240.
34. Saeed M, Higgins CB, Geschwind JF, Wendland MF. T 1-relaxation kinetics of extracellular, intracellular and intravascular MR contrast agents in normal and acutely reperfused infarcted myocardium using echo-planar MR imaging. Eur. Radiol. 2000; 10: 310-318.
35. Federle MP, Chezmar JL, Rubin DL, Weinreb JC, Freeny PC, Semelka RC, Brown JJ, Borello JA, Lee JK, Mattrey R, Dachman AH, Sami S, Harmon B, Fenstermacher M, Pelsang RE, Harms SE, Mitchell DG, Halford HH, Anderson MW, Johnson CD, Francis IR, Bova JG, Kenney PJ, Klippenstein DL, Foster GS, Turner DA. Safety and efficacy of mangafodipir trisodium (MnDPDP) injection for hepatic MRI in adults: results of the U.S. multicenter phase III clinical trials (safety). J. Magn. Reson. Imag. 2000; 12: 186-197.
36. Wendland MF, Saeed M, Lund G, Higgins CB. Contrast-enhanced MRI for quantification of myocardial viability. J. Magn. Reson. Imag. 1999; 10: 694-702.
37. Brurok H, Skoglund T, Berg K, Skarra S, Karlsson JO, Jynge P. Myocardial manganese elevation and proton relaxivity enhancement with manganese dipyridoxyl diphosphate. Ex vivo assessments in normally perfused and ischemic guinea pig hearts. NMR Biomed. 1999; 12 364-372.
38. Bremerich J, Saeed M, Arheden H, Higgins CB, Wendland MF. Normal and infarcted myocardium: differentiation with cellular uptake of manganese at MR imaging in a rat model. Radiology 2000; 216: 524-530.
39. Gallez B, Bacic GG, Swartz HM. Evidence for the dissociation of the hepatobiliary MRI contrast agent Mn-DPDP. Magn. Reson. Med. 1996; 35: 14-19.
40. Barbeau A. Manganese and extrapyramidal disorders (a critical review and tribute to Dr. George C. Cotzias). Neurotoxicology 1984; 5: 13-35.
41. London RE, Toney G, Gabel SA, Funk A. Magnetic resonance imaging studies of the brains of anesthetized rats treated with manganese chloride. Brain Res. Bull. 1989; 23: 229-235.
42. Wan XM, Fu TC, Smith PH, Brainard JR, London RE. Magnetic resonance imaging study of the rat cerebral ventricular system utilizing intracerebrally administered contrast agents. Magn. Reson. Med. 1991; 21: 97-106.
43. Newland MC, Ceckler TL, Kordower JH, Weiss B. Visualizing manganese in the primate basal ganglia with magnetic resonance imaging. Exp. Neurol. 1989; 106: 251-258.
44. Lucchini R, Albini E, Placidi D, Gasparotti R, Pigozzi MG, Montani G, Alessio L. Brain magnetic resonance imaging and manganese exposure. Neurotoxicology 2000; 21: 769-775.
45. Murphy VA, Rosenberg JM, Smith QR, Rapoport SI. Elevation of brain manganese in calcium-deficient rats. Neurotoxicology 1991; 12: 255-263.
46. Rabin O, Hegedus L, Bourre JM, Smith QR. Rapid brain uptake of manganese(II) across the blood-brain barrier. J. Neurochem. 1993; 61: 509-517.
47. Sloot WN, Gramsbergen JB. Axonal transport of manganese and its relevance to selective neurotoxicity in the rat basal ganglia. Brain Res. 1994; 657: 124-132.
48. Takeda A, Sawashita J, Okada S. Localization in rat brain of the trace metals, zinc and manganese, after intracerebroventricular injection. Brain Res. 1994; 658: 252-254.
49. Liu CH, D'Arceuil HE, de Crespigny AJ. Direct CSF injection of MnCl(2) for dynamic manganese-enhanced MRI. Magn. Reson. Med. 2004; 51: 978-987.
50. Drapeau P, Nachshen DA. Manganese fluxes and manganese-dependent neurotransmitter release in presynaptic nerve endings isolated from rat brain. J. Physiol 1984; 348: 493-510.
51. Narita K, Kawasaki F, Kita H. Mn and Mg influxes through Ca channels of motor nerve terminals are prevented by verapamil in frogs. Brain Res. 1990; 510: 289-295.
52. Hunter DR, Haworth RA, Berkoff HA. Cellular manganese uptake by the isolated perfused rat heart: a probe for the sarcolemma calcium channel. J. Mol. Cell Cardiol. 1981; 13: 823-832.
53. Hallam TJ, Rink TJ. Agonists stimulate divalent cation channels in the plasma membrane of human platelets. FEBS Lett. 1985; 186: 175-179.
54. Shibuya I, Douglas WW. Indications from Mn-quenching of Fura-2 fluorescence in melanotrophs that dopamine and baclofen close Ca channels that are spontaneously open but not those opened by high [K+]O; and that Cd preferentially blocks the latter. Cell Calcium 1993; 14: 33-44.
55. Neuwelt EA, Frenkel EP, Diehl JT, Maravilla KR, Vu LH, Clark WK, Rapoport SI, Barnett PA, Hill SA, Lewis SE, Ehle AL, Beyer CW Jr, Moore RJ. Osmotic blood-brain barrier disruption: a new means of increasing chemotherapeutic agent delivery. Trans. Am. Neurol. Assoc. 1979; 104: 256-260.
56. Silva AC, Zhang W, Williams DS, Koretsky AP. Estimation of water extraction fractions in rat brain using magnetic resonance measurement of perfusion with arterial spin labeling. Magn. Reson. Med. 1997; 37: 58-68.
57. Morita H, Ogino T, Seo Y, Fujiki N, Tanaka K, Takamata A, Nakamura S, Murakami M. Detection of hypothalamic activation by manganese ion contrasted T(1)-weighted magnetic resonance imaging in rats. Neurosci. Lett. 2002; 326: 101-104.
58. Aoki I, Ebisu T, Tanaka C, Katsuta K, Fujikawa A, Umeda M, Fukunaga M, Takegami T, Shapiro EM, Naruse S. Detection of the anoxic depolarization of focal ischemia using manganese-enhanced MRI. Magn. Reson. Med. 2003; 50: 7-12.
59. 2 and MnDPDP on the isolated and perfused rat heart. Invest. Radiol. 1997; 32: 581-588.
60. Tjalve H, Henriksson J, Tallkvist J, Larsson BS, Lindquist NG. Uptake of manganese and cadmium from the nasal mucosa into the central nervous system via olfactory pathways in rats. Pharmac. Toxicol. 1996; 79: 347-356.
61. Pautler RG, Mongeau R, Jacobs RE. In vivo trans-synaptic tract tracing from the murine striatum and amygdala utilizing manganese enhanced MRI (MEMRI). Magn. Reson. Med. 2003; 50: 33-39.
62. Tindemans I, Verhoye M, Balthazart J, Van der LA. In vivo dynamic ME-MRI reveals differential functional responses of RA- and area X-projecting neurons in the HVC of canaries exposed to conspecific song. Eur. J. Neurosci. 2003; 18: 3352-3360.
63. Van Meir V, Verhoye M, Absil P, Eens M, Balthazart J, Van der Linden A. Differential effects of testosterone on neuronal populations and their connections in a sensorimotor brain nucleus controlling song production in songbirds: a manganese enhanced-magnetic resonance imaging study. Neuroimage 2004; 21: 914-923.